Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-04

AUTHORS

Xuanyao Liu, Yushimah Yunus, Dongsheng Lu, Farhang Aghakhanian, Woei-Yuh Saw, Lian Deng, Mohammad Ali, Xu Wang, Fadzilah Ghazali, Thuhairah Abdul Rahman, Shahrul Azlin Shaari, Mohd Zaki Salleh, Maude E. Phipps, Rick Twee-Hee Ong, Shuhua Xu, Yik-Ying Teo, Boon-Peng Hoh

ABSTRACT

The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection. More... »

PAGES

375-392

References to SciGraph publications

  • 2007-09. Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease in MEDICAL MOLECULAR MORPHOLOGY
  • 2004-12. The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs in HUMAN GENOMICS
  • 2008-02. Genotype, haplotype and copy-number variation in worldwide human populations in NATURE
  • 2011-07-13. Genomics for the world in NATURE
  • 2012-06. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance in NATURE GENETICS
  • 2007-10-18. Genome-wide detection and characterization of positive selection in human populations in NATURE
  • 2014-11. Reappraisal of known malaria resistance loci in a large multicenter study in NATURE GENETICS
  • 2013-03. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women’s Health Initiative SHARe Study in HUMAN GENETICS
  • 2007-12. Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations in BMC GENETICS
  • 2002-12. The impact of malaria on common lipid parameters in PARASITOLOGY RESEARCH
  • 2004-01. Evidence for a cluster of genes on chromosome 17q11–q21 controlling susceptibility to tuberculosis and leprosy in Brazilians in GENES & IMMUNITY
  • 2014-12. Evaluating the possibility of detecting evidence of positive selection across Asia with sparse genotype data from the HUGO Pan-Asian SNP Consortium in BMC GENOMICS
  • 2009-08. Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 1995-07. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria in NATURE
  • 2007-12. Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice in BMC GENOMICS
  • 2010-09. Integrating common and rare genetic variation in diverse human populations in NATURE
  • 2013-12. Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns in BMC INFECTIOUS DISEASES
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2014-09. The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia in HUMAN GENETICS
  • 2001-11. Haemoglobin C protects against clinical Plasmodium falciparum malaria in NATURE
  • 2013-12. Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis in MALARIA JOURNAL
  • 2012-10. The genetics of attention deficit/hyperactivity disorder in adults, a review in MOLECULAR PSYCHIATRY
  • 2001-11. Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa in GENES & IMMUNITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00439-014-1525-2

    DOI

    http://dx.doi.org/10.1007/s00439-014-1525-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024693724

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25634076


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptation, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cadherins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heme Oxygenase-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphotoxin-alpha", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaysia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nitric Oxide Synthase Type II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Population Groups", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Selection, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "fas Receptor", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "NUS Graduate School for Integrative Science and Engineering, National University of Singapore, 117456, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Xuanyao", 
            "id": "sg:person.01013600010.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013600010.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yunus", 
            "givenName": "Yushimah", 
            "id": "sg:person.0737765012.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737765012.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai Institutes for Biological Sciences", 
              "id": "https://www.grid.ac/institutes/grid.419092.7", 
              "name": [
                "Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Dongsheng", 
            "id": "sg:person.01336632622.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336632622.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Subang Jaya, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aghakhanian", 
            "givenName": "Farhang", 
            "id": "sg:person.01054213412.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054213412.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Life Sciences Institute, National University of Singapore, Singapore, Singapore", 
                "Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saw", 
            "givenName": "Woei-Yuh", 
            "id": "sg:person.01354642310.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354642310.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai Institutes for Biological Sciences", 
              "id": "https://www.grid.ac/institutes/grid.419092.7", 
              "name": [
                "Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deng", 
            "givenName": "Lian", 
            "id": "sg:person.01170442012.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170442012.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Life Sciences Institute, National University of Singapore, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ali", 
            "givenName": "Mohammad", 
            "id": "sg:person.01234172704.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234172704.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xu", 
            "id": "sg:person.01062013407.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062013407.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghazali", 
            "givenName": "Fadzilah", 
            "id": "sg:person.01353003612.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353003612.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdul Rahman", 
            "givenName": "Thuhairah", 
            "id": "sg:person.0634563630.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634563630.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shaari", 
