The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer. View Full Text


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Article Info

DATE

2019-04-08

AUTHORS

Jiajing Cai, Qi Qi, Xuemeng Qian, Jia Han, Xinfang Zhu, Qi Zhang, Rong Xia

ABSTRACT

PURPOSE: During the past decades, PD-1/PD-L1 axis blockade has become a remarkable promising therapy which has exerted durable anti-tumor effect and long-term remissions on part of cancers. However, there are still some patients which do not show good response to the PD-1/PD-L1 targeted monotherapy. Till now, the widely accepted anti-tumor mechanism of PD-1/PD-L1 blockade is rejuvenating T cells, there is lack of studies which focus on other components of the tumor environment in the treatment of cancer with PD-1/PD-L1 blockade, especially the complicated relationship between macrophages and PD-1/PD-L1 pathway during the progression and treatment of cancer. METHODS: The relevant literatures from PubMed have been reviewed in this article. RESULTS: Even though the widely accepted anti-tumor mechanism of PD-1/PD-L1 blockade therapy is rejuvenating T cells, latest studies have demonstrated the complicated relationship between macrophages and PD-1/PD-L1 pathway during the progression and treatment of cancer and their engagement has serious implications for the therapeutic effect of PD-1/PD-L1 blockade agents. We focus on the dual regulation mechanisms between PD-1/PD-L1 axis and macrophages, and further clarify the mechanisms of resistance to PD-1/PD-L1 inhibitors related with macrophages. CONCLUSION: The combination of PD-1/PD-L1 blockade and macrophage-targeted therapy will exert synergetic anti-tumor effect and shape the future of cancer immunology and immunotherapy. More... »

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00432-019-02879-2

    DOI

    http://dx.doi.org/10.1007/s00432-019-02879-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30963235


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