Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-05

AUTHORS

Thomas M. Atkinson, Jennifer L. Hay, Alexander Shoushtari, Yuelin Li, Daniel J. Paucar, Sloane C. Smith, Ragini R. Kudchadkar, Austin Doyle, Jeffrey A. Sosman, Jorge Fernando Quevedo, Mohammed M. Milhem, Anthony M. Joshua, Gerald P. Linette, Thomas F. Gajewski, Jose Lutzky, David H. Lawson, Christopher D. Lao, Patrick J. Flynn, Mark R. Albertini, Takami Sato, Karl Lewis, Brian Marr, David H. Abramson, Mark Andrew Dickson, Gary K. Schwartz, Richard D. Carvajal

ABSTRACT

PurposeClinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied.MethodsData from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed. Patients reported HRQoL at baseline, after 1 month, and end of treatment (n = 118), whereas physicians adjudicated AEs via CTCAE. Mean HRQoL scores were compared between patient randomization arms, as well as between those patients who did/did not receive dose modifications.ResultsNinety-four percent had a CTCAE grade ≥1 for at least one treatment-associated AE, with 18% undergoing dose modification due to toxicity. Mean HRQoL scores did not significantly differ at each of the three time points. Patient and physician-adjudicated reports of nausea were significantly correlated at the start (r = 0.31, p < 0.01) and end of treatment (r = 0.42, p < 0.05). There were no significant correlations between need for dose modification and HRQoL scores.ConclusionsDespite the high rate of physician-adjudicated AEs and need for dose modifications with selumetinib, patient-reported HRQoL was not impacted by treatment. Since HRQoL did not differ in the subgroup of patients who received dosage reductions due to AEs, patients may be willing to tolerate select AEs without dose modification (if medically appropriate). More research is needed to determine how to best integrate HRQoL data into clinical trial conduct. More... »

PAGES

439-445

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-016-2318-x

DOI

http://dx.doi.org/10.1007/s00432-016-2318-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042833891

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27921276


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug-Related Side Effects and Adverse Reactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Reported Outcome Measures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physicians", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uveal Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atkinson", 
        "givenName": "Thomas M.", 
        "id": "sg:person.01015127741.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015127741.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hay", 
        "givenName": "Jennifer L.", 
        "id": "sg:person.01207537147.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207537147.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoushtari", 
        "givenName": "Alexander", 
        "id": "sg:person.01121172646.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121172646.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Yuelin", 
        "id": "sg:person.010434553207.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010434553207.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paucar", 
        "givenName": "Daniel J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Sloane C.", 
        "id": "sg:person.016463010113.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016463010113.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Winship Cancer Institute of Emory University, Atlanta, GA, USA", 
          "id": "http://www.grid.ac/institutes/grid.516089.3", 
          "name": [
            "Winship Cancer Institute of Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kudchadkar", 
        "givenName": "Ragini R.", 
        "id": "sg:person.01001716007.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001716007.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doyle", 
        "givenName": "Austin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.516096.d", 
          "name": [
            "Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sosman", 
        "givenName": "Jeffrey A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quevedo", 
        "givenName": "Jorge Fernando", 
        "id": "sg:person.01262567220.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262567220.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa Carver College of Medicine, Iowa City, IA, USA", 
          "id": "http://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "University of Iowa Carver College of Medicine, Iowa City, IA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milhem", 
        "givenName": "Mohammed M.", 
