Ontology type: schema:ScholarlyArticle
2008-01-08
AUTHORSXiaogang Liu, Lan-Juan Zhao, Yong-Jun Liu, Dong-Hai Xiong, Robert R. Recker, Hong-Wen Deng
ABSTRACTAlong with aging, human body composition undergoes notable changes and may incur sarcopenia, obesity or osteoporosis. Sarcopenia is related to a wide series of human health problems and can be largely characterized by loss of lean body mass (LBM). Studies have showed relevance of methylenetetrahydrofolate reductase (MTHFR) with variation in LBM and fat body mass (FBM). To test if polymorphism of the MTHFR gene is underlying the pathology of sarcopenia and obesity, we concurrently tested five single nucleotide polymorphisms (SNPs) of the MTHFR gene for association with LBM, FBM and body mass index (BMI) in 405 Caucasian nuclear families comprising 1,873 individuals. After correction for multiple testing, we detected significant associations for LBM with rs2066470 (P = 0.0006), rs4846048 (P = 0.0007) and with rs3737964 (P = 0.004), as well as for BMI with rs4846048 (P = 0.009). Polymorphism of rs2066470 explains 3.67% of LBM variation in this sample. The association between BMI and rs4846048 diminished after adjusting for LBM, suggesting that the association between BMI and rs4846048 is largely due to LBM instead of the fat component. In concert, no significant associations were identified for FBM with any of the studied SNPs. The results of single-locus association analyses were corroborated by haplotype-based analyses. In summary, the MTHFR gene polymorphism is associated with LBM, suggesting that MTHFR may play an important role in LBM variation. In addition, the MTHFR gene polymorphism is not associated with FBM or obesity in this sample. More... »
PAGES189-196
http://scigraph.springernature.com/pub.10.1007/s00439-007-0463-7
DOIhttp://dx.doi.org/10.1007/s00439-007-0463-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029520616
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18180959
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adipose Tissue",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Composition",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Mass Index",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Weight",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Haplotypes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Linkage Disequilibrium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methylenetetrahydrofolate Reductase (NADPH2)",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Obesity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Single Nucleotide",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA",
"id": "http://www.grid.ac/institutes/grid.266756.6",
"name": [
"The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi\u2019an Jiaotong University, 710049, Xi\u2019an Shaanxi, People\u2019s Republic of China",
"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA"
],
"type": "Organization"
},
"familyName": "Liu",
"givenName": "Xiaogang",
"id": "sg:person.0770115472.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770115472.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA",
"id": "http://www.grid.ac/institutes/grid.266756.6",
"name": [
"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA"
],
"type": "Organization"
},
"familyName": "Zhao",
"givenName": "Lan-Juan",
"id": "sg:person.010375516677.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010375516677.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA",
"id": "http://www.grid.ac/institutes/grid.266756.6",
"name": [
"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA"
],
"type": "Organization"
},
"familyName": "Liu",
"givenName": "Yong-Jun",
"id": "sg:person.01144162103.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144162103.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 68131, Omaha, NE, USA",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 68131, Omaha, NE, USA"
],
"type": "Organization"
},
"familyName": "Xiong",
"givenName": "Dong-Hai",
"id": "sg:person.013720675057.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013720675057.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 68131, Omaha, NE, USA",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 68131, Omaha, NE, USA"
],
"type": "Organization"
},
"familyName": "Recker",
"givenName": "Robert R.",
"id": "sg:person.016325222544.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016325222544.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081, Changsha Hunan, People\u2019s Republic of China",
"id": "http://www.grid.ac/institutes/grid.411427.5",
"name": [
"The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi\u2019an Jiaotong University, 710049, Xi\u2019an Shaanxi, People\u2019s Republic of China",
"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, 64108, Kansas City, MO, USA",
"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081, Changsha Hunan, People\u2019s Republic of China"
],
"type": "Organization"
},
"familyName": "Deng",
"givenName": "Hong-Wen",
"id": "sg:person.015262343607.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015262343607.40"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s007260170037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050483829",
