Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12-12

AUTHORS

Shohei Koyama, Naoto Koike, Shinya Adachi

ABSTRACT

.Purpose: TNF-related apoptosis-inducing ligand (TRAIL) and its receptors have recently been known to be responsible for apoptotic signaling molecules in tumor cell lines and tissues. These molecules have been reported to be expressed on merely a transcription level, but not on a protein level. Moreover, little is known about TRAIL-mediated apoptosis in human carcinoma in vivo. Methods: We investigated the presence and functional status of TRAIL and its receptors, DR4, DR5, and DcR2 on tumor as well as tumor-infiltrating lymphocytes (TIL) in primary (n=37), and metastatic gastric carcinoma from malignant ascites (n=37) by a flow cytometry. In addition, phenotypic proportions of major T-cell subsets or B-cells in TIL were also determined. Results: Membrane-bound TRAIL/its receptors are constitutively expressed at high levels in primary and metastatic carcinomas in nearly all the patients. Apoptotic tumor cells detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick and labeling (TUNEL) were barely identified in primary and metastatic carcinomas. TIL in primary carcinoma showed a very low level of expression of TRAIL/its receptors and TUNEL-positive cells. In metastatic carcinoma, however, there was significant overexpression of TRAIL/its receptors in TIL associated with a higher frequency of apoptotic cell death detected by TUNEL. The TIL within metastatic carcinoma, but not within primary carcinoma, revealed the increased proportions of CD3+ T cells bearing CD8+CD11b–, CD8+CD11b+, and CD4+CD62L–, CD4+CD62L+ surface phenotype in patients. Conclusions: These results suggest that TRAIL+ and DcR2+ metastatic carcinoma from malignant ascites could not only have resistance to DR4/DR5-induced apoptosis, but also might take the TRAIL-mediated counterattack against activated CD3+ T cells. These functions of the cancer cells would neutralize host immune responses at the effector phase, and accelerate further invasion and/or metastasis of carcinoma through the escape from immune attack. More... »

