Mutational and functional analysis of the neurofibromatosis type 1 (NF1) gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-12

AUTHORS

M. Upadhyaya, Michael J. Osborn, Julie Maynard, Mee Rhan Kim, Fuyuhiko Tamanoi, David N. Cooper

ABSTRACT

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders. It is caused by mutations in the NF1 gene which comprises 60 exons and is located on chromosome 17q. The NF1 gene product, neurofibromin, displays partial homology to GTPase-activating protein (GAP). The GAP-related domain (GRD), encoded by exons 20-27a, is the only region of neurofibromin to which a biological function has been ascribed. A total of 320 unrelated NF1 patients were screened for mutations in the GRD-encoding region of the NF1 gene. Sixteen different lesions in the NF1 GRD region were identified in a total of 20 patients. Of these lesions, 14 are novel and together comprise three missense, two nonsense and three splice site mutations plus six deletions of between 1 and 4 bp. The effect of one of the missense mutations (R1391S) was studied by in vitro expression of a site-directed mutant and GAP activity assay. The mutant protein, R1391S, was found to be some 300-fold less active than wild-type NF1 GRD. The mutations reported in this study therefore provide further material for the functional analysis of neurofibromin as well as an insight into the mutational spectrum of the NF1 GRD. More... »

PAGES

88-92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004390050317

DOI

http://dx.doi.org/10.1007/s004390050317

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018023260

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9003501


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