        "id": "sg:person.0655657210.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655657210.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess Margaret Hospital University Health Network, Toronto, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Princess Margaret Hospital University Health Network, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joshua", 
        "givenName": "Anthony M.", 
        "id": "sg:person.0774245543.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774245543.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Penn Medicine, Philadelphia, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.412701.1", 
          "name": [
            "Penn Medicine, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linette", 
        "givenName": "Gerald P.", 
        "id": "sg:person.0733064563.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733064563.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "University of Chicago, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gajewski", 
        "givenName": "Thomas F.", 
        "id": "sg:person.01060637247.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060637247.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mount Sinai Medical Center, Miami Beach, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.410396.9", 
          "name": [
            "Mount Sinai Medical Center, Miami Beach, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lutzky", 
        "givenName": "Jose", 
        "id": "sg:person.0700352724.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700352724.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Winship Cancer Institute of Emory University, Atlanta, GA, USA", 
          "id": "http://www.grid.ac/institutes/grid.516089.3", 
          "name": [
            "Winship Cancer Institute of Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lawson", 
        "givenName": "David H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan, Ann Arbor, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lao", 
        "givenName": "Christopher D.", 
        "id": "sg:person.01220766140.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220766140.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minnesota Oncology, Woodbury, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.492844.7", 
          "name": [
            "Minnesota Oncology, Woodbury, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flynn", 
        "givenName": "Patrick J.", 
        "id": "sg:person.0625242133.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625242133.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Univeristy of Wisconsin School of Medicine and Public Health, Madison, WI, USA", 
          "id": "http://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Univeristy of Wisconsin School of Medicine and Public Health, Madison, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albertini", 
        "givenName": "Mark R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Takami", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Colorado \u2013 Denver, Denver, CO, USA", 
          "id": "http://www.grid.ac/institutes/grid.241116.1", 
          "name": [
            "University of Colorado \u2013 Denver, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "Karl", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marr", 
        "givenName": "Brian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abramson", 
        "givenName": "David H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dickson", 
        "givenName": "Mark Andrew", 
        "id": "sg:person.0756437553.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756437553.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University Medical Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Columbia University Medical Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "Gary K.", 
        "id": "sg:person.012707142152.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707142152.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University Medical Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Columbia University Medical Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvajal", 
        "givenName": "Richard D.", 
        "id": "sg:person.0726366600.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrclinonc.2015.222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043404213", 
          "https://doi.org/10.1038/nrclinonc.2015.222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-016-3297-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021957349", 
          "https://doi.org/10.1007/s00520-016-3297-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2010.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018135061", 
          "https://doi.org/10.1038/clpt.2010.79"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11136-013-0470-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018077371", 
          "https://doi.org/10.1007/s11136-013-0470-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12-05", 