PAGES

73-79

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004320100292

DOI

http://dx.doi.org/10.1007/s004320100292

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019545972

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11862476


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ascites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes, Tumor-Infiltrating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Tumor Necrosis Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor Decoy Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki 305-8575, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki 305-8575, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koyama", 
        "givenName": "Shohei", 
        "id": "sg:person.0657656236.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657656236.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koike", 
        "givenName": "Naoto", 
        "id": "sg:person.01330372147.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330372147.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adachi", 
        "givenName": "Shinya", 
        "id": "sg:person.0743060207.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743060207.94"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001-12-12", 
    "datePublishedReg": "2001-12-12", 
    "description": "Abstract.Purpose: TNF-related apoptosis-inducing ligand (TRAIL) and its receptors have recently been known to be responsible for apoptotic signaling molecules in tumor cell lines and tissues. These molecules have been reported to be expressed on merely a transcription level, but not on a protein level. Moreover, little is known about TRAIL-mediated apoptosis in human carcinoma in vivo. Methods: We investigated the presence and functional status of TRAIL and its receptors, DR4, DR5, and DcR2 on tumor as well as tumor-infiltrating lymphocytes (TIL) in primary (n=37), and metastatic gastric carcinoma from malignant ascites (n=37) by a flow cytometry. In addition, phenotypic proportions of major T-cell subsets or B-cells in TIL were also determined. Results: Membrane-bound TRAIL/its receptors are constitutively expressed at high levels in primary and metastatic carcinomas in nearly all the patients. Apoptotic tumor cells detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick and labeling (TUNEL) were barely identified in primary and metastatic carcinomas. TIL in primary carcinoma showed a very low level of expression of TRAIL/its receptors and TUNEL-positive cells. In metastatic carcinoma, however, there was significant overexpression of TRAIL/its receptors in TIL associated with a higher frequency of apoptotic cell death detected by TUNEL. The TIL within metastatic carcinoma, but not within primary carcinoma, revealed the increased proportions of CD3+ T cells bearing CD8+CD11b\u2013, CD8+CD11b+, and CD4+CD62L\u2013, CD4+CD62L+ surface phenotype in patients. Conclusions: These results suggest that TRAIL+ and DcR2+ metastatic carcinoma from malignant ascites could not only have resistance to DR4/DR5-induced apoptosis, but also might take the TRAIL-mediated counterattack against activated CD3+ T cells. These functions of the cancer cells would neutralize host immune responses at the effector phase, and accelerate further invasion and/or metastasis of carcinoma through the escape from immune attack.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004320100292", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "128"
      }
    ], 
    "keywords": [
      "apoptosis-inducing ligand", 
      "TRAIL/", 
      "tumor-infiltrating lymphocytes", 
      "apoptotic cell death", 
      "metastatic carcinoma", 
      "transcription levels", 
      "further invasion", 
      "cell death", 
      "tumor cell lines", 
      "malignant ascites", 
      "primary carcinoma", 
      "T cells", 
      "gastric carcinoma", 
      "protein levels", 
      "cell lines", 
      "phenotypic proportions", 
      "cancer cells", 
      "major T cell subsets", 
      "terminal deoxynucleotidyl transferase", 
      "human carcinomas", 
      "proportion of CD3", 
      "T cell subsets", 
      "dUTP nick", 
      "metastatic gastric carcinoma", 
      "host immune response", 
      "expression of TNF", 
      "immune evasion", 
      "apoptosis", 
      "apoptotic tumor cells", 
      "cells", 
      "TUNEL-positive cells", 
      "significant overexpression", 
      "metastasis of carcinomas", 
      "flow cytometry", 
      "receptors", 
      "deoxynucleotidyl transferase", 
      "expression", 
      "functional status", 
      "effector phase", 
      "tumor cells", 
      "immune attack", 
      "immune response", 
      "surface phenotype", 
      "carcinoma", 
      "B cells", 
