The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-11-17

AUTHORS

Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Yuji Ataka, Nao Nishida, Naoyuki Tsuchiya, Ryutaro Ohtsuka, Jun Ohashi

ABSTRACT

Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI ≥ 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations. More... »

PAGES

287-294

References to SciGraph publications

  • 1999-08. Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-05-13. Variation in FTO contributes to childhood obesity and severe adult obesity in NATURE GENETICS
  • 2002-08-21. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil in INTERNATIONAL JOURNAL OF OBESITY
  • 2002-05-17. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference in INTERNATIONAL JOURNAL OF OBESITY
  • 1995-11-01. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects in NATURE MEDICINE
  • 1999-03-03. Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Québec Family Study in INTERNATIONAL JOURNAL OF OBESITY
  • 2001-03. Slow boat to Melanesia? in NATURE
  • 2005-01-20. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents in JOURNAL OF HUMAN HYPERTENSION
  • 1994-12. Positional cloning of the mouse obese gene and its human homologue in NATURE
  • 2006-03-10. Polymorphisms in the ABO blood group gene in three populations in the New Georgia group of the Solomon Islands in JOURNAL OF HUMAN GENETICS
  • 2000-04. Association of Trp64Arg polymorphism of the β3-adrenergic receptor gene and no association of Gln223Arg polymorphism of the leptin receptor gene in Japanese schoolchildren with obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2001-03. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women in HUMAN GENETICS
  • 1988-11. Express train to Polynesia in NATURE
  • 2006-08. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 1996-06. Leptin activation in hypothalamus in NATURE
  • 2001-11. Partial leptin deficiency and human adiposity in NATURE
  • 2007-10-11. FTO polymorphisms in oceanic populations in JOURNAL OF HUMAN GENETICS
  • 1997-09. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity in DIABETOLOGIA
  • Journal

    TITLE

    Human Genetics

    ISSUE

    3

    VOLUME

    127

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00439-009-0768-9

    DOI

    http://dx.doi.org/10.1007/s00439-009-0768-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031130180