    "datePublishedReg": "2016-12-05", 
    "description": "PurposeClinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied.MethodsData from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed. Patients reported HRQoL at baseline, after 1\u00a0month, and end of treatment (n\u00a0=\u00a0118), whereas physicians adjudicated AEs via CTCAE. \nMean HRQoL scores were compared between patient randomization arms, as well as between those patients who did/did not receive dose modifications.ResultsNinety-four percent had a CTCAE grade \u22651 for at least one treatment-associated AE, with 18% undergoing dose modification due to toxicity. Mean HRQoL scores did not significantly differ at each of the three time points. Patient and physician-adjudicated reports of nausea were significantly correlated at the start (r\u00a0=\u00a00.31, p\u00a0<\u00a00.01) and end of treatment (r\u00a0=\u00a00.42, p\u00a0<\u00a00.05). There were no significant correlations between need for dose modification and HRQoL scores.ConclusionsDespite the high rate of physician-adjudicated AEs and need for dose modifications with selumetinib, patient-reported HRQoL was not impacted by treatment. Since HRQoL did not differ in the subgroup of patients who received dosage reductions due to AEs, patients may be willing to tolerate select AEs without dose modification (if medically appropriate). More research is needed to determine how to best integrate HRQoL data into clinical trial conduct.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00432-016-2318-x", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438861", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438872", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "143"
      }
    ], 
    "keywords": [
      "patient-reported health-related quality", 
      "health-related quality", 
      "mean HRQoL scores", 
      "dose modification", 
      "end of treatment", 
      "metastatic uveal melanoma", 
      "HRQoL scores", 
      "adverse events", 
      "uveal melanoma", 
      "phase II clinical trial", 
      "oral MEK inhibitor", 
      "patient-reported HRQoL", 
      "Common Terminology Criteria", 
      "phase II trial", 
      "subgroup of patients", 
      "adverse event assessment", 
      "clinical trial conduct", 
      "PurposeClinical trials", 
      "Terminology Criteria", 
      "randomization arm", 
      "II trial", 
      "ResultsNinety-four percent", 
      "CTCAE grade", 
      "AE assessment", 
      "dosage reduction", 
      "HRQoL data", 
      "clinical trials", 
      "HRQoL", 
      "patients", 
      "trial conduct", 
      "MEK inhibitors", 
      "time points", 
      "trials", 
      "significant correlation", 
      "selumetinib", 
      "melanoma", 
      "high rate", 
      "treatment", 
      "scores", 
      "event assessment", 
      "more research", 
      "life data", 
      "CTCAE", 
      "nausea", 
      "chemotherapy", 
      "MethodsData", 
      "physicians", 
      "oncology", 
      "baseline", 
      "months", 
      "assessment", 
      "Ae", 
      "subgroups", 
      "inhibitors", 
      "toxicity", 
      "report", 
      "events", 
      "percent", 
      "grade", 
      "arm", 
      "need", 
      "data", 
      "quality", 
      "criteria", 
      "relationship", 
      "start", 
      "life", 
      "modification", 
      "rate", 
      "end", 
      "correlation", 
      "reduction", 
      "conduct", 
      "research", 
      "point", 
      "AES"
    ], 
    "name": "Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma", 
    "pagination": "439-445", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042833891"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-016-2318-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27921276"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-016-2318-x", 
      "https://app.dimensions.ai/details/publication/pub.1042833891"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_708.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00432-016-2318-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-016-2318-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-016-2318-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-016-2318-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-016-2318-x'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      119 URIs      106 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-016-2318-x schema:about N151f62200226429d97de403168026088
2 N61951e2e9cc4489e99d2941aa7a739d5
3 N725e5edab38741819351dcba1d363bfb
4 N803036c4d92b4040b4d3916df395092b
5 N84e173882f2b4a1d9c5774753f4f0532
6 N96be5e432b4c43de815dfecfcefbc67a
7 N9d8edd6889e141f5b0c7129285253d78
8 Nab2f055b329a45e6a7f63fad516f71ab
9 Nbf6c887dcd7d412a859444bd9394a5c3
10 Nc22b2bb02c454c11bc4c6d111a41e1d7
11 Nc2faea7f528f4f0091def769f43f35b6
12 Ndaa4fbf592344731baee0edcfaef3eca
