Immunopathological assessments of human Blastocystis spp. in experimentally infected immunocompetent and immunosuppresed mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

Ekhlas H. Abdel-Hafeez, Azza K. Ahmad, Noha H. Abdelgelil, Manal Z. M. Abdellatif, Amany M. Kamal, Kamel M. A. Hassanin, Abdel-Razik H. Abdel-Razik, Ehab M. Abdel-Raheem

ABSTRACT

Blastocystis spp., one of the most common parasites colonizing the human intestine, is an extracellular, luminal protozoan with controversial pathogenesis. The host's immune response against Blastocystis spp. infection has also not been defined yet. Therefore, this research aimed to assess the potential pathogenicity of this parasite and its ability to modulate the immune response in experimental infected immunocompetent and immunosuppresed mice. These results demonstrated that the infected immunosuppressed mice were more affected than infected immunocompetent mice. Histopathological examination of the small intestine in the infected immunosuppressed mice showed that Blastocystis spp. infiltrated all the layers. Moreover, the epithelia showed exfoliation and inflammatory cell infiltration in submucosa compared to that of the infected immunocompetent mice. As well, examination of the large intestine of the infected immunosuppressed group showed severe goblet cell hyperplasia. Blastocystis spp. infiltrated all the large intestine layers compared to that of the infected immunocompetent group. Furthermore, there was a significant upregulation of the expression of proinflammatory cytokines: interleukin 12 (IL-12) and tumor necrosis factor alpha (TNF-α) in the infected immunosuppressed mice compared to that of the infected immunocompetent ones (p ≤ 0.004 and p ≤ 0.002, respectively). However, the expression of anti-inflammatory cytokines (IL-4 and IL-10) was significantly downregulated in the infected immunosuppressed group compared to that of the infected immunocompetent group one at 10 days postinfection (p ≤ 0.002 and p ≤ 0.001, respectively). The results of this study revealed that Blastocystis spp. affected the production of pro- and anti-inflammatory cytokines in both groups of mice compared to healthy normal (naive) group. Additionally, these data showed that there was a significant upregulation (p ≤ 0.005) of the locally synthesized antibody: secretary IgA (sIgA) in the gut of the infected immunocompetent mice when compared to that of the infected immunosuppressed ones. More... »

PAGES

2061-2071

References to SciGraph publications

  • 2010-08. Pathogenic potential of Blastocystis hominis in laboratory mice in PARASITOLOGY RESEARCH
  • 2008-04. Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats in PARASITOLOGY RESEARCH
  • 2005-11. Degradation of human secretory immunoglobulin A by Blastocystis in PARASITOLOGY RESEARCH
  • 2009-10. Kinetic analysis of antibody responses to Blastocystis hominis in sera and intestinal secretions of orally infected mice in PARASITOLOGY RESEARCH
  • 2014-12. Prevalence of antibiotic resistance in lactic acid bacteria isolated from the faeces of broiler chicken in Malaysia in GUT PATHOGENS
  • 2006-02. Predominance of amoeboid forms of Blastocystis hominis in isolates from symptomatic patients in PARASITOLOGY RESEARCH
  • 2012-03. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine in NATURE
  • 2008-02. Goblet cells: are they an unspecific barrier against Giardia intestinalis or a gate? in PARASITOLOGY RESEARCH
  • 1991-05. Pathogenicity of Blastocystis hominis in INFECTION
  • 1997-04. Experimental Blastocystis hominis infection in laboratory mice in PARASITOLOGY RESEARCH
  • 2008-12. Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection in FILARIA JOURNAL
  • 2010-05. Urinary hyaluronidase activity in rats infected with Blastocystis hominis—evidence for invasion? in PARASITOLOGY RESEARCH
  • 2014-08. Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients in GUT PATHOGENS
  • 2009-06. Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis sp. strain RN94-9 in PARASITOLOGY RESEARCH
  • 2011-08. In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and black pepper used in diet in PARASITOLOGY RESEARCH
  • 2010-08. Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteria in PARASITOLOGY RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00436-016-4951-3

    DOI

    http://dx.doi.org/10.1007/s00436-016-4951-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031775029

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26860840


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blastocystis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blastocystis Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Goblet Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestine, Large", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdel-Hafeez", 
            "givenName": "Ekhlas H.", 
            "id": "sg:person.01267415760.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267415760.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahmad", 
            "givenName": "Azza K.", 
            "id": "sg:person.01147456061.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147456061.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdelgelil", 
            "givenName": "Noha H.", 
            "id": "sg:person.01147531213.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147531213.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdellatif", 
