Expression of phosphorylated estrogen receptor beta is an independent negative prognostic factor for pancreatic ductal adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Ioannis Pozios, Thomas Knösel, Yue Zhao, Gerald Assmann, Iraklis Pozios, Mario H. Müller, Christiane J. Bruns, Martin E. Kreis, Hendrik Seeliger

ABSTRACT

PURPOSE: The role of estrogen receptor beta (ER-β) expression in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. Ligand-independent phosphorylation and activation of ER-β may play a relevant role in the IL-6/STAT3 signaling pathway and, as a result, in tumor progression. Here, we examined the effect of ER-β, phosphorylated ER-β (pER-β), STAT3, phosphorylated STAT3 (pSTAT3) and IL-6 expression on the overall and recurrence-free survival in a cohort of patients with resected PDAC. METHODS: We identified 175 patients who underwent pancreatic resection for PDAC. Tissue microarrays were constructed from the archival tumor specimens. These were stained with specific antibodies for the above molecules. The expression of the markers was then correlated with clinicopathological parameters and survival analysis was performed. RESULTS: High nuclear expression of ER-β was found in 61.7% and pER-β in 80.6% of the tumors. STAT3 was expressed in 54.3% of the tumor samples, pSTAT3 in 68% and IL-6 in 76.6%. The median overall survival for patients with low pER-β expression was 29 months, whereas for patients with high pER-β expression was 15.1 months (p = 0.016). Multivariate analysis revealed that pER-β expression was an independent factor correlating with shorter overall survival (hazard ratio 1.9; p = 0.013) and disease-free survival (hazard ratio 1.9; p = 0.029). CONCLUSIONS: Expression of pER-β constitutes an independent prognostic marker for PDAC and is correlated with poor prognosis. These data may help in identifying novel drug targets in PDAC and patients who could benefit from additional therapeutic regimens, including selective estrogen receptor modulators. More... »

PAGES

1887-1897

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-018-2717-2

DOI

http://dx.doi.org/10.1007/s00432-018-2717-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105830346

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30046904


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Receptor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT3 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Campus Benjamin Franklin", 
          "id": "https://www.grid.ac/institutes/grid.412753.6", 
          "name": [
            "Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pozios", 
        "givenName": "Ioannis", 
        "id": "sg:person.012655201007.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012655201007.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kn\u00f6sel", 
        "givenName": "Thomas", 
        "id": "sg:person.01343630646.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343630646.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Yue", 
        "id": "sg:person.01172333547.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172333547.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Assmann", 
        "givenName": "Gerald", 
        "id": "sg:person.01244452123.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244452123.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Johns Hopkins Hypertrophic Cardiomyopathy Center of Excellence, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pozios", 
        "givenName": "Iraklis", 
        "id": "sg:person.01216630025.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216630025.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Vivantes Neuk\u00f6lln Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Mario H.", 
        "id": "sg:person.01074146470.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074146470.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruns", 
        "givenName": "Christiane J.", 
        "id": "sg:person.01230436235.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230436235.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Campus Benjamin Franklin", 
          "id": "https://www.grid.ac/institutes/grid.412753.6", 
          "name": [
            "Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kreis", 
        "givenName": "Martin E.", 
        "id": "sg:person.01022345761.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022345761.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Campus Benjamin Franklin", 
          "id": "https://www.grid.ac/institutes/grid.412753.6", 
          "name": [
            "Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seeliger", 
        "givenName": "Hendrik", 
        "id": "sg:person.0752555661.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752555661.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1997.02724.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000401492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001874243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001874243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00026.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002306145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-0760(98)00147-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002647757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e32809b4ccd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004838550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e32809b4ccd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004838550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-11-0960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005661619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ssu.10018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006035850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-005-0047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596087", 
          "https://doi.org/10.1007/s00262-005-0047-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-005-0047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596087", 