13 Ne942521996134a8481c4de226da32be3
14 anzsrc-for:11
15 anzsrc-for:1103
16 anzsrc-for:1112
17 schema:author N29e8986ef9404f1caa8b13223cd96c74
18 schema:citation sg:pub.10.1007/s00520-016-3297-9
19 sg:pub.10.1007/s11136-013-0470-1
20 sg:pub.10.1038/clpt.2010.79
21 sg:pub.10.1038/nrclinonc.2015.222
22 schema:datePublished 2016-12-05
23 schema:datePublishedReg 2016-12-05
24 schema:description PurposeClinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied.MethodsData from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed. Patients reported HRQoL at baseline, after 1 month, and end of treatment (n = 118), whereas physicians adjudicated AEs via CTCAE. Mean HRQoL scores were compared between patient randomization arms, as well as between those patients who did/did not receive dose modifications.ResultsNinety-four percent had a CTCAE grade ≥1 for at least one treatment-associated AE, with 18% undergoing dose modification due to toxicity. Mean HRQoL scores did not significantly differ at each of the three time points. Patient and physician-adjudicated reports of nausea were significantly correlated at the start (r = 0.31, p < 0.01) and end of treatment (r = 0.42, p < 0.05). There were no significant correlations between need for dose modification and HRQoL scores.ConclusionsDespite the high rate of physician-adjudicated AEs and need for dose modifications with selumetinib, patient-reported HRQoL was not impacted by treatment. Since HRQoL did not differ in the subgroup of patients who received dosage reductions due to AEs, patients may be willing to tolerate select AEs without dose modification (if medically appropriate). More research is needed to determine how to best integrate HRQoL data into clinical trial conduct.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N3f9e678ffc1844feb46ed8cc02d312d8
28 N4e2b3c53d0844d99b15882d41c6dfd31
29 sg:journal.1313647
30 schema:keywords AE assessment
31 AES
32 Ae
33 CTCAE
34 CTCAE grade
35 Common Terminology Criteria
36 HRQoL
37 HRQoL data
38 HRQoL scores
39 II trial
40 MEK inhibitors
41 MethodsData
42 PurposeClinical trials
43 ResultsNinety-four percent
44 Terminology Criteria
45 adverse event assessment
46 adverse events
47 arm
48 assessment
49 baseline
50 chemotherapy
51 clinical trial conduct
52 clinical trials
53 conduct
54 correlation
55 criteria
56 data
57 dosage reduction
58 dose modification
59 end
60 end of treatment
61 event assessment
62 events
63 grade
64 health-related quality
65 high rate
66 inhibitors
67 life
68 life data
69 mean HRQoL scores
70 melanoma
71 metastatic uveal melanoma
72 modification
73 months
74 more research
75 nausea
76 need
77 oncology
78 oral MEK inhibitor
79 patient-reported HRQoL
80 patient-reported health-related quality
81 patients
82 percent
83 phase II clinical trial
84 phase II trial
85 physicians
86 point
87 quality
88 randomization arm
89 rate
90 reduction
91 relationship
92 report
93 research
94 scores
95 selumetinib
96 significant correlation
97 start
98 subgroup of patients
99 subgroups
100 time points
101 toxicity
102 treatment
103 trial conduct
104 trials
105 uveal melanoma
106 schema:name Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma
107 schema:pagination 439-445
108 schema:productId N234020dfd16646528bc81327cf90dd54
109 N68746b2d559a468f993545df743263f6
110 N9e94b8a28cc14b7389e188b141c2dcab
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042833891
112 https://doi.org/10.1007/s00432-016-2318-x
113 schema:sdDatePublished 2022-12-01T06:35
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher Nc7cd8723e6cb48d58dfd81bd4d5e80cd
116 schema:url https://doi.org/10.1007/s00432-016-2318-x
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N01a41b6f47064c9584578fcd0b43f8ef schema:affiliation grid-institutes:grid.51462.34
121 schema:familyName Abramson
122 schema:givenName David H.
123 rdf:type schema:Person
124 N0aecee1be33a428597c4203deb9cc5e6 schema:affiliation grid-institutes:grid.51462.34
125 schema:familyName Marr
126 schema:givenName Brian
127 rdf:type schema:Person
128 N10defc852f7443e883924179ff355ace schema:affiliation grid-institutes:grid.241116.1
129 schema:familyName Lewis
130 schema:givenName Karl
131 rdf:type schema:Person
132 N11a49859a4254fed9c0e7c8e1f492ff3 rdf:first sg:person.010434553207.49
133 rdf:rest N72e4560010994646a46b7c8ac2987a02
134 N151f62200226429d97de403168026088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Physicians
136 rdf:type schema:DefinedTerm
137 N176df5be774149bca47abdccc5631642 rdf:first sg:person.0625242133.07
138 rdf:rest N92f9a40310b446faadc6cb25e49fc512
139 N18a48b5fded44661a621113c54e6f127 schema:affiliation grid-institutes:grid.516096.d
140 schema:familyName Sosman
141 schema:givenName Jeffrey A.
142 rdf:type schema:Person
143 N19f35850391f438d91fa8675a5bd32cb schema:affiliation grid-institutes:grid.14003.36
144 schema:familyName Albertini
145 schema:givenName Mark R.