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20183928


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Substitution", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arginine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Frequency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Association Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Linkage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetics, Population", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glutamic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pacific Islands", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prevalence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Leptin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furusawa", 
            "givenName": "Takuro", 
            "id": "sg:person.01063541463.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063541463.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naka", 
            "givenName": "Izumi", 
            "id": "sg:person.01270026746.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270026746.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan", 
              "id": "http://www.grid.ac/institutes/grid.39158.36", 
              "name": [
                "Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamauchi", 
            "givenName": "Taro", 
            "id": "sg:person.011023124005.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011023124005.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.444853.a", 
              "name": [
                "School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Natsuhara", 
            "givenName": "Kazumi", 
            "id": "sg:person.01133427520.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133427520.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.267625.2", 
              "name": [
                "Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Ryosuke", 
            "id": "sg:person.0624243455.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health, Graduate School of Medical Sciences, Gunma University, Gunma, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Public Health, Graduate School of Medical Sciences, Gunma University, Gunma, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakazawa", 
            "givenName": "Minato", 
            "id": "sg:person.01006605255.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006605255.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishida", 
            "givenName": "Takafumi", 
            "id": "sg:person.015576331772.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inaoka", 
            "givenName": "Tsukasa", 
            "id": "sg:person.0705040763.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705040763.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Faculty of Health Care, Kiryu University, Gunma, Japan", 
              "id": "http://www.grid.ac/institutes/grid.448781.6", 
              "name": [
                "Faculty of Health Care, Kiryu University, Gunma, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumura", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.013241054552.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241054552.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258777.8", 
              "name": [
                "School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ataka", 
            "givenName": "Yuji", 
            "id": "sg:person.01065141161.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065141161.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishida", 
            "givenName": "Nao", 
            "id": "sg:person.01035566470.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035566470.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsuchiya", 
            "givenName": "Naoyuki", 
            "id": "sg:person.01306724021.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306724021.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japan Wildlife Research Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Japan Wildlife Research Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohtsuka", 
            "givenName": "Ryutaro", 
            "id": "sg:person.0674751503.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674751503.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohashi", 
            "givenName": "Jun", 
            "id": "sg:person.0646643507.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/372425a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052657184", 
              "https://doi.org/10.1038/372425a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047123449", 
              "https://doi.org/10.1038/35065520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1195-1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049565526", 
              "https://doi.org/10.1038/nm1195-1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390100468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033541247", 
              "https://doi.org/10.1007/s004390100468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801990", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013481813", 
              "https://doi.org/10.1038/sj.ijo.0801990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007443701", 
              "https://doi.org/10.1038/sj.ijo.0802067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/336307a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032340039", 
              "https://doi.org/10.1038/336307a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001250050808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021131569", 
              "https://doi.org/10.1007/s001250050808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040780005", 
