Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05-21

AUTHORS

Denise Harold, Timothy Peirce, Valentina Moskvina, Amanda Myers, Susan Jones, Paul Hollingworth, Pamela Moore, Simon Lovestone, John Powell, Catherine Foy, Nicola Archer, Sarah Walter, Amanda Edmonson, Stephen McIlroy, David Craig, Peter A. Passmore, Alison Goate, John Hardy, Michael O'Donovan, Julie Williams, Malcolm Liddell, Michael J. Owen, Lesley Jones

ABSTRACT

There is substantial evidence for a susceptibility gene for late-onset Alzheimer's disease (AD) on chromosome 10. One of the characteristic features of AD is the degeneration and dysfunction of the cholinergic system. The genes encoding choline acetyltransferase (ChAT) and its vesicular transporter (VAChT), CHAT and SLC18A3 respectively, map to the linked region of chromosome 10 and are therefore both positional and obvious functional candidate genes for late-onset AD. We have screened both genes for sequence variants and investigated each for association with late-onset AD in up to 500 late-onset AD cases and 500 control DNAs collected in the UK. We detected a total of 17 sequence variants. Of these, 14 were in CHAT, comprising three non-synonymous variants (D7N in the S exon, A120T in exon 5 and L243F in exon 8), one synonymous change (H547H), nine single-nucleotide polymorphisms in intronic, untranslated or promoter regions, and a variable number of tandem repeats in intron 7. Three non-coding SNPs were detected in SLC18A3. None demonstrated any reproducible association with late-onset AD in our samples. Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium. More... »

PAGES

258-267

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00439-003-0960-2

DOI

http://dx.doi.org/10.1007/s00439-003-0960-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017179029

