Laminar high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelium. A quantitative analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05-20

AUTHORS

Tetsu Yamane, Masako Mitsumata, Noriko Yamaguchi, Tadao Nakazawa, Kunio Mochizuki, Tetsuo Kondo, Tomonori Kawasaki, Shin-ichi Murata, Yoji Yoshida, Ryohei Katoh

ABSTRACT

Remodeling of endothelial basement membrane is important in atherogenesis. Since little is known about the actual relationship between type IV collagen and matrix metalloprotease−2 (MMP-2) in endothelial cells (ECs) under shear stress by blood flow, we performed quantitative analysis for type IV collagen and MMP-2 in ECs under high shear stress. The mRNA of type IV collagen from ECs exposed to high shear stress (10 and 30 dyn/cm2) had a higher expression compared to ECs exposed to a static condition or low shear stress (3 dyn/cm2) (P < 0.01). 3H-proline uptake analysis and fluorography revealed a remarkable increase of type IV collagen under high shear stress (P < 0.01). In contrast, zymography revealed that exposing to high shear stress, however similar positivity was leveled in the intracellular MMP-2 in the control and high shear stress-exposed ECs, reduced the secretion of MMP-2 in ECs. The results of Northern blotting, gelatin zymography and monitoring the intracellular trafficking of GFP-labeled MMP-2 revealed that MMP-2 secretion by ECs was completely suppressed by high shear stress, but the intracellular mRNA expression, protein synthesis, and transport of MMP-2 were not affected. In conclusion, we suggest that high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in ECs, which plays an important role in remodeling of the endothelial basement membrane and may suppress atherogenesis. More... »

PAGES

471-479

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00441-010-0968-6

DOI

http://dx.doi.org/10.1007/s00441-010-0968-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022822237

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20490867


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