      "overexpression", 
      "phenotype", 
      "ascites", 
      "patients", 
      "CD3", 
      "TNF", 
      "lymphocytes", 
      "molecules", 
      "transferase", 
      "DcR2", 
      "possible mechanism", 
      "tumors", 
      "nick", 
      "high levels", 
      "DR5", 
      "low levels", 
      "ligands", 
      "invasion", 
      "membrane", 
      "vivo", 
      "TUNEL", 
      "cytometry", 
      "trails", 
      "levels", 
      "evasion", 
      "labeling", 
      "tissue", 
      "metastasis", 
      "high frequency", 
      "mechanism", 
      "DR4", 
      "proportion", 
      "lines", 
      "death", 
      "escape", 
      "function", 
      "resistance", 
      "response", 
      "status", 
      "subset", 
      "counterattack", 
      "presence", 
      "addition", 
      "frequency", 
      "results", 
      "attacks", 
      "phase"
    ], 
    "name": "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor", 
    "pagination": "73-79", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019545972"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004320100292"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11862476"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004320100292", 
      "https://app.dimensions.ai/details/publication/pub.1019545972"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_315.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004320100292"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004320100292'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004320100292'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004320100292'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004320100292'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      20 PREDICATES      147 URIs      139 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004320100292 schema:about N0284a754001942eaa4cd1139629bcf60
2 N05395f6d307546a38ce055de0f91c8ec
3 N057ae23fe4f044baa485ba93f946773e
4 N0bcc5b7fa5d0465585649616162ccb49
5 N165875282b7e4283963469926d2ed499
6 N1ae1404d2f844840a30c3b4d2a338240
7 N2742517f3c394e6b8d443b13fe7fa226
8 N29360767d4e24e2c8ca912e86d973aac
9 N32d4c1177e3e451ca22dbe806529552d
10 N34e95afa2d6d44d595e19c2164e881e8
11 N45f9539cb12b4bdd8e9c040efa797c9f
12 N48b45f511f854b219e81bdfadb21372f
13 N4e014f8422954a9cb393bfb43bc89021
14 N52bebdb4f1dd4a5992fcc9e087036c7d
15 N54a3e8745d8b44608cae6edbf295ee41
16 N59c22b98df2e44359cf9469a22d15b7f
17 N6fe824eee8c14e359d125e404503956a
18 N77c2aa4b14074b7c9e77ecbc53d7c03b
19 N7848a52c113b43ca89636ac7c064b9a7
20 N81774ef134734325ad61c38c2994bda6
21 N8b8a5d189cd942e1baedbb7959fd6003
22 N954cb983626a458da6d2b44779c7aa44
23 N9f69e0a4d95c4b51aec3469dd704b603
24 Na36463e028104bc58b90e16cc4cd6e82
25 Na53710a63c33405182f61a2c90084027
26 Nade166e3041242e69bb916cc094e40e9
27 Nbdada7af3a8047819f38878ab3f7179f
28 Nc144742abbe943378f06cc1a2e9d4a1a
29 Ncee413c244634bd0b0af3bd7ccee6a1d
30 Ne4840d2fc8c540f78e121390118267b0
31 anzsrc-for:11
32 anzsrc-for:1107
33 schema:author N236d3f3455554de49c47903007c8a574
34 schema:datePublished 2001-12-12
35 schema:datePublishedReg 2001-12-12
36 schema:description Abstract.Purpose: TNF-related apoptosis-inducing ligand (TRAIL) and its receptors have recently been known to be responsible for apoptotic signaling molecules in tumor cell lines and tissues. These molecules have been reported to be expressed on merely a transcription level, but not on a protein level. Moreover, little is known about TRAIL-mediated apoptosis in human carcinoma in vivo. Methods: We investigated the presence and functional status of TRAIL and its receptors, DR4, DR5, and DcR2 on tumor as well as tumor-infiltrating lymphocytes (TIL) in primary (n=37), and metastatic gastric carcinoma from malignant ascites (n=37) by a flow cytometry. In addition, phenotypic proportions of major T-cell subsets or B-cells in TIL were also determined. Results: Membrane-bound TRAIL/its receptors are constitutively expressed at high levels in primary and metastatic carcinomas in nearly all the patients. Apoptotic tumor cells detected by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick and labeling (TUNEL) were barely identified in primary and metastatic carcinomas. TIL in primary carcinoma showed a very low level of expression of TRAIL/its receptors and TUNEL-positive cells. In metastatic carcinoma, however, there was significant overexpression of TRAIL/its receptors in TIL associated with a higher frequency of apoptotic cell death detected by TUNEL. The TIL within metastatic carcinoma, but not within primary carcinoma, revealed the increased proportions of CD3+ T cells bearing CD8+CD11b–, CD8+CD11b+, and CD4+CD62L–, CD4+CD62L+ surface phenotype in patients. Conclusions: These results suggest that TRAIL+ and DcR2+ metastatic carcinoma from malignant ascites could not only have resistance to DR4/DR5-induced apoptosis, but also might take the TRAIL-mediated counterattack against activated CD3+ T cells. These functions of the cancer cells would neutralize host immune responses at the effector phase, and accelerate further invasion and/or metastasis of carcinoma through the escape from immune attack.
