The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-10

AUTHORS

Uwe Ernsberger, Thomas Deller, Hermann Rohrer

ABSTRACT

During the last 30 years, our understanding of the development and diversification of postganglionic sympathetic neurons has dramatically increased. In parallel, the list of target structures has been critically extended from the cardiovascular system and selected glandular structures to metabolically relevant tissues such as white and brown adipose tissue, lymphoid tissues, bone, and bone marrow. A critical question now emerges for the integration of the diverse sympathetic neuron classes into neural circuits specific for these different target tissues to achieve the homeostatic regulation of the physiological ends affected. More... »

PAGES

455-475

References to SciGraph publications

  • 2021-04-30. Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord in NATURE COMMUNICATIONS
  • 2020-11-30. Recent progress on peripheral neural interface technology towards bioelectronic medicine in BIOELECTRONIC MEDICINE
  • 2016-01-27. Generating trunk neural crest from human pluripotent stem cells in SCIENTIFIC REPORTS
  • 2019-04-23. Obesity, kidney dysfunction and hypertension: mechanistic links in NATURE REVIEWS NEPHROLOGY
  • 2017-06-19. Regulation of neural circuit formation by protocadherins in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2020-09-15. The diversity of neuronal phenotypes in rodent and human autonomic ganglia in CELL AND TISSUE RESEARCH
  • 2018-03-15. Combination Therapy of Renin Angiotensin System Inhibitors and β-Blockers in Patients with Heart Failure in HEART FAILURE: FROM RESEARCH TO CLINICAL PRACTICE
  • 1999-05. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives in NATURE
  • 2021-02-15. Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons in NATURE NEUROSCIENCE
  • 2017-07-24. Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries in NATURE GENETICS
  • 2012-03-29. Renal Denervation in Human Hypertension: Mechanisms, Current Findings, and Future Prospects in CURRENT HYPERTENSION REPORTS
  • 2011-06-19. Sympatho-renal axis in chronic disease in CLINICAL RESEARCH IN CARDIOLOGY
  • 2021-01-06. Neuroblastoma and the epigenome in CANCER AND METASTASIS REVIEWS
  • 2021-02-13. Autonomic Cardiovascular Alterations in Chronic Kidney Disease: Effects of Dialysis, Kidney Transplantation, and Renal Denervation in CURRENT HYPERTENSION REPORTS
  • 2017-10-02. From proliferation to target innervation: signaling molecules that direct sympathetic nervous system development in CELL AND TISSUE RESEARCH
  • 2020-05-29. Refocusing on the Primary Prevention of Heart Failure in CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE
  • 2017-06-26. Neuroblastoma is composed of two super-enhancer-associated differentiation states in NATURE GENETICS
  • 2021-04-08. Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin in NATURE GENETICS
  • 2018-09-13. Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies in NEURAL DEVELOPMENT
  • 2005-11. Long-Term Mathematical Model Involving Renal Sympathetic Nerve Activity, Arterial Pressure, and Sodium Excretion in ANNALS OF BIOMEDICAL ENGINEERING
  • 2019-12-09. ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry in NATURE COMMUNICATIONS
  • 2016-09-24. Leptin as a Mediator of Obesity-Induced Hypertension in CURRENT OBESITY REPORTS
  • 2020-01-08. Spectrum of diabetic neuropathies in DIABETOLOGY INTERNATIONAL
  • 2008-04-01. Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration in NATURE NEUROSCIENCE
  • 2006-05. The sympathetic control of blood pressure in NATURE REVIEWS NEUROSCIENCE
  • 2021-03-25. Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma in NATURE GENETICS
  • 2017-12-08. Neuroblastoma pathogenesis: deregulation of embryonic neural crest development in CELL AND TISSUE RESEARCH
  • 2018-02-10. Cardiovascular Autonomic Dysfunction: Link Between Multiple Sclerosis Osteoporosis and Neurodegeneration in NEUROMOLECULAR MEDICINE
  • 2017-12-05. Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2007-07-16. Prevalence and functional consequence of PHOX2B mutations in neuroblastoma in ONCOGENE
  • 2021-03-02. Further evidence against the role renal medullary perfusion in short-term control of arterial pressure in normotensive and mildly or overtly hypertensive rats in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2005-02-20. Leptin regulation of bone resorption by the sympathetic nervous system and CART in NATURE
  • 2019-12-12. Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes in SCIENTIFIC REPORTS
  • 2016-08-29. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control in NATURE NEUROSCIENCE
  • 2020-03-11. Obesity: sex and sympathetics in BIOLOGY OF SEX DIFFERENCES
  • 2018-01-19. Epigenetic regulation of neuroblastoma development in CELL AND TISSUE RESEARCH
  • 2012-05-22. Differential control of efferent sympathetic activity revisited in THE JOURNAL OF PHYSIOLOGICAL SCIENCES
  • 2017-09-21. Coordinate expression of pan-neuronal and functional signature genes in sympathetic neurons in CELL AND TISSUE RESEARCH
  • 2019-11-27. Obesity: a neuroimmunometabolic perspective in NATURE REVIEWS ENDOCRINOLOGY
  • 2011-11-03. Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications in HYPERTENSION RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00441-021-03548-y

