The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

Fong-Ming Chang, Judith R. Kidd, Kenneth J. Livak, Andrew J. Pakstis, K. K. Kidd

ABSTRACT

The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there is an imperfect tandem repeat of 48 base pairs (bp) coding for 16 amino acids; alleles have been identified with 2 (32 amino acids) to 10 (160 amino acids) repeats. The imperfect nature of the repeats is responsible for a more subtle level of variation since alleles with the same number of repeats can differ in the exact sequences or in the order of the variants of the 48-bp unit. We have undertaken a global survey of this expressed polymorphism as one approach to understanding the evolutionary significance and origins of the polymorphism as well as understanding what selective forces, if any, may be operating at this locus. As the first step, we have determined the repeat number genotype of the DRD4 repeat polymorphism in 1,327 individuals from 36 different populations. The allele frequencies differ considerably among the different populations. The 4-repeat allele was the most prevalent (global mean allele frequency = 64.3%) and appeared in every population with a frequency ranging from 0.16 to 0.96. The 7-repeat allele was the second most common (global mean = 20.6%), appearing quite frequently in the Americas (mean frequency = 48.3%) but only occasionally in East and South Asia (mean frequency = 1.9%). The 2-repeat allele was the third most common (global mean frequency = 8.2%) and was quite frequent in East and South Asia (mean frequency = 18.1%) while uncommon in the Americas (mean frequency = 2.9%) and Africa (mean frequency = 1.7%). The universality of the polymorphism with only three common repeat-number alleles (4, 7, and 2) indicates that the polymorphism is ancient and arose before the global dispersion of modern humans. The diversity of actual allele frequencies for this expressed polymorphism among different populations emphasizes the importance of population considerations in the design and interpretation of any association studies carried out with this polymorphism. More... »

PAGES

91-101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004390050166

DOI

http://dx.doi.org/10.1007/s004390050166

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037060781

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8682515


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Africa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle East", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "North America", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pacific Ocean", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine D4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repetitive Sequences, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "South America", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine,  New Haven, CT 06520-8005, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Fong-Ming", 
        "id": "sg:person.0712425201.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712425201.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine,  New Haven, CT 06520-8005, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kidd", 
        "givenName": "Judith R.", 
        "id": "sg:person.01216111541.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216111541.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "The Du Pont Merck Pharmaceutical Company,  Experimental Station, Wilmington, Delaware, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Livak", 
        "givenName": "Kenneth J.", 
        "id": "sg:person.011551776474.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011551776474.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine,  New Haven, CT 06520-8005, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pakstis", 
        "givenName": "Andrew J.", 
        "id": "sg:person.01147776341.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147776341.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine,  New Haven, CT 06520-8005, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kidd", 
        "givenName": "K. K.", 
        "id": "sg:person.013056040102.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013056040102.90"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1996-05", 
    "datePublishedReg": "1996-05-01", 
    "description": "The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there is an imperfect tandem repeat of 48 base pairs (bp) coding for 16 amino acids; alleles have been identified with 2 (32 amino acids) to 10 (160 amino acids) repeats. The imperfect nature of the repeats is responsible for a more subtle level of variation since alleles with the same number of repeats can differ in the exact sequences or in the order of the variants of the 48-bp unit. We have undertaken a global survey of this expressed polymorphism as one approach to understanding the evolutionary significance and origins of the polymorphism as well as understanding what selective forces, if any, may be operating at this locus. As the first step, we have determined the repeat number genotype of the DRD4 repeat polymorphism in 1,327 individuals from 36 different populations. The allele frequencies differ considerably among the different populations. The 4-repeat allele was the most prevalent (global mean allele frequency = 64.3%) and appeared in every population with a frequency ranging from 0.16 to 0.96. The 7-repeat allele was the second most common (global mean = 20.6%), appearing quite frequently in the Americas (mean frequency = 48.3%) but only occasionally in East and South Asia (mean frequency = 1.9%). The 2-repeat allele was the third most common (global mean frequency = 8.2%) and was quite frequent in East and South Asia (mean frequency = 18.1%) while uncommon in the Americas (mean frequency = 2.9%) and Africa (mean frequency = 1.7%). The universality of the polymorphism with only three common repeat-number alleles (4, 7, and 2) indicates that the polymorphism is ancient and arose before the global dispersion of modern humans. The diversity of actual allele frequencies for this expressed polymorphism among different populations emphasizes the importance of population considerations in the design and interpretation of any association studies carried out with this polymorphism.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s004390050166", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2443054", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2635947", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439357", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2546292", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1085982", 
        "issn": [
          "0340-6717", 
          "1432-1203"
        ], 
        "name": "Human Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "98"
      }
    ], 
    "name": "The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus", 
    "pagination": "91-101", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b08b55a814395e46c650c4c1d0d1ffbc8968e11719928d62e30923ee2109b407"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8682515"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7613873"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004390050166"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037060781"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004390050166", 
      "https://app.dimensions.ai/details/publication/pub.1037060781"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs004390050166"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004390050166'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004390050166'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004390050166'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004390050166'


 

This table displays all metadata directly associated to this object as RDF triples.