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12759818


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choline O-Acetyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "European Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Restriction Fragment Length", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United Kingdom", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vesicular Acetylcholine Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vesicular Transport Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harold", 
        "givenName": "Denise", 
        "id": "sg:person.01140735322.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140735322.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peirce", 
        "givenName": "Timothy", 
        "id": "sg:person.010457502607.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010457502607.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moskvina", 
        "givenName": "Valentina", 
        "id": "sg:person.0613737175.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613737175.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Myers", 
        "givenName": "Amanda", 
        "id": "sg:person.0715161543.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715161543.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Susan", 
        "id": "sg:person.010415237162.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010415237162.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hollingworth", 
        "givenName": "Paul", 
        "id": "sg:person.01073712032.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073712032.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moore", 
        "givenName": "Pamela", 
        "id": "sg:person.01052706362.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052706362.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lovestone", 
        "givenName": "Simon", 
        "id": "sg:person.01104331402.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104331402.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Powell", 
        "givenName": "John", 
        "id": "sg:person.015366547602.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015366547602.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foy", 
        "givenName": "Catherine", 
        "id": "sg:person.01324367032.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324367032.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Archer", 
        "givenName": "Nicola", 
        "id": "sg:person.01167134762.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167134762.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walter", 
        "givenName": "Sarah", 
        "id": "sg:person.01235250162.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235250162.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edmonson", 
        "givenName": "Amanda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McIlroy", 
        "givenName": "Stephen", 
        "id": "sg:person.0603632222.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603632222.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Craig", 
        "givenName": "David", 
        "id": "sg:person.01051210667.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051210667.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passmore", 
        "givenName": "Peter A.", 
        "id": "sg:person.0751705456.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751705456.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Psychiatry and Neurology, Washington University School of Medicine, 660 S Euclid, MO 63110, St Louis, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Departments of Psychiatry and Neurology, Washington University School of Medicine, 660 S Euclid, MO 63110, St Louis, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goate", 
        "givenName": "Alison", 
        "id": "sg:person.01353175712.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353175712.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardy", 
        "givenName": "John", 
        "id": "sg:person.011567711257.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011567711257.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Donovan", 
        "givenName": "Michael", 
        "id": "sg:person.012010266137.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010266137.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Julie", 
        "id": "sg:person.016062032414.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016062032414.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liddell", 
        "givenName": "Malcolm", 
        "id": "sg:person.01364006603.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364006603.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Owen", 
        "givenName": "Michael J.", 
        "id": "sg:person.011253462352.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253462352.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Medical Genetics, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK", 
            "Institute of Medical Genetics, University of Wales College of Medicine, CF14 4XN, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Lesley", 
        "id": "sg:person.014255227172.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014255227172.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00439-001-0614-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008260064", 
          "https://doi.org/10.1007/s00439-001-0614-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02800504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049103196", 
          "https://doi.org/10.1007/bf02800504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-199819060-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027652033", 
          "https://doi.org/10.2165/00002018-199819060-00004"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-05-21", 
    "datePublishedReg": "2003-05-21", 
    "description": "There is substantial evidence for a susceptibility gene for late-onset Alzheimer's disease (AD) on chromosome\u00a010. One of the characteristic features of AD is the degeneration and dysfunction of the cholinergic system. The genes encoding choline acetyltransferase (ChAT) and its vesicular transporter (VAChT), CHAT and SLC18A3 respectively, map to the linked region of chromosome\u00a010 and are therefore both positional and obvious functional candidate genes for late-onset AD. We have screened both genes for sequence variants and investigated each for association with late-onset AD in up to 500 late-onset AD cases and 500 control DNAs collected in the UK. We detected a total of 17 sequence variants. Of these, 14 were in CHAT, comprising three non-synonymous variants (D7N in the S\u00a0exon, A120T in exon\u00a05 and L243F in exon\u00a08), one synonymous change (H547H), nine single-nucleotide polymorphisms in intronic, untranslated or promoter regions, and a variable number of tandem repeats in intron\u00a07. Three non-coding SNPs were detected in SLC18A3. None demonstrated any reproducible association with late-onset AD in our samples. Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00439-003-0960-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2446676", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2686916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696250", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2708237", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440028", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440013", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1085982", 
        "issn": [
          "0340-6717", 
          "1432-1203"
        ], 
        "name": "Human Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "113"
      }
    ], 
    "keywords": [
      "ChAT locus", 
      "sequence variants", 
      "non-coding SNPs", 
      "regions of chromosomes", 
      "linkage disequilibrium", 
      "functional candidate genes", 
      "late-onset Alzheimer's disease", 
      "non-synonymous variants", 
      "synonymous changes", 
      "sequence variation", 
      "promoter region", 
      "candidate genes", 
      "single-nucleotide polymorphisms", 
      "tandem repeats", 
      "genes", 
      "vesicular transporters", 
      "complete linkage disequilibrium", 
      "A120T", 
      "susceptibility genes", 
      "chromosomes", 
      "reproducible association", 
      "control DNA", 
      "loci", 
      "Alzheimer's disease", 
      "disequilibrium", 
      "variants", 
      "variable number", 
      "late-onset AD cases", 
      "introns", 
      "SLC18A3", 
      "repeats", 
      "DNA", 
      "transporters", 
      "SNPs", 
      "polymorphism", 
      "acetyltransferase", 
      "D7N", 
      "region", 
      "substantial evidence", 
      "AD cases", 
      "characteristic features", 
      "disease", 
      "association", 
      "variation", 
      "choline acetyltransferase", 
      "evidence", 
      "levels", 
      "degeneration", 
      "changes", 
      "number", 
      "dysfunction", 
      "features", 
      "cholinergic system", 
      "total", 
      "system", 
      "samples", 
      "ChAT", 
      "cases", 
      "UK", 
      "obvious functional candidate genes"
    ], 
    "name": "Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease", 
    "pagination": "258-267", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017179029"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00439-003-0960-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12759818"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00439-003-0960-2", 
      "https://app.dimensions.ai/details/publication/pub.1017179029"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_374.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00439-003-0960-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00439-003-0960-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00439-003-0960-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00439-003-0960-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00439-003-0960-2'


 

This table displays all metadata directly associated to this object as RDF triples.

