Ontology type: schema:ScholarlyArticle
2017-09-21
AUTHORSU. Ernsberger, M. Kramer, K. Tsarovina, T. Deller, H. Rohrer
ABSTRACTNeuron subtypes of the mature nervous system differ in the expression of characteristic marker genes while they share the expression of generic neuronal genes. The regulatory logic that maintains subtype-specific and pan-neuronal genes is not well understood. To begin to address this issue, we analyze RNA sequencing results from whole sympathetic ganglia and single sympathetic neurons in the mouse. We focus on gene products involved in the neuronal cytoskeleton, neurotransmitter synthesis and storage, transmitter release and reception and electrical information processing. We find a particular high correlation in the expression of stathmin 2 and several members of the tubulin beta family, classical pan-neuronal markers. Noradrenergic transmitter-synthesizing enzymes and transporters are also well correlated in their cellular transcript levels. In addition, noradrenergic marker transcript levels correlate well with selected pan-neuronal markers. Such a correlation in transcript levels is also seen between a number of selected ion channel, receptor and synaptic protein genes. These results provide the foundation for the analyses of the coordinated expression of downstream target genes in nerve cells. More... »
PAGES227-241
http://scigraph.springernature.com/pub.10.1007/s00441-017-2688-7
DOIhttp://dx.doi.org/10.1007/s00441-017-2688-7
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28936781
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