            "givenName": "Manal Z. M.", 
            "id": "sg:person.01362401204.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362401204.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamal", 
            "givenName": "Amany M.", 
            "id": "sg:person.0666306715.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666306715.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Biochemistry, Faculty of Veterinary Medicine, Minia University, 61519, Minia, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hassanin", 
            "givenName": "Kamel M. A.", 
            "id": "sg:person.0617423037.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617423037.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beni-Suef University", 
              "id": "https://www.grid.ac/institutes/grid.411662.6", 
              "name": [
                "Department of Histology, Faculty of Veterinary Medicine, Beni-Suef University, 62511, Beni Suef, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdel-Razik", 
            "givenName": "Abdel-Razik H.", 
            "id": "sg:person.01010062321.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010062321.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Minia University", 
              "id": "https://www.grid.ac/institutes/grid.411806.a", 
              "name": [
                "Department of Tropical Medicine, Minia University Hospital, Minia University, 61519, Minya, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abdel-Raheem", 
            "givenName": "Ehab M.", 
            "id": "sg:person.0721352032.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721352032.57"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ijpara.2006.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001528297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-011-2265-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005366109", 
              "https://doi.org/10.1007/s00436-011-2265-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1556-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006904877", 
              "https://doi.org/10.1007/s00436-009-1556-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1556-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006904877", 
              "https://doi.org/10.1007/s00436-009-1556-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1556-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006904877", 
              "https://doi.org/10.1007/s00436-009-1556-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1556-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006904877", 
              "https://doi.org/10.1007/s00436-009-1556-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01643249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007048818", 
              "https://doi.org/10.1007/bf01643249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01643249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007048818", 
              "https://doi.org/10.1007/bf01643249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-005-0033-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007259941", 
              "https://doi.org/10.1007/s00436-005-0033-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-005-0033-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007259941", 
              "https://doi.org/10.1007/s00436-005-0033-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-005-0033-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007259941", 
              "https://doi.org/10.1007/s00436-005-0033-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1002545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009575122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13099-014-0034-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009626208", 
              "https://doi.org/10.1186/s13099-014-0034-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13099-014-0034-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009626208", 
              "https://doi.org/10.1186/s13099-014-0034-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1373-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016062603", 
              "https://doi.org/10.1007/s00436-009-1373-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-009-1373-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016062603", 
              "https://doi.org/10.1007/s00436-009-1373-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1918-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017036843", 
              "https://doi.org/10.1007/s00436-010-1918-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1918-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017036843", 
              "https://doi.org/10.1007/s00436-010-1918-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1918-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017036843", 
              "https://doi.org/10.1007/s00436-010-1918-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-4749-6-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017828458", 
