Identification of BACH2 as a susceptibility gene for Graves’ disease in the Chinese Han population based on a three-stage genome-wide ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-12

AUTHORS

Wei Liu, Hai-Ning Wang, Zhao-Hui Gu, Shao-Ying Yang, Xiao-Ping Ye, Chun-Ming Pan, Shuang-Xia Zhao, Li-Qiong Xue, Hui-Jun Xie, Sha-Sha Yu, Cui-Cui Guo, Wen-Hua Du, Jun Liang, Xiao-Mei Zhang, Guo-Yue Yuan, Chang-Gui Li, Qing Su, Guan-Qi Gao, Huai-Dong Song, The China Consortium for the Genetics of Autoimmune Thyroid Disease

ABSTRACT

The BACH2 gene regulates B cell differentiation and function and has been reported to be a shared susceptibility gene for several autoimmune diseases. Our previous genome-wide association study (GWAS) indicated that several single nucleotide polymorphisms (SNPs) in the BACH2 gene are associated with Graves’ disease (GD) in the Chinese Han population; however, the association did not achieve genome-wide significance levels. Recently, this association of BACH2 with GD was confirmed in Caucasians in the UK population, but fine mapping in this region has not yet been reported. Here, we provide a refined analysis of a 331-kb region in the BACH2 gene, which harbors 359 SNPs, using GWAS data from 1,442 GD patients and 1,468 controls. The SNPs rs2474619 and rs9344996 were implied as the independent variants associated with GD by forward and two-locus logistic regression analysis. We genotyped eight out of 10 tagSNPs with P < 1 × 10−3 in 3,508 GD patients and 3,209 controls, the results also showed that rs2474619 was independently associated with GD in the combined population from GWAS and the second stage (P = 1.81 × 10−5). The rs2474619 and rs9344996 were further genotyped in the third stage cohorts, and rs2474619 showed evidence of association with GD at genome-wide significance levels in the combined population (P = 3.28 × 10−8, odds ratio = 1.13). The association of rs9344996 with GD can be explained by its linkage to rs2474619 in the combined population. Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population and further supported rs2474619, in intron 2 of BACH2, is the best association signal with GD. However, the mechanism by which BACH2 confers increased risk of GD requires further study. More... »

PAGES

661-671

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00439-013-1404-2

DOI

http://dx.doi.org/10.1007/s00439-013-1404-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002082874

