Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins: a multicenter study ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-19

AUTHORS

Wan Song, Dong Hyeon Lee, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Jong Wook Kim, SangChul Lee, Seok-Soo Byun, Chang Wook Jeong, Cheol Kwak, Jin Seon Cho, Hanjong Ahn, Seong Soo Jeon

ABSTRACT

PurposeOncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients.MethodsA retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR.ResultsDuring the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8–10.ConclusionsIn patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis. More... »

PAGES

2393-2400

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-017-2502-7

DOI

http://dx.doi.org/10.1007/s00432-017-2502-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091244483

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28823006


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23 schema:description PurposeOncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients.MethodsA retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR.ResultsDuring the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8–10.ConclusionsIn patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.
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30 schema:keywords BCR-free survival
31 Cancer Research Committee
32 Committee
33 Cox proportional hazards model
34 GS 6
35 GS 7
36 Gleason score
37 Kaplan-Meier survival analysis
38 MethodsA retrospective
39 Nx
40 Nx PCa
41 Nx prostate cancer
42 PCa
43 Prostate Cancer Research Committee
44 PurposeOncologic outcomes
45 Research Committee
46 analysis
47 basis
48 biochemical recurrence
49 cancer
50 characteristics
51 clinicopathologic characteristics
52 counsel patients
53 disease
54 factors
55 findings
56 hazards model
57 impact
58 independent predictors
59 individual basis
60 margin
61 model
62 months
63 multicenter study
64 multivariate analysis
65 only significant prognostic factor
66 onset
67 onset of BCR
68 outcomes
69 pT3aN0/Nx
70 pT3aN0/Nx PCa
71 pathologic Gleason score
72 patients
73 period
74 positive surgical margins
75 predictors
76 prognosis
77 prognosis of disease
78 prognostic factors
79 proportional hazards model
80 prostate cancer
81 prostatectomy
82 radical prostatectomy
83 recurrence
84 retrospective
85 risk
86 risk stratification
87 scores
88 significant prognostic factors
89 sole independent predictor
90 strategies
91 stratification
92 study
93 surgical margins
94 survival
95 survival analysis
96 timing
97 timing of BCR
98 treatment strategies
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