Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-11-18

AUTHORS

Adama Gansané, Souleymane Sanon, Lamoussa P. Ouattara, Abdoulaye Traoré, Sébastien Hutter, Evelyne Ollivier, Nadine Azas, Alfred S. Traore, Innocent P. Guissou, Sodiomon B. Sirima, Issa Nebié

ABSTRACT

In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa. The evaluated parts are bark of trunk for Zanthoxylum zanthoxyloides and leaves for Sarcocephalus latifolius instead of roots, and leaves for Combretum molle and Anogeissus leiocarpus instead of stem bark. The antiplasmodial activity of extracts of these plants was evaluated in vitro using the multi-resistant strain (W2) of Plasmodium falciparum. Antiproliferative activity was also assessed, using K562S human monocyte cell lines, along with calculation of the selectivity index (SI) of each extract. The highest in vitro antiplasmodial activity was found in the alkaloid extract of trunk bark from Z. zanthoxyloides and from the MeOH extract of A. leiocarpus leaves (IC50 = 1.2 µg/mL and 4.9 µg/mL, respectively) with good selectivity index. Moderate activity was found in the MeOH extract (IC50 = 5.7 µg/mL) and MeOH/H2O extract (IC50 = 7.9 µg/mL) of C. molle leaves. Moderate activity was also found in the MeOH/H20 extract (IC50 = 5.2 µg/mL) and the decoction (IC50 = 8.2 µg/mL) from leaves of A. leiocarpus. No good activity was found with extracts from roots of S. latifolius. All extracts tested displayed low levels of cytotoxicity against K562S cells. The data generated clearly show that the trunk bark for Z. zanthoxyloides and the leaves for A. leiocarpus and C. molle could be used for the treatment of malaria instead of roots and stem bark. More... »

PAGES

335

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00436-009-1663-y

DOI

http://dx.doi.org/10.1007/s00436-009-1663-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006107438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19921259