146 rdf:type schema:Person
147 N21c410ce4c3e41d89ac2b5a7f6f4a619 rdf:first sg:person.01121172646.82
148 rdf:rest N11a49859a4254fed9c0e7c8e1f492ff3
149 N234020dfd16646528bc81327cf90dd54 schema:name dimensions_id
150 schema:value pub.1042833891
151 rdf:type schema:PropertyValue
152 N26d4d3dfc1c1414fb139e60fe211e191 rdf:first N10defc852f7443e883924179ff355ace
153 rdf:rest Ndcae184a4b434f35b90be52bd96b1d8f
154 N29e8986ef9404f1caa8b13223cd96c74 rdf:first sg:person.01015127741.83
155 rdf:rest Neca7491071d3443da2b9fd0e2a60bd4f
156 N33ced0485b6547da96c973668a0f6f42 rdf:first N01a41b6f47064c9584578fcd0b43f8ef
157 rdf:rest Nc60caa67182748ea9b06f59b65471247
158 N3f9e678ffc1844feb46ed8cc02d312d8 schema:issueNumber 3
159 rdf:type schema:PublicationIssue
160 N4a628952b76b4b51972dc2087d3b3e99 rdf:first sg:person.01262567220.44
161 rdf:rest Nfde0f9d1bf714ebabcef58217a9c0545
162 N4e2b3c53d0844d99b15882d41c6dfd31 schema:volumeNumber 143
163 rdf:type schema:PublicationVolume
164 N5a21f09bff75492da3b8642ac8321391 schema:affiliation grid-institutes:grid.240283.f
165 schema:familyName Paucar
166 schema:givenName Daniel J.
167 rdf:type schema:Person
168 N5a222e94e6d54b849deb31453134eccd rdf:first Nf5392a4838dc4d288c054c02d1a221e0
169 rdf:rest N84ab8ebe89624e0686712c070b7ddcca
170 N61951e2e9cc4489e99d2941aa7a739d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Patient Reported Outcome Measures
172 rdf:type schema:DefinedTerm
173 N68746b2d559a468f993545df743263f6 schema:name pubmed_id
174 schema:value 27921276
175 rdf:type schema:PropertyValue
176 N70891b6a94b14647bbdee8bcf4203920 rdf:first sg:person.0774245543.30
177 rdf:rest Nf5f325ca7146498dac3f361af976a771
178 N725e5edab38741819351dcba1d363bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Middle Aged
180 rdf:type schema:DefinedTerm
181 N72e4560010994646a46b7c8ac2987a02 rdf:first N5a21f09bff75492da3b8642ac8321391
182 rdf:rest Ne9377bd51f064cdda34ab5fa1fd460f0
183 N803036c4d92b4040b4d3916df395092b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Aged
185 rdf:type schema:DefinedTerm
186 N84ab8ebe89624e0686712c070b7ddcca rdf:first sg:person.01220766140.50
187 rdf:rest N176df5be774149bca47abdccc5631642
188 N84e173882f2b4a1d9c5774753f4f0532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Drug-Related Side Effects and Adverse Reactions
190 rdf:type schema:DefinedTerm
191 N92f9a40310b446faadc6cb25e49fc512 rdf:first N19f35850391f438d91fa8675a5bd32cb
192 rdf:rest Ne5f3da22f7fe49a78a0741d05697efd6
193 N96be5e432b4c43de815dfecfcefbc67a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Humans
195 rdf:type schema:DefinedTerm
196 N9d8edd6889e141f5b0c7129285253d78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Benzimidazoles
198 rdf:type schema:DefinedTerm
199 N9e94b8a28cc14b7389e188b141c2dcab schema:name doi
200 schema:value 10.1007/s00432-016-2318-x
201 rdf:type schema:PropertyValue