              "https://doi.org/10.1038/sj.jhh.1001824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035360497", 
              "https://doi.org/10.1038/sj.ijo.0801177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10038-006-0375-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036387975", 
              "https://doi.org/10.1007/s10038-006-0375-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040135512", 
              "https://doi.org/10.1038/ng2048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011996859", 
              "https://doi.org/10.1038/35102112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006391541", 
              "https://doi.org/10.1038/sj.ijo.0800809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10038-007-0198-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015898872", 
              "https://doi.org/10.1007/s10038-007-0198-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/381745a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012292892", 
              "https://doi.org/10.1038/381745a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029112552", 
              "https://doi.org/10.1038/sj.ijo.0800931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-006-9045-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011394897", 
              "https://doi.org/10.1007/s10654-006-9045-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-11-17", 
        "datePublishedReg": "2009-11-17", 
        "description": "Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI\u00a0\u2265\u00a030) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P\u00a0=\u00a00.0009) and BMI (P\u00a0=\u00a00.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P\u00a0=\u00a00.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00439-009-0768-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1085982", 
            "issn": [
              "0340-6717", 
              "1432-1203"
            ], 
            "name": "Human Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "127"
          }
        ], 
        "keywords": [
          "body mass index", 
          "leptin receptor gene", 
          "body weight", 
          "Q223R polymorphism", 
          "LEPR Q223R polymorphism", 
          "prevalence of obesity", 
          "Pacific Islanders", 
          "leptin gene", 
          "Pacific Island populations", 
          "higher body weight", 
          "mass index", 
          "high prevalence", 
          "high risk", 
          "obesity", 
          "promoter polymorphism", 
          "study subjects", 
          "single nucleotide polymorphisms", 
          "marked increase", 
          "receptor gene", 
          "prevalence", 
          "K109R", 
          "nucleotide polymorphisms", 
          "polymorphism", 
          "non-synonymous single nucleotide polymorphisms", 
          "Q223R", 
          "population", 
          "Islanders", 
          "weight", 
          "alleles", 
          "age", 
          "total", 
          "risk", 
          "association", 
          "genes", 
          "subjects", 
          "past decade", 
          "participants", 
          "gender", 
          "population differences", 
          "index", 
          "carriers", 
          "factors", 
          "differences", 
          "study", 
          "increase", 
          "comparison", 
          "decades", 
          "results", 
          "island populations", 
          "Austronesian", 
          "Various Pacific Island populations", 
          "alleles of LEPR", 
          "AN-speaking study subjects"
        ], 
        "name": "The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders", 
        "pagination": "287-294", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031130180"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00439-009-0768-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20183928"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00439-009-0768-9", 
          "https://app.dimensions.ai/details/publication/pub.1031130180"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:13", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_484.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00439-009-0768-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00439-009-0768-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00439-009-0768-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00439-009-0768-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00439-009-0768-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    389 TRIPLES      22 PREDICATES      117 URIs      91 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00439-009-0768-9 schema:about N00161ad849b0484aa08670509416c98b
    2 N17d1b186430f41389e0f5aa20ce914b2
    3 N1d5a1545c385465f812d80d16da3019d
    4 N2fa5ad10eec04057a0cd781aafabdbb9
    5 N39b33e499cd14348ab5735a1d52a04be
    6 N43904d3f9e274ba4bd72eea127418758
    7 N53ac9d0fd54e45b086794153fc4a6343
    8 N54660bdf21f64da0aa5c4f363a602fb5
    9 N6044959b88594d27875ceaae68054e9b
    10 N6dd28330736b41e4ae9ae2fa71b4074a
    11 N89ef49d4744d483fb052bb7a75417024
    12 N8ca38716757642ba83ed02a76507e7a7
    13 N92268b2965464ee681a3c161777d9cef
    14 Na90586012ee843d386c9f3b55060f5b4
    15 Nb077e2c9c4814b519cf98e12f041a829
    16 Ne5188a981cde4a58b208fae37f6885fe
    17 Ne9e0675128834dfa80eb669a9c8ba5be
    18 Neb0f5914b24c4231b3e973933e70edec
    19 Nf52d569d02994a07b0667074dd7dddca
    20 Nf712893f580c44cbbf562b24a27ca42f
    21 anzsrc-for:11
    22 anzsrc-for:1103
    23 schema:author N88c06decaf934df18c81e78b37cb7182
    24 schema:citation sg:pub.10.1007/s001250050808
    25 sg:pub.10.1007/s004390100468
    26 sg:pub.10.1007/s10038-006-0375-8
    27 sg:pub.10.1007/s10038-007-0198-2
    28 sg:pub.10.1007/s10654-006-9045-6
