Linkage of the apo CIII microsatellite with isolated low high-density lipoprotein cholesterol View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-03

AUTHORS

Cecilia M. Devlin, Valerie L. Prenger, Michael Miller

ABSTRACT

To evaluate whether a highly polymorphic microsatellite region within intron 3 of the apolipoprotein (apo) CIII gene is linked to the isolated low HDL-C phenotype, we studied eight unrelated probands (mean HDL-C = 10+/-5 mg/dl) and 157 biological family members. After PCR amplification of genomic DNA and denaturing polyacrylamide gel electrophoresis, 26 alleles were identified in this microsatellite including 9 alleles heretofore unreported. Quantitative sib-pair linkage analysis demonstrated strong evidence of linkage between the isolated low HDL-C phenotype and the apo CIII microsatellite region (P = 0.007). The microsatellite was also linked to apo AI (P = 0.001), the primary apolipoprotein of HDL-C. Therefore, this highly polymorphic microsatellite region is a potentially important marker in the genetic evaluation of the isolated low HDL-C phenotype. More... »

PAGES

273-281

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004390050691

DOI

http://dx.doi.org/10.1007/s004390050691

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033604309

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9544838


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