Differential molecular pathways expression in HER2 positive early breast cancer according to hormone receptor status View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Claudia Omarini, Stefania Bettelli, Cecilia Caprera, Samantha Manfredini, Monica Barbolini, Luca Moscetti, Chrystel Isca, Angela Toss, Elena Barbieri, Laura Cortesi, Shaniko Kaleci, Antonino Maiorana, Giovanni Tazzioli, Stefano Cascinu, Federico Piacentini

ABSTRACT

PURPOSE: Hormone receptors (HR) status in HER2 + breast cancer (BC) is a recognized stratification factor with relevant clinical implication. According to HR expression, HER2 + BC show different clinical characteristics, treatment sensitivity and prognosis. The interaction between HR and HER2 pathways remains incompletely understood. METHODS: Thirty-four HER2 + BC were included: 18 tumors with HER2+/HR + and 16 with HER2+/HR-. The expression of 770 genes and 13 molecular pathways were evaluated using Nanostring PanCancer Pathway panel performed on FFPE BC biopsies. RESULTS: Gene expression analysis identified 127 genes with significantly different expression between the two cohorts. 83% of these genes were overexpressed in HER2+/HR- cohort. Globally, 23% of them belonged to PI3K pathway (41 genes), 15% to Trascriptional regulation (26 genes) and 12% to MAPK (22 genes). Regarding pathway expression, PI3K, MAPK and NOTCH were significantly differently expressed between the two groups (p = 0.003, p = 0.0018 and p = 0.02, respectively), all of them were overexpressed in HER2+/HR- tumors. CONCLUSIONS: According to HR status, HER2 + tumors express different pathways profiles: the overexpression of PI3K, MAPK and NOTCH pathways in HER2+/HR- group could justify different survival outcomes and treatment sensitivity. The identification of tumor driver pathways may be a useful instrument for individualized pathway-directed therapies. Further clinical implications are warranted. More... »

PAGES

821-828

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-018-02833-8

DOI

http://dx.doi.org/10.1007/s00432-018-02833-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111057429