37 schema:genre article
38 schema:isAccessibleForFree false
39 schema:isPartOf N56926b52df4542259e4482aa63a09971
40 Ned9a684aec1a4483a71b3b798ead21c0
41 sg:journal.1313647
42 schema:keywords B cells
43 CD3
44 DR4
45 DR5
46 DcR2
47 T cell subsets
48 T cells
49 TNF
50 TRAIL/
51 TUNEL
52 TUNEL-positive cells
53 addition
54 apoptosis
55 apoptosis-inducing ligand
56 apoptotic cell death
57 apoptotic tumor cells
58 ascites
59 attacks
60 cancer cells
61 carcinoma
62 cell death
63 cell lines
64 cells
65 counterattack
66 cytometry
67 dUTP nick
68 death
69 deoxynucleotidyl transferase
70 effector phase
71 escape
72 evasion
73 expression
74 expression of TNF
75 flow cytometry
76 frequency
77 function
78 functional status
79 further invasion
80 gastric carcinoma
81 high frequency
82 high levels
83 host immune response
84 human carcinomas
85 immune attack
86 immune evasion
87 immune response
88 invasion
89 labeling
90 levels
91 ligands
92 lines
93 low levels
94 lymphocytes
95 major T cell subsets
96 malignant ascites
97 mechanism
98 membrane
99 metastasis
100 metastasis of carcinomas
101 metastatic carcinoma
102 metastatic gastric carcinoma
103 molecules
104 nick
105 overexpression
106 patients
107 phase
108 phenotype
109 phenotypic proportions
110 possible mechanism
111 presence
112 primary carcinoma
113 proportion
114 proportion of CD3
115 protein levels
116 receptors
117 resistance
118 response
119 results
120 significant overexpression
121 status
122 subset
123 surface phenotype
124 terminal deoxynucleotidyl transferase
125 tissue
126 trails
127 transcription levels
128 transferase
129 tumor cell lines
130 tumor cells
131 tumor-infiltrating lymphocytes
132 tumors
133 vivo
134 schema:name Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor
135 schema:pagination 73-79
136 schema:productId N66b3d1cb85414c77961e614164c507be
137 Nbce9dd0e38b5484bb171efc33f4323ef
138 Nf6cb5b435374418bb9e6ef6f374f556e
139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019545972
140 https://doi.org/10.1007/s004320100292
141 schema:sdDatePublished 2022-10-01T06:30
142 schema:sdLicense https://scigraph.springernature.com/explorer/license/
143 schema:sdPublisher N730f2e632821407391e2fda9a17dd91d
144 schema:url https://doi.org/10.1007/s004320100292
145 sgo:license sg:explorer/license/
146 sgo:sdDataset articles
147 rdf:type schema:ScholarlyArticle
148 N0284a754001942eaa4cd1139629bcf60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Antigens, CD
150 rdf:type schema:DefinedTerm
151 N05395f6d307546a38ce055de0f91c8ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Apoptosis
153 rdf:type schema:DefinedTerm
154 N057ae23fe4f044baa485ba93f946773e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N0bcc5b7fa5d0465585649616162ccb49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Aged
159 rdf:type schema:DefinedTerm
160 N12420caefd174800a310fb9559907ab7 rdf:first sg:person.0743060207.94
161 rdf:rest rdf:nil
162 N165875282b7e4283963469926d2ed499 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Tumor Necrosis Factor-alpha
164 rdf:type schema:DefinedTerm
165 N1ae1404d2f844840a30c3b4d2a338240 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Stomach Neoplasms
167 rdf:type schema:DefinedTerm
168 N236d3f3455554de49c47903007c8a574 rdf:first sg:person.0657656236.00
169 rdf:rest Ne114c08051cb44599c1c645124600d69
170 N2742517f3c394e6b8d443b13fe7fa226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Lymphocytes, Tumor-Infiltrating
172 rdf:type schema:DefinedTerm
173 N29360767d4e24e2c8ca912e86d973aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Signal Transduction
175 rdf:type schema:DefinedTerm
176 N32d4c1177e3e451ca22dbe806529552d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name TNF-Related Apoptosis-Inducing Ligand
178 rdf:type schema:DefinedTerm
179 N34e95afa2d6d44d595e19c2164e881e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Membrane Proteins
181 rdf:type schema:DefinedTerm
182 N45f9539cb12b4bdd8e9c040efa797c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Phenotype
184 rdf:type schema:DefinedTerm
185 N48b45f511f854b219e81bdfadb21372f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Neoplasm Metastasis
187 rdf:type schema:DefinedTerm
188 N4e014f8422954a9cb393bfb43bc89021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Tumor Necrosis Factor Decoy Receptors
190 rdf:type schema:DefinedTerm
