Stages in the development of Parkinson’s disease-related pathology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-08-24

AUTHORS

Heiko Braak, Estifanos Ghebremedhin, Udo Rüb, Hansjürgen Bratzke, Kelly Del Tredici

ABSTRACT

The synucleinopathy, idiopathic Parkinson’s disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. The intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites begins at defined induction sites and advances in a topographically predictable sequence. As the disease progresses, components of the autonomic, limbic, and somatomotor systems become particularly badly damaged. During presymptomatic stages 1–2, inclusion body pathology is confined to the medulla oblongata/pontine tegmentum and olfactory bulb/anterior olfactory nucleus. In stages 3–4, the substantia nigra and other nuclear grays of the midbrain and forebrain become the focus of initially slight and, then, severe pathological changes. At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5–6, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions. More... »

PAGES

121-134

References to SciGraph publications

  • 1994-12. Amygdala pathology in Parkinson's disease in ACTA NEUROPATHOLOGICA
  • 1997-08. α-Synuclein in Lewy bodies in NATURE
  • 1980. Architectonics of the Human Telencephalic Cortex in NONE
  • 1992. Dementia of the Alzheimer Type Recapitulates Ontogeny Inversely on Specific Ordinal and Temporal Parameters in NEURODEVELOPMENT, AGING AND COGNITION
  • 1996-07. Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis in ACTA NEUROPATHOLOGICA
  • 2004. Parkinson's Disease in ENCYCLOPEDIC REFERENCE OF MOLECULAR PHARMACOLOGY
  • 1998. Structure and Organisation of Fibre Systems in THE CENTRAL NERVOUS SYSTEM OF VERTEBRATES
  • 1990-04. Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system in ACTA NEUROPATHOLOGICA
  • 1994-03. Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease in ACTA NEUROPATHOLOGICA
  • 2000-04. Preclinical (premotor) Parkinson’s disease in JOURNAL OF NEUROLOGY
  • 2000-03. Parkinson’s disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system in ACTA NEUROPATHOLOGICA
  • 1996-11. Cognitive deficits in Parkinson’s disease in JOURNAL OF NEUROLOGY
  • 2000-02. The cerebral proteopathies in MOLECULAR NEUROBIOLOGY
  • 1999-12. Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 2001. Alpha-Synuclein in NEUROPATHOLOGY AND GENETICS OF DEMENTIA
  • 2003-05. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen in JOURNAL OF NEURAL TRANSMISSION
  • 1992. Ontogenetic Development and Decline of Memory Functions in Nonhuman Primates in NEURODEVELOPMENT, AGING AND COGNITION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00441-004-0956-9

    DOI

    http://dx.doi.org/10.1007/s00441-004-0956-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037884335

