Leishmaniasis treatment—a challenge that remains: a review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-04-04

AUTHORS

Dilvani O. Santos, Carlos E. R. Coutinho, Maria F. Madeira, Carolina G. Bottino, Rodrigo T. Vieira, Samara B. Nascimento, Alice Bernardino, Saulo C. Bourguignon, Suzana Corte-Real, Rosa T. Pinho, Carlos Rangel Rodrigues, Helena C. Castro

ABSTRACT

Leishmaniasis is a disease caused by flagellate protozoan Leishmania spp. and represents an emergent illness with high morbidity and mortality in the tropics and subtropics. Since the discovery of the first drugs for Leishmaniasis treatment (i.e., pentavalent antimonials), until the current days, the search for substances with antileishmanial activity, without toxic effects, and able to overcome the emergence of drug resistant strains still remains as the current goal. This article reports the development of new chemotherapies through the rational design of new drugs, the use of products derived from microorganisms and plants, and treatments related to immunity as new alternatives for the chemotherapy of leishmaniasis. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00436-008-0943-2

DOI

http://dx.doi.org/10.1007/s00436-008-0943-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042372484

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18389282


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