          "https://doi.org/10.1007/s00262-005-0047-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(20000215)42:3<239::aid-pros10>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009210825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.69.031905.160319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009904616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.51.5.712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011275541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyi082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012904134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.8.617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014116947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2010-0016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015304549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2009.01359.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017776432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2009.01359.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017776432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2014.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018524022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31823cdd10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022070728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31823cdd10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022070728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-013-2168-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022781896", 
          "https://doi.org/10.1007/s11605-013-2168-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(01)00563-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023940237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-29-51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027237201", 
          "https://doi.org/10.1186/1756-9966-29-51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.28571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028224815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.steroids.2013.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029312380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000151479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030778162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031819756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/28.1.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033663178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-128x(02)00110-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034903544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-128x(02)00110-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034903544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800800341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034907830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2009.02510.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035489324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2009.02510.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035489324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199404000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035498726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199404000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035498726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpa.0000226893.09194.ec", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037135575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpa.0000226893.09194.ec", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037135575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-010-0082-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642946", 
          "https://doi.org/10.1007/s13277-010-0082-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.283.6294.751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038660357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01601-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041177101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2013.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041518269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044442993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80479-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044604868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2006/354295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045968556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5009/gnl.2012.6.4.417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047467783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/10.suppl_4.s131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049544692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2006.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049961872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050152736", 
          "https://doi.org/10.1007/s00018-009-0017-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050152736", 
          "https://doi.org/10.1007/s00018-009-0017-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-009-0017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050152736", 
          "https://doi.org/10.1007/s00018-009-0017-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)02296-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052424271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.05178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053283940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.05178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053283940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800840812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054296419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1621100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062496034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064244690", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.141.1.7270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i28.4466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2013.2770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2013.2770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074488962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074740358", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074849701", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075021196", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079672148", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082700124", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083321491", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10", 
