Monoaminergic system and depression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-10

AUTHORS

L. Perez-Caballero, S. Torres-Sanchez, C. Romero-López-Alberca, F. González-Saiz, J. A. Mico, Esther Berrocoso

ABSTRACT

Major depressive disorder is a severe, disabling disorder that affects around 4.7% of the population worldwide. Based on the monoaminergic hypothesis of depression, monoamine reuptake inhibitors have been developed as antidepressants and nowadays, they are used widely in clinical practice. However, these drugs have a limited efficacy and a slow onset of therapeutic action. Several strategies have been implemented to overcome these limitations, including switching to other drugs or introducing combined or augmentation therapies. In clinical practice, the most often used augmenting drugs are lithium, triiodothyronine, atypical antipsychotics, buspirone, and pindolol, although some others are in the pipeline. Moreover, multitarget antidepressants have been developed to improve efficacy. Despite the enormous effort exerted to improve these monoaminergic drugs, they still fail to produce a rapid and sustained antidepressant response in a substantial proportion of depressed patients. Recently, new compounds that target other neurotransmission system, such as the glutamatergic system, have become the focus of research into fast-acting antidepressant agents. These promising alternatives could represent a new pharmacological trend in the management of depression. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00441-018-2978-8

DOI

http://dx.doi.org/10.1007/s00441-018-2978-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111312178

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30627806


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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RDF/XML is a standard XML format for linked data.

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