Valeriana wallichii root extracts and fractions with activity against Leishmania spp View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04

AUTHORS

Subhalakshmi Ghosh, Sukalyani Debnath, Sudipta Hazra, Andreas Hartung, Katja Thomale, Martina Schultheis, Petra Kapkova, Uta Schurigt, Heidrun Moll, Ulrike Holzgrabe, Banasri Hazra

ABSTRACT

Leishmanial diseases, posing a public health problem worldwide, are caused by Leishmania parasites with a dimorphic life cycle alternating between the promastigote and amastigote forms. Promastigotes transmitted by the vector are transformed into amastigotes residing in the host tissue macrophages. Presently, new antiparasitic agents are needed against Leishmania donovani and Leishmania major, the respective organisms causing visceral and cutaneous leishmaniasis, since the available treatments are unsatisfactory due to toxicity, high cost, and emerging drug resistance. Over the years, traditional medicinal flora throughout the world enriched the modern pharmacopeia. Hence, roots of 'Indian Valerian' (Valeriana wallichii DC) were studied for its antileishmanial activity for the first time. The methanol and chloroform extracts showed activity against L. donovani promastigotes and both promastigotes and amastigotes of L. major. The most active fraction, F3, obtained from the chloroform extract, showed IC(50) at ∼ 3-7 μg/ml against both the promastigotes and 0.3 μg/ml against L. major amastigotes. On investigation of the mechanism of cytotoxicity in L. donovani promastigotes, the 'hall-mark' events of morphological degeneration, DNA fragmentation, externalization of phosphatidyl serine, and mitochondrial membrane depolarization indicated that F3 could induce apoptotic death in leishmanial cells. Therefore, the present study revealed a novel and unconventional property of V. wallichii root as a prospective source of effective antileishmanial agents. More... »

PAGES

861-871

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00436-010-2127-0

DOI

http://dx.doi.org/10.1007/s00436-010-2127-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049971295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21085992


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Download the RDF metadata as:  json-ld nt turtle xml License info

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00436-010-2127-0'


 

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