            "givenName": "Shahrul Azlin", 
            "id": "sg:person.0675512712.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675512712.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Integrative Pharmacogenomics Institute, Universiti Teknologi MARA, 42300, Puncak Alam, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salleh", 
            "givenName": "Mohd Zaki", 
            "id": "sg:person.01113617415.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113617415.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Subang Jaya, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phipps", 
            "givenName": "Maude E.", 
            "id": "sg:person.01332031744.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332031744.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ong", 
            "givenName": "Rick Twee-Hee", 
            "id": "sg:person.011776531702.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011776531702.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai Institutes for Biological Sciences", 
              "id": "https://www.grid.ac/institutes/grid.419092.7", 
              "name": [
                "Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Shuhua", 
            "id": "sg:person.0675220571.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675220571.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "NUS Graduate School for Integrative Science and Engineering, National University of Singapore, 117456, Singapore, Singapore", 
                "Life Sciences Institute, National University of Singapore, Singapore, Singapore", 
                "Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore", 
                "Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore", 
                "Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teo", 
            "givenName": "Yik-Ying", 
            "id": "sg:person.01260753642.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260753642.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universiti Teknologi MARA", 
              "id": "https://www.grid.ac/institutes/grid.412259.9", 
              "name": [
                "Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoh", 
            "givenName": "Boon-Peng", 
            "id": "sg:person.01104105532.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104105532.69"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.coi.2014.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000468965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0042752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003446063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddq562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004850752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006031494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006031494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meegid.2010.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006690680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0051954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007837560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35104556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008333288", 
              "https://doi.org/10.1038/35104556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35104556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008333288", 
              "https://doi.org/10.1038/35104556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008801427", 
              "https://doi.org/10.1186/1471-2164-15-332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/421330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008987909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.094052.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010760027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011171459", 
              "https://doi.org/10.1186/1475-2875-12-442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/475163a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012197070", 
              "https://doi.org/10.1038/475163a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/432519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013319026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/432519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013319026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2014.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013481510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013729483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0049420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013781968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.m800345-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014114062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-8-452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015324104", 
              "https://doi.org/10.1186/1471-2164-8-452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0054224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015628688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddp135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015689209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.genom.9.081307.164258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015816507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018458573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000113874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020090233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020577290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020959085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.32042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022169974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022356000", 
              "https://doi.org/10.1038/ng.2274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022356000", 
              "https://doi.org/10.1038/ng.2274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-012-1246-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022662430", 
              "https://doi.org/10.1007/s00439-012-1246-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-012-1246-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022662430", 