389 TRIPLES      22 PREDICATES      108 URIs      97 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00439-003-0960-2 schema:about N03f42bad64124529bad463587c71dbe3
2 N06c9c2dbbd164d88838ddff4a73831b4
3 N0e193d9e7d6140c8831149d380d9b29b
4 N1e2921bd4b694f5699a78a00f75e058f
5 N43a76c34e23d4f8fb6feb7da0cf45f9d
6 N473ab4902f674f14a48131e056ea6135
7 N4de62041d0784c568c1029dbe9d5332f
8 N507898e5a3ba47678e7e085ec37cb5ac
9 N528d2680d2824d8daff63e2e5d059d0d
10 N722cbde388c545748735d14854ffa60e
11 N78249a59681744cf8f55a6b88818d5a6
12 N7dfed849d78e454bbe3f2a44f03ea6bc
13 N960a879f0dea459a9ab35ba4b53ea226
14 Nb4af401746354a188b3fe1c27df522a1
15 Nca5e6a0f52b0470185eec8bcdb007c1b
16 Nd2ba9e2902d3470b8576c1579f70745a
17 Nde8cf8f36f5e41c6be9f2f309fa296f5
18 Ne656cde95fea485fba5431c7bb422fe4
19 Nf0f92aeaff7649a7a385ac38015c1a2b
20 anzsrc-for:06
21 anzsrc-for:0604
22 schema:author N075b9860b02f4693832eda64bc41deae
23 schema:citation sg:pub.10.1007/bf02800504
24 sg:pub.10.1007/s00439-001-0614-1
25 sg:pub.10.2165/00002018-199819060-00004
26 schema:datePublished 2003-05-21
27 schema:datePublishedReg 2003-05-21
28 schema:description There is substantial evidence for a susceptibility gene for late-onset Alzheimer's disease (AD) on chromosome 10. One of the characteristic features of AD is the degeneration and dysfunction of the cholinergic system. The genes encoding choline acetyltransferase (ChAT) and its vesicular transporter (VAChT), CHAT and SLC18A3 respectively, map to the linked region of chromosome 10 and are therefore both positional and obvious functional candidate genes for late-onset AD. We have screened both genes for sequence variants and investigated each for association with late-onset AD in up to 500 late-onset AD cases and 500 control DNAs collected in the UK. We detected a total of 17 sequence variants. Of these, 14 were in CHAT, comprising three non-synonymous variants (D7N in the S exon, A120T in exon 5 and L243F in exon 8), one synonymous change (H547H), nine single-nucleotide polymorphisms in intronic, untranslated or promoter regions, and a variable number of tandem repeats in intron 7. Three non-coding SNPs were detected in SLC18A3. None demonstrated any reproducible association with late-onset AD in our samples. Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf Na126f61a7d8a4f2eb3bb2e6207259ebd
33 Nc8e522464fa24b648bb061e29796a926
34 sg:journal.1085982
35 schema:keywords A120T
36 AD cases
37 Alzheimer's disease
38 ChAT
39 ChAT locus
40 D7N
41 DNA
42 SLC18A3
43 SNPs
44 UK
45 acetyltransferase
46 association
47 candidate genes
48 cases
49 changes
50 characteristic features
51 choline acetyltransferase
52 cholinergic system
53 chromosomes
54 complete linkage disequilibrium
55 control DNA
56 degeneration
57 disease
58 disequilibrium
59 dysfunction
60 evidence
61 features
62 functional candidate genes
63 genes
64 introns
65 late-onset AD cases
66 late-onset Alzheimer's disease
67 levels
68 linkage disequilibrium
69 loci
70 non-coding SNPs
71 non-synonymous variants
72 number
73 obvious functional candidate genes
74 polymorphism
75 promoter region
76 region
77 regions of chromosomes
78 repeats
79 reproducible association
80 samples
81 sequence variants
82 sequence variation
83 single-nucleotide polymorphisms
84 substantial evidence
85 susceptibility genes
86 synonymous changes
87 system
88 tandem repeats
89 total
90 transporters
91 variable number
92 variants
93 variation
94 vesicular transporters
95 schema:name Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
96 schema:pagination 258-267
97 schema:productId N20e3d44c08384857a6c913c867734ea2
98 N5c6954bc5255468185fdaa7b1a17e8c8
99 Nc790af8a121c4a598ac952d1f9dc3ad8