191 N52bebdb4f1dd4a5992fcc9e087036c7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Binding Sites
193 rdf:type schema:DefinedTerm
194 N54a3e8745d8b44608cae6edbf295ee41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Gene Expression Regulation, Neoplastic
196 rdf:type schema:DefinedTerm
197 N56926b52df4542259e4482aa63a09971 schema:volumeNumber 128
198 rdf:type schema:PublicationVolume
199 N59c22b98df2e44359cf9469a22d15b7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Carcinoma
201 rdf:type schema:DefinedTerm
202 N66b3d1cb85414c77961e614164c507be schema:name dimensions_id
203 schema:value pub.1019545972
204 rdf:type schema:PropertyValue
205 N6fe824eee8c14e359d125e404503956a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Apoptosis Regulatory Proteins
207 rdf:type schema:DefinedTerm
208 N730f2e632821407391e2fda9a17dd91d schema:name Springer Nature - SN SciGraph project
209 rdf:type schema:Organization
210 N77c2aa4b14074b7c9e77ecbc53d7c03b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Receptors, TNF-Related Apoptosis-Inducing Ligand
212 rdf:type schema:DefinedTerm
213 N7848a52c113b43ca89636ac7c064b9a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Middle Aged
215 rdf:type schema:DefinedTerm
216 N81774ef134734325ad61c38c2994bda6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Flow Cytometry
218 rdf:type schema:DefinedTerm
219 N8b8a5d189cd942e1baedbb7959fd6003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Adult
221 rdf:type schema:DefinedTerm
222 N954cb983626a458da6d2b44779c7aa44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Ascites
224 rdf:type schema:DefinedTerm
225 N9f69e0a4d95c4b51aec3469dd704b603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Antineoplastic Agents
227 rdf:type schema:DefinedTerm
228 Na36463e028104bc58b90e16cc4cd6e82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Receptors, Tumor Necrosis Factor
230 rdf:type schema:DefinedTerm
231 Na53710a63c33405182f61a2c90084027 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Down-Regulation
233 rdf:type schema:DefinedTerm
234 Nade166e3041242e69bb916cc094e40e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Neoplasm Invasiveness
236 rdf:type schema:DefinedTerm
237 Nbce9dd0e38b5484bb171efc33f4323ef schema:name pubmed_id
238 schema:value 11862476
239 rdf:type schema:PropertyValue
240 Nbdada7af3a8047819f38878ab3f7179f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
241 schema:name Male
242 rdf:type schema:DefinedTerm
243 Nc144742abbe943378f06cc1a2e9d4a1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name In Situ Nick-End Labeling
245 rdf:type schema:DefinedTerm
246 Ncee413c244634bd0b0af3bd7ccee6a1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Female
248 rdf:type schema:DefinedTerm
249 Ne114c08051cb44599c1c645124600d69 rdf:first sg:person.01330372147.74
250 rdf:rest N12420caefd174800a310fb9559907ab7
251 Ne4840d2fc8c540f78e121390118267b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
252 schema:name Membrane Glycoproteins
253 rdf:type schema:DefinedTerm
254 Ned9a684aec1a4483a71b3b798ead21c0 schema:issueNumber 2
255 rdf:type schema:PublicationIssue
256 Nf6cb5b435374418bb9e6ef6f374f556e schema:name doi
257 schema:value 10.1007/s004320100292
258 rdf:type schema:PropertyValue
259 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
260 schema:name Medical and Health Sciences
261 rdf:type schema:DefinedTerm
262 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
263 schema:name Immunology
264 rdf:type schema:DefinedTerm
265 sg:journal.1313647 schema:issn 0171-5216
266 1432-1335
267 schema:name Journal of Cancer Research and Clinical Oncology
268 schema:publisher Springer Nature
269 rdf:type schema:Periodical
270 sg:person.01330372147.74 schema:affiliation grid-institutes:grid.20515.33
271 schema:familyName Koike
272 schema:givenName Naoto
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330372147.74
274 rdf:type schema:Person
275 sg:person.0657656236.00 schema:affiliation grid-institutes:grid.20515.33
276 schema:familyName Koyama
277 schema:givenName Shohei
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657656236.00
279 rdf:type schema:Person
280 sg:person.0743060207.94 schema:affiliation grid-institutes:grid.20515.33
281 schema:familyName Adachi
282 schema:givenName Shinya
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743060207.94
284 rdf:type schema:Person
285 grid-institutes:grid.20515.33 schema:alternateName Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki 305-8575, Japan
286 Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan
287 schema:name Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki 305-8575, Japan
288 Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-City, Ibaraki, Japan
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...