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30603906


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omarini", 
        "givenName": "Claudia", 
        "id": "sg:person.0604777611.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604777611.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bettelli", 
        "givenName": "Stefania", 
        "id": "sg:person.0614113333.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614113333.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caprera", 
        "givenName": "Cecilia", 
        "id": "sg:person.01363730623.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730623.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manfredini", 
        "givenName": "Samantha", 
        "id": "sg:person.010321452625.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321452625.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbolini", 
        "givenName": "Monica", 
        "id": "sg:person.013304603341.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013304603341.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moscetti", 
        "givenName": "Luca", 
        "id": "sg:person.01276454760.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276454760.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Isca", 
        "givenName": "Chrystel", 
        "id": "sg:person.07427753523.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07427753523.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toss", 
        "givenName": "Angela", 
        "id": "sg:person.01316046602.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316046602.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbieri", 
        "givenName": "Elena", 
        "id": "sg:person.01005763331.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005763331.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cortesi", 
        "givenName": "Laura", 
        "id": "sg:person.01121403256.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121403256.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaleci", 
        "givenName": "Shaniko", 
        "id": "sg:person.01322616375.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322616375.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maiorana", 
        "givenName": "Antonino", 
        "id": "sg:person.01124706505.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124706505.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Oncologic Breast Surgery Unit, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tazzioli", 
        "givenName": "Giovanni", 
        "id": "sg:person.01041762574.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041762574.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cascinu", 
        "givenName": "Stefano", 
        "id": "sg:person.01157163143.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157163143.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico di Modena", 
          "id": "https://www.grid.ac/institutes/grid.413363.0", 
          "name": [
            "Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piacentini", 
        "givenName": "Federico", 
        "id": "sg:person.01207232355.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207232355.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1524-4741.2009.00822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001316307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4741.2009.00822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001316307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005258025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006324258", 
          "https://doi.org/10.1038/onc.2010.626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70336-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006777850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602468103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007483223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1004827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009875344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009951628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013979828", 
          "https://doi.org/10.1038/nrc3309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015285825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219651110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015558853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021697146", 
          "https://doi.org/10.1038/onc.2008.149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.1661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028339567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035499857", 
          "https://doi.org/10.1038/onc.2011.279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00051-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036326245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2014.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037750098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61847-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043834514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)70138-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047423727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70397-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049634463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051019497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2012.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053445571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.sabcs11-s5-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063221081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986712799320691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069162421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.9.6.1163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071536765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.29.15_suppl.554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083948249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2018.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103182990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2018/2415489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105422645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15384047.2018.1480287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105949822"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "PURPOSE: Hormone receptors (HR) status in HER2\u2009+\u2009breast cancer (BC) is a recognized stratification factor with relevant clinical implication. According to HR expression, HER2\u2009+\u2009BC show different clinical characteristics, treatment sensitivity and prognosis. The interaction between HR and HER2 pathways remains incompletely understood.\nMETHODS: Thirty-four HER2\u2009+\u2009BC were included: 18 tumors with HER2+/HR\u2009+\u2009and 16 with HER2+/HR-. The expression of 770 genes and 13 molecular pathways were evaluated using Nanostring PanCancer Pathway panel performed on FFPE BC biopsies.\nRESULTS: Gene expression analysis identified 127 genes with significantly different expression between the two cohorts. 83% of these genes were overexpressed in HER2+/HR- cohort. Globally, 23% of them belonged to PI3K pathway (41 genes), 15% to Trascriptional regulation (26 genes) and 12% to MAPK (22 genes). Regarding pathway expression, PI3K, MAPK and NOTCH were significantly differently expressed between the two groups (p\u2009=\u20090.003, p\u2009=\u20090.0018 and p\u2009=\u20090.02, respectively), all of them were overexpressed in HER2+/HR- tumors.\nCONCLUSIONS: According to HR status, HER2\u2009+\u2009tumors express different pathways profiles: the overexpression of PI3K, MAPK and NOTCH pathways in HER2+/HR- group could justify different survival outcomes and treatment sensitivity. The identification of tumor driver pathways may be a useful instrument for individualized pathway-directed therapies. Further clinical implications are warranted.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-018-02833-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "145"
      }
    ], 
    "name": "Differential molecular pathways expression in HER2 positive early breast cancer according to hormone receptor status", 
    "pagination": "821-828", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "559d7c8ccc7bd22da59d33b678d31334f4f96ed7783007c8f31baf25aba84754"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30603906"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-018-02833-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111057429"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-018-02833-8", 
      "https://app.dimensions.ai/details/publication/pub.1111057429"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78950_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00432-018-02833-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-02833-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-02833-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-02833-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-018-02833-8'


 

This table displays all metadata directly associated to this object as RDF triples.