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0607", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Plant Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimalarials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Burkina Faso", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complex Mixtures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibitory Concentration 50", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Bark", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Leaves", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Stems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plants, Medicinal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.507461.1", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gansan\u00e9", 
        "givenName": "Adama", 
        "id": "sg:person.01370213017.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370213017.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.507461.1", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanon", 
        "givenName": "Souleymane", 
        "id": "sg:person.01076570544.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076570544.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.507461.1", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ouattara", 
        "givenName": "Lamoussa P.", 
        "id": "sg:person.01252266015.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252266015.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.507461.1", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Traor\u00e9", 
        "givenName": "Abdoulaye", 
        "id": "sg:person.01320401215.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320401215.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutter", 
        "givenName": "S\u00e9bastien", 
        "id": "sg:person.01305550557.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305550557.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ollivier", 
        "givenName": "Evelyne", 
        "id": "sg:person.01114415134.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114415134.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France", 
          "id": "http://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Facult\u00e9 de Pharmacie, UMR MD3, Universit\u00e9 de la M\u00e9diterran\u00e9e, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azas", 
        "givenName": "Nadine", 
        "id": "sg:person.01100374046.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100374046.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pharmacology and Clinical Biochemistry of CRSBAN, UFR/SVT, University of Ouagadougou, Ouagadougou, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.218069.4", 
          "name": [
            "Laboratory of Pharmacology and Clinical Biochemistry of CRSBAN, UFR/SVT, University of Ouagadougou, Ouagadougou, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Traore", 
        "givenName": "Alfred S.", 
        "id": "sg:person.016466717302.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016466717302.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Toxicology, UFR/SDS, University of Ouagadougou, Ouagadougou, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.218069.4", 
          "name": [
            "Department of Pharmacology and Toxicology, UFR/SDS, University of Ouagadougou, Ouagadougou, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guissou", 
        "givenName": "Innocent P.", 
        "id": "sg:person.01256502435.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256502435.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Groupe de Recherche et d\u2019Action en Sant\u00e9 (GRAS), 06 POB 10 248, Ouagadougou 06, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
            "Groupe de Recherche et d\u2019Action en Sant\u00e9 (GRAS), 06 POB 10 248, Ouagadougou 06, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sirima", 
        "givenName": "Sodiomon B.", 
        "id": "sg:person.01023230004.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023230004.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso", 
          "id": "http://www.grid.ac/institutes/grid.507461.1", 
          "name": [
            "Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nebi\u00e9", 
        "givenName": "Issa", 
        "id": "sg:person.0635025104.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635025104.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00436-008-0879-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008864496", 
          "https://doi.org/10.1007/s00436-008-0879-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004360100454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012308546", 
          "https://doi.org/10.1007/s004360100454"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-11-18", 
    "datePublishedReg": "2009-11-18", 