202 Na2d0728d6c91487aa8cd914619acf7e2 rdf:first sg:person.0700352724.15
203 rdf:rest N5a222e94e6d54b849deb31453134eccd
204 Nab2f055b329a45e6a7f63fad516f71ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Uveal Neoplasms
206 rdf:type schema:DefinedTerm
207 Nbf6c887dcd7d412a859444bd9394a5c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Female
209 rdf:type schema:DefinedTerm
210 Nc10ff14dc3b84ac9832a2f5712aa4dee rdf:first sg:person.01001716007.11
211 rdf:rest Nc3df0aa268444e17afa77638f50f201f
212 Nc22b2bb02c454c11bc4c6d111a41e1d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Male
214 rdf:type schema:DefinedTerm
215 Nc2faea7f528f4f0091def769f43f35b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Melanoma
217 rdf:type schema:DefinedTerm
218 Nc3df0aa268444e17afa77638f50f201f rdf:first Nd9cec976cff94ecb9b024c6200c5b371
219 rdf:rest Ne7d96946f77f4266922eab4a942365ea
220 Nc536e840fa954ccebb7c40cf07bb0beb rdf:first sg:person.012707142152.08
221 rdf:rest Nd541f642c3cb405e93c727d68743b99e
222 Nc60caa67182748ea9b06f59b65471247 rdf:first sg:person.0756437553.23
223 rdf:rest Nc536e840fa954ccebb7c40cf07bb0beb
224 Nc7cd8723e6cb48d58dfd81bd4d5e80cd schema:name Springer Nature - SN SciGraph project
225 rdf:type schema:Organization
226 Ncd4b89425abb444390f30bf7bf45a3f8 rdf:first sg:person.01060637247.03
227 rdf:rest Na2d0728d6c91487aa8cd914619acf7e2
228 Nd541f642c3cb405e93c727d68743b99e rdf:first sg:person.0726366600.25
229 rdf:rest rdf:nil
230 Nd9cec976cff94ecb9b024c6200c5b371 schema:affiliation grid-institutes:grid.48336.3a
231 schema:familyName Doyle
232 schema:givenName Austin
233 rdf:type schema:Person
234 Ndaa4fbf592344731baee0edcfaef3eca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Adult
236 rdf:type schema:DefinedTerm
237 Ndcae184a4b434f35b90be52bd96b1d8f rdf:first N0aecee1be33a428597c4203deb9cc5e6
238 rdf:rest N33ced0485b6547da96c973668a0f6f42
239 Ne326f86e04ce44f68571df5e2b23f447 schema:affiliation grid-institutes:grid.265008.9
240 schema:familyName Sato
241 schema:givenName Takami
242 rdf:type schema:Person
243 Ne5f3da22f7fe49a78a0741d05697efd6 rdf:first Ne326f86e04ce44f68571df5e2b23f447
244 rdf:rest N26d4d3dfc1c1414fb139e60fe211e191
245 Ne7d96946f77f4266922eab4a942365ea rdf:first N18a48b5fded44661a621113c54e6f127
246 rdf:rest N4a628952b76b4b51972dc2087d3b3e99
247 Ne9377bd51f064cdda34ab5fa1fd460f0 rdf:first sg:person.016463010113.22
248 rdf:rest Nc10ff14dc3b84ac9832a2f5712aa4dee
249 Ne942521996134a8481c4de226da32be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Quality of Life
251 rdf:type schema:DefinedTerm
252 Neca7491071d3443da2b9fd0e2a60bd4f rdf:first sg:person.01207537147.58
253 rdf:rest N21c410ce4c3e41d89ac2b5a7f6f4a619
254 Nf5392a4838dc4d288c054c02d1a221e0 schema:affiliation grid-institutes:grid.516089.3
255 schema:familyName Lawson
256 schema:givenName David H.