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24346624


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic-Leucine Zipper Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "China", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethnicity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graves Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
            "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Wei", 
        "id": "sg:person.014252467675.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014252467675.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Hai-Ning", 
        "id": "sg:person.01204347234.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204347234.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Center for Systems Biomedicine, SJTU, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
            "Shanghai Center for Systems Biomedicine, SJTU, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gu", 
        "givenName": "Zhao-Hui", 
        "id": "sg:person.01105076466.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105076466.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
            "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Shao-Ying", 
        "id": "sg:person.0705557034.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705557034.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Xiao-Ping", 
        "id": "sg:person.0647564444.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647564444.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Chun-Ming", 
        "id": "sg:person.01022005434.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022005434.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
            "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Shuang-Xia", 
        "id": "sg:person.01246621334.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246621334.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xue", 
        "givenName": "Li-Qiong", 
        "id": "sg:person.0753672234.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753672234.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Hui-Jun", 
        "id": "sg:person.01312550444.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312550444.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Sha-Sha", 
        "id": "sg:person.0764013044.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764013044.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412277.5", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Cui-Cui", 
        "id": "sg:person.0673656570.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673656570.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, People\u2019s Hospital of Linyi, Linyi, Shandong, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology, People\u2019s Hospital of Linyi, Linyi, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Du", 
        "givenName": "Wen-Hua", 
        "id": "sg:person.01237160262.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237160262.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College, Xuzhou, Jiangsu, China", 
          "id": "http://www.grid.ac/institutes/grid.452207.6", 
          "name": [
            "Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College, Xuzhou, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liang", 
        "givenName": "Jun", 
        "id": "sg:person.0652556715.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652556715.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The First Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China", 
          "id": "http://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Endocrinology, The First Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiao-Mei", 
        "id": "sg:person.01366711034.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366711034.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, The Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, China", 
          "id": "http://www.grid.ac/institutes/grid.452247.2", 
          "name": [
            "Department of Endocrinology, The Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Guo-Yue", 
        "id": "sg:person.01056047705.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056047705.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology and Gout Laboratory, Medical School Hospital of Qingdao University, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410645.2", 
          "name": [
            "Department of Endocrinology and Gout Laboratory, Medical School Hospital of Qingdao University, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Chang-Gui", 
        "id": "sg:person.0676564741.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676564741.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Xin-Hua Hospital Affiliated to SJTU School of Medicine, 200092, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "Department of Endocrinology, Xin-Hua Hospital Affiliated to SJTU School of Medicine, 200092, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Qing", 
        "id": "sg:person.01045201054.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045201054.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, People\u2019s Hospital of Linyi, Linyi, Shandong, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology, People\u2019s Hospital of Linyi, Linyi, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Guan-Qi", 
        "id": "sg:person.01073761734.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073761734.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China", 
            "Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Huai-Dong", 
        "id": "sg:person.01142075134.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142075134.59"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "The China Consortium for the Genetics of Autoimmune Thyroid Disease", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038635012", 