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017179029
101 https://doi.org/10.1007/s00439-003-0960-2
102 schema:sdDatePublished 2022-01-01T18:13
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N79915e751df741db8976decdbc742c4a
105 schema:url https://doi.org/10.1007/s00439-003-0960-2
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0025b3955df246e28c9b928c7ac3538b rdf:first sg:person.010415237162.30
110 rdf:rest N09061373f56c41e1b00725f4a418d228
111 N0309a09500a741c2b98381a5ca22922e rdf:first sg:person.01353175712.38
112 rdf:rest N47ca01eb572740a9b1b36b19800686c3
113 N03f42bad64124529bad463587c71dbe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Female
115 rdf:type schema:DefinedTerm
116 N06c9c2dbbd164d88838ddff4a73831b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Alzheimer Disease
118 rdf:type schema:DefinedTerm
119 N075b9860b02f4693832eda64bc41deae rdf:first sg:person.01140735322.27
120 rdf:rest Ne44760cd151e41c091866ae5dec4628e
121 N09061373f56c41e1b00725f4a418d228 rdf:first sg:person.01073712032.71
122 rdf:rest N5f67d99d0d4146bb9c8c37ce0cdef5e6
123 N0e193d9e7d6140c8831149d380d9b29b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Vesicular Acetylcholine Transport Proteins
125 rdf:type schema:DefinedTerm
126 N1b737e5bf82b4acb998de3edadd39312 rdf:first sg:person.0613737175.83
127 rdf:rest N55bdc1740fd74fc79fede1b521bf276e
128 N1c5788e4b8ea4581adbcfdfff18002b2 rdf:first sg:person.015366547602.30
129 rdf:rest N77d16c7f68384eeab3b367d9986df2c0
130 N1e2921bd4b694f5699a78a00f75e058f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Genetic Predisposition to Disease
132 rdf:type schema:DefinedTerm
133 N20e3d44c08384857a6c913c867734ea2 schema:name pubmed_id
134 schema:value 12759818
135 rdf:type schema:PropertyValue
136 N24b5039c07634df9b40b95dedd63d52b rdf:first sg:person.01364006603.10
137 rdf:rest N89f1a4245b4e4080be3e2097a45fa100
138 N2b01d4bb0d34489aa0ab921ee5e6d82b rdf:first sg:person.01104331402.29
139 rdf:rest N1c5788e4b8ea4581adbcfdfff18002b2
140 N2b5a990b656c4e6c88e301cb15e49552 rdf:first sg:person.01051210667.55
141 rdf:rest Nefca695a96684ad186d40928cabc57aa
142 N2c4ddfdeb4334cfa8307c8c472686e68 rdf:first sg:person.012010266137.38
143 rdf:rest Nd5252aae0cc8446f8092f639270f51be
144 N43a76c34e23d4f8fb6feb7da0cf45f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Aged
146 rdf:type schema:DefinedTerm
147 N473ab4902f674f14a48131e056ea6135 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Case-Control Studies
149 rdf:type schema:DefinedTerm
150 N47ca01eb572740a9b1b36b19800686c3 rdf:first sg:person.011567711257.54
151 rdf:rest N2c4ddfdeb4334cfa8307c8c472686e68
152 N4de62041d0784c568c1029dbe9d5332f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Choline O-Acetyltransferase
154 rdf:type schema:DefinedTerm
155 N507898e5a3ba47678e7e085ec37cb5ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Polymerase Chain Reaction
157 rdf:type schema:DefinedTerm
158 N528d2680d2824d8daff63e2e5d059d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name United Kingdom
160 rdf:type schema:DefinedTerm
161 N55bdc1740fd74fc79fede1b521bf276e rdf:first sg:person.0715161543.14
162 rdf:rest N0025b3955df246e28c9b928c7ac3538b
163 N5c6954bc5255468185fdaa7b1a17e8c8 schema:name dimensions_id
164 schema:value pub.1017179029
165 rdf:type schema:PropertyValue
166 N5f67d99d0d4146bb9c8c37ce0cdef5e6 rdf:first sg:person.01052706362.45
167 rdf:rest N2b01d4bb0d34489aa0ab921ee5e6d82b
168 N722cbde388c545748735d14854ffa60e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Carrier Proteins
170 rdf:type schema:DefinedTerm
171 N77d16c7f68384eeab3b367d9986df2c0 rdf:first sg:person.01324367032.31
