Extreme individual marker FST values do not imply population-specific selection in humans: the NRG1 example View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Michelle Gardner, Scott Williamson, Ferran Casals, Elena Bosch, Arcadi Navarro, Francesc Calafell, Jaume Bertranpetit, David Comas

ABSTRACT

Extreme population differentiation, as measured by the F(ST) value, has been suggested as an indicator of recent population-specific positive selection. Elevated F(ST) values indicating high differentiation between continental groups were previously reported on a linkage disequilibrium region in the Neuregulin 1 gene, a gene which has been associated to schizophrenia. In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene. More... »

PAGES

759-762

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00439-007-0364-9

DOI

http://dx.doi.org/10.1007/s00439-007-0364-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005397351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17457614


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