    "description": "In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa. The evaluated parts are bark of trunk for Zanthoxylum zanthoxyloides and leaves for Sarcocephalus latifolius instead of roots, and leaves for Combretum molle and Anogeissus leiocarpus instead of stem bark. The antiplasmodial activity of extracts of these plants was evaluated in vitro using the multi-resistant strain (W2) of Plasmodium falciparum. Antiproliferative activity was also assessed, using K562S human monocyte cell lines, along with calculation of the selectivity index (SI) of each extract. The highest in vitro antiplasmodial activity was found in the alkaloid extract of trunk bark from Z. zanthoxyloides and from the MeOH extract of A. leiocarpus leaves (IC50\u2009=\u20091.2\u00a0\u00b5g/mL and 4.9\u00a0\u00b5g/mL, respectively) with good selectivity index. Moderate activity was found in the MeOH extract (IC50\u2009=\u20095.7\u00a0\u00b5g/mL) and MeOH/H2O extract (IC50\u2009=\u20097.9\u00a0\u00b5g/mL) of C. molle leaves. Moderate activity was also found in the MeOH/H20 extract (IC50\u2009=\u20095.2\u00a0\u00b5g/mL) and the decoction (IC50\u2009=\u20098.2\u00a0\u00b5g/mL) from leaves of A. leiocarpus. No good activity was found with extracts from roots of S. latifolius. All extracts tested displayed low levels of cytotoxicity against K562S cells. The data generated clearly show that the trunk bark for Z. zanthoxyloides and the leaves for A. leiocarpus and C. molle could be used for the treatment of malaria instead of roots and stem bark.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00436-009-1663-y", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096949", 
        "issn": [
          "0932-0113", 
          "1432-1955"
        ], 
        "name": "Parasitology Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "106"
      }
    ], 
    "keywords": [
      "treatment of malaria", 
      "antiplasmodial activity", 
      "selectivity index", 
      "human monocyte cell line", 
      "Z. zanthoxyloides", 
      "multi-resistant strains", 
      "monocyte cell line", 
      "good selectivity index", 
      "moderate activity", 
      "MeOH extract", 
      "Plasmodium falciparum", 
      "C. molle", 
      "traditional healers", 
      "stem bark", 
      "cell lines", 
      "Zanthoxylum zanthoxyloides", 
      "K562 cells", 
      "malaria", 
      "A. leiocarpus", 
      "antiproliferative activity", 
      "Saharan Africa", 
      "treatment", 
      "H2O extracts", 
      "alkaloid extract", 
      "trunk bark", 
      "low levels", 
      "medicinal plants", 
      "extract", 
      "Sarcocephalus latifolius", 
      "Burkina Faso", 
      "activity", 
      "S. latifolius", 
      "crude extract", 
      "falciparum", 
      "Combretum molle", 
      "decoction", 
      "index", 
      "trunk", 
      "vitro", 
      "good activity", 
      "toxicity", 
      "cytotoxicity", 
      "healers", 
      "evaluated parts", 
      "cells", 
      "levels", 
      "bark", 
      "destruction", 
      "Faso", 
      "preservation", 
      "strains", 
      "part", 
      "flora", 
      "molle", 
      "data", 
      "Anogeissus", 
      "lines", 
      "Africa", 
      "roots", 
      "latifolius", 
      "leaves", 
      "contribution", 
      "order", 
      "alternative parts", 
      "plants", 
      "ecology", 
      "calculations"
    ], 
    "name": "Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation", 
    "pagination": "335", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006107438"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00436-009-1663-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19921259"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00436-009-1663-y", 
      "https://app.dimensions.ai/details/publication/pub.1006107438"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_480.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00436-009-1663-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00436-009-1663-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00436-009-1663-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00436-009-1663-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00436-009-1663-y'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      110 URIs      100 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00436-009-1663-y schema:about N06527ec11ffb484dbdb822f508cb2ead
2 N1465f4a1806d4fc2a06deb2e9776ca47
3 N1a290bcea61c45d391b4a8ae27dfe017
4 N2d9484599f3244f1b5ad1e0b2128d7f2
5 N2e7ceadc330244c7b8034b3e2b4666ec
6 N39f5112492e14497888351775b4a5db8
7 N3dc0964224f14b81b956094b8328bac3
8 N3e23824a97e24e3ea69fdefbddd0119d
9 N75c1c45f9e0b4a15b498146fbc38b75e
10 N81cbd175c71143839cf5e6e83b2002ed
11 N8a5be624725f4d61801e8ea7aee01317
12 Na41ce1a7e5db480fa65a6ee878452091
13 Na6f9d035b6d54ac6a79d00193667ce52
14 Nbe7181b9d2564c09b60842e5c55bda31
15 Nd30d4b8d17b54c6eb92dca608f02d14b
16 Nefda90fbbecf4704877a2cad93945979
17 anzsrc-for:06
18 anzsrc-for:0607
19 schema:author N091258980f134f418d70303a53e539e1
20 schema:citation sg:pub.10.1007/s00436-008-0879-6
21 sg:pub.10.1007/s004360100454
22 schema:datePublished 2009-11-18
23 schema:datePublishedReg 2009-11-18
24 schema:description In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa. The evaluated parts are bark of trunk for Zanthoxylum zanthoxyloides and leaves for Sarcocephalus latifolius instead of roots, and leaves for Combretum molle and Anogeissus leiocarpus instead of stem bark. The antiplasmodial activity of extracts of these plants was evaluated in vitro using the multi-resistant strain (W2) of Plasmodium falciparum. Antiproliferative activity was also assessed, using K562S human monocyte cell lines, along with calculation of the selectivity index (SI) of each extract. The highest in vitro antiplasmodial activity was found in the alkaloid extract of trunk bark from Z. zanthoxyloides and from the MeOH extract of A. leiocarpus leaves (IC50 = 1.2 µg/mL and 4.9 µg/mL, respectively) with good selectivity index. Moderate activity was found in the MeOH extract (IC50 = 5.7 µg/mL) and MeOH/H2O extract (IC50 = 7.9 µg/mL) of C. molle leaves. Moderate activity was also found in the MeOH/H20 extract (IC50 = 5.2 µg/mL) and the decoction (IC50 = 8.2 µg/mL) from leaves of A. leiocarpus. No good activity was found with extracts from roots of S. latifolius. All extracts tested displayed low levels of cytotoxicity against K562S cells. The data generated clearly show that the trunk bark for Z. zanthoxyloides and the leaves for A. leiocarpus and C. molle could be used for the treatment of malaria instead of roots and stem bark.
