Ontology type: schema:ScholarlyArticle
1998-08
AUTHORSC. Olano, A. M. Rodriguez, J.-M. Michel, C. Méndez, M.-C. Raynal, J. A. Salas
ABSTRACTA 6-kb region from the chromosome of Streptomyces antibioticus, an oleandomycin producer, was cloned and sequenced. This region was located between the 3' end of the gene encoding the third subunit of the oleandomycin type I polyketide synthase and the oleP and oleB genes, which encode a cytochrome P450 monooxygenase and an oleandomycin resistance gene, respectively. Analysis of the nucleotide sequence revealed the presence of five genes encoding a cytochrome P450-like protein (oleP1), two glycosyltransferases (oleG1 and oleG2) involved in the transfer of the two 6-deoxysugars (L-oleandrose and D-desosamine) to the oleandomycin macrolactone ring, a methyltransferase (oleM1), and a gene (oleY) of unknown function. Insertional inactivation of this region by gene disruption generated an oleandomycin non-producing mutant which accumulated a compound that, according to mass spectrometry analysis, could correspond to the oleandomycin macrolactone ring (oleandolide), suggesting that the mutation affects oleandrosyl glycosyltransferase. More... »
PAGES299-308
http://scigraph.springernature.com/pub.10.1007/s004380050816
DOIhttp://dx.doi.org/10.1007/s004380050816
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9749673
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