              "https://doi.org/10.1007/s00439-012-1246-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1996.0153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022685368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2013.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023037248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0011141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024294072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025605016", 
              "https://doi.org/10.1038/ejhg.2009.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0048136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026788710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6363797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027049439", 
              "https://doi.org/10.1038/sj.gene.6363797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6363797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027049439", 
              "https://doi.org/10.1038/sj.gene.6363797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6364029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027088073", 
              "https://doi.org/10.1038/sj.gene.6364029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6364029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027088073", 
              "https://doi.org/10.1038/sj.gene.6364029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2009.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027661998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.095000.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029664825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-7364-1-4-274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030594734", 
              "https://doi.org/10.1186/1479-7364-1-4-274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.micinf.2007.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030822683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0040072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030948598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0040072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030948598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031016105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031429813", 
              "https://doi.org/10.1038/ng1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031429813", 
              "https://doi.org/10.1038/ng1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-13-215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031820446", 
              "https://doi.org/10.1186/1471-2334-13-215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijerph7020675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033326721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2156-8-52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035861351", 
              "https://doi.org/10.1186/1471-2156-8-52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3349/ymj.2013.54.6.1305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036027575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036876479", 
              "https://doi.org/10.1038/nature06250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037825612", 
              "https://doi.org/10.1038/nature06742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci34261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038834108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-014-1459-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039298505", 
              "https://doi.org/10.1007/s00439-014-1459-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-014-1459-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039298505", 
              "https://doi.org/10.1007/s00439-014-1459-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1177074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039839810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1177074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039839810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhevol.2006.08.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041271789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0018312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043295886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376246a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043839051", 
              "https://doi.org/10.1038/376246a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043904525", 
              "https://doi.org/10.1038/mp.2011.138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.01175-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044042233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.087577.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044062201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00795-007-0364-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045993991", 
              "https://doi.org/10.1007/s00795-007-0364-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00795-007-0364-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045993991", 
              "https://doi.org/10.1007/s00795-007-0364-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0100371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047265244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048198889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050063186", 
              "https://doi.org/10.1038/ng.3107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-002-0712-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050752417", 
              "https://doi.org/10.1007/s00436-002-0712-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pnpbp.2013.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051532312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052177809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/521987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052475645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052674054", 
              "https://doi.org/10.1038/nature09298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052674054", 
