Adjuvant chemotherapy for soft tissue sarcomas: a 10-year mono-institutional experience View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03

AUTHORS

Antonella Brunello, Mario Domenico Rizzato, Marco Rastrelli, Anna Roma, Marco Maruzzo, Umberto Basso, Pasquale Fiduccia, Maria Samaritana Buzzaccarini, Giovanni Scarzello, Carlo Riccardo Rossi, Vittorina Zagonel

ABSTRACT

PURPOSE: The role of adjuvant chemotherapy (ACT) for soft tissue sarcomas (STS) is not standard practice. We investigated effectiveness and tolerability of ACT in patients (pts) with operated high-risk STS in clinical practice. METHODS: Medical records of pts with localized STS referred to Istituto Oncologico Veneto, Padova, from January 1, 2003 to July 07, 2012 were reviewed. Data were collected for pts with high-risk STS (size ≥5 cm, high grade and stage III). For those who received ACT, regimens used, drug doses, number of cycles, toxicity, and reasons for dose reduction or treatment interruption were recorded. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method. RESULTS: Out of 96 eligible pts, median age 62 years, 36 received ACT after loco-regional treatment. Median DFS was 29.6 months (95 % CI 13.2-46.0) in pts receiving ACT and 7.8 months (95 % CI 3.9-11.7) in untreated pts (p < 0.0001); median OS was 67.0 months (95 % CI 25.4-108.6) in treated and 33.7 months (95 % CI 23.3-44.2) in untreated pts (p = 0.005). Among pts receiving ACT, a significant difference in DFS was observed between pts with limb/girdle disease (median DFS 82.4 months; 95 % CI 0.0-184.7) and pts with other primary sites (median DFS 18.3 months; 95 % CI 8.0-28.5) (p = 0.052). Grade ≥3 toxicities occurred in 20 pts (20.8 %), leading to dose reductions, delays, and treatment discontinuation in five cases. There was no treatment-related death. CONCLUSION: Our data confirm benefit of ACT with regard to DFS and OS in pts with high-risk STS, greatest for limb/girdle STS. More... »

PAGES

679-685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4

DOI

http://dx.doi.org/10.1007/s00432-015-2065-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051133968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26547435


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This table displays all metadata directly associated to this object as RDF triples.

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