Evolution of a multigene family that encodes the Kunitz chymotrypsin inhibitor in winged bean: a possible intermediate in the generation ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-03

AUTHORS

Y. Habu, S. Peyachoknagul, Y. Sakata, K. Fukasawa, T. Ohno

ABSTRACT

Winged bean Kunitz chymotrypsin inhibitor (WCI) accumulates in an organ-specific and temporally regulated manner. The protein is encoded by a multigene family that includes at least four putative inhibitor-coding genes and three pseudogenes. The structure of the WCI genes indicates that an insertion at a 5′ proximal site occurred after duplication of the ancestral WCI gene and that several gene conversion events subsequently contributed to the evolution of this gene family. Analysis of the promoter activity of the 5′ regions of the WCI genes in transgenic tobacco showed that only the 5′ regions of the WCI-3a and WCI-3b genes, which encode the major WCI protein in winged bean, promoted the organ-specific and temporally regulated expression of a reporter gene. The 5′ region of a pseudogene, the WCI-P1 gene which contains frameshift mutations, exhibited constitutive promoter activity in tobacco, an indication that the 5′ region of the WCI-P1 gene might spontaneously have acquired new regulatory sequences during evolution. Since gene conversion is a relatively frequent event and since the homology between the WCI-P1 and WCI-3a/b genes is disrupted at a 5′ proximal site by remnants of an inserted sequence, the WCI-P1 gene appears to be a possible intermediate that could be converted into a new functional gene with a distinct pattern of expression by a single gene-conversion event. More... »

PAGES

73-80

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004380050392

DOI

http://dx.doi.org/10.1007/s004380050392

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000158677

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9108292


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204 schema:name Department of Applied Bioscience, Hokkaido University, Sapporo 060, Japan, JP
205 rdf:type schema:Organization
 




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