257 rdf:type schema:Person
258 Nf5f325ca7146498dac3f361af976a771 rdf:first sg:person.0733064563.68
259 rdf:rest Ncd4b89425abb444390f30bf7bf45a3f8
260 Nfde0f9d1bf714ebabcef58217a9c0545 rdf:first sg:person.0655657210.70
261 rdf:rest N70891b6a94b14647bbdee8bcf4203920
262 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
263 schema:name Medical and Health Sciences
264 rdf:type schema:DefinedTerm
265 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
266 schema:name Clinical Sciences
267 rdf:type schema:DefinedTerm
268 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
269 schema:name Oncology and Carcinogenesis
270 rdf:type schema:DefinedTerm
271 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1007/s00432-016-2318-x
272 rdf:type schema:MonetaryGrant
273 sg:grant.2438861 http://pending.schema.org/fundedItem sg:pub.10.1007/s00432-016-2318-x
274 rdf:type schema:MonetaryGrant
275 sg:grant.2438872 http://pending.schema.org/fundedItem sg:pub.10.1007/s00432-016-2318-x
276 rdf:type schema:MonetaryGrant
277 sg:journal.1313647 schema:issn 0171-5216
278 1432-1335
279 schema:name Journal of Cancer Research and Clinical Oncology
280 schema:publisher Springer Nature
281 rdf:type schema:Periodical
282 sg:person.01001716007.11 schema:affiliation grid-institutes:grid.516089.3
283 schema:familyName Kudchadkar
284 schema:givenName Ragini R.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001716007.11
286 rdf:type schema:Person
287 sg:person.01015127741.83 schema:affiliation grid-institutes:grid.51462.34
288 schema:familyName Atkinson
289 schema:givenName Thomas M.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015127741.83
291 rdf:type schema:Person
292 sg:person.010434553207.49 schema:affiliation grid-institutes:grid.51462.34
293 schema:familyName Li
294 schema:givenName Yuelin
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010434553207.49
296 rdf:type schema:Person
297 sg:person.01060637247.03 schema:affiliation grid-institutes:grid.170205.1
298 schema:familyName Gajewski
299 schema:givenName Thomas F.
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060637247.03
301 rdf:type schema:Person
302 sg:person.01121172646.82 schema:affiliation grid-institutes:grid.51462.34
303 schema:familyName Shoushtari
304 schema:givenName Alexander
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121172646.82
306 rdf:type schema:Person
307 sg:person.01207537147.58 schema:affiliation grid-institutes:grid.51462.34
308 schema:familyName Hay
309 schema:givenName Jennifer L.
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207537147.58
311 rdf:type schema:Person
312 sg:person.01220766140.50 schema:affiliation grid-institutes:grid.214458.e
313 schema:familyName Lao
314 schema:givenName Christopher D.
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220766140.50
316 rdf:type schema:Person
317 sg:person.01262567220.44 schema:affiliation grid-institutes:grid.66875.3a
318 schema:familyName Quevedo
319 schema:givenName Jorge Fernando
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262567220.44
321 rdf:type schema:Person
322 sg:person.012707142152.08 schema:affiliation grid-institutes:grid.239585.0
323 schema:familyName Schwartz
324 schema:givenName Gary K.
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707142152.08
326 rdf:type schema:Person
327 sg:person.016463010113.22 schema:affiliation grid-institutes:grid.51462.34
328 schema:familyName Smith
329 schema:givenName Sloane C.
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016463010113.22
331 rdf:type schema:Person
332 sg:person.0625242133.07 schema:affiliation grid-institutes:grid.492844.7
333 schema:familyName Flynn
334 schema:givenName Patrick J.
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625242133.07
336 rdf:type schema:Person
337 sg:person.0655657210.70 schema:affiliation grid-institutes:grid.214572.7
338 schema:familyName Milhem
339 schema:givenName Mohammed M.
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655657210.70
341 rdf:type schema:Person
342 sg:person.0700352724.15 schema:affiliation grid-institutes:grid.410396.9
343 schema:familyName Lutzky
344 schema:givenName Jose
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700352724.15
346 rdf:type schema:Person
347 sg:person.0726366600.25 schema:affiliation grid-institutes:grid.239585.0
348 schema:familyName Carvajal
349 schema:givenName Richard D.
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25
351 rdf:type schema:Person
352 sg:person.0733064563.68 schema:affiliation grid-institutes:grid.412701.1
353 schema:familyName Linette
354 schema:givenName Gerald P.
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733064563.68
356 rdf:type schema:Person
357 sg:person.0756437553.23 schema:affiliation grid-institutes:grid.51462.34
358 schema:familyName Dickson
359 schema:givenName Mark Andrew
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756437553.23
361 rdf:type schema:Person
362 sg:person.0774245543.30 schema:affiliation grid-institutes:grid.415224.4
363 schema:familyName Joshua
364 schema:givenName Anthony M.