              "https://doi.org/10.1038/nature09298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/302879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058610435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/338628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058637905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1109792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062451600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3125610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062592548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074702389", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077461452", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080546723", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082687240", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-04", 
        "datePublishedReg": "2015-04-01", 
        "description": "The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00439-014-1525-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7015369", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1085982", 
            "issn": [
              "0340-6717", 
              "1432-1203"
            ], 
            "name": "Human Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "134"
          }
        ], 
        "name": "Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia", 
        "pagination": "375-392", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "75a427370646f21628cd81f65fb7ac6d807a6495ae427a4df9ec5631f1d9c5a8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25634076"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7613873"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00439-014-1525-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024693724"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00439-014-1525-2", 
          "https://app.dimensions.ai/details/publication/pub.1024693724"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89824_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00439-014-1525-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00439-014-1525-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00439-014-1525-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00439-014-1525-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00439-014-1525-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    512 TRIPLES      21 PREDICATES      120 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00439-014-1525-2 schema:about N030c2891102a495c92743ee575299a20
    2 N0546a2d96cb5478e8f75a310ce854e0f
    3 N17bc7638dcb14322a360e95f8c74cd38
    4 N46f24371a39d4469be3fc614539606bd
    5 N5d92e8ead4c843f59bd3569e9ba27841
    6 N5db6727e7f2a4b0bbfc1c3a45822c0c8
    7 N5dcb48875fc848afa514e72739daf284
    8 N81ee6dcd376f4203b1d0160fcb743ecc
    9 N90aa1011c1504efaae44e74f9d201c70
    10 N91a04a6c56ec4d65831c11afd5ec15d1
    11 Na3bfbb0c20664dfd8f73b4ad26a31728
    12 Nc18843627cb84e3b84ab70c2af512b9f
    13 Ncb791fc77cb54430beec1195a6e93720
    14 Nd02f8e8c12674a7e8667ae818eb49cfe
    15 Nd35c7d57b7d9443f8677e4cd86a90541
    16 Ndaf3eac524ed46539f85b2930cbf408b
    17 anzsrc-for:06
    18 anzsrc-for:0604
    19 schema:author Nba39f27f8ec7407e9456661a6a0f29a8
    20 schema:citation sg:pub.10.1007/s00436-002-0712-6
    21 sg:pub.10.1007/s00439-012-1246-3
    22 sg:pub.10.1007/s00439-014-1459-8
    23 sg:pub.10.1007/s00795-007-0364-9
    24 sg:pub.10.1038/35104556
    25 sg:pub.10.1038/376246a0
    26 sg:pub.10.1038/475163a
    27 sg:pub.10.1038/ejhg.2009.8
    28 sg:pub.10.1038/mp.2011.138
    29 sg:pub.10.1038/nature06250
    30 sg:pub.10.1038/nature06742
    31 sg:pub.10.1038/nature09298
    32 sg:pub.10.1038/ng.2274
    33 sg:pub.10.1038/ng.3107
    34 sg:pub.10.1038/ng1847
    35 sg:pub.10.1038/sj.gene.6363797
    36 sg:pub.10.1038/sj.gene.6364029
    37 sg:pub.10.1186/1471-2156-8-52
    38 sg:pub.10.1186/1471-2164-15-332
    39 sg:pub.10.1186/1471-2164-8-452
    40 sg:pub.10.1186/1471-2334-13-215
    41 sg:pub.10.1186/1475-2875-12-442
    42 sg:pub.10.1186/1479-7364-1-4-274
    43 https://app.dimensions.ai/details/publication/pub.1074702389
    44 https://app.dimensions.ai/details/publication/pub.1077461452
    45 https://app.dimensions.ai/details/publication/pub.1080546723
    46 https://app.dimensions.ai/details/publication/pub.1082687240
    47 https://doi.org/10.1002/ajmg.b.32042
    48 https://doi.org/10.1006/geno.1996.0153
    49 https://doi.org/10.1016/j.ajhg.2013.04.021
    50 https://doi.org/10.1016/j.coi.2014.05.001
    51 https://doi.org/10.1016/j.coi.2014.06.004
    52 https://doi.org/10.1016/j.immuni.2009.01.001
    53 https://doi.org/10.1016/j.jhevol.2006.08.011
    54 https://doi.org/10.1016/j.meegid.2010.09.009
    55 https://doi.org/10.1016/j.micinf.2007.04.011
    56 https://doi.org/10.1016/j.pnpbp.2013.01.004
    57 https://doi.org/10.1016/j.tig.2009.12.010
    58 https://doi.org/10.1086/302879
    59 https://doi.org/10.1086/338628
    60 https://doi.org/10.1086/421330
    61 https://doi.org/10.1086/432519
    62 https://doi.org/10.1086/519795
    63 https://doi.org/10.1086/521987
    64 https://doi.org/10.1093/hmg/ddp135
    65 https://doi.org/10.1093/hmg/ddq562
    66 https://doi.org/10.1101/gr.087577.108
    67 https://doi.org/10.1101/gr.094052.109
    68 https://doi.org/10.1101/gr.095000.109
    69 https://doi.org/10.1126/science.1109792
    70 https://doi.org/10.1126/science.1177074
    71 https://doi.org/10.1126/science.3125610
    72 https://doi.org/10.1128/iai.01175-12
    73 https://doi.org/10.1146/annurev.genom.9.081307.164258
    74 https://doi.org/10.1146/annurev.immunol.24.021605.090513
    75 https://doi.org/10.1159/000113874
    76 https://doi.org/10.1172/jci34261
    77 https://doi.org/10.1194/jlr.m800345-jlr200
    78 https://doi.org/10.1371/journal.pbio.0040072
    79 https://doi.org/10.1371/journal.pgen.1002066
    80 https://doi.org/10.1371/journal.pgen.1002355
    81 https://doi.org/10.1371/journal.pgen.1002607
    82 https://doi.org/10.1371/journal.pgen.1002641
    83 https://doi.org/10.1371/journal.pgen.1002695
    84 https://doi.org/10.1371/journal.pgen.1003509
    85 https://doi.org/10.1371/journal.pone.0011141
    86 https://doi.org/10.1371/journal.pone.0018312
    87 https://doi.org/10.1371/journal.pone.0042752
    88 https://doi.org/10.1371/journal.pone.0048136
    89 https://doi.org/10.1371/journal.pone.0049420
    90 https://doi.org/10.1371/journal.pone.0051954
    91 https://doi.org/10.1371/journal.pone.0054224
    92 https://doi.org/10.1371/journal.pone.0100371
    93 https://doi.org/10.3349/ymj.2013.54.6.1305
    94 https://doi.org/10.3390/ijerph7020675
    95 schema:datePublished 2015-04
    96 schema:datePublishedReg 2015-04-01
    97 schema:description The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.