    DOI

    http://dx.doi.org/10.1007/s00441-021-03548-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142500147

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34757495


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neural Pathways", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sympathetic Nervous System", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ernsberger", 
            "givenName": "Uwe", 
            "id": "sg:person.0724350451.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724350451.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deller", 
            "givenName": "Thomas", 
            "id": "sg:person.01125311260.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125311260.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rohrer", 
            "givenName": "Hermann", 
            "id": "sg:person.0620151030.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620151030.20"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41593-020-00795-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135362169", 
              "https://doi.org/10.1038/s41593-020-00795-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-017-2688-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091886382", 
              "https://doi.org/10.1007/s00441-017-2688-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-017-2747-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099703895", 
              "https://doi.org/10.1007/s00441-017-2747-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12017-018-8481-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100960481", 
              "https://doi.org/10.1007/s12017-018-8481-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12576-012-0208-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004575038", 
              "https://doi.org/10.1007/s12576-012-0208-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-020-00286-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125557888", 
              "https://doi.org/10.1186/s13293-020-00286-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029599671", 
              "https://doi.org/10.1038/nature03398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-020-03279-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130847840", 
              "https://doi.org/10.1007/s00441-020-03279-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090882901", 
              "https://doi.org/10.1038/ng.3921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-55382-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123306621", 
              "https://doi.org/10.1038/s41598-019-55382-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-021-00806-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136652391", 
              "https://doi.org/10.1038/s41588-021-00806-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep19727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025794985", 
              "https://doi.org/10.1038/srep19727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045814782", 
              "https://doi.org/10.1038/nn.4376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-017-2773-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100477504", 
              "https://doi.org/10.1007/s00441-017-2773-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-021-02534-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135850671", 
              "https://doi.org/10.1007/s00424-021-02534-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13064-018-0117-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106945588", 
              "https://doi.org/10.1186/s13064-018-0117-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086174245", 
              "https://doi.org/10.1038/ng.3899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s42234-020-00059-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1132949529", 
              "https://doi.org/10.1186/s42234-020-00059-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007292845", 
              "https://doi.org/10.1038/20700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2011.173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037826516", 
              "https://doi.org/10.1038/hr.2011.173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-017-2693-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092065401", 
              "https://doi.org/10.1007/s00441-017-2693-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009793770", 
              "https://doi.org/10.1038/sj.onc.1210659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11906-021-01129-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135368863", 
              "https://doi.org/10.1007/s11906-021-01129-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031858688", 
              "https://doi.org/10.1038/nn.2114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-021-00818-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136995642", 
              "https://doi.org/10.1038/s41588-021-00818-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-020-09946-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1134365508", 