365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774245543.30
366 rdf:type schema:Person
367 sg:pub.10.1007/s00520-016-3297-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021957349
368 https://doi.org/10.1007/s00520-016-3297-9
369 rdf:type schema:CreativeWork
370 sg:pub.10.1007/s11136-013-0470-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018077371
371 https://doi.org/10.1007/s11136-013-0470-1
372 rdf:type schema:CreativeWork
373 sg:pub.10.1038/clpt.2010.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018135061
374 https://doi.org/10.1038/clpt.2010.79
375 rdf:type schema:CreativeWork
376 sg:pub.10.1038/nrclinonc.2015.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043404213
377 https://doi.org/10.1038/nrclinonc.2015.222
378 rdf:type schema:CreativeWork
379 grid-institutes:grid.14003.36 schema:alternateName Univeristy of Wisconsin School of Medicine and Public Health, Madison, WI, USA
380 schema:name Univeristy of Wisconsin School of Medicine and Public Health, Madison, WI, USA
381 rdf:type schema:Organization
382 grid-institutes:grid.170205.1 schema:alternateName University of Chicago, Chicago, IL, USA
383 schema:name University of Chicago, Chicago, IL, USA
384 rdf:type schema:Organization
385 grid-institutes:grid.214458.e schema:alternateName University of Michigan, Ann Arbor, MI, USA
386 schema:name University of Michigan, Ann Arbor, MI, USA
387 rdf:type schema:Organization
388 grid-institutes:grid.214572.7 schema:alternateName University of Iowa Carver College of Medicine, Iowa City, IA, USA
389 schema:name University of Iowa Carver College of Medicine, Iowa City, IA, USA
390 rdf:type schema:Organization
391 grid-institutes:grid.239585.0 schema:alternateName Columbia University Medical Center, New York, NY, USA
392 schema:name Columbia University Medical Center, New York, NY, USA
393 rdf:type schema:Organization
394 grid-institutes:grid.240283.f schema:alternateName Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY, USA
395 schema:name Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY, USA
396 rdf:type schema:Organization
397 grid-institutes:grid.241116.1 schema:alternateName University of Colorado – Denver, Denver, CO, USA
398 schema:name University of Colorado – Denver, Denver, CO, USA
399 rdf:type schema:Organization
400 grid-institutes:grid.265008.9 schema:alternateName Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
401 schema:name Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
402 rdf:type schema:Organization
403 grid-institutes:grid.410396.9 schema:alternateName Mount Sinai Medical Center, Miami Beach, FL, USA
404 schema:name Mount Sinai Medical Center, Miami Beach, FL, USA
405 rdf:type schema:Organization
406 grid-institutes:grid.412701.1 schema:alternateName Penn Medicine, Philadelphia, PA, USA
407 schema:name Penn Medicine, Philadelphia, PA, USA
408 rdf:type schema:Organization
409 grid-institutes:grid.415224.4 schema:alternateName Princess Margaret Hospital University Health Network, Toronto, ON, Canada
410 schema:name Princess Margaret Hospital University Health Network, Toronto, ON, Canada
411 rdf:type schema:Organization
412 grid-institutes:grid.48336.3a schema:alternateName Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA
413 schema:name Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA
414 rdf:type schema:Organization
415 grid-institutes:grid.492844.7 schema:alternateName Minnesota Oncology, Woodbury, MN, USA
416 schema:name Minnesota Oncology, Woodbury, MN, USA
417 rdf:type schema:Organization
418 grid-institutes:grid.51462.34 schema:alternateName Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA
419 schema:name Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave., 7th Floor, 10022, New York, NY, USA
420 rdf:type schema:Organization
421 grid-institutes:grid.516089.3 schema:alternateName Winship Cancer Institute of Emory University, Atlanta, GA, USA
422 schema:name Winship Cancer Institute of Emory University, Atlanta, GA, USA
423 rdf:type schema:Organization
424 grid-institutes:grid.516096.d schema:alternateName Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
425 schema:name Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
426 rdf:type schema:Organization
427 grid-institutes:grid.66875.3a schema:alternateName Mayo Clinic, Rochester, MN, USA
428 schema:name Mayo Clinic, Rochester, MN, USA
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...