Adjuvant chemotherapy for soft tissue sarcomas: a 10-year mono-institutional experience View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03

AUTHORS

Antonella Brunello, Mario Domenico Rizzato, Marco Rastrelli, Anna Roma, Marco Maruzzo, Umberto Basso, Pasquale Fiduccia, Maria Samaritana Buzzaccarini, Giovanni Scarzello, Carlo Riccardo Rossi, Vittorina Zagonel

ABSTRACT

PURPOSE: The role of adjuvant chemotherapy (ACT) for soft tissue sarcomas (STS) is not standard practice. We investigated effectiveness and tolerability of ACT in patients (pts) with operated high-risk STS in clinical practice. METHODS: Medical records of pts with localized STS referred to Istituto Oncologico Veneto, Padova, from January 1, 2003 to July 07, 2012 were reviewed. Data were collected for pts with high-risk STS (size ≥5 cm, high grade and stage III). For those who received ACT, regimens used, drug doses, number of cycles, toxicity, and reasons for dose reduction or treatment interruption were recorded. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method. RESULTS: Out of 96 eligible pts, median age 62 years, 36 received ACT after loco-regional treatment. Median DFS was 29.6 months (95 % CI 13.2-46.0) in pts receiving ACT and 7.8 months (95 % CI 3.9-11.7) in untreated pts (p < 0.0001); median OS was 67.0 months (95 % CI 25.4-108.6) in treated and 33.7 months (95 % CI 23.3-44.2) in untreated pts (p = 0.005). Among pts receiving ACT, a significant difference in DFS was observed between pts with limb/girdle disease (median DFS 82.4 months; 95 % CI 0.0-184.7) and pts with other primary sites (median DFS 18.3 months; 95 % CI 8.0-28.5) (p = 0.052). Grade ≥3 toxicities occurred in 20 pts (20.8 %), leading to dose reductions, delays, and treatment discontinuation in five cases. There was no treatment-related death. CONCLUSION: Our data confirm benefit of ACT with regard to DFS and OS in pts with high-risk STS, greatest for limb/girdle STS. More... »

PAGES

679-685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4

DOI

http://dx.doi.org/10.1007/s00432-015-2065-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051133968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26547435