              "https://doi.org/10.1007/s10555-020-09946-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-019-13515-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123225576", 
              "https://doi.org/10.1038/s41467-019-13515-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41581-019-0145-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113639526", 
              "https://doi.org/10.1038/s41581-019-0145-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10439-005-5976-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044233604", 
              "https://doi.org/10.1007/s10439-005-5976-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13679-016-0231-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037615576", 
              "https://doi.org/10.1007/s13679-016-0231-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-017-2090-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093155504", 
              "https://doi.org/10.1007/s00424-017-2090-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-017-2572-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086101655", 
              "https://doi.org/10.1007/s00018-017-2572-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41574-019-0283-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1122916643", 
              "https://doi.org/10.1038/s41574-019-0283-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033414309", 
              "https://doi.org/10.1038/nrn1902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00392-011-0335-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000314765", 
              "https://doi.org/10.1007/s00392-011-0335-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11906-012-0264-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004313574", 
              "https://doi.org/10.1007/s11906-012-0264-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13340-019-00424-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123956496", 
              "https://doi.org/10.1007/s13340-019-00424-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/5584_2018_179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101518394", 
              "https://doi.org/10.1007/5584_2018_179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11936-020-00811-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128009984", 
              "https://doi.org/10.1007/s11936-020-00811-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-021-22691-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1137617921", 
              "https://doi.org/10.1038/s41467-021-22691-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-11-10", 
        "datePublishedReg": "2021-11-10", 
        "description": "During the last 30 years, our understanding of the development and diversification of postganglionic sympathetic neurons has dramatically increased. In parallel, the list of target structures has been critically extended from the cardiovascular system and selected glandular structures to metabolically relevant tissues such as white and brown adipose tissue, lymphoid tissues, bone, and bone marrow. A critical question now emerges for the integration of the diverse sympathetic neuron classes into neural circuits specific for these different target tissues to achieve the homeostatic regulation of the physiological ends affected.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00441-021-03548-y", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1019675", 
            "issn": [
              "0302-766X", 
              "1432-0878"
            ], 
            "name": "Cell and Tissue Research", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "386"
          }
        ], 
        "keywords": [
          "peripheral sympathetic nervous system", 
          "postganglionic sympathetic neurons", 
          "sympathetic nervous system", 
          "brown adipose tissue", 
          "different target tissues", 
          "sympathetic neurons", 
          "lymphoid tissue", 
          "adipose tissue", 
          "bone marrow", 
          "nervous system", 
          "cardiovascular system", 
          "neural circuits", 
          "neuron classes", 
          "neuronal differentiation", 
          "target tissues", 
          "glandular structures", 
          "homeostatic regulation", 
          "tissue", 
          "functional organization", 
          "relevant tissues", 
          "physiological end", 
          "marrow", 
          "neurons", 
          "bone", 
          "target structure", 
          "years", 
          "differentiation", 
          "regulation", 
          "body", 
          "critical questions", 
          "list", 
          "development", 
          "end", 
          "understanding", 
          "questions", 
          "system", 
          "parallel", 
          "organization", 
          "class", 
          "circuit", 
          "integration", 
          "structure", 
          "sympathy", 
          "diversification"
        ], 
        "name": "The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system", 
        "pagination": "455-475", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1142500147"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00441-021-03548-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34757495"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00441-021-03548-y", 
