Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-19

AUTHORS

Lars A. Forsberg

ABSTRACT

Recent discoveries have shown that harboring cells without the Y chromosome in the peripheral blood is associated with increased risk for all-cause mortality and disease such as different forms of cancer, Alzheimer’s disease, as well as other conditions in aging men. In the entire world, the life expectancy of men is shorter compared to women, a sex difference that has been known for centuries, but the underlying mechanism(s) are not well understood. As a male-specific genetic risk factor, an increased risk for pathology and mortality associated with mosaic loss of chromosome Y (LOY) in blood cells could help to explain that men on average live shorter lives compared to women. This review primarily focuses on observed associations between LOY in blood and various diseases in aging men. Other topics covered are known risk factors for LOY, methods to detect LOY, and a discussion regarding mechanisms such as immunosurveillance, that could possibly explain how an acquired mutation in blood cells can be associated with disease processes in other organs. More... »

PAGES

657-663

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00439-017-1799-2

DOI

http://dx.doi.org/10.1007/s00439-017-1799-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084928250

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28424864


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