    29 sg:pub.10.1038/336307a0
    30 sg:pub.10.1038/35065520
    31 sg:pub.10.1038/35102112
    32 sg:pub.10.1038/372425a0
    33 sg:pub.10.1038/381745a0
    34 sg:pub.10.1038/ng2048
    35 sg:pub.10.1038/nm1195-1155
    36 sg:pub.10.1038/sj.ijo.0800809
    37 sg:pub.10.1038/sj.ijo.0800931
    38 sg:pub.10.1038/sj.ijo.0801177
    39 sg:pub.10.1038/sj.ijo.0801990
    40 sg:pub.10.1038/sj.ijo.0802067
    41 sg:pub.10.1038/sj.jhh.1001824
    42 schema:datePublished 2009-11-17
    43 schema:datePublishedReg 2009-11-17
    44 schema:description Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI ≥ 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.
    45 schema:genre article
    46 schema:inLanguage en
    47 schema:isAccessibleForFree false
    48 schema:isPartOf N1c28fe45c19943c48ac81cdaccf4ba43
    49 N265de7f143be42489df9195e57b6c362
    50 sg:journal.1085982
    51 schema:keywords AN-speaking study subjects
    52 Austronesian
    53 Islanders
    54 K109R
    55 LEPR Q223R polymorphism
    56 Pacific Island populations
    57 Pacific Islanders
    58 Q223R
    59 Q223R polymorphism
    60 Various Pacific Island populations
    61 age
    62 alleles
    63 alleles of LEPR
    64 association
    65 body mass index
    66 body weight
    67 carriers
    68 comparison
    69 decades
    70 differences
    71 factors
    72 gender
    73 genes
    74 high prevalence
    75 high risk
    76 higher body weight
    77 increase
    78 index
    79 island populations
    80 leptin gene
    81 leptin receptor gene
    82 marked increase
    83 mass index
    84 non-synonymous single nucleotide polymorphisms
    85 nucleotide polymorphisms
    86 obesity
    87 participants
    88 past decade
    89 polymorphism
    90 population
    91 population differences
    92 prevalence
    93 prevalence of obesity
    94 promoter polymorphism
    95 receptor gene
    96 results
    97 risk
    98 single nucleotide polymorphisms
    99 study
    100 study subjects
    101 subjects
    102 total
    103 weight
    104 schema:name The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    105 schema:pagination 287-294
    106 schema:productId N37fd16b2da3d4656b75ec4d91679931e
    107 N89fbf6c4f4b64158b53ddd54280aa210
    108 Nd90c5ea8cd0744cf91fc7ab18b95afc6
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031130180
    110 https://doi.org/10.1007/s00439-009-0768-9
    111 schema:sdDatePublished 2021-11-01T18:13
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher N6f0ac3a71f5d488486c87f890bb0b959
    114 schema:url https://doi.org/10.1007/s00439-009-0768-9
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N00161ad849b0484aa08670509416c98b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Adolescent
    120 rdf:type schema:DefinedTerm
    121 N17d1b186430f41389e0f5aa20ce914b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Receptors, Leptin
    123 rdf:type schema:DefinedTerm
    124 N1c28fe45c19943c48ac81cdaccf4ba43 schema:issueNumber 3
    125 rdf:type schema:PublicationIssue
    126 N1d5a1545c385465f812d80d16da3019d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Aged
    128 rdf:type schema:DefinedTerm
    129 N1d99c75ee7984a209934b0f492089da2 rdf:first sg:person.01035566470.85
    130 rdf:rest Na54c05139499437f8dbb4a5d00a2c6fd
    131 N265de7f143be42489df9195e57b6c362 schema:volumeNumber 127
    132 rdf:type schema:PublicationVolume
    133 N2a6c100aa27048f7b55706ead7c2450d rdf:first sg:person.015576331772.42
    134 rdf:rest Nc8bb5a13bb634837a25c8c18f50d80de
    135 N2fa5ad10eec04057a0cd781aafabdbb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Young Adult
    137 rdf:type schema:DefinedTerm
    138 N32ac62f737eb402282baafd84f4ad362 rdf:first sg:person.011023124005.26
    139 rdf:rest Ne8503ab901aa4d5e8fafea10b8e12f91
    140 N37fd16b2da3d4656b75ec4d91679931e schema:name pubmed_id
    141 schema:value 20183928
    142 rdf:type schema:PropertyValue
    143 N39b33e499cd14348ab5735a1d52a04be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Glutamic Acid
    145 rdf:type schema:DefinedTerm
    146 N43904d3f9e274ba4bd72eea127418758 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Amino Acid Substitution
    148 rdf:type schema:DefinedTerm
    149 N51c035c779be4731af685b82da67f5a3 rdf:first sg:person.0646643507.05
    150 rdf:rest rdf:nil
    151 N53ac9d0fd54e45b086794153fc4a6343 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Adult
    153 rdf:type schema:DefinedTerm
    154 N54660bdf21f64da0aa5c4f363a602fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Humans
    156 rdf:type schema:DefinedTerm
    157 N6044959b88594d27875ceaae68054e9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Arginine
    159 rdf:type schema:DefinedTerm
    160 N6dd28330736b41e4ae9ae2fa71b4074a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Middle Aged
    162 rdf:type schema:DefinedTerm
    163 N6f0ac3a71f5d488486c87f890bb0b959 schema:name Springer Nature - SN SciGraph project
    164 rdf:type schema:Organization
    165 N71eb24c1197a45d5963996ca5f8544ea rdf:first sg:person.013241054552.08
    166 rdf:rest N7eea840e13864cdea9376bc8a1edbf33
    167 N7adc984c364f4262970e3f12d4a65d84 rdf:first sg:person.01270026746.37
    168 rdf:rest N32ac62f737eb402282baafd84f4ad362
    169 N7eea840e13864cdea9376bc8a1edbf33 rdf:first sg:person.01065141161.63
    170 rdf:rest N1d99c75ee7984a209934b0f492089da2
    171 N88c06decaf934df18c81e78b37cb7182 rdf:first sg:person.01063541463.54
    172 rdf:rest N7adc984c364f4262970e3f12d4a65d84
    173 N89ef49d4744d483fb052bb7a75417024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Gene Frequency
    175 rdf:type schema:DefinedTerm
    176 N89fbf6c4f4b64158b53ddd54280aa210 schema:name dimensions_id
    177 schema:value pub.1031130180
    178 rdf:type schema:PropertyValue
