Outcome and toxicity profiles in the treatment of locally advanced lung cancer with volumetric modulated arc therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Marta Scorsetti, Piera Navarria, Fiorenza De Rose, AnnaMaria Ascolese, Elena Clerici, Ciro Franzese, Francesca Lobefalo, Giacomo Reggiori, Pietro Mancosu, Stefano Tomatis, Antonella Fogliata, Luca Cozzi

ABSTRACT

PURPOSE: To report about the outcome of radiation treatment of advanced lung cancer patients with volumetric modulated arcs [RapidArc (RA)]. PATIENTS AND METHODS: Seventy-five consecutive patients (all stages IIIA and IIIB) were treated with RA. Among them 71 % were men; 25.4 % presented unspecified non-small cell lung cancer, 41.3% adenocarcinoma and 33.3 % squamous cell carcinoma. Of them, 54.7 % received sequential chemotherapy while 45.3% were treated with concomitant regimen. Dose prescription ranged from 54 to 72 Gy. Analysis included survival, local control (LC) and toxicity profiles. RESULTS: Median follow-up was 21.2 months (range 6-75). One- two- and five-year actuarial LC was 91.9 ± 3.2, 79.5 ± 5.7 and 67.4 ± 9.5 %, respectively. Median survival was 19.0 ± 1.1 months. Actuarial survival at 1-2-5 years was 80.0 ± 4.6, 38.5 ± 5.9 and 15.2 ± 4.9 %, respectively. Acute toxicity of G2 was reported in 24, 25.3 and 4.0 % of patients for lung, esophageal and hematological profiles. A total of 2.7 % of patients reported G3 toxicity in the esophagus and 5.3 % of the patients experienced G3-G4 hematological toxicity. Significant differences were observed in all cases between concomitant and sequential chemotherapy regiments. Only 1.3 % (1 patient) showed G2 lung late toxicity. No significant correlation was found between toxicity and organ's irradiation levels. CONCLUSION: RA proved to be a safe and advantageous treatment modality for advanced lung cancer with results in line with expectations from earlier literature. More... »

PAGES

1937-1945

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-014-1739-7

DOI

http://dx.doi.org/10.1007/s00432-014-1739-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031943538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24934724


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-014-1739-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-014-1739-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-014-1739-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-014-1739-7'


 

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