    "datePublishedReg": "2018-10-01", 
    "description": "PURPOSE: The role of estrogen receptor beta (ER-\u03b2) expression in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. Ligand-independent phosphorylation and activation of ER-\u03b2 may play a relevant role in the IL-6/STAT3 signaling pathway and, as a result, in tumor progression. Here, we examined the effect of ER-\u03b2, phosphorylated ER-\u03b2 (pER-\u03b2), STAT3, phosphorylated STAT3 (pSTAT3) and IL-6 expression on the overall and recurrence-free survival in a cohort of patients with resected PDAC.\nMETHODS: We identified 175 patients who underwent pancreatic resection for PDAC. Tissue microarrays were constructed from the archival tumor specimens. These were stained with specific antibodies for the above molecules. The expression of the markers was then correlated with clinicopathological parameters and survival analysis was performed.\nRESULTS: High nuclear expression of ER-\u03b2 was found in 61.7% and pER-\u03b2 in 80.6% of the tumors. STAT3 was expressed in 54.3% of the tumor samples, pSTAT3 in 68% and IL-6 in 76.6%. The median overall survival for patients with low pER-\u03b2 expression was 29 months, whereas for patients with high pER-\u03b2 expression was 15.1 months (p\u2009=\u20090.016). Multivariate analysis revealed that pER-\u03b2 expression was an independent factor correlating with shorter overall survival (hazard ratio 1.9; p\u2009=\u20090.013) and disease-free survival (hazard ratio 1.9; p\u2009=\u20090.029).\nCONCLUSIONS: Expression of pER-\u03b2 constitutes an independent prognostic marker for PDAC and is correlated with poor prognosis. These data may help in identifying novel drug targets in PDAC and patients who could benefit from additional therapeutic regimens, including selective estrogen receptor modulators.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-018-2717-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "144"
      }
    ], 
    "name": "Expression of phosphorylated estrogen receptor beta is an independent negative prognostic factor for pancreatic ductal adenocarcinoma", 
    "pagination": "1887-1897", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "97895f5db4a1532ec38a92d7cf97ecf7e1b9ffceaf2726dc424b8bed7a8bc6f1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30046904"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-018-2717-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105830346"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-018-2717-2", 
      "https://app.dimensions.ai/details/publication/pub.1105830346"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00432-018-2717-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-2717-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-2717-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-2717-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-2717-2'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      104 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-018-2717-2 schema:about N0464cf56729b4854b92737971a646749
2 N05ff75c6947649358c35c217ae70ee41
3 N07b04f6052d049f282f86ac39a43e384
4 N2ed0519272f54e43bdd1a119ed8b96c6
5 N364828c576374918adb7a80015a20d70
6 N437a8550b4ef4606ab131d7a1a056230
7 N755886d2406348de89c4ccf7b5d483c8
8 N7668c278fa204f8e9d3293da5a7631bf
9 N883c8da9338a424b9885b84fb95dda0d
10 N8f2dbb566b14436a8fd1548ece675383
11 N96c7f51a3eb64eaa8babd85c2b268d9f
12 Nbb73b853d8a04a9cb610290934e435e4
13 Ncc5d03f586fb467bb627db12af9e5629
14 Ndee8de0c14c140a3bc0d1aa5b7579ded
15 Ndfa9521bb676484b9b615bbda0f6ca3f
16 Ne1d4544b6c44486aa63763ea96b9c5f4
17 Ne635fd7138544a00828c68bb36f9f2ff
18 Ne8b51e3d329c41968f20ec87951a1543
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Ned9d3ff674b84e958831fbaa6c90e727
22 schema:citation sg:pub.10.1007/s00018-009-0017-3
23 sg:pub.10.1007/s00262-005-0047-0
24 sg:pub.10.1007/s11605-013-2168-7
25 sg:pub.10.1007/s13277-010-0082-0
26 sg:pub.10.1186/1756-9966-29-51
27 https://app.dimensions.ai/details/publication/pub.1064244690
28 https://app.dimensions.ai/details/publication/pub.1074488962
29 https://app.dimensions.ai/details/publication/pub.1074740358
30 https://app.dimensions.ai/details/publication/pub.1074849701
31 https://app.dimensions.ai/details/publication/pub.1075021196
32 https://app.dimensions.ai/details/publication/pub.1079672148
33 https://app.dimensions.ai/details/publication/pub.1082700124
34 https://app.dimensions.ai/details/publication/pub.1083321491
35 https://doi.org/10.1002/(sici)1097-0045(20000215)42:3<239::aid-pros10>3.0.co;2-g
36 https://doi.org/10.1002/bjs.1800800341
37 https://doi.org/10.1002/bjs.1800840812
38 https://doi.org/10.1002/ijc.28571
39 https://doi.org/10.1002/jcp.21253
40 https://doi.org/10.1002/ssu.10018
41 https://doi.org/10.1016/j.canlet.2013.07.014
42 https://doi.org/10.1016/j.ccr.2011.03.009
43 https://doi.org/10.1016/j.jss.2006.10.015
44 https://doi.org/10.1016/j.smim.2014.01.002
45 https://doi.org/10.1016/j.steroids.2013.01.008
46 https://doi.org/10.1016/s0014-5793(00)02296-1
47 https://doi.org/10.1016/s0039-128x(02)00110-1
48 https://doi.org/10.1016/s0304-3835(01)00563-8
49 https://doi.org/10.1016/s0960-0760(98)00147-2
50 https://doi.org/10.1016/s1097-2765(00)80479-7
51 https://doi.org/10.1046/j.1365-2168.1997.02724.x
52 https://doi.org/10.1093/annonc/10.suppl_4.s131
53 https://doi.org/10.1093/jjco/28.1.12
54 https://doi.org/10.1093/jjco/hyi082
55 https://doi.org/10.1093/jnci/94.8.617
56 https://doi.org/10.1097/00000658-199404000-00001
57 https://doi.org/10.1097/00000658-199506000-00011
58 https://doi.org/10.1097/00000658-199709000-00004
59 https://doi.org/10.1097/01.mpa.0000226893.09194.ec