25 schema:genre article
26 schema:isAccessibleForFree false
27 schema:isPartOf N14cfdbcedefd481ab2abf32371c5899e
28 Na2237fb9a0e74f20b9b542a9f6f8535b
29 sg:journal.1096949
30 schema:keywords A. leiocarpus
31 Africa
32 Anogeissus
33 Burkina Faso
34 C. molle
35 Combretum molle
36 Faso
37 H2O extracts
38 K562 cells
39 MeOH extract
40 Plasmodium falciparum
41 S. latifolius
42 Saharan Africa
43 Sarcocephalus latifolius
44 Z. zanthoxyloides
45 Zanthoxylum zanthoxyloides
46 activity
47 alkaloid extract
48 alternative parts
49 antiplasmodial activity
50 antiproliferative activity
51 bark
52 calculations
53 cell lines
54 cells
55 contribution
56 crude extract
57 cytotoxicity
58 data
59 decoction
60 destruction
61 ecology
62 evaluated parts
63 extract
64 falciparum
65 flora
66 good activity
67 good selectivity index
68 healers
69 human monocyte cell line
70 index
71 latifolius
72 leaves
73 levels
74 lines
75 low levels
76 malaria
77 medicinal plants
78 moderate activity
79 molle
80 monocyte cell line
81 multi-resistant strains
82 order
83 part
84 plants
85 preservation
86 roots
87 selectivity index
88 stem bark
89 strains
90 toxicity
91 traditional healers
92 treatment
93 treatment of malaria
94 trunk
95 trunk bark
96 vitro
97 schema:name Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation
98 schema:pagination 335
99 schema:productId N009e96d9a3d546c4ae8962a49676c21a
100 N0c8d8f700a1744cc8f800ef0f466ce9b
101 N492b13142fb54221975f5ee04c2b5dad
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006107438
103 https://doi.org/10.1007/s00436-009-1663-y
104 schema:sdDatePublished 2022-12-01T06:27
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N50354c33625c4f838f4c49cbd610206e
107 schema:url https://doi.org/10.1007/s00436-009-1663-y
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N009e96d9a3d546c4ae8962a49676c21a schema:name doi
112 schema:value 10.1007/s00436-009-1663-y
113 rdf:type schema:PropertyValue
114 N06527ec11ffb484dbdb822f508cb2ead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Plant Stems
116 rdf:type schema:DefinedTerm
117 N091258980f134f418d70303a53e539e1 rdf:first sg:person.01370213017.48
118 rdf:rest Ne6a3d449adeb42ee83387105291405b0
119 N0c8d8f700a1744cc8f800ef0f466ce9b schema:name pubmed_id
120 schema:value 19921259
121 rdf:type schema:PropertyValue
122 N1465f4a1806d4fc2a06deb2e9776ca47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Plants, Medicinal
124 rdf:type schema:DefinedTerm
125 N14cfdbcedefd481ab2abf32371c5899e schema:issueNumber 2
126 rdf:type schema:PublicationIssue
127 N1a290bcea61c45d391b4a8ae27dfe017 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Plant Extracts
129 rdf:type schema:DefinedTerm
130 N2d9484599f3244f1b5ad1e0b2128d7f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 N2e7ceadc330244c7b8034b3e2b4666ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Proliferation
135 rdf:type schema:DefinedTerm
136 N34044261366e4a239dd20b43ff7b6c18 rdf:first sg:person.01256502435.75
137 rdf:rest Nf7a348f56ec24a1fa81266e39d781274
138 N39f5112492e14497888351775b4a5db8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Antimalarials
140 rdf:type schema:DefinedTerm
141 N3dc0964224f14b81b956094b8328bac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Monocytes
143 rdf:type schema:DefinedTerm
144 N3e23824a97e24e3ea69fdefbddd0119d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Plasmodium falciparum
146 rdf:type schema:DefinedTerm
147 N492b13142fb54221975f5ee04c2b5dad schema:name dimensions_id
148 schema:value pub.1006107438
149 rdf:type schema:PropertyValue
150 N50354c33625c4f838f4c49cbd610206e schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N5c68f6c372aa47e3b3ff242540eef29a rdf:first sg:person.01114415134.44
153 rdf:rest Nc486f4b3501d4b5e94c5237452b042c6
154 N715e343cc5434a77b02e0efde68bd7f8 rdf:first sg:person.0635025104.24
155 rdf:rest rdf:nil
156 N75c1c45f9e0b4a15b498146fbc38b75e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Burkina Faso
158 rdf:type schema:DefinedTerm
159 N81cbd175c71143839cf5e6e83b2002ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Complex Mixtures
161 rdf:type schema:DefinedTerm
162 N8a5be624725f4d61801e8ea7aee01317 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Inhibitory Concentration 50
164 rdf:type schema:DefinedTerm
165 N8e4f30a8bd824c45a76e8c2484b96348 rdf:first sg:person.016466717302.31
166 rdf:rest N34044261366e4a239dd20b43ff7b6c18
167 N902d8ba95e894730b4ae3c21d5d306fe rdf:first sg:person.01252266015.48
168 rdf:rest Nbbee54bfd7c74778a0f591be60e0239a
169 Na2237fb9a0e74f20b9b542a9f6f8535b schema:volumeNumber 106
170 rdf:type schema:PublicationVolume
171 Na41ce1a7e5db480fa65a6ee878452091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Plant Leaves
173 rdf:type schema:DefinedTerm
174 Na6f9d035b6d54ac6a79d00193667ce52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Antineoplastic Agents
176 rdf:type schema:DefinedTerm
177 Nbbee54bfd7c74778a0f591be60e0239a rdf:first sg:person.01320401215.05
178 rdf:rest Ncb16c087945b4e2bac645a6bab414dc2
179 Nbe7181b9d2564c09b60842e5c55bda31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Plant Bark