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15338272


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parkinson Disease", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braak", 
            "givenName": "Heiko", 
            "id": "sg:person.01053255500.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghebremedhin", 
            "givenName": "Estifanos", 
            "id": "sg:person.0577364531.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577364531.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00fcb", 
            "givenName": "Udo", 
            "id": "sg:person.0637231010.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637231010.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Forensic Medicine, J.W. Goethe University, Kennedy Allee 104, 60596, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Forensic Medicine, J.W. Goethe University, Kennedy Allee 104, 60596, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bratzke", 
            "givenName": "Hansj\u00fcrgen", 
            "id": "sg:person.01016041057.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016041057.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Del Tredici", 
            "givenName": "Kelly", 
            "id": "sg:person.01340323332.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s004010051150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027173126", 
              "https://doi.org/10.1007/s004010051150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00022910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022972110", 
              "https://doi.org/10.1007/pl00022910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00296742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027936571", 
              "https://doi.org/10.1007/bf00296742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00007725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047801253", 
              "https://doi.org/10.1007/pl00007725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-18262-4_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035449581", 
              "https://doi.org/10.1007/978-3-642-18262-4_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00014170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000461959", 
              "https://doi.org/10.1007/pl00014170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00702-002-0808-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006623533", 
              "https://doi.org/10.1007/s00702-002-0808-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00294234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035447956", 
              "https://doi.org/10.1007/bf00294234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4684-6805-2_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052974768", 
              "https://doi.org/10.1007/978-1-4684-6805-2_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/42166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029460877", 
              "https://doi.org/10.1038/42166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-29832-0_1214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028414355", 
              "https://doi.org/10.1007/3-540-29832-0_1214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051409290", 
              "https://doi.org/10.1007/s004010050508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4684-6805-2_21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001886745", 
              "https://doi.org/10.1007/978-1-4684-6805-2_21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-1249-3_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028126708", 
              "https://doi.org/10.1007/978-1-4615-1249-3_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/mn:21:1-2:083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034619546", 
              "https://doi.org/10.1385/mn:21:1-2:083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-81522-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016830478", 
              "https://doi.org/10.1007/978-3-642-81522-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00296485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040316891", 
              "https://doi.org/10.1007/bf00296485"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-08-24", 
        "datePublishedReg": "2004-08-24", 
        "description": "The synucleinopathy, idiopathic Parkinson\u2019s disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. The intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites begins at defined induction sites and advances in a topographically predictable sequence. As the disease progresses, components of the autonomic, limbic, and somatomotor systems become particularly badly damaged. During presymptomatic stages 1\u20132, inclusion body pathology is confined to the medulla oblongata/pontine tegmentum and olfactory bulb/anterior olfactory nucleus. In stages 3\u20134, the substantia nigra and other nuclear grays of the midbrain and forebrain become the focus of initially slight and, then, severe pathological changes. At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5\u20136, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00441-004-0956-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019675", 
            "issn": [
              "0302-766X", 
              "1432-0878"
            ], 
            "name": "Cell and Tissue Research", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "318"
          }
        ], 
        "keywords": [
          "disease-related pathology", 
          "Parkinson's disease-related pathology", 
          "anterior olfactory nucleus", 
          "severe pathological changes", 
          "idiopathic Parkinson's disease", 
          "nerve cell types", 
          "inclusion body pathology", 
          "nuclear grays", 
          "olfactory nucleus", 
          "pontine tegmentum", 
          "substantia nigra", 
          "Lewy bodies", 
          "somatomotor system", 
          "symptomatic phase", 
          "mature neocortex", 
          "multisystem disorder", 
          "pathological changes", 
          "Parkinson's disease", 
          "nervous system", 
          "human nervous system", 
          "clinical dimensions", 
          "intracerebral formation", 
          "disease", 
          "induction site", 
          "stage 3", 
          "stage 1", 
          "pathology", 
          "cell types", 
          "most individuals", 
          "limbic", 
          "tegmentum", 