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epirubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ifosfamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soft Tissue Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Via Gattamelata 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunello", 
        "givenName": "Antonella", 
        "id": "sg:person.01166507035.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166507035.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Radiation Therapy Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rizzato", 
        "givenName": "Mario Domenico", 
        "id": "sg:person.01200374137.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200374137.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Melanoma and Sarcoma Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rastrelli", 
        "givenName": "Marco", 
        "id": "sg:person.01075267263.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075267263.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Via Gattamelata 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roma", 
        "givenName": "Anna", 
        "id": "sg:person.01302735435.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302735435.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Via Gattamelata 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maruzzo", 
        "givenName": "Marco", 
        "id": "sg:person.0715477107.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715477107.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Via Gattamelata 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "Umberto", 
        "id": "sg:person.01203712757.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203712757.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Clinical Trials and Biostatics Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fiduccia", 
        "givenName": "Pasquale", 
        "id": "sg:person.01120567126.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120567126.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Radiation Therapy Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buzzaccarini", 
        "givenName": "Maria Samaritana", 
        "id": "sg:person.0753560237.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753560237.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Radiation Therapy Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scarzello", 
        "givenName": "Giovanni", 
        "id": "sg:person.0717411455.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717411455.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Melanoma and Sarcoma Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Carlo Riccardo", 
        "id": "sg:person.013321165112.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV \u2013 IRCCS, Via Gattamelata 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zagonel", 
        "givenName": "Vittorina", 
        "id": "sg:person.0622706463.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622706463.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.11365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000222610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001337137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000073366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002440437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005813030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.37.7218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006575538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198209000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010528683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198209000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010528683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198209000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010528683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-200307000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011552203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-200307000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011552203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)08165-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014870691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015073140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-4296(03)00031-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017567845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-4296(03)00031-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017567845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021162382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021817259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70346-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027612064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-1739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036116543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036749848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1997.02824.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040859716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042541650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.1968.tb02103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045116797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198212000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045278392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198212000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045278392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050285662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cam4.209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051206305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800841213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054296553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.5.1238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074777227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.3.869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082882791"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-03", 
    "datePublishedReg": "2016-03-01", 