    98 schema:genre research_article
    99 schema:inLanguage en
    100 schema:isAccessibleForFree false
    101 schema:isPartOf N69054e3b73494c1dab4293957066835d
    102 Nca0112b99f7a449bb3955d1e44db837e
    103 sg:journal.1085982
    104 schema:name Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia
    105 schema:pagination 375-392
    106 schema:productId N15c1537fd80141739b4e54e8621ba25b
    107 N4c9178f5265f4758867afa0fbc13f42a
    108 N7330bc0a70a3434dacc240ca2eda6953
    109 Ncecbeed8042248a6b03c3ad137c065d1
    110 Nf94e8eac5f43470b88879cba35f0d151
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024693724
    112 https://doi.org/10.1007/s00439-014-1525-2
    113 schema:sdDatePublished 2019-04-11T10:03
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher Nd18f9b6e356d4f64a087ff659beb2405
    116 schema:url https://link.springer.com/10.1007%2Fs00439-014-1525-2
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N030c2891102a495c92743ee575299a20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Cadherins
    122 rdf:type schema:DefinedTerm
    123 N0546a2d96cb5478e8f75a310ce854e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Polymorphism, Single Nucleotide
    125 rdf:type schema:DefinedTerm
    126 N139f691370d94eba8df07a4cbfb324e9 rdf:first sg:person.0737765012.33
    127 rdf:rest N7b79f5f7eb344c078544dbe4c012f0e2
    128 N15c1537fd80141739b4e54e8621ba25b schema:name nlm_unique_id
    129 schema:value 7613873
    130 rdf:type schema:PropertyValue
    131 N17bc7638dcb14322a360e95f8c74cd38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Malaysia
    133 rdf:type schema:DefinedTerm
    134 N198423cfa90848499a5cd9d7557cf56f rdf:first sg:person.0634563630.12
    135 rdf:rest Nf3b8bfb14e2941149c9cf8367c70461d
    136 N1b832302b63b4efe81c6228e58a6efe7 rdf:first sg:person.01354642310.31
    137 rdf:rest N901b8b245d3d4c20a93fb9cae8b0a581
    138 N2de36bf5f07042b7b184a5f77ec7c610 rdf:first sg:person.01113617415.80
    139 rdf:rest N35bcdb3243814c1896a4d68b7d654f0d
    140 N35bcdb3243814c1896a4d68b7d654f0d rdf:first sg:person.01332031744.05
    141 rdf:rest Nbe2fcd4f73154af1a02521cba71ba4fe
    142 N3f613bbc5e97467bbc2a41099b8a6f48 rdf:first sg:person.01353003612.60
    143 rdf:rest N198423cfa90848499a5cd9d7557cf56f
    144 N45432c1a48db496cb0f028775f6881d8 schema:name Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Subang Jaya, Selangor, Malaysia
    145 rdf:type schema:Organization
    146 N46f24371a39d4469be3fc614539606bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Lymphotoxin-alpha
    148 rdf:type schema:DefinedTerm
    149 N4c9178f5265f4758867afa0fbc13f42a schema:name doi
    150 schema:value 10.1007/s00439-014-1525-2
    151 rdf:type schema:PropertyValue
    152 N4dddcda5546d493889ab2a4b4738c464 rdf:first sg:person.01062013407.40
    153 rdf:rest N3f613bbc5e97467bbc2a41099b8a6f48
    154 N52c959186208434880a17c35d7709ffc rdf:first sg:person.0675220571.65
    155 rdf:rest Nb94696f9fabb476eb5c8ae081ed9863e
    156 N57e1dd6a45b04ec2bfff91d72baad7b3 rdf:first sg:person.01054213412.59
    157 rdf:rest N1b832302b63b4efe81c6228e58a6efe7
    158 N59c1cd7d9ee8449f91355d3b6ccbed81 rdf:first sg:person.01104105532.69
    159 rdf:rest rdf:nil
    160 N5d92e8ead4c843f59bd3569e9ba27841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Nitric Oxide Synthase Type II
    162 rdf:type schema:DefinedTerm
    163 N5db6727e7f2a4b0bbfc1c3a45822c0c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Population Groups
    165 rdf:type schema:DefinedTerm
    166 N5dcb48875fc848afa514e72739daf284 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Malaria
    168 rdf:type schema:DefinedTerm
    169 N69054e3b73494c1dab4293957066835d schema:issueNumber 4
    170 rdf:type schema:PublicationIssue
    171 N7330bc0a70a3434dacc240ca2eda6953 schema:name readcube_id
    172 schema:value 75a427370646f21628cd81f65fb7ac6d807a6495ae427a4df9ec5631f1d9c5a8
    173 rdf:type schema:PropertyValue
    174 N7b79f5f7eb344c078544dbe4c012f0e2 rdf:first sg:person.01336632622.29
    175 rdf:rest N57e1dd6a45b04ec2bfff91d72baad7b3
    176 N81ee6dcd376f4203b1d0160fcb743ecc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 N901b8b245d3d4c20a93fb9cae8b0a581 rdf:first sg:person.01170442012.29
    180 rdf:rest Nfeafa95ded044835b67adbaf1f62652d
    181 N90aa1011c1504efaae44e74f9d201c70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Selection, Genetic
    183 rdf:type schema:DefinedTerm
    184 N91a04a6c56ec4d65831c11afd5ec15d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Disease Resistance
    186 rdf:type schema:DefinedTerm
    187 Na3bfbb0c20664dfd8f73b4ad26a31728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Genome-Wide Association Study
    189 rdf:type schema:DefinedTerm
    190 Nb94696f9fabb476eb5c8ae081ed9863e rdf:first sg:person.01260753642.13
    191 rdf:rest N59c1cd7d9ee8449f91355d3b6ccbed81
    192 Nba39f27f8ec7407e9456661a6a0f29a8 rdf:first sg:person.01013600010.49
    193 rdf:rest N139f691370d94eba8df07a4cbfb324e9
    194 Nbe2fcd4f73154af1a02521cba71ba4fe rdf:first sg:person.011776531702.77
    195 rdf:rest N52c959186208434880a17c35d7709ffc
    196 Nc18843627cb84e3b84ab70c2af512b9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Adaptation, Biological
    198 rdf:type schema:DefinedTerm
    199 Nca0112b99f7a449bb3955d1e44db837e schema:volumeNumber 134
    200 rdf:type schema:PublicationVolume
    201 Ncb791fc77cb54430beec1195a6e93720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name fas Receptor
    203 rdf:type schema:DefinedTerm
    204 Ncecbeed8042248a6b03c3ad137c065d1 schema:name dimensions_id
    205 schema:value pub.1024693724
    206 rdf:type schema:PropertyValue
    207 Nd02f8e8c12674a7e8667ae818eb49cfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Transcriptome
    209 rdf:type schema:DefinedTerm
    210 Nd18f9b6e356d4f64a087ff659beb2405 schema:name Springer Nature - SN SciGraph project
    211 rdf:type schema:Organization