181 rdf:type schema:DefinedTerm
182 Nc486f4b3501d4b5e94c5237452b042c6 rdf:first sg:person.01100374046.44
183 rdf:rest N8e4f30a8bd824c45a76e8c2484b96348
184 Ncb16c087945b4e2bac645a6bab414dc2 rdf:first sg:person.01305550557.24
185 rdf:rest N5c68f6c372aa47e3b3ff242540eef29a
186 Nd30d4b8d17b54c6eb92dca608f02d14b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Cell Line, Tumor
188 rdf:type schema:DefinedTerm
189 Ne6a3d449adeb42ee83387105291405b0 rdf:first sg:person.01076570544.29
190 rdf:rest N902d8ba95e894730b4ae3c21d5d306fe
191 Nefda90fbbecf4704877a2cad93945979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Humans
193 rdf:type schema:DefinedTerm
194 Nf7a348f56ec24a1fa81266e39d781274 rdf:first sg:person.01023230004.19
195 rdf:rest N715e343cc5434a77b02e0efde68bd7f8
196 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
197 schema:name Biological Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:0607 schema:inDefinedTermSet anzsrc-for:
200 schema:name Plant Biology
201 rdf:type schema:DefinedTerm
202 sg:journal.1096949 schema:issn 0932-0113
203 1432-1955
204 schema:name Parasitology Research
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.01023230004.19 schema:affiliation grid-institutes:None
208 schema:familyName Sirima
209 schema:givenName Sodiomon B.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023230004.19
211 rdf:type schema:Person
212 sg:person.01076570544.29 schema:affiliation grid-institutes:grid.507461.1
213 schema:familyName Sanon
214 schema:givenName Souleymane
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076570544.29
216 rdf:type schema:Person
217 sg:person.01100374046.44 schema:affiliation grid-institutes:grid.5399.6
218 schema:familyName Azas
219 schema:givenName Nadine
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100374046.44
221 rdf:type schema:Person
222 sg:person.01114415134.44 schema:affiliation grid-institutes:grid.5399.6
223 schema:familyName Ollivier
224 schema:givenName Evelyne
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114415134.44
226 rdf:type schema:Person
227 sg:person.01252266015.48 schema:affiliation grid-institutes:grid.507461.1
228 schema:familyName Ouattara
229 schema:givenName Lamoussa P.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252266015.48
231 rdf:type schema:Person
232 sg:person.01256502435.75 schema:affiliation grid-institutes:grid.218069.4
233 schema:familyName Guissou
234 schema:givenName Innocent P.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256502435.75
236 rdf:type schema:Person
237 sg:person.01305550557.24 schema:affiliation grid-institutes:grid.5399.6
238 schema:familyName Hutter
239 schema:givenName Sébastien
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305550557.24
241 rdf:type schema:Person
242 sg:person.01320401215.05 schema:affiliation grid-institutes:grid.507461.1
243 schema:familyName Traoré
244 schema:givenName Abdoulaye
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320401215.05
246 rdf:type schema:Person
247 sg:person.01370213017.48 schema:affiliation grid-institutes:grid.507461.1
248 schema:familyName Gansané
249 schema:givenName Adama
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370213017.48
251 rdf:type schema:Person
252 sg:person.016466717302.31 schema:affiliation grid-institutes:grid.218069.4
253 schema:familyName Traore
254 schema:givenName Alfred S.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016466717302.31
256 rdf:type schema:Person
257 sg:person.0635025104.24 schema:affiliation grid-institutes:grid.507461.1
258 schema:familyName Nebié
259 schema:givenName Issa
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635025104.24
261 rdf:type schema:Person
262 sg:pub.10.1007/s00436-008-0879-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008864496
263 https://doi.org/10.1007/s00436-008-0879-6
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s004360100454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012308546
266 https://doi.org/10.1007/s004360100454
267 rdf:type schema:CreativeWork
268 grid-institutes:None schema:alternateName Groupe de Recherche et d’Action en Santé (GRAS), 06 POB 10 248, Ouagadougou 06, Burkina Faso
269 schema:name Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso
270 Groupe de Recherche et d’Action en Santé (GRAS), 06 POB 10 248, Ouagadougou 06, Burkina Faso
271 rdf:type schema:Organization
272 grid-institutes:grid.218069.4 schema:alternateName Department of Pharmacology and Toxicology, UFR/SDS, University of Ouagadougou, Ouagadougou, Burkina Faso
273 Laboratory of Pharmacology and Clinical Biochemistry of CRSBAN, UFR/SVT, University of Ouagadougou, Ouagadougou, Burkina Faso
274 schema:name Department of Pharmacology and Toxicology, UFR/SDS, University of Ouagadougou, Ouagadougou, Burkina Faso
275 Laboratory of Pharmacology and Clinical Biochemistry of CRSBAN, UFR/SVT, University of Ouagadougou, Ouagadougou, Burkina Faso
276 rdf:type schema:Organization
277 grid-institutes:grid.507461.1 schema:alternateName Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso
278 schema:name Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso
279 rdf:type schema:Organization
280 grid-institutes:grid.5399.6 schema:alternateName Faculté de Pharmacie, UMR MD3, Université de la Méditerranée, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France
281 schema:name Faculté de Pharmacie, UMR MD3, Université de la Méditerranée, 27 Bd Jean Moulin, 13 385, Marseille Cedex 5, France
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...