    "description": "PURPOSE: The role of adjuvant chemotherapy (ACT) for soft tissue sarcomas (STS) is not standard practice. We investigated effectiveness and tolerability of ACT in patients (pts) with operated high-risk STS in clinical practice.\nMETHODS: Medical records of pts with localized STS referred to Istituto Oncologico Veneto, Padova, from January 1, 2003 to July 07, 2012 were reviewed. Data were collected for pts with high-risk STS (size \u22655 cm, high grade and stage III). For those who received ACT, regimens used, drug doses, number of cycles, toxicity, and reasons for dose reduction or treatment interruption were recorded. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method.\nRESULTS: Out of 96 eligible pts, median age 62 years, 36 received ACT after loco-regional treatment. Median DFS was 29.6 months (95 % CI 13.2-46.0) in pts receiving ACT and 7.8 months (95 % CI 3.9-11.7) in untreated pts (p < 0.0001); median OS was 67.0 months (95 % CI 25.4-108.6) in treated and 33.7 months (95 % CI 23.3-44.2) in untreated pts (p = 0.005). Among pts receiving ACT, a significant difference in DFS was observed between pts with limb/girdle disease (median DFS 82.4 months; 95 % CI 0.0-184.7) and pts with other primary sites (median DFS 18.3 months; 95 % CI 8.0-28.5) (p = 0.052). Grade \u22653 toxicities occurred in 20 pts (20.8 %), leading to dose reductions, delays, and treatment discontinuation in five cases. There was no treatment-related death.\nCONCLUSION: Our data confirm benefit of ACT with regard to DFS and OS in pts with high-risk STS, greatest for limb/girdle STS.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-015-2065-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "142"
      }
    ], 
    "name": "Adjuvant chemotherapy for soft tissue sarcomas: a 10-year mono-institutional experience", 
    "pagination": "679-685", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f395605fb5e4c20f31a1d188ab363ebd5b8b66b09b3e04b3b15d7a2c31ec79bf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26547435"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-015-2065-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051133968"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-015-2065-4", 
      "https://app.dimensions.ai/details/publication/pub.1051133968"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88248_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00432-015-2065-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-015-2065-4'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      21 PREDICATES      70 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-015-2065-4 schema:about N0bd732f5061549e697891a1bce4fa50d
2 N10191d87087f49d2b6ca72468ec36be7
3 N1c0c832698c14e139596f13be788d16d
4 N229e9a0d004f45ecb56f909dfd89b173
5 N22fd48d65701426ca30480245458cd27
6 N33d6997d0407412788c519181894b192
7 N3463689e975b44478a5b16f6f25be8fa
8 N6674a45a533248daaa1986e7068160ff
9 N7a473f2085b5463c968b9dee543cf299
10 N7cde1a868b4844c1a43f5ae98783e3db
11 N918337b2cdef47cb8494c954b062b5fb
12 N9707181bd8ec435987bc7a9c694a3b80
13 Nbe9c4fcb904c4bba9223d157fed73a06
14 Ndbdde127bc9f45da96a981ffcf11ccbc
15 Ne0138a2270024c4e8f5ad7bdbfaa8382
16 Neb00b0952d3b4320823c4de85de734ee
17 anzsrc-for:11
18 anzsrc-for:1117
19 schema:author Nfe1dd4d29da0408d9e738f6b39e3d0b2
20 schema:citation https://doi.org/10.1002/bjs.1800841213
21 https://doi.org/10.1002/cam4.209
22 https://doi.org/10.1002/cncr.11365
23 https://doi.org/10.1002/cncr.23592
24 https://doi.org/10.1002/cncr.27555
25 https://doi.org/10.1002/cncr.28885
26 https://doi.org/10.1016/s0140-6736(97)08165-8
27 https://doi.org/10.1016/s1053-4296(03)00031-6
28 https://doi.org/10.1016/s1470-2045(12)70346-7
29 https://doi.org/10.1046/j.1365-2168.1997.02824.x
30 https://doi.org/10.1056/nejmra041866
31 https://doi.org/10.1093/annonc/mdh058
32 https://doi.org/10.1093/annonc/mds253
33 https://doi.org/10.1093/annonc/mdt031
34 https://doi.org/10.1093/annonc/mdu460
35 https://doi.org/10.1097/00000421-198212000-00014
36 https://doi.org/10.1097/00000658-198209000-00009
37 https://doi.org/10.1097/00002371-200307000-00001
38 https://doi.org/10.1111/j.1532-5415.1968.tb02103.x
39 https://doi.org/10.1158/0008-5472.can-13-1739
40 https://doi.org/10.1159/000073366
41 https://doi.org/10.1200/jco.1996.14.3.869
42 https://doi.org/10.1200/jco.2001.19.5.1238
43 https://doi.org/10.1200/jco.2011.37.7218
44 https://doi.org/10.3322/caac.21166
45 schema:datePublished 2016-03
46 schema:datePublishedReg 2016-03-01
47 schema:description PURPOSE: The role of adjuvant chemotherapy (ACT) for soft tissue sarcomas (STS) is not standard practice. We investigated effectiveness and tolerability of ACT in patients (pts) with operated high-risk STS in clinical practice. METHODS: Medical records of pts with localized STS referred to Istituto Oncologico Veneto, Padova, from January 1, 2003 to July 07, 2012 were reviewed. Data were collected for pts with high-risk STS (size ≥5 cm, high grade and stage III). For those who received ACT, regimens used, drug doses, number of cycles, toxicity, and reasons for dose reduction or treatment interruption were recorded. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method. RESULTS: Out of 96 eligible pts, median age 62 years, 36 received ACT after loco-regional treatment. Median DFS was 29.6 months (95 % CI 13.2-46.0) in pts receiving ACT and 7.8 months (95 % CI 3.9-11.7) in untreated pts (p < 0.0001); median OS was 67.0 months (95 % CI 25.4-108.6) in treated and 33.7 months (95 % CI 23.3-44.2) in untreated pts (p = 0.005). Among pts receiving ACT, a significant difference in DFS was observed between pts with limb/girdle disease (median DFS 82.4 months; 95 % CI 0.0-184.7) and pts with other primary sites (median DFS 18.3 months; 95 % CI 8.0-28.5) (p = 0.052). Grade ≥3 toxicities occurred in 20 pts (20.8 %), leading to dose reductions, delays, and treatment discontinuation in five cases. There was no treatment-related death. CONCLUSION: Our data confirm benefit of ACT with regard to DFS and OS in pts with high-risk STS, greatest for limb/girdle STS.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N1c49c60146f1441f89b2145c2cdbad69
52 N5837b9d8c8444bfcb59acfb2898431af
53 sg:journal.1313647
