Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07

AUTHORS

Sara Lindström, Marine Germain, Marta Crous-Bou, Erin N. Smith, Pierre-Emmanuel Morange, Astrid van Hylckama Vlieg, Hugoline G. de Haan, Daniel Chasman, Paul Ridker, Jennifer Brody, Mariza de Andrade, John A. Heit, Weihong Tang, Immaculata DeVivo, Francine Grodstein, Nicholas L. Smith, David Tregouet, Christopher Kabrhel, for the INVENT Consortium

ABSTRACT

Observational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due to reverse causation or confounding bias. We conducted a Mendelian Randomization study of body mass index (BMI) and VTE. We identified 95 single nucleotide polymorphisms (SNPs) that have been previously associated with BMI and assessed the association between genetically predicted high BMI and VTE leveraging data from a previously conducted GWAS within the INVENT consortium comprising a total of 7507 VTE cases and 52,632 controls of European ancestry. Five BMI SNPs were associated with VTE at P < 0.05, with the strongest association seen for the FTO SNP rs1558902 (OR 1.07, 95% CI 1.02-1.12, P = 0.005). In addition, we observed a significant association between genetically predicted BMI and VTE (OR = 1.59, 95% CI 1.30-1.93 per standard deviation increase in BMI, P = 5.8 × 10-6). Our study provides evidence for a causal relationship between high BMI and risk of VTE. Reducing obesity levels will likely result in lower incidence in VTE. More... »

PAGES

897-902

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00439-017-1811-x

DOI

http://dx.doi.org/10.1007/s00439-017-1811-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085456782

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28528403


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