          "https://app.dimensions.ai/details/publication/pub.1142500147"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:31", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_909.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00441-021-03548-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00441-021-03548-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00441-021-03548-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00441-021-03548-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00441-021-03548-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    304 TRIPLES      22 PREDICATES      116 URIs      68 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00441-021-03548-y schema:about N13405451f2c84638b4a253fbf624183b
    2 N2078b29ffde243a09e73f035da5a9b1f
    3 N957c78fa544b4e599dc6fd026e16daec
    4 Nc95b9e2276344eeb86d14829145aba63
    5 Nd0c5538144da44838954e85166d967c1
    6 Nd5c76232a2a84e33bbe4254082c26c82
    7 anzsrc-for:11
    8 anzsrc-for:1109
    9 schema:author Nbf1c618d83a04e33a163f142d52d4492
    10 schema:citation sg:pub.10.1007/5584_2018_179
    11 sg:pub.10.1007/s00018-017-2572-3
    12 sg:pub.10.1007/s00392-011-0335-y
    13 sg:pub.10.1007/s00424-017-2090-z
    14 sg:pub.10.1007/s00424-021-02534-1
    15 sg:pub.10.1007/s00441-017-2688-7
    16 sg:pub.10.1007/s00441-017-2693-x
    17 sg:pub.10.1007/s00441-017-2747-0
    18 sg:pub.10.1007/s00441-017-2773-y
    19 sg:pub.10.1007/s00441-020-03279-6
    20 sg:pub.10.1007/s10439-005-5976-4
    21 sg:pub.10.1007/s10555-020-09946-y
    22 sg:pub.10.1007/s11906-012-0264-9
    23 sg:pub.10.1007/s11906-021-01129-6
    24 sg:pub.10.1007/s11936-020-00811-3
    25 sg:pub.10.1007/s12017-018-8481-2
    26 sg:pub.10.1007/s12576-012-0208-9
    27 sg:pub.10.1007/s13340-019-00424-7
    28 sg:pub.10.1007/s13679-016-0231-x
    29 sg:pub.10.1038/20700
    30 sg:pub.10.1038/hr.2011.173
    31 sg:pub.10.1038/nature03398
    32 sg:pub.10.1038/ng.3899
    33 sg:pub.10.1038/ng.3921
    34 sg:pub.10.1038/nn.2114
    35 sg:pub.10.1038/nn.4376
    36 sg:pub.10.1038/nrn1902
    37 sg:pub.10.1038/s41467-019-13515-5
    38 sg:pub.10.1038/s41467-021-22691-2
    39 sg:pub.10.1038/s41574-019-0283-6
    40 sg:pub.10.1038/s41581-019-0145-4
    41 sg:pub.10.1038/s41588-021-00806-1
    42 sg:pub.10.1038/s41588-021-00818-x
    43 sg:pub.10.1038/s41593-020-00795-0
    44 sg:pub.10.1038/s41598-019-55382-6
    45 sg:pub.10.1038/sj.onc.1210659
    46 sg:pub.10.1038/srep19727
    47 sg:pub.10.1186/s13064-018-0117-6
    48 sg:pub.10.1186/s13293-020-00286-8
    49 sg:pub.10.1186/s42234-020-00059-z
    50 schema:datePublished 2021-11-10
    51 schema:datePublishedReg 2021-11-10
    52 schema:description During the last 30 years, our understanding of the development and diversification of postganglionic sympathetic neurons has dramatically increased. In parallel, the list of target structures has been critically extended from the cardiovascular system and selected glandular structures to metabolically relevant tissues such as white and brown adipose tissue, lymphoid tissues, bone, and bone marrow. A critical question now emerges for the integration of the diverse sympathetic neuron classes into neural circuits specific for these different target tissues to achieve the homeostatic regulation of the physiological ends affected.
    53 schema:genre article
    54 schema:inLanguage en
    55 schema:isAccessibleForFree true
    56 schema:isPartOf N737ae00ae22d4ca09512324e6d56ec1c
    57 N81ce01f1c3374245a201a4a2d0ba6d34
    58 sg:journal.1019675
    59 schema:keywords adipose tissue
    60 body
    61 bone
    62 bone marrow
    63 brown adipose tissue
    64 cardiovascular system
    65 circuit
    66 class
    67 critical questions
    68 development
    69 different target tissues
    70 differentiation
    71 diversification
    72 end
    73 functional organization
    74 glandular structures
    75 homeostatic regulation
    76 integration
    77 list
    78 lymphoid tissue
    79 marrow
    80 nervous system
    81 neural circuits
    82 neuron classes
    83 neuronal differentiation
    84 neurons
    85 organization
    86 parallel
    87 peripheral sympathetic nervous system
    88 physiological end
    89 postganglionic sympathetic neurons
    90 questions
    91 regulation
    92 relevant tissues
    93 structure
    94 sympathetic nervous system
    95 sympathetic neurons
    96 sympathy
    97 system
    98 target structure
    99 target tissues
    100 tissue
    101 understanding
    102 years
    103 schema:name The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system
    104 schema:pagination 455-475
    105 schema:productId N9aa8aa046a71492ea689f3695016c254
    106 Ndd47a6d16dda43e8af8033f75196852a
    107 Neb00e0408f3e4b0e9264fc9a29432f52
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142500147
    109 https://doi.org/10.1007/s00441-021-03548-y
    110 schema:sdDatePublished 2022-05-10T10:31
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N35e9a37e1476492882da69bff8b74172
    113 schema:url https://doi.org/10.1007/s00441-021-03548-y