54 schema:name Adjuvant chemotherapy for soft tissue sarcomas: a 10-year mono-institutional experience
55 schema:pagination 679-685
56 schema:productId N18b131efcecc4fa7b7f9cb77ef87cc6f
57 N4e7be6c55e5346d8bd5253232136e010
58 N6ca4e84e2c9846399d115c4069e9ec87
59 Nb702cb72f55543069202b39ba4dbbcf8
60 Nbec165b4b6214ddfabd03ee703df7722
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051133968
62 https://doi.org/10.1007/s00432-015-2065-4
63 schema:sdDatePublished 2019-04-11T13:10
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N27f0b2c2e2d34d29b18ea0bce42d6ad7
66 schema:url http://link.springer.com/10.1007/s00432-015-2065-4
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N093e17ef78814a72b81fe8e50af4a86e schema:name Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128, Padua, Italy
71 rdf:type schema:Organization
72 N0bd732f5061549e697891a1bce4fa50d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Sarcoma
74 rdf:type schema:DefinedTerm
75 N10191d87087f49d2b6ca72468ec36be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Middle Aged
77 rdf:type schema:DefinedTerm
78 N10844379d91449ea8e2733c7195931c2 rdf:first sg:person.01075267263.75
79 rdf:rest Ne3f41fb5b2a145fda5b28962b17387e7
80 N12166f6fb0ee4d86bffb97e210b720c6 schema:name Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128, Padua, Italy
81 rdf:type schema:Organization
82 N18b131efcecc4fa7b7f9cb77ef87cc6f schema:name pubmed_id
83 schema:value 26547435
84 rdf:type schema:PropertyValue
85 N1c0c832698c14e139596f13be788d16d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Survival Analysis
87 rdf:type schema:DefinedTerm
88 N1c49c60146f1441f89b2145c2cdbad69 schema:issueNumber 3
89 rdf:type schema:PublicationIssue
90 N229e9a0d004f45ecb56f909dfd89b173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Humans
92 rdf:type schema:DefinedTerm
93 N22fd48d65701426ca30480245458cd27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Retrospective Studies
95 rdf:type schema:DefinedTerm
96 N24a9a61177184848994ae082dde755b3 rdf:first sg:person.0717411455.81
97 rdf:rest Nd1b511245e0a4878a9744f265d8a8755
98 N27f0b2c2e2d34d29b18ea0bce42d6ad7 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N33d6997d0407412788c519181894b192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Adult
102 rdf:type schema:DefinedTerm
103 N3463689e975b44478a5b16f6f25be8fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Ifosfamide
105 rdf:type schema:DefinedTerm
106 N4e7be6c55e5346d8bd5253232136e010 schema:name nlm_unique_id
107 schema:value 7902060
108 rdf:type schema:PropertyValue
109 N5837b9d8c8444bfcb59acfb2898431af schema:volumeNumber 142
110 rdf:type schema:PublicationVolume
111 N6060d8b251df4ccc9af9e12d43c793db rdf:first sg:person.01200374137.95
112 rdf:rest N10844379d91449ea8e2733c7195931c2
113 N6254ff88d2ca41a3a252673604a9f8cd rdf:first sg:person.01203712757.65
114 rdf:rest Nd4f90508f5614064b334a97e9640fe84
115 N6674a45a533248daaa1986e7068160ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Female
117 rdf:type schema:DefinedTerm
118 N6ca4e84e2c9846399d115c4069e9ec87 schema:name dimensions_id
119 schema:value pub.1051133968
120 rdf:type schema:PropertyValue
121 N6d90226cb6434860a2e650a53be15926 schema:name Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128, Padua, Italy
122 rdf:type schema:Organization
123 N7a473f2085b5463c968b9dee543cf299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Soft Tissue Neoplasms
125 rdf:type schema:DefinedTerm
126 N7cde1a868b4844c1a43f5ae98783e3db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Chemotherapy, Adjuvant
128 rdf:type schema:DefinedTerm
129 N914c0e4d91d4439fbce3042c02d11483 schema:name Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128, Padua, Italy
130 rdf:type schema:Organization
131 N918337b2cdef47cb8494c954b062b5fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged, 80 and over
133 rdf:type schema:DefinedTerm
134 N9697d6f90e8e4a9d9c41eb6e376a3c7f rdf:first sg:person.0715477107.17
135 rdf:rest N6254ff88d2ca41a3a252673604a9f8cd
136 N9707181bd8ec435987bc7a9c694a3b80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Young Adult
138 rdf:type schema:DefinedTerm
139 Na904492e2c0a413a97a5d71f5e6565bd schema:name Medical Oncology 1 Unit, Istituto Oncologico Veneto IOV – IRCCS, Via Gattamelata 64, 35128, Padua, Italy
140 rdf:type schema:Organization
141 Nb702cb72f55543069202b39ba4dbbcf8 schema:name doi
142 schema:value 10.1007/s00432-015-2065-4
143 rdf:type schema:PropertyValue
144 Nbc15de4aa76a41968eb9e538487b710b rdf:first sg:person.0753560237.45
145 rdf:rest N24a9a61177184848994ae082dde755b3
146 Nbe9c4fcb904c4bba9223d157fed73a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Male
148 rdf:type schema:DefinedTerm
149 Nbec165b4b6214ddfabd03ee703df7722 schema:name readcube_id
150 schema:value f395605fb5e4c20f31a1d188ab363ebd5b8b66b09b3e04b3b15d7a2c31ec79bf
151 rdf:type schema:PropertyValue
152 Ncb7fa9456f4e49209211dc76a890d04e rdf:first sg:person.0622706463.81
153 rdf:rest rdf:nil
154 Nd1b511245e0a4878a9744f265d8a8755 rdf:first sg:person.013321165112.41
155 rdf:rest Ncb7fa9456f4e49209211dc76a890d04e
156 Nd4f90508f5614064b334a97e9640fe84 rdf:first sg:person.01120567126.22
157 rdf:rest Nbc15de4aa76a41968eb9e538487b710b
158 Ndbdde127bc9f45da96a981ffcf11ccbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Antineoplastic Combined Chemotherapy Protocols
160 rdf:type schema:DefinedTerm
161 Ne0138a2270024c4e8f5ad7bdbfaa8382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Epirubicin
163 rdf:type schema:DefinedTerm
164 Ne3f41fb5b2a145fda5b28962b17387e7 rdf:first sg:person.01302735435.75
165 rdf:rest N9697d6f90e8e4a9d9c41eb6e376a3c7f
166 Neb00b0952d3b4320823c4de85de734ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Aged
168 rdf:type schema:DefinedTerm
169 Nfe1dd4d29da0408d9e738f6b39e3d0b2 rdf:first sg:person.01166507035.48
170 rdf:rest N6060d8b251df4ccc9af9e12d43c793db
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
175 schema:name Public Health and Health Services
176 rdf:type schema:DefinedTerm
177 sg:journal.1313647 schema:issn 0171-5216
178 1432-1335
179 schema:name Journal of Cancer Research and Clinical Oncology
180 rdf:type schema:Periodical
181 sg:person.01075267263.75 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
