Regulation of tumor necrosis factor alpha and its specific receptors during Toxoplasma gondii infection in human monocytic cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10-12

AUTHORS

A. Belloni, I. Villena, J. Gomez, H. Pelloux, A. Bonhomme, M. Guenounou, J. Pinon, D. Aubert

ABSTRACT

. The coccidian Toxoplasma gondii is an obligate intracellular parasite which can infect all cell types. Among the cytokines elicited by the immune response to Toxoplasma, tumor necrosis factor alpha (TNF-α) acts synergistically with gamma interferon (IFN-γ) and plays a major role in host cell resistance. We have previously reported that TNF-α production induced by IFN-γ/LPS decreases after T. gondii infection of human myelomonocytic THP-1 cells. Here, we investigated the regulation of TNF-α and its specific receptors during T. gondii infection of THP-1 cells. We found that TNF-α production was regulated at a post-transcriptional level and that TNF receptor expression was regulated at a pretranscriptional level. The TNF receptor I shedding and the fall in TNF-α levels observed after T. gondii infection would thus be induced by a parasite component with serine protease activity. These findings indicate that T. gondii participates not only in controlling the cytotoxic effects of TNF-α during the infection process, but also in signal transduction mediated mainly by TNF receptor I. More... »

PAGES

207-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00436-002-0735-z

DOI

http://dx.doi.org/10.1007/s00436-002-0735-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075222230

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12541063


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