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N13405451f2c84638b4a253fbf624183b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Neurons
    119 rdf:type schema:DefinedTerm
    120 N2078b29ffde243a09e73f035da5a9b1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Neural Pathways
    122 rdf:type schema:DefinedTerm
    123 N35e9a37e1476492882da69bff8b74172 schema:name Springer Nature - SN SciGraph project
    124 rdf:type schema:Organization
    125 N737ae00ae22d4ca09512324e6d56ec1c schema:issueNumber 3
    126 rdf:type schema:PublicationIssue
    127 N81ce01f1c3374245a201a4a2d0ba6d34 schema:volumeNumber 386
    128 rdf:type schema:PublicationVolume
    129 N87fcc81ce4274529a4af1b32b76eaf3e rdf:first sg:person.01125311260.54
    130 rdf:rest Na3d964b0413740b4bdd2e7fb0cb16718
    131 N957c78fa544b4e599dc6fd026e16daec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Cell Differentiation
    133 rdf:type schema:DefinedTerm
    134 N9aa8aa046a71492ea689f3695016c254 schema:name dimensions_id
    135 schema:value pub.1142500147
    136 rdf:type schema:PropertyValue
    137 Na3d964b0413740b4bdd2e7fb0cb16718 rdf:first sg:person.0620151030.20
    138 rdf:rest rdf:nil
    139 Nbf1c618d83a04e33a163f142d52d4492 rdf:first sg:person.0724350451.57
    140 rdf:rest N87fcc81ce4274529a4af1b32b76eaf3e
    141 Nc95b9e2276344eeb86d14829145aba63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Humans
    143 rdf:type schema:DefinedTerm
    144 Nd0c5538144da44838954e85166d967c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Animals
    146 rdf:type schema:DefinedTerm
    147 Nd5c76232a2a84e33bbe4254082c26c82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Sympathetic Nervous System
    149 rdf:type schema:DefinedTerm
    150 Ndd47a6d16dda43e8af8033f75196852a schema:name pubmed_id
    151 schema:value 34757495
    152 rdf:type schema:PropertyValue
    153 Neb00e0408f3e4b0e9264fc9a29432f52 schema:name doi
    154 schema:value 10.1007/s00441-021-03548-y
    155 rdf:type schema:PropertyValue
    156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Medical and Health Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Neurosciences
    161 rdf:type schema:DefinedTerm
    162 sg:journal.1019675 schema:issn 0302-766X
    163 1432-0878
    164 schema:name Cell and Tissue Research
    165 schema:publisher Springer Nature
    166 rdf:type schema:Periodical
    167 sg:person.01125311260.54 schema:affiliation grid-institutes:grid.7839.5
    168 schema:familyName Deller
    169 schema:givenName Thomas
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125311260.54
    171 rdf:type schema:Person
    172 sg:person.0620151030.20 schema:affiliation grid-institutes:grid.7839.5
    173 schema:familyName Rohrer
    174 schema:givenName Hermann
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620151030.20
    176 rdf:type schema:Person
    177 sg:person.0724350451.57 schema:affiliation grid-institutes:grid.7839.5
    178 schema:familyName Ernsberger
    179 schema:givenName Uwe
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724350451.57
    181 rdf:type schema:Person
    182 sg:pub.10.1007/5584_2018_179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101518394
    183 https://doi.org/10.1007/5584_2018_179
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/s00018-017-2572-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086101655
    186 https://doi.org/10.1007/s00018-017-2572-3
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1007/s00392-011-0335-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000314765
    189 https://doi.org/10.1007/s00392-011-0335-y
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1007/s00424-017-2090-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093155504
    192 https://doi.org/10.1007/s00424-017-2090-z
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s00424-021-02534-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135850671
    195 https://doi.org/10.1007/s00424-021-02534-1
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/s00441-017-2688-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091886382
    198 https://doi.org/10.1007/s00441-017-2688-7
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/s00441-017-2693-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092065401
    201 https://doi.org/10.1007/s00441-017-2693-x
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s00441-017-2747-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099703895
    204 https://doi.org/10.1007/s00441-017-2747-0
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s00441-017-2773-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1100477504
    207 https://doi.org/10.1007/s00441-017-2773-y
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s00441-020-03279-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130847840
    210 https://doi.org/10.1007/s00441-020-03279-6
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s10439-005-5976-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044233604
    213 https://doi.org/10.1007/s10439-005-5976-4
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s10555-020-09946-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1134365508
    216 https://doi.org/10.1007/s10555-020-09946-y
