Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Nathaniel Melling, Kai Bachmann, Bianca Hofmann, Alexander Tarek El Gammal, Matthias Reeh, Oliver Mann, Christoph Moebius, Marco Blessmann, Jakob Robert Izbicki, Katharina Grupp

ABSTRACT

INTRODUCTION: Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS: This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we took advantage of our tissue microarray (TMA) containing more than 600 NSCLC specimens. RESULTS: While nuclear RBM3 staining was always high in normal lung tissue, high RBM3 staining was only seen in 77.1% of 467 interpretable non-metastatic NSCLCs. Reduced RBM3 staining was significantly associated with advanced pathological tumor stage (pT) in NSCLCs (p = 0.0031). Subset analysis revealed that the association between reduced RBM3 staining and advanced pT stage was largely driven by the histological subgroup of lung adenocarcinoma (LUACs) (p = 0.0036). In addition, reduced RBM3 expression predicted shortened survival in LUAC patients (p = 0.0225). CONCLUSIONS: In summary, our study shows that loss of RBM3 expression predicts worse clinical outcome in LUAC patients. More... »

PAGES

873-879

References to SciGraph publications

  • 2010-12. Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-12. Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer in BMC UROLOGY
  • 2010-01. The RNA-Binding Protein RBM3 Is Required for Cell Proliferation and Protects Against Serum Deprivation-Induced Cell Death in PEDIATRIC RESEARCH
  • 2008-07. Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe in ONCOGENE
  • 2014-12. High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death in BIOMARKER RESEARCH
  • 2009-12. Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer in MODERN PATHOLOGY
  • 2012-12. High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma in DIAGNOSTIC PATHOLOGY
  • 2011-12. High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression in DIAGNOSTIC PATHOLOGY
  • 2010-07-21. Recipient Block TMA Technique in TISSUE MICROARRAYS
  • 2011-12. Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study in JOURNAL OF TRANSLATIONAL MEDICINE
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00432-019-02850-1

    DOI

    http://dx.doi.org/10.1007/s00432-019-02850-1

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30758670


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    32 schema:description INTRODUCTION: Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS: This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we took advantage of our tissue microarray (TMA) containing more than 600 NSCLC specimens. RESULTS: While nuclear RBM3 staining was always high in normal lung tissue, high RBM3 staining was only seen in 77.1% of 467 interpretable non-metastatic NSCLCs. Reduced RBM3 staining was significantly associated with advanced pathological tumor stage (pT) in NSCLCs (p = 0.0031). Subset analysis revealed that the association between reduced RBM3 staining and advanced pT stage was largely driven by the histological subgroup of lung adenocarcinoma (LUACs) (p = 0.0036). In addition, reduced RBM3 expression predicted shortened survival in LUAC patients (p = 0.0225). CONCLUSIONS: In summary, our study shows that loss of RBM3 expression predicts worse clinical outcome in LUAC patients.
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