    212 Nd35c7d57b7d9443f8677e4cd86a90541 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Heme Oxygenase-1
    214 rdf:type schema:DefinedTerm
    215 Nd3a1f44b9afa42d09f18dc9027ce3ac4 schema:name Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Subang Jaya, Selangor, Malaysia
    216 rdf:type schema:Organization
    217 Ndaf3eac524ed46539f85b2930cbf408b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Tumor Necrosis Factor-alpha
    219 rdf:type schema:DefinedTerm
    220 Nf3b8bfb14e2941149c9cf8367c70461d rdf:first sg:person.0675512712.50
    221 rdf:rest N2de36bf5f07042b7b184a5f77ec7c610
    222 Nf94e8eac5f43470b88879cba35f0d151 schema:name pubmed_id
    223 schema:value 25634076
    224 rdf:type schema:PropertyValue
    225 Nfeafa95ded044835b67adbaf1f62652d rdf:first sg:person.01234172704.60
    226 rdf:rest N4dddcda5546d493889ab2a4b4738c464
    227 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Biological Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Genetics
    232 rdf:type schema:DefinedTerm
    233 sg:grant.7015369 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-014-1525-2
    234 rdf:type schema:MonetaryGrant
    235 sg:journal.1085982 schema:issn 0340-6717
    236 1432-1203
    237 schema:name Human Genetics
    238 rdf:type schema:Periodical
    239 sg:person.01013600010.49 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    240 schema:familyName Liu
    241 schema:givenName Xuanyao
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013600010.49
    243 rdf:type schema:Person
    244 sg:person.01054213412.59 schema:affiliation N45432c1a48db496cb0f028775f6881d8
    245 schema:familyName Aghakhanian
    246 schema:givenName Farhang
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054213412.59
    248 rdf:type schema:Person
    249 sg:person.01062013407.40 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    250 schema:familyName Wang
    251 schema:givenName Xu
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062013407.40
    253 rdf:type schema:Person
    254 sg:person.01104105532.69 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    255 schema:familyName Hoh
    256 schema:givenName Boon-Peng
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104105532.69
    258 rdf:type schema:Person
    259 sg:person.01113617415.80 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    260 schema:familyName Salleh
    261 schema:givenName Mohd Zaki
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113617415.80
    263 rdf:type schema:Person
    264 sg:person.01170442012.29 schema:affiliation https://www.grid.ac/institutes/grid.419092.7
    265 schema:familyName Deng
    266 schema:givenName Lian
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170442012.29
    268 rdf:type schema:Person
    269 sg:person.011776531702.77 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    270 schema:familyName Ong
    271 schema:givenName Rick Twee-Hee
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011776531702.77
    273 rdf:type schema:Person
    274 sg:person.01234172704.60 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    275 schema:familyName Ali
    276 schema:givenName Mohammad
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234172704.60
    278 rdf:type schema:Person
    279 sg:person.01260753642.13 schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    280 schema:familyName Teo
    281 schema:givenName Yik-Ying
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260753642.13
    283 rdf:type schema:Person
    284 sg:person.01332031744.05 schema:affiliation Nd3a1f44b9afa42d09f18dc9027ce3ac4
    285 schema:familyName Phipps
    286 schema:givenName Maude E.
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332031744.05
    288 rdf:type schema:Person
    289 sg:person.01336632622.29 schema:affiliation https://www.grid.ac/institutes/grid.419092.7
    290 schema:familyName Lu
    291 schema:givenName Dongsheng
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336632622.29
    293 rdf:type schema:Person
    294 sg:person.01353003612.60 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    295 schema:familyName Ghazali
    296 schema:givenName Fadzilah
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353003612.60
    298 rdf:type schema:Person
    299 sg:person.01354642310.31 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    300 schema:familyName Saw
    301 schema:givenName Woei-Yuh
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354642310.31
    303 rdf:type schema:Person
    304 sg:person.0634563630.12 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    305 schema:familyName Abdul Rahman
    306 schema:givenName Thuhairah
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634563630.12
    308 rdf:type schema:Person
    309 sg:person.0675220571.65 schema:affiliation https://www.grid.ac/institutes/grid.419092.7
    310 schema:familyName Xu
    311 schema:givenName Shuhua
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675220571.65
    313 rdf:type schema:Person
    314 sg:person.0675512712.50 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    315 schema:familyName Shaari
    316 schema:givenName Shahrul Azlin
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675512712.50
    318 rdf:type schema:Person
    319 sg:person.0737765012.33 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
    320 schema:familyName Yunus
    321 schema:givenName Yushimah
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737765012.33
    323 rdf:type schema:Person
    324 sg:pub.10.1007/s00436-002-0712-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050752417
    325 https://doi.org/10.1007/s00436-002-0712-6
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s00439-012-1246-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022662430
    328 https://doi.org/10.1007/s00439-012-1246-3