258 TRIPLES      21 PREDICATES      57 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-018-02833-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Ne980fc66066c486898250776955e9b86
4 schema:citation sg:pub.10.1038/nature11412
5 sg:pub.10.1038/nrc3309
6 sg:pub.10.1038/onc.2008.149
7 sg:pub.10.1038/onc.2010.626
8 sg:pub.10.1038/onc.2011.279
9 https://doi.org/10.1016/j.breast.2012.03.004
10 https://doi.org/10.1016/j.breast.2018.03.006
11 https://doi.org/10.1016/j.ctrv.2014.12.005
12 https://doi.org/10.1016/s0140-6736(11)61847-3
13 https://doi.org/10.1016/s1470-2045(11)70336-9
14 https://doi.org/10.1016/s1470-2045(11)70397-7
15 https://doi.org/10.1016/s1470-2045(14)70138-x
16 https://doi.org/10.1016/s1470-2045(15)00051-0
17 https://doi.org/10.1073/pnas.0602468103
18 https://doi.org/10.1073/pnas.1219651110
19 https://doi.org/10.1080/15384047.2018.1480287
20 https://doi.org/10.1093/annonc/mdt287
21 https://doi.org/10.1093/jnci/djh166
22 https://doi.org/10.1111/j.1524-4741.2009.00822.x
23 https://doi.org/10.1155/2018/2415489
24 https://doi.org/10.1158/0008-5472.can-08-4490
25 https://doi.org/10.1158/0008-5472.sabcs11-s5-2
26 https://doi.org/10.1200/jco.2009.24.1661
27 https://doi.org/10.1200/jco.2011.29.15_suppl.554
28 https://doi.org/10.1371/journal.pcbi.1004827
29 https://doi.org/10.1371/journal.pmed.1000279
30 https://doi.org/10.2174/092986712799320691
31 https://doi.org/10.3892/or.9.6.1163
32 schema:datePublished 2019-04
33 schema:datePublishedReg 2019-04-01
34 schema:description PURPOSE: Hormone receptors (HR) status in HER2 + breast cancer (BC) is a recognized stratification factor with relevant clinical implication. According to HR expression, HER2 + BC show different clinical characteristics, treatment sensitivity and prognosis. The interaction between HR and HER2 pathways remains incompletely understood. METHODS: Thirty-four HER2 + BC were included: 18 tumors with HER2+/HR + and 16 with HER2+/HR-. The expression of 770 genes and 13 molecular pathways were evaluated using Nanostring PanCancer Pathway panel performed on FFPE BC biopsies. RESULTS: Gene expression analysis identified 127 genes with significantly different expression between the two cohorts. 83% of these genes were overexpressed in HER2+/HR- cohort. Globally, 23% of them belonged to PI3K pathway (41 genes), 15% to Trascriptional regulation (26 genes) and 12% to MAPK (22 genes). Regarding pathway expression, PI3K, MAPK and NOTCH were significantly differently expressed between the two groups (p = 0.003, p = 0.0018 and p = 0.02, respectively), all of them were overexpressed in HER2+/HR- tumors. CONCLUSIONS: According to HR status, HER2 + tumors express different pathways profiles: the overexpression of PI3K, MAPK and NOTCH pathways in HER2+/HR- group could justify different survival outcomes and treatment sensitivity. The identification of tumor driver pathways may be a useful instrument for individualized pathway-directed therapies. Further clinical implications are warranted.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N62ed9b08cb2b449f97f357732aaadc66
39 N6efbdff6937e47a3919b1374da78d398
40 sg:journal.1313647
41 schema:name Differential molecular pathways expression in HER2 positive early breast cancer according to hormone receptor status
42 schema:pagination 821-828
43 schema:productId N44a30b5a9aa346c6b04035e36c5c9131
44 N6c3e47627c464774bedd67142df5a582
45 N841ef6d852e44bd68c9473136c0b1192
46 Naebc8d068e0143139d8306d841ff3587
47 Ndc3bfa26bf8c46ebb5142e32fc9f68e0
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111057429
49 https://doi.org/10.1007/s00432-018-02833-8
50 schema:sdDatePublished 2019-04-11T13:19
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher Nde1a045ec2984692a92f200e6a91182c
53 schema:url https://link.springer.com/10.1007%2Fs00432-018-02833-8
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N2cae78fbeedb4df5a561fda59cbc6f4e rdf:first sg:person.01005763331.27
58 rdf:rest Nf25e21ceea7d42e89d593e630209a5c3
59 N3643899a6fe441dabf12ecd3539519c4 rdf:first sg:person.013304603341.51
60 rdf:rest N63405ad5ca8e476fb37e84a969c4b162
61 N44a30b5a9aa346c6b04035e36c5c9131 schema:name pubmed_id
62 schema:value 30603906
63 rdf:type schema:PropertyValue
64 N62ed9b08cb2b449f97f357732aaadc66 schema:issueNumber 4
65 rdf:type schema:PublicationIssue
66 N63405ad5ca8e476fb37e84a969c4b162 rdf:first sg:person.01276454760.26
67 rdf:rest Nf2b460cc57104d86a5b1d6f1a7c06ddc
68 N6c3e47627c464774bedd67142df5a582 schema:name nlm_unique_id
69 schema:value 7902060
70 rdf:type schema:PropertyValue
71 N6d890f571e3a4811a87b1b532e9f7a9d rdf:first sg:person.01157163143.28
72 rdf:rest Ndf816a204cad4b55959eb61b8110c27d
73 N6efbdff6937e47a3919b1374da78d398 schema:volumeNumber 145
74 rdf:type schema:PublicationVolume
75 N7dbb22a3859d4fed832be1c57242ac5e rdf:first sg:person.01363730623.04
76 rdf:rest Naf5a0b9f62924eb5afdbc99132e581f1
77 N841ef6d852e44bd68c9473136c0b1192 schema:name doi