              "https://doi.org/10.1186/1757-4749-6-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1999.tb01329.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019064413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1550-7408.2003.tb00108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020196133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1550-7408.2003.tb00108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020196133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-3305-1-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020949645", 
              "https://doi.org/10.1186/1756-3305-1-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1462-5822.2012.01814.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022095416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.vetpar.2004.09.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022413212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-007-0790-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027564356", 
              "https://doi.org/10.1007/s00436-007-0790-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-007-0790-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027564356", 
              "https://doi.org/10.1007/s00436-007-0790-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-007-0790-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027564356", 
              "https://doi.org/10.1007/s00436-007-0790-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028225229", 
              "https://doi.org/10.1038/nature10863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.00113-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029481864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.00022-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030535404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1922-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034415005", 
              "https://doi.org/10.1007/s00436-010-1922-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1922-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034415005", 
              "https://doi.org/10.1007/s00436-010-1922-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-005-1461-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580149", 
              "https://doi.org/10.1007/s00436-005-1461-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-005-1461-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580149", 
              "https://doi.org/10.1007/s00436-005-1461-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1825-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040531286", 
              "https://doi.org/10.1007/s00436-010-1825-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1825-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040531286", 
              "https://doi.org/10.1007/s00436-010-1825-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0037-86822008000600004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040905684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tmaid.2004.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041583520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajg.2011.11.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042151916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-007-0833-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043769127", 
              "https://doi.org/10.1007/s00436-007-0833-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-007-0833-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043769127", 
              "https://doi.org/10.1007/s00436-007-0833-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2005.03.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044576516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2005.03.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044576516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1542-3565(05)00427-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045033352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2005.03868.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045275793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2005.03868.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045275793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0031182000085838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046065160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mib.2011.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046164414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004360050256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047441927", 
              "https://doi.org/10.1007/s004360050256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004360050256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047441927", 
