DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal: correlation with Gm haplotypes and hypotheses ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

Patricia Dard, Alicia Sanchez-Mazas, Jean-Michel Dugoujon, Gerda De Lange, André Langaney, Marie-Paule Lefranc, Gérard Lefranc

ABSTRACT

This study presents restriction fragment length polymorphism (RFLP) and serological analyses of the immunoglobulin CH loci in a sample of 100 individuals from a Senegalese Mandenka population. The RFLP variability is mostly the result of large DNA insertions or deletions in the non-coding flanking regions of the IGHG genes, and to variable number of tandem repeat-like patterns within their 5'-switch sequences. However, part of the IGHG3 polymorphism also corresponds to a variable number of exons coding for the flexible hinge segment of the IgG3 antibody (the 4-exon and 3-exon forms, and a newly described 2-exon form). This diversity presents relevant associations with Gm haplotypes, suggesting that molecular rearrangements of the G3 hinge are related to the evolution of the Gm polymorphism. Non-significant correlation coefficients are found between Gm haplotypes and A2m alleles in the Mandenka, indicating that these loci may have reached equilibrium through recombination. The effect of recombination on linkage disequilibrium is more generally revealed, across the Ig CH genomic region, by a significant decrease of D' values with increasing physical distances between the loci on the chromosome. More... »

PAGES

36-47

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004390050156

DOI

http://dx.doi.org/10.1007/s004390050156

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052174591

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8682504


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