Interval between neoadjuvant treatment and definitive surgery in locally advanced rectal cancer: impact on response and oncologic outcomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Felipe A. Calvo, Virginia Morillo, Marcos Santos, Javier Serrano, Marina Gomez-Espí, Marcos Rodriguez, Emilio del Vale, Jose Luis Gracia-Sabrido, Carlos Ferrer, Claudio Sole

ABSTRACT

PURPOSE: The optimal waiting period between neoadjuvant treatment completion and surgery in locally advanced rectal cancer (LARC) is controversial. The specific purpose of this study was to evaluate the effect of prolonging this interval on the pathologic response, postoperative morbidity, and long-term oncologic outcomes. METHODS: Retrospective data analysis is reported from LARC patients who had been treated with chemoradiation followed by surgery and intra-operative radiotherapy, between February 1995 and December 2012. In total, two groups were studied, according to the time elapsed between neoadjuvant treatment and surgery: conventional interval (CI; <6 weeks) and delayed interval (DI; ≥6 weeks). Clinicopathological data related to tumor response, postoperative morbidity, and oncologic outcomes were compared. RESULTS: This study included 335 consecutive LARC patients. There was a higher proportion of patients with clinical staging nodal involvement (cN+) in the DI group (76.6 vs. 64.1 %; p = 0.01). The pathologic complete response (pCR) was not significantly different among groups (8.8 vs. 12.1 %; p = 0.34). Longer intervals did not affect complication incidence or severity or hospital admission length. Certain postneoadjuvant tumor effect parameters were significantly increased in the DI group, including N-downstaging and T-downsizing. After a median follow-up of 71 months, patients in the DI group presented with superior 5-year overall survival (OS) (55.9 vs. 70.4 %, p = 0.014); however, no statistically significant differences were observed in 5-year disease-free survival (DFS) or 5-year local control (LC) (69.9 vs. 74.9 %, p = 0.223; 90.4 vs. 94.5 %, p = 0.123, respectively). CONCLUSIONS: A modest surgical interval delay (≥6 weeks) did not increase postoperative complications and was identified as a favorable prognostic factor for OS, although no differences were observed in pCR, LC, or DFS. Innovative multidisciplinary strategies incorporating further time extension of the surgical interval can be safely explored. More... »

PAGES

1651-1660

References to SciGraph publications

  • 2003-04. Longer Time Interval Between Completion of Neoadjuvant Chemoradiation and Surgical Resection Does Not Improve Downstaging of Rectal Carcinoma in DISEASES OF THE COLON & RECTUM
  • 2004-03. Rate of Pathologic Complete Response With Increased Interval Between Preoperative Combined Modality Therapy and Rectal Cancer Resection in DISEASES OF THE COLON & RECTUM
  • 2012-09. Complete Pathologic Response after Combined Modality Treatment for Rectal Cancer and Long-Term Survival: A Meta-Analysis in ANNALS OF SURGICAL ONCOLOGY
  • 2008-10. An Interval >7 Weeks between Neoadjuvant Therapy and Surgery Improves Pathologic Complete Response and Disease–Free Survival in Patients with Locally Advanced Rectal Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2014-03. Clinical tumour size and nodal status predict pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2014-02. Preoperative chemoradiation with or without induction oxaliplatin plus 5-fluorouracil in locally advanced rectal cancer in STRAHLENTHERAPIE UND ONKOLOGIE
  • 2007-05. Preoperative radiation therapy for locally advanced rectal cancer: a comparison between two different time intervals to surgery in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2011-03. Neoadjuvant Therapy for Rectal Cancer: The Impact of Longer Interval Between Chemoradiation and Surgery in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2012-09. Impact of Interval between Neoadjuvant Chemoradiotherapy and TME for Locally Advanced Rectal Cancer on Pathologic Response and Oncologic Outcome in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00432-014-1718-z

    DOI

    http://dx.doi.org/10.1007/s00432-014-1718-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049043231

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24880919


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