              "https://doi.org/10.1007/s004360050256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0031182008004381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048463199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049805895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(88)90896-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050048424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0950268809002672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053868753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0950268809002672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053868753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/clinids/21.1.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059474125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.4.1.61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062710837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12816/0010854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064686062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074856729", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075283995", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2003.69.213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075929421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.2004.70.383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076828463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077213196", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077320910", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079484650", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-05", 
        "datePublishedReg": "2016-05-01", 
        "description": "Blastocystis spp., one of the most common parasites colonizing the human intestine, is an extracellular, luminal protozoan with controversial pathogenesis. The host's immune response against Blastocystis spp. infection has also not been defined yet. Therefore, this research aimed to assess the potential pathogenicity of this parasite and its ability to modulate the immune response in experimental infected immunocompetent and immunosuppresed mice. These results demonstrated that the infected immunosuppressed mice were more affected than infected immunocompetent mice. Histopathological examination of the small intestine in the infected immunosuppressed mice showed that Blastocystis spp. infiltrated all the layers. Moreover, the epithelia showed exfoliation and inflammatory cell infiltration in submucosa compared to that of the infected immunocompetent mice. As well, examination of the large intestine of the infected immunosuppressed group showed severe goblet cell hyperplasia. Blastocystis spp. infiltrated all the large intestine layers compared to that of the infected immunocompetent group. Furthermore, there was a significant upregulation of the expression of proinflammatory cytokines: interleukin 12 (IL-12) and tumor necrosis factor alpha (TNF-\u03b1) in the infected immunosuppressed mice compared to that of the infected immunocompetent ones (p\u2009\u2264\u20090.004 and p\u2009\u2264\u20090.002, respectively). However, the expression of anti-inflammatory cytokines (IL-4 and IL-10) was significantly downregulated in the infected immunosuppressed group compared to that of the infected immunocompetent group one at 10\u00a0days postinfection (p\u2009\u2264\u20090.002 and p\u2009\u2264\u20090.001, respectively). The results of this study revealed that Blastocystis spp. affected the production of pro- and anti-inflammatory cytokines in both groups of mice compared to healthy normal (naive) group. Additionally, these data showed that there was a significant upregulation (p\u2009\u2264\u20090.005) of the locally synthesized antibody: secretary IgA (sIgA) in the gut of the infected immunocompetent mice when compared to that of the infected immunosuppressed ones. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00436-016-4951-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096949", 
            "issn": [
              "0932-0113", 
              "1432-1955"
            ], 
            "name": "Parasitology Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "115"
          }
        ], 
        "name": "Immunopathological assessments of human Blastocystis spp. in experimentally infected immunocompetent and immunosuppresed mice", 
        "pagination": "2061-2071", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "975eacfaf7ef782755a6141cd710716396be6658da3c385d075991b88358f006"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26860840"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8703571"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00436-016-4951-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031775029"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00436-016-4951-3", 
          "https://app.dimensions.ai/details/publication/pub.1031775029"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54310_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00436-016-4951-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00436-016-4951-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00436-016-4951-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00436-016-4951-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00436-016-4951-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    316 TRIPLES      21 PREDICATES      86 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00436-016-4951-3 schema:about N11ad867e3f0a44ccaeb9c967212f1825
    2 N3f1d4f553c51423fbf9842345ec71630
    3 N421a933bcf744d4ba6d7a9beb235610b
    4 N4bef0909f7bd40a2a4e4bedd44526987
    5 N6aeded24b48245068ff9aea9e40693b7
    6 N6f1543dcc67141e0ad1f0cb2dc61887b
    7 N831b6fd6a0b843439927b3ff122438d7
    8 N8e8c76bac25e403c993dc93a21d222b1
    9 Nada11ad95e7e4d66a89e1a3e7f28adc7
    10 Nb339803afbea4863a8328d5225bb4fb5
    11 Nd00fc1d827e44cb59f3ad518418ea245
    12 anzsrc-for:11
    13 anzsrc-for:1107
    14 schema:author N32275c8fc0f5432a9d2e9dc67a30a907
    15 schema:citation sg:pub.10.1007/bf01643249
    16 sg:pub.10.1007/s00436-005-0033-7
    17 sg:pub.10.1007/s00436-005-1461-0