          "https://doi.org/10.1038/nature10251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050156935", 
          "https://doi.org/10.1038/ng.2272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002559443", 
          "https://doi.org/10.1038/ng.898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046979341", 
          "https://doi.org/10.1038/ng2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019025470", 
          "https://doi.org/10.1038/ng.717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004357092", 
          "https://doi.org/10.1038/nature01621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003424220", 
          "https://doi.org/10.1038/ng.249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050960747", 
          "https://doi.org/10.1038/ng.543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011250834", 
          "https://doi.org/10.1038/nature02596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052626361", 
          "https://doi.org/10.1038/ng.381"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12-12", 
    "datePublishedReg": "2013-12-12", 
    "description": "The BACH2 gene regulates B cell differentiation and function and has been reported to be a shared susceptibility gene for several autoimmune diseases. Our previous genome-wide association study (GWAS) indicated that several single nucleotide polymorphisms (SNPs) in the BACH2 gene are associated with Graves\u2019 disease (GD) in the Chinese Han population; however, the association did not achieve genome-wide significance levels. Recently, this association of BACH2 with GD was confirmed in Caucasians in the UK population, but fine mapping in this region has not yet been reported. Here, we provide a refined analysis of a 331-kb region in the BACH2 gene, which harbors 359 SNPs, using GWAS data from 1,442 GD patients and 1,468 controls. The SNPs rs2474619 and rs9344996 were implied as the independent variants associated with GD by forward and two-locus logistic regression analysis. We genotyped eight out of 10 tagSNPs with P\u00a0<\u00a01\u00a0\u00d7\u00a010\u22123 in 3,508 GD patients and 3,209 controls, the results also showed that rs2474619 was independently associated with GD in the combined population from GWAS and the second stage (P\u00a0=\u00a01.81\u00a0\u00d7\u00a010\u22125). The rs2474619 and rs9344996 were further genotyped in the third stage cohorts, and rs2474619 showed evidence of association with GD at genome-wide significance levels in the combined population (P\u00a0=\u00a03.28\u00a0\u00d7\u00a010\u22128, odds ratio\u00a0=\u00a01.13). The association of rs9344996 with GD can be explained by its linkage to rs2474619 in the combined population. Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population and further supported rs2474619, in intron 2 of BACH2, is the best association signal with GD. However, the mechanism by which BACH2 confers increased risk of GD requires further study.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00439-013-1404-2", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085982", 
        "issn": [
          "0340-6717", 
          "1432-1203"
        ], 
        "name": "Human Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "133"
      }
    ], 
    "keywords": [
      "genome-wide association studies", 
      "genome-wide significance level", 
      "single nucleotide polymorphisms", 
      "BACH2 gene", 
      "susceptibility genes", 
      "association studies", 
      "three-stage genome-wide association study", 
      "previous genome-wide association study", 
      "fine mapping", 
      "GWAS data", 
      "association signals", 
      "B cell differentiation", 
      "cell differentiation", 
      "best association signal", 
      "genes", 
      "Bach2", 
      "intron 2", 
      "nucleotide polymorphisms", 
      "independent variants", 
      "Chinese Han population", 
      "evidence of association", 
      "stage cohort", 
      "Han population", 
      "risk of GD", 
      "population", 
      "differentiation", 
      "confers", 
      "polymorphism", 
      "tagSNPs", 
      "region", 
      "variants", 
      "Further studies", 
      "identification", 
      "mechanism", 
      "association", 
      "GD patients", 
      "levels", 
      "disease", 
      "linkage", 
      "autoimmune diseases", 
      "function", 
      "mapping", 
      "analysis", 
      "study", 
      "stage", 
      "control", 
      "signals", 
      "refined analysis", 
      "evidence", 
      "UK population", 
      "significance level", 
      "data", 
      "results", 
      "Caucasians", 
      "Gd", 
      "Graves", 
      "risk", 
      "cohort", 
      "second stage", 
      "patients", 
      "regression analysis", 
      "logistic regression analysis"
    ], 
    "name": "Identification of BACH2 as a susceptibility gene for Graves\u2019 disease in the Chinese Han population based on a three-stage genome-wide association study", 
    "pagination": "661-671", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002082874"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00439-013-1404-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24346624"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00439-013-1404-2", 
      "https://app.dimensions.ai/details/publication/pub.1002082874"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_596.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00439-013-1404-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00439-013-1404-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00439-013-1404-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00439-013-1404-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00439-013-1404-2'