    179 N8ca38716757642ba83ed02a76507e7a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Prevalence
    181 rdf:type schema:DefinedTerm
    182 N92268b2965464ee681a3c161777d9cef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Polymorphism, Single Nucleotide
    184 rdf:type schema:DefinedTerm
    185 Na54c05139499437f8dbb4a5d00a2c6fd rdf:first sg:person.01306724021.01
    186 rdf:rest Ndc5d97146f44490d99108ad4902d0ef9
    187 Na86aed8a90a54e45bd8cfe41c856294b rdf:first sg:person.0624243455.41
    188 rdf:rest Nf41734074d714863833cd3ffdf47cd03
    189 Na90586012ee843d386c9f3b55060f5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Pacific Islands
    191 rdf:type schema:DefinedTerm
    192 Nb077e2c9c4814b519cf98e12f041a829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Genetics, Population
    194 rdf:type schema:DefinedTerm
    195 Nc8bb5a13bb634837a25c8c18f50d80de rdf:first sg:person.0705040763.44
    196 rdf:rest N71eb24c1197a45d5963996ca5f8544ea
    197 Nd90c5ea8cd0744cf91fc7ab18b95afc6 schema:name doi
    198 schema:value 10.1007/s00439-009-0768-9
    199 rdf:type schema:PropertyValue
    200 Ndc5d97146f44490d99108ad4902d0ef9 rdf:first sg:person.0674751503.28
    201 rdf:rest N51c035c779be4731af685b82da67f5a3
    202 Ne5188a981cde4a58b208fae37f6885fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Genetic Association Studies
    204 rdf:type schema:DefinedTerm
    205 Ne8503ab901aa4d5e8fafea10b8e12f91 rdf:first sg:person.01133427520.40
    206 rdf:rest Na86aed8a90a54e45bd8cfe41c856294b
    207 Ne9e0675128834dfa80eb669a9c8ba5be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Genetic Linkage
    209 rdf:type schema:DefinedTerm
    210 Neb0f5914b24c4231b3e973933e70edec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Male
    212 rdf:type schema:DefinedTerm
    213 Nf41734074d714863833cd3ffdf47cd03 rdf:first sg:person.01006605255.48
    214 rdf:rest N2a6c100aa27048f7b55706ead7c2450d
    215 Nf52d569d02994a07b0667074dd7dddca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Obesity
    217 rdf:type schema:DefinedTerm
    218 Nf712893f580c44cbbf562b24a27ca42f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Female
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical and Health Sciences
    223 rdf:type schema:DefinedTerm
    224 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Clinical Sciences
    226 rdf:type schema:DefinedTerm
    227 sg:journal.1085982 schema:issn 0340-6717
    228 1432-1203
    229 schema:name Human Genetics
    230 schema:publisher Springer Nature
    231 rdf:type schema:Periodical
    232 sg:person.01006605255.48 schema:affiliation grid-institutes:grid.256642.1
    233 schema:familyName Nakazawa
    234 schema:givenName Minato
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006605255.48
    236 rdf:type schema:Person
    237 sg:person.01035566470.85 schema:affiliation grid-institutes:grid.26999.3d
    238 schema:familyName Nishida
    239 schema:givenName Nao
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035566470.85
    241 rdf:type schema:Person
    242 sg:person.01063541463.54 schema:affiliation grid-institutes:grid.26999.3d
    243 schema:familyName Furusawa
    244 schema:givenName Takuro
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063541463.54
    246 rdf:type schema:Person
    247 sg:person.01065141161.63 schema:affiliation grid-institutes:grid.258777.8
    248 schema:familyName Ataka
    249 schema:givenName Yuji
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065141161.63
    251 rdf:type schema:Person
    252 sg:person.011023124005.26 schema:affiliation grid-institutes:grid.39158.36
    253 schema:familyName Yamauchi
    254 schema:givenName Taro
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011023124005.26
    256 rdf:type schema:Person
    257 sg:person.01133427520.40 schema:affiliation grid-institutes:grid.444853.a
    258 schema:familyName Natsuhara
    259 schema:givenName Kazumi
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133427520.40
    261 rdf:type schema:Person
    262 sg:person.01270026746.37 schema:affiliation grid-institutes:grid.20515.33
    263 schema:familyName Naka
    264 schema:givenName Izumi
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270026746.37
    266 rdf:type schema:Person
    267 sg:person.01306724021.01 schema:affiliation grid-institutes:grid.20515.33
    268 schema:familyName Tsuchiya
    269 schema:givenName Naoyuki
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306724021.01
    271 rdf:type schema:Person
    272 sg:person.013241054552.08 schema:affiliation grid-institutes:grid.448781.6
    273 schema:familyName Matsumura
    274 schema:givenName Yasuhiro
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241054552.08
    276 rdf:type schema:Person
    277 sg:person.015576331772.42 schema:affiliation grid-institutes:grid.26999.3d
    278 schema:familyName Ishida
    279 schema:givenName Takafumi
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42
    281 rdf:type schema:Person
    282 sg:person.0624243455.41 schema:affiliation grid-institutes:grid.267625.2
    283 schema:familyName Kimura
    284 schema:givenName Ryosuke
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41
    286 rdf:type schema:Person
    287 sg:person.0646643507.05 schema:affiliation grid-institutes:grid.20515.33
    288 schema:familyName Ohashi
    289 schema:givenName Jun
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05
    291 rdf:type schema:Person
    292 sg:person.0674751503.28 schema:affiliation grid-institutes:None
    293 schema:familyName Ohtsuka
    294 schema:givenName Ryutaro
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674751503.28
    296 rdf:type schema:Person
    297 sg:person.0705040763.44 schema:affiliation grid-institutes:grid.412339.e