172 rdf:rest N9df45f23f63e463c8e26aa59eb53fe9d
173 N78249a59681744cf8f55a6b88818d5a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Linkage Disequilibrium
175 rdf:type schema:DefinedTerm
176 N79915e751df741db8976decdbc742c4a schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N7dfed849d78e454bbe3f2a44f03ea6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Polymorphism, Single Nucleotide
180 rdf:type schema:DefinedTerm
181 N89f1a4245b4e4080be3e2097a45fa100 rdf:first sg:person.011253462352.60
182 rdf:rest Ne06f5c597d514d0e814f0c32affb8ce2
183 N960a879f0dea459a9ab35ba4b53ea226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 N9df45f23f63e463c8e26aa59eb53fe9d rdf:first sg:person.01167134762.63
187 rdf:rest Nf47869e807504780a3ac43d642a4a6f7
188 Na126f61a7d8a4f2eb3bb2e6207259ebd schema:volumeNumber 113
189 rdf:type schema:PublicationVolume
190 Nb4af401746354a188b3fe1c27df522a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Alleles
192 rdf:type schema:DefinedTerm
193 Nb61ccc4dd3514a48bab2d42e1d07b233 rdf:first Nd4f9ebfbdbc1442eb19ae12cef90badd
194 rdf:rest Nd189e945b90d4408ac6cc2557f8089ab
195 Nc790af8a121c4a598ac952d1f9dc3ad8 schema:name doi
196 schema:value 10.1007/s00439-003-0960-2
197 rdf:type schema:PropertyValue
198 Nc8e522464fa24b648bb061e29796a926 schema:issueNumber 3
199 rdf:type schema:PublicationIssue
200 Nca5e6a0f52b0470185eec8bcdb007c1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Vesicular Transport Proteins
202 rdf:type schema:DefinedTerm
203 Nd189e945b90d4408ac6cc2557f8089ab rdf:first sg:person.0603632222.08
204 rdf:rest N2b5a990b656c4e6c88e301cb15e49552
205 Nd2ba9e2902d3470b8576c1579f70745a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Polymorphism, Restriction Fragment Length
207 rdf:type schema:DefinedTerm
208 Nd4f9ebfbdbc1442eb19ae12cef90badd schema:affiliation grid-institutes:grid.13097.3c
209 schema:familyName Edmonson
210 schema:givenName Amanda
211 rdf:type schema:Person
212 Nd5252aae0cc8446f8092f639270f51be rdf:first sg:person.016062032414.10
213 rdf:rest N24b5039c07634df9b40b95dedd63d52b
214 Nde8cf8f36f5e41c6be9f2f309fa296f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name European Continental Ancestry Group
216 rdf:type schema:DefinedTerm
217 Ne06f5c597d514d0e814f0c32affb8ce2 rdf:first sg:person.014255227172.91
218 rdf:rest rdf:nil
219 Ne44760cd151e41c091866ae5dec4628e rdf:first sg:person.010457502607.17
220 rdf:rest N1b737e5bf82b4acb998de3edadd39312
221 Ne656cde95fea485fba5431c7bb422fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Membrane Transport Proteins
223 rdf:type schema:DefinedTerm
224 Nefca695a96684ad186d40928cabc57aa rdf:first sg:person.0751705456.81
225 rdf:rest N0309a09500a741c2b98381a5ca22922e
226 Nf0f92aeaff7649a7a385ac38015c1a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Male
228 rdf:type schema:DefinedTerm
229 Nf47869e807504780a3ac43d642a4a6f7 rdf:first sg:person.01235250162.37
230 rdf:rest Nb61ccc4dd3514a48bab2d42e1d07b233
231 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
232 schema:name Biological Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
235 schema:name Genetics
236 rdf:type schema:DefinedTerm
237 sg:grant.2440013 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
238 rdf:type schema:MonetaryGrant
239 sg:grant.2440028 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
240 rdf:type schema:MonetaryGrant
241 sg:grant.2446676 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
242 rdf:type schema:MonetaryGrant
243 sg:grant.2686916 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
244 rdf:type schema:MonetaryGrant
245 sg:grant.2696250 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
246 rdf:type schema:MonetaryGrant