 

This table displays all metadata directly associated to this object as RDF triples.

368 TRIPLES      21 PREDICATES      110 URIs      92 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00439-013-1404-2 schema:about N0610bb95d31049e493258280a327a8c9
2 N1e9b89a40700464f82c3d9c1c20a3b50
3 N1fb8bb075bc34c4aa83f09e563e8467d
4 N51605542566c4a559ac404092ef1ef05
5 N52b550a530954cecac523987770007b9
6 N647e5013e7004f4ab305f50dd1a0c0ed
7 N6777fef6f9ce47aca0b974d82c3f3b23
8 N826a61c9b7dd493e9938e298c1639376
9 Nb1a2941dc72a4a1088a3baa5bde83312
10 Nd23157cf8b404cb88abee73e99b04c9f
11 Nd5bb8f66a6cd49cd92db9ef7b8595768
12 Ndc0688ad00314e4ca58685ccd23bf4f2
13 Ne0caabfc36004fad91d0325909603ba2
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N185374e6fd704491ba8ad07bccd4c08a
17 schema:citation sg:pub.10.1038/nature01621
18 sg:pub.10.1038/nature02596
19 sg:pub.10.1038/nature10251
20 sg:pub.10.1038/ng.2272
21 sg:pub.10.1038/ng.249
22 sg:pub.10.1038/ng.381
23 sg:pub.10.1038/ng.543
24 sg:pub.10.1038/ng.717
25 sg:pub.10.1038/ng.898
26 sg:pub.10.1038/ng2088
27 schema:datePublished 2013-12-12
28 schema:datePublishedReg 2013-12-12
29 schema:description The BACH2 gene regulates B cell differentiation and function and has been reported to be a shared susceptibility gene for several autoimmune diseases. Our previous genome-wide association study (GWAS) indicated that several single nucleotide polymorphisms (SNPs) in the BACH2 gene are associated with Graves’ disease (GD) in the Chinese Han population; however, the association did not achieve genome-wide significance levels. Recently, this association of BACH2 with GD was confirmed in Caucasians in the UK population, but fine mapping in this region has not yet been reported. Here, we provide a refined analysis of a 331-kb region in the BACH2 gene, which harbors 359 SNPs, using GWAS data from 1,442 GD patients and 1,468 controls. The SNPs rs2474619 and rs9344996 were implied as the independent variants associated with GD by forward and two-locus logistic regression analysis. We genotyped eight out of 10 tagSNPs with P < 1 × 10−3 in 3,508 GD patients and 3,209 controls, the results also showed that rs2474619 was independently associated with GD in the combined population from GWAS and the second stage (P = 1.81 × 10−5). The rs2474619 and rs9344996 were further genotyped in the third stage cohorts, and rs2474619 showed evidence of association with GD at genome-wide significance levels in the combined population (P = 3.28 × 10−8, odds ratio = 1.13). The association of rs9344996 with GD can be explained by its linkage to rs2474619 in the combined population. Our study clearly demonstrated that BACH2 is a susceptibility gene for GD in the Chinese Han population and further supported rs2474619, in intron 2 of BACH2, is the best association signal with GD. However, the mechanism by which BACH2 confers increased risk of GD requires further study.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N75aad3425117420eacb18f6ac5b72679
33 N9847b16de6d2421d924ea47261ef1d4c
34 sg:journal.1085982
35 schema:keywords B cell differentiation
36 BACH2 gene
37 Bach2
38 Caucasians
39 Chinese Han population
40 Further studies
41 GD patients
42 GWAS data
43 Gd
44 Graves
45 Han population
46 UK population
47 analysis
48 association
49 association signals
50 association studies
51 autoimmune diseases
52 best association signal
53 cell differentiation
54 cohort
55 confers
56 control
57 data
58 differentiation
59 disease
60 evidence
61 evidence of association
62 fine mapping
63 function
64 genes
65 genome-wide association studies
66 genome-wide significance level
67 identification
68 independent variants
69 intron 2
70 levels
71 linkage
72 logistic regression analysis
73 mapping
74 mechanism
75 nucleotide polymorphisms
76 patients
77 polymorphism
78 population
79 previous genome-wide association study
80 refined analysis
81 region
82 regression analysis
83 results
84 risk
85 risk of GD
86 second stage
87 signals
88 significance level
89 single nucleotide polymorphisms
90 stage
91 stage cohort
92 study
93 susceptibility genes
94 tagSNPs
95 three-stage genome-wide association study
96 variants
97 schema:name Identification of BACH2 as a susceptibility gene for Graves’ disease in the Chinese Han population based on a three-stage genome-wide association study
98 schema:pagination 661-671
99 schema:productId N9e1161e2b43e4233bcc11402d7f956f0
100 N9fe65aad07444242bcb0a07651372441
101 Necf51555d7ab4e86987ba336728a8dc4
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002082874
103 https://doi.org/10.1007/s00439-013-1404-2
104 schema:sdDatePublished 2022-12-01T06:30