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s11906-012-0264-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004313574
    219 https://doi.org/10.1007/s11906-012-0264-9
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s11906-021-01129-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135368863
    222 https://doi.org/10.1007/s11906-021-01129-6
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s11936-020-00811-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128009984
    225 https://doi.org/10.1007/s11936-020-00811-3
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s12017-018-8481-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100960481
    228 https://doi.org/10.1007/s12017-018-8481-2
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s12576-012-0208-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004575038
    231 https://doi.org/10.1007/s12576-012-0208-9
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s13340-019-00424-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123956496
    234 https://doi.org/10.1007/s13340-019-00424-7
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s13679-016-0231-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037615576
    237 https://doi.org/10.1007/s13679-016-0231-x
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/20700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007292845
    240 https://doi.org/10.1038/20700
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/hr.2011.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037826516
    243 https://doi.org/10.1038/hr.2011.173
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature03398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029599671
    246 https://doi.org/10.1038/nature03398
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ng.3899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086174245
    249 https://doi.org/10.1038/ng.3899
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ng.3921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090882901
    252 https://doi.org/10.1038/ng.3921
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nn.2114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031858688
    255 https://doi.org/10.1038/nn.2114
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nn.4376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045814782
    258 https://doi.org/10.1038/nn.4376
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nrn1902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033414309
    261 https://doi.org/10.1038/nrn1902
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/s41467-019-13515-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123225576
    264 https://doi.org/10.1038/s41467-019-13515-5
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/s41467-021-22691-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137617921
    267 https://doi.org/10.1038/s41467-021-22691-2
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/s41574-019-0283-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1122916643
    270 https://doi.org/10.1038/s41574-019-0283-6
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/s41581-019-0145-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113639526
    273 https://doi.org/10.1038/s41581-019-0145-4
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/s41588-021-00806-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136652391
    276 https://doi.org/10.1038/s41588-021-00806-1
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/s41588-021-00818-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1136995642
    279 https://doi.org/10.1038/s41588-021-00818-x
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/s41593-020-00795-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135362169
    282 https://doi.org/10.1038/s41593-020-00795-0
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/s41598-019-55382-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123306621
    285 https://doi.org/10.1038/s41598-019-55382-6
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/sj.onc.1210659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009793770
    288 https://doi.org/10.1038/sj.onc.1210659
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/srep19727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025794985
    291 https://doi.org/10.1038/srep19727
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1186/s13064-018-0117-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106945588
    294 https://doi.org/10.1186/s13064-018-0117-6
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1186/s13293-020-00286-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125557888
    297 https://doi.org/10.1186/s13293-020-00286-8
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1186/s42234-020-00059-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1132949529
    300 https://doi.org/10.1186/s42234-020-00059-z
    301 rdf:type schema:CreativeWork
    302 grid-institutes:grid.7839.5 schema:alternateName Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany
    303 schema:name Institute for Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany
    304 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...