247 sg:grant.2708237 http://pending.schema.org/fundedItem sg:pub.10.1007/s00439-003-0960-2
248 rdf:type schema:MonetaryGrant
249 sg:journal.1085982 schema:issn 0340-6717
250 1432-1203
251 schema:name Human Genetics
252 schema:publisher Springer Nature
253 rdf:type schema:Periodical
254 sg:person.010415237162.30 schema:affiliation grid-institutes:grid.5600.3
255 schema:familyName Jones
256 schema:givenName Susan
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010415237162.30
258 rdf:type schema:Person
259 sg:person.010457502607.17 schema:affiliation grid-institutes:grid.5600.3
260 schema:familyName Peirce
261 schema:givenName Timothy
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010457502607.17
263 rdf:type schema:Person
264 sg:person.01051210667.55 schema:affiliation grid-institutes:grid.4777.3
265 schema:familyName Craig
266 schema:givenName David
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051210667.55
268 rdf:type schema:Person
269 sg:person.01052706362.45 schema:affiliation grid-institutes:grid.5600.3
270 schema:familyName Moore
271 schema:givenName Pamela
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052706362.45
273 rdf:type schema:Person
274 sg:person.01073712032.71 schema:affiliation grid-institutes:grid.5600.3
275 schema:familyName Hollingworth
276 schema:givenName Paul
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073712032.71
278 rdf:type schema:Person
279 sg:person.01104331402.29 schema:affiliation grid-institutes:grid.13097.3c
280 schema:familyName Lovestone
281 schema:givenName Simon
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104331402.29
283 rdf:type schema:Person
284 sg:person.011253462352.60 schema:affiliation grid-institutes:grid.5600.3
285 schema:familyName Owen
286 schema:givenName Michael J.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253462352.60
288 rdf:type schema:Person
289 sg:person.01140735322.27 schema:affiliation grid-institutes:grid.5600.3
290 schema:familyName Harold
291 schema:givenName Denise
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140735322.27
293 rdf:type schema:Person
294 sg:person.011567711257.54 schema:affiliation grid-institutes:grid.94365.3d
295 schema:familyName Hardy
296 schema:givenName John
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011567711257.54
298 rdf:type schema:Person
299 sg:person.01167134762.63 schema:affiliation grid-institutes:grid.13097.3c
300 schema:familyName Archer
301 schema:givenName Nicola
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167134762.63
303 rdf:type schema:Person
304 sg:person.012010266137.38 schema:affiliation grid-institutes:grid.5600.3
305 schema:familyName O'Donovan
306 schema:givenName Michael
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010266137.38
308 rdf:type schema:Person
309 sg:person.01235250162.37 schema:affiliation grid-institutes:grid.13097.3c
310 schema:familyName Walter
311 schema:givenName Sarah
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235250162.37
313 rdf:type schema:Person
314 sg:person.01324367032.31 schema:affiliation grid-institutes:grid.13097.3c
315 schema:familyName Foy
316 schema:givenName Catherine
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324367032.31
318 rdf:type schema:Person
319 sg:person.01353175712.38 schema:affiliation grid-institutes:None
320 schema:familyName Goate
321 schema:givenName Alison
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353175712.38
323 rdf:type schema:Person
324 sg:person.01364006603.10 schema:affiliation grid-institutes:grid.5600.3
325 schema:familyName Liddell
326 schema:givenName Malcolm
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364006603.10