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s00439-014-1459-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039298505
    331 https://doi.org/10.1007/s00439-014-1459-8
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s00795-007-0364-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045993991
    334 https://doi.org/10.1007/s00795-007-0364-9
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/35104556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008333288
    337 https://doi.org/10.1038/35104556
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/376246a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043839051
    340 https://doi.org/10.1038/376246a0
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/475163a schema:sameAs https://app.dimensions.ai/details/publication/pub.1012197070
    343 https://doi.org/10.1038/475163a
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/ejhg.2009.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025605016
    346 https://doi.org/10.1038/ejhg.2009.8
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/mp.2011.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043904525
    349 https://doi.org/10.1038/mp.2011.138
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nature06250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036876479
    352 https://doi.org/10.1038/nature06250
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nature06742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037825612
    355 https://doi.org/10.1038/nature06742
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nature09298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052674054
    358 https://doi.org/10.1038/nature09298
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/ng.2274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022356000
    361 https://doi.org/10.1038/ng.2274
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/ng.3107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050063186
    364 https://doi.org/10.1038/ng.3107
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/ng1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429813
    367 https://doi.org/10.1038/ng1847
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/sj.gene.6363797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027049439
    370 https://doi.org/10.1038/sj.gene.6363797
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/sj.gene.6364029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027088073
    373 https://doi.org/10.1038/sj.gene.6364029
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1186/1471-2156-8-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035861351
    376 https://doi.org/10.1186/1471-2156-8-52
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1186/1471-2164-15-332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008801427
    379 https://doi.org/10.1186/1471-2164-15-332
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1186/1471-2164-8-452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015324104
    382 https://doi.org/10.1186/1471-2164-8-452
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1186/1471-2334-13-215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031820446
    385 https://doi.org/10.1186/1471-2334-13-215
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1186/1475-2875-12-442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011171459
    388 https://doi.org/10.1186/1475-2875-12-442
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1186/1479-7364-1-4-274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030594734
    391 https://doi.org/10.1186/1479-7364-1-4-274
    392 rdf:type schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1074702389 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1077461452 schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1080546723 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1082687240 schema:CreativeWork
    397 https://doi.org/10.1002/ajmg.b.32042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022169974
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1006/geno.1996.0153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022685368
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/j.ajhg.2013.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023037248
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/j.coi.2014.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013481510
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/j.coi.2014.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000468965
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/j.immuni.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031016105
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1016/j.jhevol.2006.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041271789
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1016/j.meegid.2010.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006690680
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/j.micinf.2007.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030822683
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.pnpbp.2013.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051532312
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.tig.2009.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027661998
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1086/302879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610435
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1086/338628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058637905
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1086/421330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008987909
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1086/432519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013319026
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1086/521987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052475645