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Nbc5ae9b69c4044a1bd0ef73f2f00809b
107 schema:url https://doi.org/10.1007/s00439-013-1404-2
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0610bb95d31049e493258280a327a8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Ethnicity
113 rdf:type schema:DefinedTerm
114 N171dfb4b71f74bdfaf2451181ad0d5a4 rdf:first sg:person.01045201054.95
115 rdf:rest N1ea0120999034394a6fe7c8ade0ffa68
116 N185374e6fd704491ba8ad07bccd4c08a rdf:first sg:person.014252467675.89
117 rdf:rest N3309687ebbed4efea4c98b207eaba9db
118 N1c40eeff229a43938719538c8f39892e rdf:first sg:person.01105076466.00
119 rdf:rest N9dc89af8be95460ca7c6bbcff20d8730
120 N1e9b89a40700464f82c3d9c1c20a3b50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Real-Time Polymerase Chain Reaction
122 rdf:type schema:DefinedTerm
123 N1ea0120999034394a6fe7c8ade0ffa68 rdf:first sg:person.01073761734.23
124 rdf:rest N641f1da0ef0843b9b84a4efbed4f101a
125 N1fb8bb075bc34c4aa83f09e563e8467d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Genome-Wide Association Study
127 rdf:type schema:DefinedTerm
128 N21a81c301b0f4a259d2f72168357bedc rdf:first sg:person.01246621334.15
129 rdf:rest N23160c461b5d48b486ae9110e47a4cba
130 N23160c461b5d48b486ae9110e47a4cba rdf:first sg:person.0753672234.99
131 rdf:rest Ne6b567395f174c41ba9f165cfb2eb0e0
132 N239ea3d237944fcb80743488af7dc7ed rdf:first sg:person.01056047705.22
133 rdf:rest Nc675099489a34494a9634fbf825630e9
134 N262bf33997894b55a3a494e80d064ef0 rdf:first sg:person.01022005434.86
135 rdf:rest N21a81c301b0f4a259d2f72168357bedc
136 N290577b6b2bc455880638c3f7e6b44eb rdf:first sg:person.0647564444.43
137 rdf:rest N262bf33997894b55a3a494e80d064ef0
138 N3309687ebbed4efea4c98b207eaba9db rdf:first sg:person.01204347234.27
139 rdf:rest N1c40eeff229a43938719538c8f39892e
140 N46be27dcb05942fe8284424fd38d00d1 rdf:first sg:person.01237160262.83
141 rdf:rest N7f400a82ff594e4a96e72368b1b43f9c
142 N51605542566c4a559ac404092ef1ef05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Autoimmune Diseases
144 rdf:type schema:DefinedTerm
145 N52b550a530954cecac523987770007b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 N641f1da0ef0843b9b84a4efbed4f101a rdf:first sg:person.01142075134.59
149 rdf:rest N9e42cea4ae7543cc8c2ab92e91ea2372
150 N647e5013e7004f4ab305f50dd1a0c0ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Graves Disease
152 rdf:type schema:DefinedTerm
153 N6777fef6f9ce47aca0b974d82c3f3b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Base Sequence
155 rdf:type schema:DefinedTerm
156 N734e5af8de804f14837f12503773ab73 rdf:first sg:person.01366711034.22
157 rdf:rest N239ea3d237944fcb80743488af7dc7ed
158 N75aad3425117420eacb18f6ac5b72679 schema:issueNumber 5
159 rdf:type schema:PublicationIssue
160 N7f400a82ff594e4a96e72368b1b43f9c rdf:first sg:person.0652556715.98
161 rdf:rest N734e5af8de804f14837f12503773ab73
162 N826a61c9b7dd493e9938e298c1639376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Basic-Leucine Zipper Transcription Factors
164 rdf:type schema:DefinedTerm
165 N9847b16de6d2421d924ea47261ef1d4c schema:volumeNumber 133
166 rdf:type schema:PublicationVolume
167 N9dc89af8be95460ca7c6bbcff20d8730 rdf:first sg:person.0705557034.30
168 rdf:rest N290577b6b2bc455880638c3f7e6b44eb
169 N9e1161e2b43e4233bcc11402d7f956f0 schema:name pubmed_id
170 schema:value 24346624
171 rdf:type schema:PropertyValue
172 N9e42cea4ae7543cc8c2ab92e91ea2372 rdf:first N9e431a634a4042d5b0aba533bef9b33e
173 rdf:rest rdf:nil
174 N9e431a634a4042d5b0aba533bef9b33e schema:familyName The China Consortium for the Genetics of Autoimmune Thyroid Disease
175 rdf:type schema:Person
176 N9fe65aad07444242bcb0a07651372441 schema:name doi
177 schema:value 10.1007/s00439-013-1404-2
178 rdf:type schema:PropertyValue
179 Nb1a2941dc72a4a1088a3baa5bde83312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name DNA Primers
181 rdf:type schema:DefinedTerm
182 Nb640a170d9484331b15b6b9201eca61a rdf:first sg:person.0673656570.03
183 rdf:rest N46be27dcb05942fe8284424fd38d00d1
184 Nbc5ae9b69c4044a1bd0ef73f2f00809b schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 Nc675099489a34494a9634fbf825630e9 rdf:first sg:person.0676564741.16
187 rdf:rest N171dfb4b71f74bdfaf2451181ad0d5a4
188 Nc920c6e927614fecafbfc6534a692d20 rdf:first sg:person.0764013044.06
189 rdf:rest Nb640a170d9484331b15b6b9201eca61a
190 Nd23157cf8b404cb88abee73e99b04c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Genetic Predisposition to Disease
192 rdf:type schema:DefinedTerm
193 Nd5bb8f66a6cd49cd92db9ef7b8595768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Polymorphism, Single Nucleotide