60 https://doi.org/10.1097/cej.0b013e32809b4ccd
61 https://doi.org/10.1097/mpa.0b013e31823cdd10
62 https://doi.org/10.1111/j.1349-7006.2009.01359.x
63 https://doi.org/10.1111/j.1600-0463.2009.02510.x
64 https://doi.org/10.1126/science.1621100
65 https://doi.org/10.1128/jvi.01601-08
66 https://doi.org/10.1136/bmj.283.6294.751
67 https://doi.org/10.1136/gut.51.5.712
68 https://doi.org/10.1146/annurev.physiol.69.031905.160319
69 https://doi.org/10.1152/physrev.00026.2006
70 https://doi.org/10.1155/2006/354295
71 https://doi.org/10.1158/1535-7163.mct-11-0960
72 https://doi.org/10.1159/000151479
73 https://doi.org/10.1210/endo.141.1.7270
74 https://doi.org/10.1210/er.2010-0016
75 https://doi.org/10.1593/neo.05178
76 https://doi.org/10.3748/wjg.v12.i28.4466
77 https://doi.org/10.3892/or.2013.2770
78 https://doi.org/10.5009/gnl.2012.6.4.417
79 schema:datePublished 2018-10
80 schema:datePublishedReg 2018-10-01
81 schema:description PURPOSE: The role of estrogen receptor beta (ER-β) expression in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. Ligand-independent phosphorylation and activation of ER-β may play a relevant role in the IL-6/STAT3 signaling pathway and, as a result, in tumor progression. Here, we examined the effect of ER-β, phosphorylated ER-β (pER-β), STAT3, phosphorylated STAT3 (pSTAT3) and IL-6 expression on the overall and recurrence-free survival in a cohort of patients with resected PDAC. METHODS: We identified 175 patients who underwent pancreatic resection for PDAC. Tissue microarrays were constructed from the archival tumor specimens. These were stained with specific antibodies for the above molecules. The expression of the markers was then correlated with clinicopathological parameters and survival analysis was performed. RESULTS: High nuclear expression of ER-β was found in 61.7% and pER-β in 80.6% of the tumors. STAT3 was expressed in 54.3% of the tumor samples, pSTAT3 in 68% and IL-6 in 76.6%. The median overall survival for patients with low pER-β expression was 29 months, whereas for patients with high pER-β expression was 15.1 months (p = 0.016). Multivariate analysis revealed that pER-β expression was an independent factor correlating with shorter overall survival (hazard ratio 1.9; p = 0.013) and disease-free survival (hazard ratio 1.9; p = 0.029). CONCLUSIONS: Expression of pER-β constitutes an independent prognostic marker for PDAC and is correlated with poor prognosis. These data may help in identifying novel drug targets in PDAC and patients who could benefit from additional therapeutic regimens, including selective estrogen receptor modulators.
82 schema:genre research_article
83 schema:inLanguage en
84 schema:isAccessibleForFree false
85 schema:isPartOf N07b34fefa7d44647bc8a004648471f02
86 N48a42e4c3bdc4a43b59be53efba52f6d
87 sg:journal.1313647
88 schema:name Expression of phosphorylated estrogen receptor beta is an independent negative prognostic factor for pancreatic ductal adenocarcinoma
89 schema:pagination 1887-1897
90 schema:productId N32b207f6b0ad49279f2eafbac516e75c
91 N54bc8c3658034fc685468cb795b3e124
92 N67fe6b5aadc64819903b5fa76bb9176e
93 Nbea3a339e4e2479a972e85d49c02d832
94 Nc48fc67acaa34c12bfce8aac4955d91f
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105830346
96 https://doi.org/10.1007/s00432-018-2717-2
97 schema:sdDatePublished 2019-04-11T00:31
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N19d7f662884c40ca8faca84ece9db767
100 schema:url http://link.springer.com/10.1007%2Fs00432-018-2717-2
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N0464cf56729b4854b92737971a646749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name STAT3 Transcription Factor
106 rdf:type schema:DefinedTerm
107 N05ff75c6947649358c35c217ae70ee41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Male
109 rdf:type schema:DefinedTerm
110 N07b04f6052d049f282f86ac39a43e384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Biomarkers, Tumor
112 rdf:type schema:DefinedTerm
113 N07b34fefa7d44647bc8a004648471f02 schema:volumeNumber 144
114 rdf:type schema:PublicationVolume
115 N198631d1748d44e29f21c48fe4ee30e9 rdf:first sg:person.01074146470.77
116 rdf:rest Nb437b03b7df64bb4bd962755c4bb66be
117 N19d7f662884c40ca8faca84ece9db767 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N2ed0519272f54e43bdd1a119ed8b96c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Estrogen Receptor beta
121 rdf:type schema:DefinedTerm
122 N32b207f6b0ad49279f2eafbac516e75c schema:name dimensions_id
123 schema:value pub.1105830346
124 rdf:type schema:PropertyValue
125 N364828c576374918adb7a80015a20d70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Phosphorylation
127 rdf:type schema:DefinedTerm
128 N437a8550b4ef4606ab131d7a1a056230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Neoplasm Recurrence, Local
130 rdf:type schema:DefinedTerm
131 N48a42e4c3bdc4a43b59be53efba52f6d schema:issueNumber 10
132 rdf:type schema:PublicationIssue
133 N4ab1a428f4454db58f2e9db2c901b1c6 rdf:first sg:person.01244452123.50
134 rdf:rest Neb841385235342628bfa0095df103c77
135 N54bc8c3658034fc685468cb795b3e124 schema:name nlm_unique_id
136 schema:value 7902060
137 rdf:type schema:PropertyValue
138 N5c55971cf83c47879492f76fc6725c08 rdf:first sg:person.01022345761.51
139 rdf:rest Nb4315c7d703d4ec78636c3255129b83f
140 N67fe6b5aadc64819903b5fa76bb9176e schema:name pubmed_id
141 schema:value 30046904
142 rdf:type schema:PropertyValue
143 N755886d2406348de89c4ccf7b5d483c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Interleukin-6
145 rdf:type schema:DefinedTerm
146 N7668c278fa204f8e9d3293da5a7631bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Aged
148 rdf:type schema:DefinedTerm
149 N883c8da9338a424b9885b84fb95dda0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 N8f2dbb566b14436a8fd1548ece675383 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Survival Rate
154 rdf:type schema:DefinedTerm
155 N96c7f51a3eb64eaa8babd85c2b268d9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged, 80 and over
157 rdf:type schema:DefinedTerm
158 Nb422a92849314c6295746b808b9d20b3 schema:name Department of Surgery, Vivantes Neukölln Hospital, Berlin, Germany