    298 schema:familyName Inaoka
    299 schema:givenName Tsukasa
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705040763.44
    301 rdf:type schema:Person
    302 sg:pub.10.1007/s001250050808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021131569
    303 https://doi.org/10.1007/s001250050808
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s004390100468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033541247
    306 https://doi.org/10.1007/s004390100468
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1007/s10038-006-0375-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036387975
    309 https://doi.org/10.1007/s10038-006-0375-8
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1007/s10038-007-0198-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015898872
    312 https://doi.org/10.1007/s10038-007-0198-2
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s10654-006-9045-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011394897
    315 https://doi.org/10.1007/s10654-006-9045-6
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/336307a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032340039
    318 https://doi.org/10.1038/336307a0
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/35065520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047123449
    321 https://doi.org/10.1038/35065520
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/35102112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011996859
    324 https://doi.org/10.1038/35102112
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/372425a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052657184
    327 https://doi.org/10.1038/372425a0
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/381745a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012292892
    330 https://doi.org/10.1038/381745a0
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/ng2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040135512
    333 https://doi.org/10.1038/ng2048
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/nm1195-1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049565526
    336 https://doi.org/10.1038/nm1195-1155
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/sj.ijo.0800809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006391541
    339 https://doi.org/10.1038/sj.ijo.0800809
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/sj.ijo.0800931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029112552
    342 https://doi.org/10.1038/sj.ijo.0800931
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/sj.ijo.0801177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035360497
    345 https://doi.org/10.1038/sj.ijo.0801177
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/sj.ijo.0801990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013481813
    348 https://doi.org/10.1038/sj.ijo.0801990
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/sj.ijo.0802067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007443701
    351 https://doi.org/10.1038/sj.ijo.0802067
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/sj.jhh.1001824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040780005
    354 https://doi.org/10.1038/sj.jhh.1001824
    355 rdf:type schema:CreativeWork
    356 grid-institutes:None schema:alternateName Japan Wildlife Research Center, Tokyo, Japan
    357 schema:name Japan Wildlife Research Center, Tokyo, Japan
    358 rdf:type schema:Organization
    359 grid-institutes:grid.20515.33 schema:alternateName Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    360 schema:name Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    361 rdf:type schema:Organization
    362 grid-institutes:grid.256642.1 schema:alternateName Department of Public Health, Graduate School of Medical Sciences, Gunma University, Gunma, Japan
    363 schema:name Department of Public Health, Graduate School of Medical Sciences, Gunma University, Gunma, Japan
    364 rdf:type schema:Organization
    365 grid-institutes:grid.258777.8 schema:alternateName School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan
    366 schema:name School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan
    367 rdf:type schema:Organization
    368 grid-institutes:grid.267625.2 schema:alternateName Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan
    369 schema:name Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan
    370 rdf:type schema:Organization
    371 grid-institutes:grid.26999.3d schema:alternateName Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan
    372 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    373 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    374 schema:name Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan
    375 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    376 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    377 rdf:type schema:Organization
    378 grid-institutes:grid.39158.36 schema:alternateName Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan
    379 schema:name Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan
    380 rdf:type schema:Organization
    381 grid-institutes:grid.412339.e schema:alternateName Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
    382 schema:name Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
    383 rdf:type schema:Organization
    384 grid-institutes:grid.444853.a schema:alternateName School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan
    385 schema:name School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.448781.6 schema:alternateName Faculty of Health Care, Kiryu University, Gunma, Japan
    388 schema:name Faculty of Health Care, Kiryu University, Gunma, Japan
    389 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...