195 rdf:type schema:DefinedTerm
196 Ndc0688ad00314e4ca58685ccd23bf4f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name China
198 rdf:type schema:DefinedTerm
199 Ne0caabfc36004fad91d0325909603ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Logistic Models
201 rdf:type schema:DefinedTerm
202 Ne6b567395f174c41ba9f165cfb2eb0e0 rdf:first sg:person.01312550444.61
203 rdf:rest Nc920c6e927614fecafbfc6534a692d20
204 Necf51555d7ab4e86987ba336728a8dc4 schema:name dimensions_id
205 schema:value pub.1002082874
206 rdf:type schema:PropertyValue
207 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biological Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
211 schema:name Genetics
212 rdf:type schema:DefinedTerm
213 sg:journal.1085982 schema:issn 0340-6717
214 1432-1203
215 schema:name Human Genetics
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01022005434.86 schema:affiliation grid-institutes:grid.412277.5
219 schema:familyName Pan
220 schema:givenName Chun-Ming
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022005434.86
222 rdf:type schema:Person
223 sg:person.01045201054.95 schema:affiliation grid-institutes:grid.16821.3c
224 schema:familyName Su
225 schema:givenName Qing
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045201054.95
227 rdf:type schema:Person
228 sg:person.01056047705.22 schema:affiliation grid-institutes:grid.452247.2
229 schema:familyName Yuan
230 schema:givenName Guo-Yue
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056047705.22
232 rdf:type schema:Person
233 sg:person.01073761734.23 schema:affiliation grid-institutes:None
234 schema:familyName Gao
235 schema:givenName Guan-Qi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073761734.23
237 rdf:type schema:Person
238 sg:person.01105076466.00 schema:affiliation grid-institutes:grid.16821.3c
239 schema:familyName Gu
240 schema:givenName Zhao-Hui
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105076466.00
242 rdf:type schema:Person
243 sg:person.01142075134.59 schema:affiliation grid-institutes:grid.16821.3c
244 schema:familyName Song
245 schema:givenName Huai-Dong
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142075134.59
247 rdf:type schema:Person
248 sg:person.01204347234.27 schema:affiliation grid-institutes:grid.412277.5
249 schema:familyName Wang
250 schema:givenName Hai-Ning
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204347234.27
252 rdf:type schema:Person
253 sg:person.01237160262.83 schema:affiliation grid-institutes:None
254 schema:familyName Du
255 schema:givenName Wen-Hua
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237160262.83
257 rdf:type schema:Person
258 sg:person.01246621334.15 schema:affiliation grid-institutes:grid.16821.3c
259 schema:familyName Zhao
260 schema:givenName Shuang-Xia
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246621334.15
262 rdf:type schema:Person
263 sg:person.01312550444.61 schema:affiliation grid-institutes:grid.412277.5
264 schema:familyName Xie
265 schema:givenName Hui-Jun
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312550444.61
267 rdf:type schema:Person
268 sg:person.01366711034.22 schema:affiliation grid-institutes:grid.252957.e
269 schema:familyName Zhang
270 schema:givenName Xiao-Mei
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366711034.22
272 rdf:type schema:Person
273 sg:person.014252467675.89 schema:affiliation grid-institutes:grid.16821.3c
274 schema:familyName Liu
275 schema:givenName Wei
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014252467675.89
277 rdf:type schema:Person
278 sg:person.0647564444.43 schema:affiliation grid-institutes:grid.412277.5
279 schema:familyName Ye
280 schema:givenName Xiao-Ping
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647564444.43
282 rdf:type schema:Person
283 sg:person.0652556715.98 schema:affiliation grid-institutes:grid.452207.6
284 schema:familyName Liang
285 schema:givenName Jun
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652556715.98
287 rdf:type schema:Person
288 sg:person.0673656570.03 schema:affiliation grid-institutes:grid.412277.5
289 schema:familyName Guo
290 schema:givenName Cui-Cui
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673656570.03
292 rdf:type schema:Person
293 sg:person.0676564741.16 schema:affiliation grid-institutes:grid.410645.2
294 schema:familyName Li
295 schema:givenName Chang-Gui
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676564741.16
297 rdf:type schema:Person
298 sg:person.0705557034.30 schema:affiliation grid-institutes:grid.16821.3c
299 schema:familyName Yang
300 schema:givenName Shao-Ying