182 schema:familyName Rastrelli
183 schema:givenName Marco
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075267263.75
185 rdf:type schema:Person
186 sg:person.01120567126.22 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
187 schema:familyName Fiduccia
188 schema:givenName Pasquale
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120567126.22
190 rdf:type schema:Person
191 sg:person.01166507035.48 schema:affiliation Na904492e2c0a413a97a5d71f5e6565bd
192 schema:familyName Brunello
193 schema:givenName Antonella
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166507035.48
195 rdf:type schema:Person
196 sg:person.01200374137.95 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
197 schema:familyName Rizzato
198 schema:givenName Mario Domenico
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200374137.95
200 rdf:type schema:Person
201 sg:person.01203712757.65 schema:affiliation N093e17ef78814a72b81fe8e50af4a86e
202 schema:familyName Basso
203 schema:givenName Umberto
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203712757.65
205 rdf:type schema:Person
206 sg:person.01302735435.75 schema:affiliation N12166f6fb0ee4d86bffb97e210b720c6
207 schema:familyName Roma
208 schema:givenName Anna
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302735435.75
210 rdf:type schema:Person
211 sg:person.013321165112.41 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
212 schema:familyName Rossi
213 schema:givenName Carlo Riccardo
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41
215 rdf:type schema:Person
216 sg:person.0622706463.81 schema:affiliation N6d90226cb6434860a2e650a53be15926
217 schema:familyName Zagonel
218 schema:givenName Vittorina
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622706463.81
220 rdf:type schema:Person
221 sg:person.0715477107.17 schema:affiliation N914c0e4d91d4439fbce3042c02d11483
222 schema:familyName Maruzzo
223 schema:givenName Marco
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715477107.17
225 rdf:type schema:Person
226 sg:person.0717411455.81 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
227 schema:familyName Scarzello
228 schema:givenName Giovanni
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717411455.81
230 rdf:type schema:Person
231 sg:person.0753560237.45 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
232 schema:familyName Buzzaccarini
233 schema:givenName Maria Samaritana
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753560237.45
235 rdf:type schema:Person
236 https://doi.org/10.1002/bjs.1800841213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054296553
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/cam4.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051206305
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/cncr.11365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000222610
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/cncr.23592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001337137
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/cncr.27555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005813030
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/cncr.28885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042541650
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0140-6736(97)08165-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014870691
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s1053-4296(03)00031-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017567845
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s1470-2045(12)70346-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027612064
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1046/j.1365-2168.1997.02824.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040859716
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejmra041866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423872
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1093/annonc/mdh058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036749848
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/annonc/mds253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015073140
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1093/annonc/mdt031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021162382
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/annonc/mdu460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050285662
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/00000421-198212000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045278392
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/00000658-198209000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010528683
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/00002371-200307000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011552203
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1532-5415.1968.tb02103.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045116797
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1158/0008-5472.can-13-1739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036116543
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1159/000073366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002440437
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1200/jco.1996.14.3.869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082882791
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1200/jco.2001.19.5.1238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074777227
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1200/jco.2011.37.7218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006575538
283 rdf:type schema:CreativeWork
284 https://doi.org/10.3322/caac.21166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021817259
285 rdf:type schema:CreativeWork
286 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
287 schema:name Clinical Trials and Biostatics Unit, Istituto Oncologico Veneto IOV – IRCCS, Padua, Italy
288 Melanoma and Sarcoma Unit, Istituto Oncologico Veneto IOV – IRCCS, Padua, Italy
289 Radiation Therapy Unit, Istituto Oncologico Veneto IOV – IRCCS, Padua, Italy
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...