Influence of cytokines on Toxoplasma gondii growth in human astrocytoma-derived cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

H. Pelloux, G. Pernod, B. Polack, E. Coursange, J. Ricard, J. M. Verna, P. Ambroise-Thomas

ABSTRACT

The effects of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin 1-α (IL-1-α), and interleukin 6 (IL-6) on the growth of the Toxoplasma gondii RH strain were studied in vitro using a human astrocytoma-derived cell line. Cells were treated with cytokines at different concentrations at 24 h prior to infection with T. gondii tachyzoites. IFN-γ did not induce any modification in T. gondii growth, whatever the concentration used. TNF-α induced a significant decrease in the total number of tachyzoites, whereas IL-1-α surprisingly induced an increase in the number of tachyzoites. Our results show that the effects of cytokines on T. gondii growth may be of great importance in the control of cerebral toxoplasmosis but that they can vary, depending on the cell type considered. More... »

PAGES

598-603

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004360050171

DOI

http://dx.doi.org/10.1007/s004360050171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011438948

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8875566


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