    18 sg:pub.10.1007/s00436-007-0790-6
    19 sg:pub.10.1007/s00436-007-0833-z
    20 sg:pub.10.1007/s00436-009-1373-5
    21 sg:pub.10.1007/s00436-009-1556-0
    22 sg:pub.10.1007/s00436-010-1825-y
    23 sg:pub.10.1007/s00436-010-1918-7
    24 sg:pub.10.1007/s00436-010-1922-y
    25 sg:pub.10.1007/s00436-011-2265-z
    26 sg:pub.10.1007/s004360050256
    27 sg:pub.10.1038/nature10863
    28 sg:pub.10.1186/1756-3305-1-40
    29 sg:pub.10.1186/1757-4749-6-1
    30 sg:pub.10.1186/s13099-014-0034-0
    31 https://app.dimensions.ai/details/publication/pub.1074856729
    32 https://app.dimensions.ai/details/publication/pub.1075283995
    33 https://app.dimensions.ai/details/publication/pub.1077213196
    34 https://app.dimensions.ai/details/publication/pub.1077320910
    35 https://app.dimensions.ai/details/publication/pub.1079484650
    36 https://doi.org/10.1016/j.ajg.2011.11.005
    37 https://doi.org/10.1016/j.ijpara.2006.09.009
    38 https://doi.org/10.1016/j.mib.2011.11.002
    39 https://doi.org/10.1016/j.tmaid.2004.06.001
    40 https://doi.org/10.1016/j.vetpar.2004.09.017
    41 https://doi.org/10.1016/j.virol.2005.03.039
    42 https://doi.org/10.1016/s0140-6736(88)90896-3
    43 https://doi.org/10.1016/s1542-3565(05)00427-1
    44 https://doi.org/10.1017/s0031182000085838
    45 https://doi.org/10.1017/s0031182008004381
    46 https://doi.org/10.1017/s0950268809002672
    47 https://doi.org/10.1093/clinids/21.1.97
    48 https://doi.org/10.1111/j.1440-1746.2005.03868.x
    49 https://doi.org/10.1111/j.1462-5822.2012.01814.x
    50 https://doi.org/10.1111/j.1550-7408.2003.tb00108.x
    51 https://doi.org/10.1111/j.1600-065x.1999.tb01329.x
    52 https://doi.org/10.1128/cmr.00022-08
    53 https://doi.org/10.1128/cmr.00113-14
    54 https://doi.org/10.1128/cmr.4.1.61
    55 https://doi.org/10.12816/0010854
    56 https://doi.org/10.1371/journal.pone.0015484
    57 https://doi.org/10.1371/journal.ppat.1002545
    58 https://doi.org/10.1590/s0037-86822008000600004
    59 https://doi.org/10.4269/ajtmh.2003.69.213
    60 https://doi.org/10.4269/ajtmh.2004.70.383
    61 schema:datePublished 2016-05
    62 schema:datePublishedReg 2016-05-01
    63 schema:description Blastocystis spp., one of the most common parasites colonizing the human intestine, is an extracellular, luminal protozoan with controversial pathogenesis. The host's immune response against Blastocystis spp. infection has also not been defined yet. Therefore, this research aimed to assess the potential pathogenicity of this parasite and its ability to modulate the immune response in experimental infected immunocompetent and immunosuppresed mice. These results demonstrated that the infected immunosuppressed mice were more affected than infected immunocompetent mice. Histopathological examination of the small intestine in the infected immunosuppressed mice showed that Blastocystis spp. infiltrated all the layers. Moreover, the epithelia showed exfoliation and inflammatory cell infiltration in submucosa compared to that of the infected immunocompetent mice. As well, examination of the large intestine of the infected immunosuppressed group showed severe goblet cell hyperplasia. Blastocystis spp. infiltrated all the large intestine layers compared to that of the infected immunocompetent group. Furthermore, there was a significant upregulation of the expression of proinflammatory cytokines: interleukin 12 (IL-12) and tumor necrosis factor alpha (TNF-α) in the infected immunosuppressed mice compared to that of the infected immunocompetent ones (p ≤ 0.004 and p ≤ 0.002, respectively). However, the expression of anti-inflammatory cytokines (IL-4 and IL-10) was significantly downregulated in the infected immunosuppressed group compared to that of the infected immunocompetent group one at 10 days postinfection (p ≤ 0.002 and p ≤ 0.001, respectively). The results of this study revealed that Blastocystis spp. affected the production of pro- and anti-inflammatory cytokines in both groups of mice compared to healthy normal (naive) group. Additionally, these data showed that there was a significant upregulation (p ≤ 0.005) of the locally synthesized antibody: secretary IgA (sIgA) in the gut of the infected immunocompetent mice when compared to that of the infected immunosuppressed ones.
    64 schema:genre research_article
    65 schema:inLanguage en
    66 schema:isAccessibleForFree false
    67 schema:isPartOf N75ad9e97bdda47769c1161894eb13850
    68 N775fdeb5ccdc4679ad2c422e8f6d1e9d
    69 sg:journal.1096949
    70 schema:name Immunopathological assessments of human Blastocystis spp. in experimentally infected immunocompetent and immunosuppresed mice
    71 schema:pagination 2061-2071
    72 schema:productId N22427fc5968148f59e388d1c109c67dd
    73 N399fa383fa534c8d811ea7c671c9c676
    74 N5261e70a50444b838526b860502d0596
    75 Na44afbff6673499691de6042244f1583
    76 Ndfd30077aa134373b69956d5240ee4e3
    77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031775029
    78 https://doi.org/10.1007/s00436-016-4951-3
    79 schema:sdDatePublished 2019-04-11T10:17
    80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    81 schema:sdPublisher Nfd9991d775f94ea4beae198d7edb2c44
    82 schema:url https://link.springer.com/10.1007%2Fs00436-016-4951-3
    83 sgo:license sg:explorer/license/
    84 sgo:sdDataset articles
    85 rdf:type schema:ScholarlyArticle