174 TRIPLES      20 PREDICATES      45 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004390050166 schema:about N1452b19cee7d4a11a8e4c3b50437f3a6
2 N248a2f964b3a4aff8bfbe29c5cf15ec5
3 N360c9f77b4b14a7da516ec044923502b
4 N3d94cb82b4ba458eb28b899b7fff2d56
5 N428eca5f50bc4539b6d9ff8bc6aa1e97
6 N49af1748c3944b94b8dd1caf99c4dcde
7 N5dc3dc1e97e84bcf9a413afc9b67e7fb
8 N79892cd4598e4c7aad79d650179dd26f
9 N85b462a0e0b84ac8913128c7eee17a88
10 N88569e6d3a814f28b55169bd4e8f4854
11 Na0c64e64f3e547be8b9267fc8c24e9cd
12 Nb06e504cb75d46fa84f493fdf441df3e
13 Nd4f068bf240d45de97db5804fc427919
14 Ndaffc6c5e9a0478ea454e782cc0823e6
15 Ne71bd9ecc60842f3a0a67ce02ac09f43
16 Nf5f203b89d1941fd83c02f3045c99ad5
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author Na6011a4141484ae7955f64f136ee7302
20 schema:datePublished 1996-05
21 schema:datePublishedReg 1996-05-01
22 schema:description The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there is an imperfect tandem repeat of 48 base pairs (bp) coding for 16 amino acids; alleles have been identified with 2 (32 amino acids) to 10 (160 amino acids) repeats. The imperfect nature of the repeats is responsible for a more subtle level of variation since alleles with the same number of repeats can differ in the exact sequences or in the order of the variants of the 48-bp unit. We have undertaken a global survey of this expressed polymorphism as one approach to understanding the evolutionary significance and origins of the polymorphism as well as understanding what selective forces, if any, may be operating at this locus. As the first step, we have determined the repeat number genotype of the DRD4 repeat polymorphism in 1,327 individuals from 36 different populations. The allele frequencies differ considerably among the different populations. The 4-repeat allele was the most prevalent (global mean allele frequency = 64.3%) and appeared in every population with a frequency ranging from 0.16 to 0.96. The 7-repeat allele was the second most common (global mean = 20.6%), appearing quite frequently in the Americas (mean frequency = 48.3%) but only occasionally in East and South Asia (mean frequency = 1.9%). The 2-repeat allele was the third most common (global mean frequency = 8.2%) and was quite frequent in East and South Asia (mean frequency = 18.1%) while uncommon in the Americas (mean frequency = 2.9%) and Africa (mean frequency = 1.7%). The universality of the polymorphism with only three common repeat-number alleles (4, 7, and 2) indicates that the polymorphism is ancient and arose before the global dispersion of modern humans. The diversity of actual allele frequencies for this expressed polymorphism among different populations emphasizes the importance of population considerations in the design and interpretation of any association studies carried out with this polymorphism.
23 schema:genre research_article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf Neb88b4ceffd542b087665c8aae2c9ae5
27 Nfbc649d30ca648efb435c802695bf4ce
28 sg:journal.1085982
29 schema:name The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
30 schema:pagination 91-101
31 schema:productId N0aaf71a6023642d5a80ed0f1737b5dde
32 N5febe2defb914966b0002a1ea81970bd
33 N61448ece5c0d45b89a756f2745960aa8
34 N628dc1003a5f417bb78695ce841a3714
35 N8ff8b0edbb97429c9a90113e56e10a3f
36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037060781
37 https://doi.org/10.1007/s004390050166
38 schema:sdDatePublished 2019-04-11T10:04
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N86cfada828c44ac2beebbe4a6cb69b47
41 schema:url https://link.springer.com/10.1007%2Fs004390050166
42 sgo:license sg:explorer/license/
43 sgo:sdDataset articles
44 rdf:type schema:ScholarlyArticle
45 N0aaf71a6023642d5a80ed0f1737b5dde schema:name dimensions_id
46 schema:value pub.1037060781
47 rdf:type schema:PropertyValue
48 N1452b19cee7d4a11a8e4c3b50437f3a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
49 schema:name Receptors, Dopamine D2
50 rdf:type schema:DefinedTerm
51 N248a2f964b3a4aff8bfbe29c5cf15ec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
52 schema:name Repetitive Sequences, Nucleic Acid
53 rdf:type schema:DefinedTerm
54 N3588410b7302455ea2a35f5620e9491a rdf:first sg:person.013056040102.90
55 rdf:rest rdf:nil
56 N360c9f77b4b14a7da516ec044923502b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Evolution, Molecular
58 rdf:type schema:DefinedTerm
59 N3d94cb82b4ba458eb28b899b7fff2d56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Gene Frequency
61 rdf:type schema:DefinedTerm
62 N428eca5f50bc4539b6d9ff8bc6aa1e97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name North America
64 rdf:type schema:DefinedTerm
65 N49af1748c3944b94b8dd1caf99c4dcde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Alleles
67 rdf:type schema:DefinedTerm
68 N5dc3dc1e97e84bcf9a413afc9b67e7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Middle East
70 rdf:type schema:DefinedTerm