328 rdf:type schema:Person
329 sg:person.014255227172.91 schema:affiliation grid-institutes:grid.5600.3
330 schema:familyName Jones
331 schema:givenName Lesley
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014255227172.91
333 rdf:type schema:Person
334 sg:person.015366547602.30 schema:affiliation grid-institutes:grid.13097.3c
335 schema:familyName Powell
336 schema:givenName John
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015366547602.30
338 rdf:type schema:Person
339 sg:person.016062032414.10 schema:affiliation grid-institutes:grid.5600.3
340 schema:familyName Williams
341 schema:givenName Julie
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016062032414.10
343 rdf:type schema:Person
344 sg:person.0603632222.08 schema:affiliation grid-institutes:grid.4777.3
345 schema:familyName McIlroy
346 schema:givenName Stephen
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603632222.08
348 rdf:type schema:Person
349 sg:person.0613737175.83 schema:affiliation grid-institutes:grid.5600.3
350 schema:familyName Moskvina
351 schema:givenName Valentina
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613737175.83
353 rdf:type schema:Person
354 sg:person.0715161543.14 schema:affiliation grid-institutes:grid.94365.3d
355 schema:familyName Myers
356 schema:givenName Amanda
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715161543.14
358 rdf:type schema:Person
359 sg:person.0751705456.81 schema:affiliation grid-institutes:grid.4777.3
360 schema:familyName Passmore
361 schema:givenName Peter A.
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751705456.81
363 rdf:type schema:Person
364 sg:pub.10.1007/bf02800504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049103196
365 https://doi.org/10.1007/bf02800504
366 rdf:type schema:CreativeWork
367 sg:pub.10.1007/s00439-001-0614-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008260064
368 https://doi.org/10.1007/s00439-001-0614-1
369 rdf:type schema:CreativeWork
370 sg:pub.10.2165/00002018-199819060-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027652033
371 https://doi.org/10.2165/00002018-199819060-00004
372 rdf:type schema:CreativeWork
373 grid-institutes:None schema:alternateName Departments of Psychiatry and Neurology, Washington University School of Medicine, 660 S Euclid, MO 63110, St Louis, USA
374 schema:name Departments of Psychiatry and Neurology, Washington University School of Medicine, 660 S Euclid, MO 63110, St Louis, USA
375 rdf:type schema:Organization
376 grid-institutes:grid.13097.3c schema:alternateName Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK
377 schema:name Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK
378 rdf:type schema:Organization
379 grid-institutes:grid.4777.3 schema:alternateName Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK
380 schema:name Department of Geriatric Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK
381 rdf:type schema:Organization
382 grid-institutes:grid.5600.3 schema:alternateName Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
383 Institute of Medical Genetics, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
384 schema:name Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
385 Institute of Medical Genetics, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
386 rdf:type schema:Organization
387 grid-institutes:grid.94365.3d schema:alternateName Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA
388 schema:name Laboratory of Neurogenetics, MSC 0900, Building 9, Room 1N108, National Institute of Aging, National Institute of Health, 9000 Rockville Pike, MD 20892, Bethesda, USA
389 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...