    86 N0b39af084d664c7580b23e9bd0587839 rdf:first sg:person.01147531213.97
    87 rdf:rest N923a2e18e3fe44998e9d8024703845c7
    88 N11ad867e3f0a44ccaeb9c967212f1825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Goblet Cells
    90 rdf:type schema:DefinedTerm
    91 N1c53d4cd7804495f9e76a6aec448d360 rdf:first sg:person.0617423037.41
    92 rdf:rest Ne8bd68fed9c540ef9d43c057ae9a474f
    93 N22427fc5968148f59e388d1c109c67dd schema:name readcube_id
    94 schema:value 975eacfaf7ef782755a6141cd710716396be6658da3c385d075991b88358f006
    95 rdf:type schema:PropertyValue
    96 N32275c8fc0f5432a9d2e9dc67a30a907 rdf:first sg:person.01267415760.20
    97 rdf:rest Nf5302aa8df8b4189969544603add8d6d
    98 N399fa383fa534c8d811ea7c671c9c676 schema:name pubmed_id
    99 schema:value 26860840
    100 rdf:type schema:PropertyValue
    101 N3f1d4f553c51423fbf9842345ec71630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Humans
    103 rdf:type schema:DefinedTerm
    104 N4005e401fb23415faf7f5f6d19dcfe89 rdf:first sg:person.0666306715.87
    105 rdf:rest N1c53d4cd7804495f9e76a6aec448d360
    106 N421a933bcf744d4ba6d7a9beb235610b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Mice
    108 rdf:type schema:DefinedTerm
    109 N4bef0909f7bd40a2a4e4bedd44526987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Cytokines
    111 rdf:type schema:DefinedTerm
    112 N5261e70a50444b838526b860502d0596 schema:name doi
    113 schema:value 10.1007/s00436-016-4951-3
    114 rdf:type schema:PropertyValue
    115 N6aeded24b48245068ff9aea9e40693b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Animals
    117 rdf:type schema:DefinedTerm
    118 N6f1543dcc67141e0ad1f0cb2dc61887b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Blastocystis
    120 rdf:type schema:DefinedTerm
    121 N733ca74dec594b49bb732bd8db3d6e50 rdf:first sg:person.0721352032.57
    122 rdf:rest rdf:nil
    123 N75ad9e97bdda47769c1161894eb13850 schema:issueNumber 5
    124 rdf:type schema:PublicationIssue
    125 N775fdeb5ccdc4679ad2c422e8f6d1e9d schema:volumeNumber 115
    126 rdf:type schema:PublicationVolume
    127 N831b6fd6a0b843439927b3ff122438d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Interleukin-10
    129 rdf:type schema:DefinedTerm
    130 N8e8c76bac25e403c993dc93a21d222b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Interleukin-4
    132 rdf:type schema:DefinedTerm
    133 N923a2e18e3fe44998e9d8024703845c7 rdf:first sg:person.01362401204.31
    134 rdf:rest N4005e401fb23415faf7f5f6d19dcfe89
    135 Na44afbff6673499691de6042244f1583 schema:name nlm_unique_id
    136 schema:value 8703571
    137 rdf:type schema:PropertyValue
    138 Nada11ad95e7e4d66a89e1a3e7f28adc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Male
    140 rdf:type schema:DefinedTerm
    141 Nb339803afbea4863a8328d5225bb4fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Blastocystis Infections
    143 rdf:type schema:DefinedTerm
    144 Nd00fc1d827e44cb59f3ad518418ea245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Intestine, Large
    146 rdf:type schema:DefinedTerm
    147 Ndfd30077aa134373b69956d5240ee4e3 schema:name dimensions_id
    148 schema:value pub.1031775029
    149 rdf:type schema:PropertyValue
    150 Ne8bd68fed9c540ef9d43c057ae9a474f rdf:first sg:person.01010062321.64
    151 rdf:rest N733ca74dec594b49bb732bd8db3d6e50
    152 Nf5302aa8df8b4189969544603add8d6d rdf:first sg:person.01147456061.97
    153 rdf:rest N0b39af084d664c7580b23e9bd0587839
    154 Nfd9991d775f94ea4beae198d7edb2c44 schema:name Springer Nature - SN SciGraph project
    155 rdf:type schema:Organization
    156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Medical and Health Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Immunology
    161 rdf:type schema:DefinedTerm
    162 sg:journal.1096949 schema:issn 0932-0113
    163 1432-1955
    164 schema:name Parasitology Research
    165 rdf:type schema:Periodical
    166 sg:person.01010062321.64 schema:affiliation https://www.grid.ac/institutes/grid.411662.6
    167 schema:familyName Abdel-Razik
    168 schema:givenName Abdel-Razik H.
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010062321.64
    170 rdf:type schema:Person
    171 sg:person.01147456061.97 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    172 schema:familyName Ahmad
    173 schema:givenName Azza K.
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147456061.97
    175 rdf:type schema:Person
    176 sg:person.01147531213.97 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    177 schema:familyName Abdelgelil
    178 schema:givenName Noha H.
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147531213.97
    180 rdf:type schema:Person
    181 sg:person.01267415760.20 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    182 schema:familyName Abdel-Hafeez
    183 schema:givenName Ekhlas H.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267415760.20
    185 rdf:type schema:Person
    186 sg:person.01362401204.31 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    187 schema:familyName Abdellatif
    188 schema:givenName Manal Z. M.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362401204.31
    190 rdf:type schema:Person
    191 sg:person.0617423037.41 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    192 schema:familyName Hassanin
    193 schema:givenName Kamel M. A.