159 rdf:type schema:Organization
160 Nb4315c7d703d4ec78636c3255129b83f rdf:first sg:person.0752555661.43
161 rdf:rest rdf:nil
162 Nb437b03b7df64bb4bd962755c4bb66be rdf:first sg:person.01230436235.65
163 rdf:rest N5c55971cf83c47879492f76fc6725c08
164 Nbb73b853d8a04a9cb610290934e435e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Prognosis
166 rdf:type schema:DefinedTerm
167 Nbea3a339e4e2479a972e85d49c02d832 schema:name doi
168 schema:value 10.1007/s00432-018-2717-2
169 rdf:type schema:PropertyValue
170 Nc1f2f7c9aedf4361a0dea323f0537429 rdf:first sg:person.01343630646.40
171 rdf:rest Nd393967fc3a147baa630b61a8a71dda2
172 Nc48fc67acaa34c12bfce8aac4955d91f schema:name readcube_id
173 schema:value 97895f5db4a1532ec38a92d7cf97ecf7e1b9ffceaf2726dc424b8bed7a8bc6f1
174 rdf:type schema:PropertyValue
175 Ncc5d03f586fb467bb627db12af9e5629 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Pancreatic Neoplasms
177 rdf:type schema:DefinedTerm
178 Nd393967fc3a147baa630b61a8a71dda2 rdf:first sg:person.01172333547.89
179 rdf:rest N4ab1a428f4454db58f2e9db2c901b1c6
180 Ndee8de0c14c140a3bc0d1aa5b7579ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Adult
182 rdf:type schema:DefinedTerm
183 Ndfa9521bb676484b9b615bbda0f6ca3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Follow-Up Studies
185 rdf:type schema:DefinedTerm
186 Ne1d4544b6c44486aa63763ea96b9c5f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Humans
188 rdf:type schema:DefinedTerm
189 Ne4f38e8fe913481da4a9d047b7960150 schema:name Johns Hopkins Hypertrophic Cardiomyopathy Center of Excellence, Baltimore, MD, USA
190 rdf:type schema:Organization
191 Ne635fd7138544a00828c68bb36f9f2ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Carcinoma, Pancreatic Ductal
193 rdf:type schema:DefinedTerm
194 Ne8b51e3d329c41968f20ec87951a1543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Female
196 rdf:type schema:DefinedTerm
197 Neb841385235342628bfa0095df103c77 rdf:first sg:person.01216630025.50
198 rdf:rest N198631d1748d44e29f21c48fe4ee30e9
199 Ned9d3ff674b84e958831fbaa6c90e727 rdf:first sg:person.012655201007.50
200 rdf:rest Nc1f2f7c9aedf4361a0dea323f0537429
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
205 schema:name Oncology and Carcinogenesis
206 rdf:type schema:DefinedTerm
207 sg:journal.1313647 schema:issn 0171-5216
208 1432-1335
209 schema:name Journal of Cancer Research and Clinical Oncology
210 rdf:type schema:Periodical
211 sg:person.01022345761.51 schema:affiliation https://www.grid.ac/institutes/grid.412753.6
212 schema:familyName Kreis
213 schema:givenName Martin E.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022345761.51
215 rdf:type schema:Person
216 sg:person.01074146470.77 schema:affiliation Nb422a92849314c6295746b808b9d20b3
217 schema:familyName Müller
218 schema:givenName Mario H.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074146470.77
220 rdf:type schema:Person
221 sg:person.01172333547.89 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
222 schema:familyName Zhao
223 schema:givenName Yue
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172333547.89
225 rdf:type schema:Person
226 sg:person.01216630025.50 schema:affiliation Ne4f38e8fe913481da4a9d047b7960150
227 schema:familyName Pozios
228 schema:givenName Iraklis
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216630025.50
230 rdf:type schema:Person
231 sg:person.01230436235.65 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
232 schema:familyName Bruns
233 schema:givenName Christiane J.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230436235.65
235 rdf:type schema:Person
236 sg:person.01244452123.50 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
237 schema:familyName Assmann
238 schema:givenName Gerald
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244452123.50
240 rdf:type schema:Person
241 sg:person.012655201007.50 schema:affiliation https://www.grid.ac/institutes/grid.412753.6
242 schema:familyName Pozios
243 schema:givenName Ioannis
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012655201007.50
245 rdf:type schema:Person
246 sg:person.01343630646.40 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
247 schema:familyName Knösel
248 schema:givenName Thomas
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343630646.40
250 rdf:type schema:Person
251 sg:person.0752555661.43 schema:affiliation https://www.grid.ac/institutes/grid.412753.6
252 schema:familyName Seeliger
253 schema:givenName Hendrik
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752555661.43
255 rdf:type schema:Person
256 sg:pub.10.1007/s00018-009-0017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050152736
257 https://doi.org/10.1007/s00018-009-0017-3
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s00262-005-0047-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006596087
260 https://doi.org/10.1007/s00262-005-0047-0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s11605-013-2168-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022781896
263 https://doi.org/10.1007/s11605-013-2168-7
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s13277-010-0082-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037642946
266 https://doi.org/10.1007/s13277-010-0082-0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1756-9966-29-51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027237201
269 https://doi.org/10.1186/1756-9966-29-51
270 rdf:type schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1064244690 schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1074488962 schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1074740358 schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1074849701 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1075021196 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1079672148 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1082700124 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1083321491 schema:CreativeWork
279 https://doi.org/10.1002/(sici)1097-0045(20000215)42:3<239::aid-pros10>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1009210825