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1093/hmg/ddp135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015689209
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1093/hmg/ddq562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004850752
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1101/gr.087577.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044062201
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1101/gr.094052.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010760027
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1101/gr.095000.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029664825
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1126/science.1109792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451600
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1126/science.1177074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039839810
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1126/science.3125610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062592548
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1128/iai.01175-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044042233
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1146/annurev.genom.9.081307.164258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015816507
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1146/annurev.immunol.24.021605.090513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458573
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1159/000113874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020090233
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1172/jci34261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038834108
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1194/jlr.m800345-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014114062
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1371/journal.pbio.0040072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030948598
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1371/journal.pgen.1002066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013729483
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1371/journal.pgen.1002355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052177809
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1371/journal.pgen.1002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006031494
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1371/journal.pgen.1002641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020577290
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1371/journal.pgen.1002695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020959085
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1371/journal.pgen.1003509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048198889
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1371/journal.pone.0011141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024294072
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1371/journal.pone.0018312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043295886
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1371/journal.pone.0042752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003446063
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1371/journal.pone.0048136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026788710
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1371/journal.pone.0049420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013781968
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1371/journal.pone.0051954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007837560
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1371/journal.pone.0054224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015628688
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1371/journal.pone.0100371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265244
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.3349/ymj.2013.54.6.1305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036027575
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.3390/ijerph7020675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033326721
    492 rdf:type schema:CreativeWork
    493 https://www.grid.ac/institutes/grid.412259.9 schema:alternateName Universiti Teknologi MARA
    494 schema:name Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia
    495 Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia
    496 Integrative Pharmacogenomics Institute, Universiti Teknologi MARA, 42300, Puncak Alam, Selangor, Malaysia
    497 rdf:type schema:Organization
    498 https://www.grid.ac/institutes/grid.418377.e schema:alternateName Genome Institute of Singapore
    499 schema:name Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore
    500 Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore, Singapore
    501 Life Sciences Institute, National University of Singapore, Singapore, Singapore
    502 NUS Graduate School for Integrative Science and Engineering, National University of Singapore, 117456, Singapore, Singapore
    503 Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore
    504 rdf:type schema:Organization
    505 https://www.grid.ac/institutes/grid.419092.7 schema:alternateName Shanghai Institutes for Biological Sciences
    506 schema:name Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, Shanghai, China
    507 rdf:type schema:Organization
    508 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
    509 schema:name Life Sciences Institute, National University of Singapore, Singapore, Singapore
    510 NUS Graduate School for Integrative Science and Engineering, National University of Singapore, 117456, Singapore, Singapore
    511 Saw Swee Hock School of Public Health, National University of Singapore, 117597, Singapore, Singapore
    512 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...