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617423037.41
    195 rdf:type schema:Person
    196 sg:person.0666306715.87 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    197 schema:familyName Kamal
    198 schema:givenName Amany M.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666306715.87
    200 rdf:type schema:Person
    201 sg:person.0721352032.57 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
    202 schema:familyName Abdel-Raheem
    203 schema:givenName Ehab M.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721352032.57
    205 rdf:type schema:Person
    206 sg:pub.10.1007/bf01643249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007048818
    207 https://doi.org/10.1007/bf01643249
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s00436-005-0033-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007259941
    210 https://doi.org/10.1007/s00436-005-0033-7
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s00436-005-1461-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038580149
    213 https://doi.org/10.1007/s00436-005-1461-0
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s00436-007-0790-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027564356
    216 https://doi.org/10.1007/s00436-007-0790-6
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00436-007-0833-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043769127
    219 https://doi.org/10.1007/s00436-007-0833-z
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00436-009-1373-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016062603
    222 https://doi.org/10.1007/s00436-009-1373-5
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00436-009-1556-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006904877
    225 https://doi.org/10.1007/s00436-009-1556-0
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00436-010-1825-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1040531286
    228 https://doi.org/10.1007/s00436-010-1825-y
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00436-010-1918-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017036843
    231 https://doi.org/10.1007/s00436-010-1918-7
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00436-010-1922-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034415005
    234 https://doi.org/10.1007/s00436-010-1922-y
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s00436-011-2265-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005366109
    237 https://doi.org/10.1007/s00436-011-2265-z
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s004360050256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047441927
    240 https://doi.org/10.1007/s004360050256
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature10863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028225229
    243 https://doi.org/10.1038/nature10863
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1186/1756-3305-1-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020949645
    246 https://doi.org/10.1186/1756-3305-1-40
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/1757-4749-6-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017828458
    249 https://doi.org/10.1186/1757-4749-6-1
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/s13099-014-0034-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009626208
    252 https://doi.org/10.1186/s13099-014-0034-0
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1074856729 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1075283995 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1077213196 schema:CreativeWork
    257 https://app.dimensions.ai/details/publication/pub.1077320910 schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1079484650 schema:CreativeWork
    259 https://doi.org/10.1016/j.ajg.2011.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042151916
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.ijpara.2006.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001528297
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.mib.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046164414
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.tmaid.2004.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041583520
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.vetpar.2004.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022413212
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.virol.2005.03.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044576516
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0140-6736(88)90896-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050048424
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s1542-3565(05)00427-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045033352
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1017/s0031182000085838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046065160
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1017/s0031182008004381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048463199
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1017/s0950268809002672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053868753
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1093/clinids/21.1.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059474125
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1111/j.1440-1746.2005.03868.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045275793
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1111/j.1462-5822.2012.01814.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022095416
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1111/j.1550-7408.2003.tb00108.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020196133
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1111/j.1600-065x.1999.tb01329.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019064413
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1128/cmr.00022-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030535404
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1128/cmr.00113-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029481864
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1128/cmr.4.1.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062710837
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.12816/0010854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064686062
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1371/journal.pone.0015484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049805895
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1371/journal.ppat.1002545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009575122
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1590/s0037-86822008000600004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040905684
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.4269/ajtmh.2003.69.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075929421
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.4269/ajtmh.2004.70.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076828463
    308 rdf:type schema:CreativeWork
    309 https://www.grid.ac/institutes/grid.411662.6 schema:alternateName Beni-Suef University
    310 schema:name Department of Histology, Faculty of Veterinary Medicine, Beni-Suef University, 62511, Beni Suef, Egypt
    311 rdf:type schema:Organization
    312 https://www.grid.ac/institutes/grid.411806.a schema:alternateName Minia University
    313 schema:name Department of Biochemistry, Faculty of Veterinary Medicine, Minia University, 61519, Minia, Egypt
    314 Department of Parasitology, Faculty of Medicine, Minia University, 61519, Minia, Egypt
    315 Department of Tropical Medicine, Minia University Hospital, Minia University, 61519, Minya, Egypt
    316 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...