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/bjs.1800800341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034907830
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/bjs.1800840812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054296419
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/ijc.28571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028224815
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/jcp.21253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044442993
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/ssu.10018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006035850
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.canlet.2013.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041518269
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.ccr.2011.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031819756
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jss.2006.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961872
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.smim.2014.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018524022
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.steroids.2013.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029312380
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0014-5793(00)02296-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052424271
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0039-128x(02)00110-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034903544
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s0304-3835(01)00563-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023940237
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0960-0760(98)00147-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002647757
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s1097-2765(00)80479-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044604868
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1046/j.1365-2168.1997.02724.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000401492
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/annonc/10.suppl_4.s131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049544692
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/jjco/28.1.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033663178
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/jjco/hyi082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012904134
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/jnci/94.8.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014116947
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/00000658-199404000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035498726
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/00000658-199506000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001874243
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/00000658-199709000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134615
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/01.mpa.0000226893.09194.ec schema:sameAs https://app.dimensions.ai/details/publication/pub.1037135575
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1097/cej.0b013e32809b4ccd schema:sameAs https://app.dimensions.ai/details/publication/pub.1004838550
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/mpa.0b013e31823cdd10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022070728
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1349-7006.2009.01359.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017776432
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1111/j.1600-0463.2009.02510.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035489324
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1126/science.1621100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062496034
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1128/jvi.01601-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041177101
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1136/bmj.283.6294.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038660357
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1136/gut.51.5.712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011275541
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1146/annurev.physiol.69.031905.160319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009904616
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1152/physrev.00026.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002306145
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1155/2006/354295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045968556
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1158/1535-7163.mct-11-0960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005661619
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1159/000151479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030778162
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1210/endo.141.1.7270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283369
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1210/er.2010-0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015304549
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1593/neo.05178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053283940
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3748/wjg.v12.i28.4466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364794
362 rdf:type schema:CreativeWork
363 https://doi.org/10.3892/or.2013.2770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071532707
364 rdf:type schema:CreativeWork
365 https://doi.org/10.5009/gnl.2012.6.4.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047467783
366 rdf:type schema:CreativeWork
367 https://www.grid.ac/institutes/grid.411097.a schema:alternateName University Hospital Cologne
368 schema:name Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.412753.6 schema:alternateName Campus Benjamin Franklin
371 schema:name Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité—Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
374 schema:name Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...