          "midbrain", 
          "illness", 
          "neocortex", 
          "forebrain", 
          "Lewy", 
          "predictable sequence", 
          "autonomic", 
          "nigra", 
          "disorders", 
          "specific regions", 
          "individuals", 
          "grey", 
          "nucleus", 
          "changes", 
          "body", 
          "threshold", 
          "advances", 
          "stage", 
          "development", 
          "sites", 
          "types", 
          "focus", 
          "region", 
          "system", 
          "components", 
          "point", 
          "formation", 
          "phase", 
          "sequence", 
          "process", 
          "dimensions", 
          "abnormal proteinaceous Lewy bodies", 
          "proteinaceous Lewy bodies", 
          "presymptomatic stages 1", 
          "body pathology", 
          "medulla oblongata/pontine tegmentum", 
          "oblongata/pontine tegmentum", 
          "olfactory bulb/anterior olfactory nucleus", 
          "bulb/anterior olfactory nucleus"
        ], 
        "name": "Stages in the development of Parkinson\u2019s disease-related pathology", 
        "pagination": "121-134", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037884335"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00441-004-0956-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15338272"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00441-004-0956-9", 
          "https://app.dimensions.ai/details/publication/pub.1037884335"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_393.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00441-004-0956-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00441-004-0956-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00441-004-0956-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00441-004-0956-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00441-004-0956-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    242 TRIPLES      22 PREDICATES      116 URIs      91 LITERALS      10 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00441-004-0956-9 schema:about N13b10524ca0242c382aee350cd56a785
    2 N76f9121a7adc46a691004c404866a05d
    3 Nac2bc0b5dd1b4a3593a9376579f2882c
    4 anzsrc-for:11
    5 anzsrc-for:1109
    6 schema:author N5dadb111c94f44088c7eb2997b66124d
    7 schema:citation sg:pub.10.1007/3-540-29832-0_1214
    8 sg:pub.10.1007/978-1-4615-1249-3_11
    9 sg:pub.10.1007/978-1-4684-6805-2_21
    10 sg:pub.10.1007/978-1-4684-6805-2_3
    11 sg:pub.10.1007/978-3-642-18262-4_3
    12 sg:pub.10.1007/978-3-642-81522-5
    13 sg:pub.10.1007/bf00294234
    14 sg:pub.10.1007/bf00296485
    15 sg:pub.10.1007/bf00296742
    16 sg:pub.10.1007/pl00007725
    17 sg:pub.10.1007/pl00014170
    18 sg:pub.10.1007/pl00022910
    19 sg:pub.10.1007/s004010050508
    20 sg:pub.10.1007/s004010051150
    21 sg:pub.10.1007/s00702-002-0808-2
    22 sg:pub.10.1038/42166
    23 sg:pub.10.1385/mn:21:1-2:083
    24 schema:datePublished 2004-08-24
    25 schema:datePublishedReg 2004-08-24
    26 schema:description The synucleinopathy, idiopathic Parkinson’s disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system. The intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites begins at defined induction sites and advances in a topographically predictable sequence. As the disease progresses, components of the autonomic, limbic, and somatomotor systems become particularly badly damaged. During presymptomatic stages 1–2, inclusion body pathology is confined to the medulla oblongata/pontine tegmentum and olfactory bulb/anterior olfactory nucleus. In stages 3–4, the substantia nigra and other nuclear grays of the midbrain and forebrain become the focus of initially slight and, then, severe pathological changes. At this point, most individuals probably cross the threshold to the symptomatic phase of the illness. In the end-stages 5–6, the process enters the mature neocortex, and the disease manifests itself in all of its clinical dimensions.
    27 schema:genre article
    28 schema:inLanguage en
    29 schema:isAccessibleForFree false
    30 schema:isPartOf N15ec2135c939470c978bd65a39af14e9
    31 Nb193d8ad04c44e7985ae4263ca6332a1
    32 sg:journal.1019675
    33 schema:keywords Lewy
    34 Lewy bodies
    35 Parkinson's disease
    36 Parkinson's disease-related pathology
    37 abnormal proteinaceous Lewy bodies
    38 advances
    39 anterior olfactory nucleus
    40 autonomic
    41 body
    42 body pathology
    43 bulb/anterior olfactory nucleus
    44 cell types
    45 changes
    46 clinical dimensions
    47 components
    48 development
    49 dimensions
    50 disease
    51 disease-related pathology
    52 disorders
    53 focus
    54 forebrain
    55 formation
    56 grey
    57 human nervous system
    58 idiopathic Parkinson's disease
    59 illness
    60 inclusion body pathology
    61 individuals
    62 induction site
    63 intracerebral formation
    64 limbic
    65 mature neocortex
    66 medulla oblongata/pontine tegmentum
    67 midbrain
    68 most individuals
    69 multisystem disorder
    70 neocortex
    71 nerve cell types
    72 nervous system
    73 nigra
    74 nuclear grays
    75 nucleus
    76 oblongata/pontine tegmentum
    77 olfactory bulb/anterior olfactory nucleus
    78 olfactory nucleus
    79 pathological changes
    80 pathology
    81 phase
    82 point
    83 pontine tegmentum
    84 predictable sequence
    85 presymptomatic stages 1
    86 process
    87 proteinaceous Lewy bodies
    88 region
    89 sequence
    90 severe pathological changes
    91 sites
    92 somatomotor system
    93 specific regions
    94 stage
    95 stage 1
    96 stage 3
    97 substantia nigra
    98 symptomatic phase
    99 system
    100 tegmentum
    101 threshold
    102 types
    103 schema:name Stages in the development of Parkinson’s disease-related pathology
    104 schema:pagination 121-134
    105 schema:productId N333f35a6ecc044f8aab859dd3a56d99d
    106 N3dc1bdbe6aaf4081974aadbee2257477
    107 N8d954ecac99e44b88b2a20acd80a71d0
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037884335
    109 https://doi.org/10.1007/s00441-004-0956-9
    110 schema:sdDatePublished 2021-11-01T18:07
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher Nf26315faffb1454b8b6b8100401b376c
    113 schema:url https://doi.org/10.1007/s00441-004-0956-9
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N039cd47af1054bd08c87a2af0be9ba9f rdf:first sg:person.01016041057.37
    118 rdf:rest N4700d042606244f8a834b5d46084c282