78 schema:value 10.1007/s00432-018-02833-8
79 rdf:type schema:PropertyValue
80 Na9b884138f4046caa1b261b852604af4 rdf:first sg:person.01322616375.83
81 rdf:rest Nc5c54bc9d5d74eb2911e62f7d2b64f63
82 Naebc8d068e0143139d8306d841ff3587 schema:name dimensions_id
83 schema:value pub.1111057429
84 rdf:type schema:PropertyValue
85 Naf5a0b9f62924eb5afdbc99132e581f1 rdf:first sg:person.010321452625.01
86 rdf:rest N3643899a6fe441dabf12ecd3539519c4
87 Nb10d02481a4344c9a1b7413cfdde12c8 rdf:first sg:person.01316046602.37
88 rdf:rest N2cae78fbeedb4df5a561fda59cbc6f4e
89 Nb1ade34bb70046f6adfc795ab495084c rdf:first sg:person.01041762574.45
90 rdf:rest N6d890f571e3a4811a87b1b532e9f7a9d
91 Nc5c54bc9d5d74eb2911e62f7d2b64f63 rdf:first sg:person.01124706505.64
92 rdf:rest Nb1ade34bb70046f6adfc795ab495084c
93 Ndc3bfa26bf8c46ebb5142e32fc9f68e0 schema:name readcube_id
94 schema:value 559d7c8ccc7bd22da59d33b678d31334f4f96ed7783007c8f31baf25aba84754
95 rdf:type schema:PropertyValue
96 Nde1a045ec2984692a92f200e6a91182c schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 Ndf816a204cad4b55959eb61b8110c27d rdf:first sg:person.01207232355.48
99 rdf:rest rdf:nil
100 Ne980fc66066c486898250776955e9b86 rdf:first sg:person.0604777611.30
101 rdf:rest Nf0f7d8a363eb46bebdfd0f229381e26c
102 Nf0f7d8a363eb46bebdfd0f229381e26c rdf:first sg:person.0614113333.17
103 rdf:rest N7dbb22a3859d4fed832be1c57242ac5e
104 Nf25e21ceea7d42e89d593e630209a5c3 rdf:first sg:person.01121403256.68
105 rdf:rest Na9b884138f4046caa1b261b852604af4
106 Nf2b460cc57104d86a5b1d6f1a7c06ddc rdf:first sg:person.07427753523.80
107 rdf:rest Nb10d02481a4344c9a1b7413cfdde12c8
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
112 schema:name Oncology and Carcinogenesis
113 rdf:type schema:DefinedTerm
114 sg:journal.1313647 schema:issn 0171-5216
115 1432-1335
116 schema:name Journal of Cancer Research and Clinical Oncology
117 rdf:type schema:Periodical
118 sg:person.01005763331.27 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
119 schema:familyName Barbieri
120 schema:givenName Elena
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005763331.27
122 rdf:type schema:Person
123 sg:person.010321452625.01 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
124 schema:familyName Manfredini
125 schema:givenName Samantha
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321452625.01
127 rdf:type schema:Person
128 sg:person.01041762574.45 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
129 schema:familyName Tazzioli
130 schema:givenName Giovanni
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041762574.45
132 rdf:type schema:Person
133 sg:person.01121403256.68 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
134 schema:familyName Cortesi
135 schema:givenName Laura
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121403256.68
137 rdf:type schema:Person
138 sg:person.01124706505.64 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
139 schema:familyName Maiorana
140 schema:givenName Antonino
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124706505.64
142 rdf:type schema:Person
143 sg:person.01157163143.28 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
144 schema:familyName Cascinu
145 schema:givenName Stefano
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157163143.28
147 rdf:type schema:Person
148 sg:person.01207232355.48 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
149 schema:familyName Piacentini
150 schema:givenName Federico
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207232355.48
152 rdf:type schema:Person
153 sg:person.01276454760.26 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
154 schema:familyName Moscetti
155 schema:givenName Luca
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276454760.26
157 rdf:type schema:Person
158 sg:person.01316046602.37 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
159 schema:familyName Toss
160 schema:givenName Angela
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316046602.37
162 rdf:type schema:Person
163 sg:person.01322616375.83 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
164 schema:familyName Kaleci
165 schema:givenName Shaniko
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322616375.83
167 rdf:type schema:Person
168 sg:person.013304603341.51 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
169 schema:familyName Barbolini
170 schema:givenName Monica
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013304603341.51
172 rdf:type schema:Person
173 sg:person.01363730623.04 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
174 schema:familyName Caprera
175 schema:givenName Cecilia
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730623.04
177 rdf:type schema:Person
178 sg:person.0604777611.30 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
179 schema:familyName Omarini
180 schema:givenName Claudia