"https://doi.org/10.1007/s007260170037"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng786",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041343500",
"https://doi.org/10.1038/ng786"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ejcn.1600513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004667692",
"https://doi.org/10.1038/sj.ejcn.1600513"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ejhg.5200979",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048999271",
"https://doi.org/10.1038/sj.ejhg.5200979"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ijo.0802793",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007614343",
"https://doi.org/10.1038/sj.ijo.0802793"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35041687",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028702240",
"https://doi.org/10.1038/35041687"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/83730",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036259529",
"https://doi.org/10.1038/83730"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-01-08",
"datePublishedReg": "2008-01-08",
"description": "Along with aging, human body composition undergoes notable changes and may incur sarcopenia, obesity or osteoporosis. Sarcopenia is related to a wide series of human health problems and can be largely characterized by loss of lean body mass (LBM). Studies have showed relevance of methylenetetrahydrofolate reductase (MTHFR) with variation in LBM and fat body mass (FBM). To test if polymorphism of the MTHFR gene is underlying the pathology of sarcopenia and obesity, we concurrently tested five single nucleotide polymorphisms (SNPs) of the MTHFR gene for association with LBM, FBM and body mass index (BMI) in 405 Caucasian nuclear families comprising 1,873 individuals. After correction for multiple testing, we detected significant associations for LBM with rs2066470 (P\u00a0=\u00a00.0006), rs4846048 (P\u00a0=\u00a00.0007) and with rs3737964 (P\u00a0=\u00a00.004), as well as for BMI with rs4846048 (P\u00a0=\u00a00.009). Polymorphism of rs2066470 explains 3.67% of LBM variation in this sample. The association between BMI and rs4846048 diminished after adjusting for LBM, suggesting that the association between BMI and rs4846048 is largely due to LBM instead of the fat component. In concert, no significant associations were identified for FBM with any of the studied SNPs. The results of single-locus association analyses were corroborated by haplotype-based analyses. In summary, the MTHFR gene polymorphism is associated with LBM, suggesting that MTHFR may play an important role in LBM variation. In addition, the MTHFR gene polymorphism is not associated with FBM or obesity in this sample.",
"genre": "article",
"id": "sg:pub.10.1007/s00439-007-0463-7",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.8173112",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2463816",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2403141",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2464496",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2516372",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2447940",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2596378",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1085982",
"issn": [
"0340-6717",
"1432-1203"
],
"name": "Human Genetics",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "123"
}
],
"keywords": [
"single nucleotide polymorphisms",
"single-locus association analysis",
"Caucasian nuclear families",
"body mass",
"haplotype-based analysis",
"association analysis",
"methylenetetrahydrofolate reductase",
"nucleotide polymorphisms",
"fat body mass",
"genes",
"human health problems",
"polymorphism",
"rs4846048",
"MTHFR gene",
"gene polymorphisms",
"important role",
"multiple testing",
"reductase",
"variation",
"concert",
"family",
"MTHFR gene polymorphisms",
"body mass index",
"lean body mass",
"nuclear families",
"notable changes",
"association",
"role",
"significant association",
"mass",
"analysis",
"composition",
"sarcopenia",
"summary",
"loss",
"components",
"individuals",
"changes",
"addition",
"wide series",
"relevance",
"mass index",
"pathology",
"body composition",
"health problems",
"samples",
"obesity",
"study",
"human body composition",
"fat component",
"results",
"osteoporosis",
"series",
"index",
"testing",
"correction",
"problem"
],
"name": "The MTHFR gene polymorphism is associated with lean body mass but not fat body mass",
"pagination": "189-196",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1029520616"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00439-007-0463-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18180959"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00439-007-0463-7",
"https://app.dimensions.ai/details/publication/pub.1029520616"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_469.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00439-007-0463-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00439-007-0463-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00439-007-0463-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00439-007-0463-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00439-007-0463-7'
This table displays all metadata directly associated to this object as RDF triples.
268 TRIPLES
21 PREDICATES
105 URIs
90 LITERALS
23 BLANK NODES