71 N5febe2defb914966b0002a1ea81970bd schema:name pubmed_id
72 schema:value 8682515
73 rdf:type schema:PropertyValue
74 N61448ece5c0d45b89a756f2745960aa8 schema:name readcube_id
75 schema:value b08b55a814395e46c650c4c1d0d1ffbc8968e11719928d62e30923ee2109b407
76 rdf:type schema:PropertyValue
77 N628dc1003a5f417bb78695ce841a3714 schema:name nlm_unique_id
78 schema:value 7613873
79 rdf:type schema:PropertyValue
80 N79892cd4598e4c7aad79d650179dd26f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Africa
82 rdf:type schema:DefinedTerm
83 N85b462a0e0b84ac8913128c7eee17a88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Exons
85 rdf:type schema:DefinedTerm
86 N86cfada828c44ac2beebbe4a6cb69b47 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N88569e6d3a814f28b55169bd4e8f4854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Humans
90 rdf:type schema:DefinedTerm
91 N8ff8b0edbb97429c9a90113e56e10a3f schema:name doi
92 schema:value 10.1007/s004390050166
93 rdf:type schema:PropertyValue
94 N9cb7a8cd55834f3cbecd02e2796f5366 rdf:first sg:person.01216111541.41
95 rdf:rest Nf7ce5e2c8afa435c995af0991bc0d58b
96 Na0c64e64f3e547be8b9267fc8c24e9cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Pacific Ocean
98 rdf:type schema:DefinedTerm
99 Na6011a4141484ae7955f64f136ee7302 rdf:first sg:person.0712425201.34
100 rdf:rest N9cb7a8cd55834f3cbecd02e2796f5366
101 Nb06e504cb75d46fa84f493fdf441df3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Asia
103 rdf:type schema:DefinedTerm
104 Nd4f068bf240d45de97db5804fc427919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Europe
106 rdf:type schema:DefinedTerm
107 Ndaffc6c5e9a0478ea454e782cc0823e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name South America
109 rdf:type schema:DefinedTerm
110 Ne1adc367cecc42f1bf4d675c243b3a28 rdf:first sg:person.01147776341.54
111 rdf:rest N3588410b7302455ea2a35f5620e9491a
112 Ne71bd9ecc60842f3a0a67ce02ac09f43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Receptors, Dopamine D4
114 rdf:type schema:DefinedTerm
115 Neb88b4ceffd542b087665c8aae2c9ae5 schema:volumeNumber 98
116 rdf:type schema:PublicationVolume
117 Nf5f203b89d1941fd83c02f3045c99ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Polymorphism, Genetic
119 rdf:type schema:DefinedTerm
120 Nf7ce5e2c8afa435c995af0991bc0d58b rdf:first sg:person.011551776474.42
121 rdf:rest Ne1adc367cecc42f1bf4d675c243b3a28
122 Nfbc649d30ca648efb435c802695bf4ce schema:issueNumber 1
123 rdf:type schema:PublicationIssue
124 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biological Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
128 schema:name Genetics
129 rdf:type schema:DefinedTerm
130 sg:grant.2439357 http://pending.schema.org/fundedItem sg:pub.10.1007/s004390050166
131 rdf:type schema:MonetaryGrant
132 sg:grant.2440866 http://pending.schema.org/fundedItem sg:pub.10.1007/s004390050166
133 rdf:type schema:MonetaryGrant
134 sg:grant.2443054 http://pending.schema.org/fundedItem sg:pub.10.1007/s004390050166
135 rdf:type schema:MonetaryGrant
136 sg:grant.2546292 http://pending.schema.org/fundedItem sg:pub.10.1007/s004390050166
137 rdf:type schema:MonetaryGrant
138 sg:grant.2635947 http://pending.schema.org/fundedItem sg:pub.10.1007/s004390050166
139 rdf:type schema:MonetaryGrant
140 sg:journal.1085982 schema:issn 0340-6717
141 1432-1203
142 schema:name Human Genetics
143 rdf:type schema:Periodical
144 sg:person.01147776341.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
145 schema:familyName Pakstis
146 schema:givenName Andrew J.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147776341.54
148 rdf:type schema:Person
149 sg:person.011551776474.42 schema:affiliation https://www.grid.ac/institutes/grid.419971.3
150 schema:familyName Livak
151 schema:givenName Kenneth J.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011551776474.42
153 rdf:type schema:Person
154 sg:person.01216111541.41 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
155 schema:familyName Kidd
156 schema:givenName Judith R.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216111541.41
158 rdf:type schema:Person
159 sg:person.013056040102.90 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
160 schema:familyName Kidd
161 schema:givenName K. K.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013056040102.90
163 rdf:type schema:Person
164 sg:person.0712425201.34 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
165 schema:familyName Chang
166 schema:givenName Fong-Ming
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712425201.34
168 rdf:type schema:Person
169 https://www.grid.ac/institutes/grid.419971.3 schema:alternateName Bristol-Myers Squibb (United States)
170 schema:name The Du Pont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware, USA, US
171 rdf:type schema:Organization
172 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
173 schema:name Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA, US
174 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...