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705557034.30
302 rdf:type schema:Person
303 sg:person.0753672234.99 schema:affiliation grid-institutes:grid.412277.5
304 schema:familyName Xue
305 schema:givenName Li-Qiong
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753672234.99
307 rdf:type schema:Person
308 sg:person.0764013044.06 schema:affiliation grid-institutes:grid.412277.5
309 schema:familyName Yu
310 schema:givenName Sha-Sha
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764013044.06
312 rdf:type schema:Person
313 sg:pub.10.1038/nature01621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004357092
314 https://doi.org/10.1038/nature01621
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nature02596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011250834
317 https://doi.org/10.1038/nature02596
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature10251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038635012
320 https://doi.org/10.1038/nature10251
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/ng.2272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050156935
323 https://doi.org/10.1038/ng.2272
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/ng.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003424220
326 https://doi.org/10.1038/ng.249
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/ng.381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052626361
329 https://doi.org/10.1038/ng.381
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/ng.543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050960747
332 https://doi.org/10.1038/ng.543
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/ng.717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019025470
335 https://doi.org/10.1038/ng.717
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/ng.898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002559443
338 https://doi.org/10.1038/ng.898
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/ng2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046979341
341 https://doi.org/10.1038/ng2088
342 rdf:type schema:CreativeWork
343 grid-institutes:None schema:alternateName Department of Endocrinology, People’s Hospital of Linyi, Linyi, Shandong, China
344 schema:name Department of Endocrinology, People’s Hospital of Linyi, Linyi, Shandong, China
345 rdf:type schema:Organization
346 grid-institutes:grid.16821.3c schema:alternateName Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China
347 Department of Endocrinology, Xin-Hua Hospital Affiliated to SJTU School of Medicine, 200092, Shanghai, China
348 Shanghai Center for Systems Biomedicine, SJTU, Shanghai, China
349 schema:name Department of Endocrinology, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital Affiliated to SJTU School of Medicine, Shanghai, China
350 Department of Endocrinology, Xin-Hua Hospital Affiliated to SJTU School of Medicine, 200092, Shanghai, China
351 Shanghai Center for Systems Biomedicine, SJTU, Shanghai, China
352 State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
353 rdf:type schema:Organization
354 grid-institutes:grid.252957.e schema:alternateName Department of Endocrinology, The First Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China
355 schema:name Department of Endocrinology, The First Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China
356 rdf:type schema:Organization
357 grid-institutes:grid.410645.2 schema:alternateName Department of Endocrinology and Gout Laboratory, Medical School Hospital of Qingdao University, Qingdao, Shandong, China
358 schema:name Department of Endocrinology and Gout Laboratory, Medical School Hospital of Qingdao University, Qingdao, Shandong, China
359 rdf:type schema:Organization
360 grid-institutes:grid.412277.5 schema:alternateName State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
361 schema:name State Key Laboratory of Medical Genomics, Molecular Medicine Center, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
362 rdf:type schema:Organization
363 grid-institutes:grid.452207.6 schema:alternateName Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College, Xuzhou, Jiangsu, China
364 schema:name Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College, Xuzhou, Jiangsu, China
365 rdf:type schema:Organization
366 grid-institutes:grid.452247.2 schema:alternateName Department of Endocrinology, The Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, China
367 schema:name Department of Endocrinology, The Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, China
368 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...