    119 N13b10524ca0242c382aee350cd56a785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Humans
    121 rdf:type schema:DefinedTerm
    122 N15ec2135c939470c978bd65a39af14e9 schema:issueNumber 1
    123 rdf:type schema:PublicationIssue
    124 N333f35a6ecc044f8aab859dd3a56d99d schema:name pubmed_id
    125 schema:value 15338272
    126 rdf:type schema:PropertyValue
    127 N3dc1bdbe6aaf4081974aadbee2257477 schema:name doi
    128 schema:value 10.1007/s00441-004-0956-9
    129 rdf:type schema:PropertyValue
    130 N4700d042606244f8a834b5d46084c282 rdf:first sg:person.01340323332.00
    131 rdf:rest rdf:nil
    132 N57217f23ce9c4baca40c65f42be747c6 rdf:first sg:person.0577364531.39
    133 rdf:rest Ne81c2a2adf944e77a3ed90b04db247eb
    134 N5dadb111c94f44088c7eb2997b66124d rdf:first sg:person.01053255500.71
    135 rdf:rest N57217f23ce9c4baca40c65f42be747c6
    136 N76f9121a7adc46a691004c404866a05d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Brain
    138 rdf:type schema:DefinedTerm
    139 N8d954ecac99e44b88b2a20acd80a71d0 schema:name dimensions_id
    140 schema:value pub.1037884335
    141 rdf:type schema:PropertyValue
    142 Nac2bc0b5dd1b4a3593a9376579f2882c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Parkinson Disease
    144 rdf:type schema:DefinedTerm
    145 Nb193d8ad04c44e7985ae4263ca6332a1 schema:volumeNumber 318
    146 rdf:type schema:PublicationVolume
    147 Ne81c2a2adf944e77a3ed90b04db247eb rdf:first sg:person.0637231010.55
    148 rdf:rest N039cd47af1054bd08c87a2af0be9ba9f
    149 Nf26315faffb1454b8b6b8100401b376c schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Neurosciences
    156 rdf:type schema:DefinedTerm
    157 sg:journal.1019675 schema:issn 0302-766X
    158 1432-0878
    159 schema:name Cell and Tissue Research
    160 schema:publisher Springer Nature
    161 rdf:type schema:Periodical
    162 sg:person.01016041057.37 schema:affiliation grid-institutes:grid.7839.5
    163 schema:familyName Bratzke
    164 schema:givenName Hansjürgen
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016041057.37
    166 rdf:type schema:Person
    167 sg:person.01053255500.71 schema:affiliation grid-institutes:grid.7839.5
    168 schema:familyName Braak
    169 schema:givenName Heiko
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053255500.71
    171 rdf:type schema:Person
    172 sg:person.01340323332.00 schema:affiliation grid-institutes:grid.7839.5
    173 schema:familyName Del Tredici
    174 schema:givenName Kelly
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340323332.00
    176 rdf:type schema:Person
    177 sg:person.0577364531.39 schema:affiliation grid-institutes:grid.7839.5
    178 schema:familyName Ghebremedhin
    179 schema:givenName Estifanos
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577364531.39
    181 rdf:type schema:Person
    182 sg:person.0637231010.55 schema:affiliation grid-institutes:grid.7839.5
    183 schema:familyName Rüb
    184 schema:givenName Udo
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637231010.55
    186 rdf:type schema:Person
    187 sg:pub.10.1007/3-540-29832-0_1214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028414355
    188 https://doi.org/10.1007/3-540-29832-0_1214
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/978-1-4615-1249-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028126708
    191 https://doi.org/10.1007/978-1-4615-1249-3_11
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/978-1-4684-6805-2_21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001886745
    194 https://doi.org/10.1007/978-1-4684-6805-2_21
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/978-1-4684-6805-2_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052974768
    197 https://doi.org/10.1007/978-1-4684-6805-2_3
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/978-3-642-18262-4_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035449581
    200 https://doi.org/10.1007/978-3-642-18262-4_3
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1007/978-3-642-81522-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016830478
    203 https://doi.org/10.1007/978-3-642-81522-5
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/bf00294234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035447956
    206 https://doi.org/10.1007/bf00294234
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/bf00296485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040316891
    209 https://doi.org/10.1007/bf00296485
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/bf00296742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027936571
    212 https://doi.org/10.1007/bf00296742
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/pl00007725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047801253
    215 https://doi.org/10.1007/pl00007725
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/pl00014170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000461959
    218 https://doi.org/10.1007/pl00014170
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/pl00022910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022972110
    221 https://doi.org/10.1007/pl00022910
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s004010050508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051409290
    224 https://doi.org/10.1007/s004010050508
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/s004010051150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027173126
    227 https://doi.org/10.1007/s004010051150
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s00702-002-0808-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006623533
    230 https://doi.org/10.1007/s00702-002-0808-2
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/42166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029460877
    233 https://doi.org/10.1038/42166
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1385/mn:21:1-2:083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034619546
    236 https://doi.org/10.1385/mn:21:1-2:083
    237 rdf:type schema:CreativeWork
    238 grid-institutes:grid.7839.5 schema:alternateName Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany
    239 Institute for Forensic Medicine, J.W. Goethe University, Kennedy Allee 104, 60596, Frankfurt/Main, Germany
    240 schema:name Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590, Frankfurt/Main, Germany
    241 Institute for Forensic Medicine, J.W. Goethe University, Kennedy Allee 104, 60596, Frankfurt/Main, Germany
    242 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...