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604777611.30
182 rdf:type schema:Person
183 sg:person.0614113333.17 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
184 schema:familyName Bettelli
185 schema:givenName Stefania
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614113333.17
187 rdf:type schema:Person
188 sg:person.07427753523.80 schema:affiliation https://www.grid.ac/institutes/grid.413363.0
189 schema:familyName Isca
190 schema:givenName Chrystel
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07427753523.80
192 rdf:type schema:Person
193 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
194 https://doi.org/10.1038/nature11412
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nrc3309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013979828
197 https://doi.org/10.1038/nrc3309
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/onc.2008.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697146
200 https://doi.org/10.1038/onc.2008.149
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/onc.2010.626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006324258
203 https://doi.org/10.1038/onc.2010.626
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/onc.2011.279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035499857
206 https://doi.org/10.1038/onc.2011.279
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.breast.2012.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053445571
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.breast.2018.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103182990
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.ctrv.2014.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037750098
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(11)61847-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043834514
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s1470-2045(11)70336-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006777850
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s1470-2045(11)70397-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049634463
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s1470-2045(14)70138-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047423727
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s1470-2045(15)00051-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036326245
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1073/pnas.0602468103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007483223
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1073/pnas.1219651110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015558853
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1080/15384047.2018.1480287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105949822
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/annonc/mdt287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009951628
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/jnci/djh166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005258025
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1524-4741.2009.00822.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001316307
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1155/2018/2415489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105422645
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1158/0008-5472.can-08-4490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051019497
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1158/0008-5472.sabcs11-s5-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063221081
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1200/jco.2009.24.1661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028339567
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1200/jco.2011.29.15_suppl.554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083948249
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1371/journal.pcbi.1004827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009875344
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1371/journal.pmed.1000279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015285825
249 rdf:type schema:CreativeWork
250 https://doi.org/10.2174/092986712799320691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162421
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3892/or.9.6.1163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071536765
253 rdf:type schema:CreativeWork
254 https://www.grid.ac/institutes/grid.413363.0 schema:alternateName Policlinico di Modena
255 schema:name Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy
256 Division of Pathological Anatomy, Department of Diagnostic, Clinical Medicine and Public Health, University Hospital of Modena, Modena, Italy
257 Oncologic Breast Surgery Unit, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Modena, Italy
258 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...