High-risk clinicopathological features and their predictive significance in Korean patients with stage II colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-22

AUTHORS

Ji Soo Park, Hong Jae Chon, Hei-Cheul Jeung, Sang Joon Shin, Sun Young Rha, Joong Bae Ahn, Kang Young Lee, Nam Kyu Kim, Hyun Cheol Chung

ABSTRACT

PurposeWe investigated the prognostic factors for recurrence in Korean patients with stage II colon cancer and evaluated their predictive significance with 5-fluorouracil (FU)-based adjuvant chemotherapy.MethodsWe analyzed the relationship between clinicopathological features and relapse-free survival (RFS) of 716 stage II colon cancer patients who underwent curative resection. Predictive values were assessed using 5-year RFS and 5-year cancer-specific survival (CSS).ResultsThe 5-year RFS, 5-year CSS, 5-year disease-free survival, and 5-year overall survival rates were 87.4, 94.9, 84.8, and 90.5 %, respectively. T4 stage (hazard ratio [HR], 2.342; 95 % confidence interval [CI], 1.348–4.068; p = 0.003), preoperative bowel obstruction or perforation (HR 2.428; 95 % CI 1.241–4.752; p = 0.010), and age older than 70 years (HR 1.740; 95 % CI 1.130–2.678; p = 0.012) were poor prognostic factors for recurrence in multiple Cox regression analyses. In 60 patients with T4 disease, 5-FU-based adjuvant chemotherapy was associated with improved 5-year CSS of the patients (90.3 vs. 46.7 %; HR 0.135; 95 % CI 0.035–0.517; p = 0.003).ConclusionsWe found discordance between the risk factors for recurrence and the predictive value for 5-FU-based adjuvant chemotherapy in Korean patients with stage II colon cancer. Future prospective clinical trials selectively targeting high-risk patients are needed. More... »

PAGES

2051-2059

References to SciGraph publications

  • 2014-07-15. The role of adjuvant chemotherapy in stage II colorectal cancer patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
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    http://scigraph.springernature.com/pub.10.1007/s00432-016-2208-2

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    http://dx.doi.org/10.1007/s00432-016-2208-2

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    https://app.dimensions.ai/details/publication/pub.1017540212

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27447697


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