Prognostic factors associated with primary cancer in curatively resected stage IV colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-03

AUTHORS

Jung Wook Huh, Woo Yong Lee, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Ho-Kyung Chun

ABSTRACT

PURPOSE: The aim of this study is to evaluate the prognostic factors associated with primary cancer in patients with curatively resected stage IV colorectal cancer, based on lymph node status. METHODS: A total of 468 consecutive patients with curatively resected stage IV colorectal cancer from October 1994 to December 2010 were prospectively enrolled. Survival curves were constructed using the Kaplan-Meier method, and multivariate analysis assessed independent prognostic factors. RESULTS: During the median follow-up period of this study, which was 37 months (range 1-177), the 3- and 5-year overall survival rates were 66.5 and 52.1%, respectively, and the 3- and 5-year disease-free survival rates were 43.0 and 38.2%, respectively. According to multivariate analysis, adjuvant chemotherapy and the preoperative serum carcinoembryonic antigen (CEA) level were independent prognostic factors for overall survival, and primary tumor location and preoperative serum CEA level were independent variables for disease-free survival. For the patients with N0 and N1 tumors, the overall survival curves in the preoperative CEA groups differed significantly (P = 0.046 and P < 0.013, respectively). However, for patients with pN2 tumors, the overall survival did not differ significantly according to the preoperative CEA (P = 0.948). CONCLUSION: The preoperative serum CEA level is a reliable predictor of recurrence and survival after curative surgery in patients with metastatic colorectal cancer. A multidisciplinary approach that combines both complete resection and adjuvant chemotherapy may achieve improved overall survival in these patients. More... »

PAGES

435-441

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-013-1580-4

DOI

http://dx.doi.org/10.1007/s00432-013-1580-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045806678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24414039


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoembryonic Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huh", 
        "givenName": "Jung Wook", 
        "id": "sg:person.01310235260.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Woo Yong", 
        "id": "sg:person.01246232354.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246232354.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Yoon Ah", 
        "id": "sg:person.01073733706.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073733706.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Yong Beom", 
        "id": "sg:person.01316440011.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316440011.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yun", 
        "givenName": "Seong Hyeon", 
        "id": "sg:person.01036042356.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036042356.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hee Cheol", 
        "id": "sg:person.0727305260.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727305260.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sungkyunkwan University", 
          "id": "https://www.grid.ac/institutes/grid.264381.a", 
          "name": [
            "Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chun", 
        "givenName": "Ho-Kyung", 
        "id": "sg:person.01244247364.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244247364.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11605-011-1725-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002866874", 
          "https://doi.org/10.1007/s11605-011-1725-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.8353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012458227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-010-1250-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014243381", 
          "https://doi.org/10.1007/s11605-010-1250-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-010-1250-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014243381", 
          "https://doi.org/10.1007/s11605-010-1250-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.11.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015531339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018300332", 
          "https://doi.org/10.1038/sj.bjc.6605508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0168-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018395516", 
          "https://doi.org/10.1245/s10434-008-0168-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2007.05178.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019382229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-007-0315-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024254359", 
          "https://doi.org/10.1007/s00384-007-0315-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-007-0315-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024254359", 
          "https://doi.org/10.1007/s00384-007-0315-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-007-0315-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024254359", 
          "https://doi.org/10.1007/s00384-007-0315-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026128215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026128215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0217-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027039902", 
          "https://doi.org/10.1245/s10434-008-0217-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032122246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032122246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4975(98)00269-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045316606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02660770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048099669", 
          "https://doi.org/10.1007/bf02660770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02660770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048099669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra040958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048848178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.09.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051354561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076895666", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-03", 
    "datePublishedReg": "2014-03-01", 
    "description": "PURPOSE: The aim of this study is to evaluate the prognostic factors associated with primary cancer in patients with curatively resected stage IV colorectal cancer, based on lymph node status.\nMETHODS: A total of 468 consecutive patients with curatively resected stage IV colorectal cancer from October 1994 to December 2010 were prospectively enrolled. Survival curves were constructed using the Kaplan-Meier method, and multivariate analysis assessed independent prognostic factors.\nRESULTS: During the median follow-up period of this study, which was 37 months (range 1-177), the 3- and 5-year overall survival rates were 66.5 and 52.1%, respectively, and the 3- and 5-year disease-free survival rates were 43.0 and 38.2%, respectively. According to multivariate analysis, adjuvant chemotherapy and the preoperative serum carcinoembryonic antigen (CEA) level were independent prognostic factors for overall survival, and primary tumor location and preoperative serum CEA level were independent variables for disease-free survival. For the patients with N0 and N1 tumors, the overall survival curves in the preoperative CEA groups differed significantly (P = 0.046 and P < 0.013, respectively). However, for patients with pN2 tumors, the overall survival did not differ significantly according to the preoperative CEA (P = 0.948).\nCONCLUSION: The preoperative serum CEA level is a reliable predictor of recurrence and survival after curative surgery in patients with metastatic colorectal cancer. A multidisciplinary approach that combines both complete resection and adjuvant chemotherapy may achieve improved overall survival in these patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-013-1580-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "140"
      }
    ], 
    "name": "Prognostic factors associated with primary cancer in curatively resected stage IV colorectal cancer", 
    "pagination": "435-441", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "da324132a6d23b840c0d057961aff0bcb21a092bac76edfb97a4b0e980e75a71"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24414039"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-013-1580-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045806678"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-013-1580-4", 
      "https://app.dimensions.ai/details/publication/pub.1045806678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000491.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00432-013-1580-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-013-1580-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-013-1580-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-013-1580-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-013-1580-4'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      21 PREDICATES      77 URIs      49 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-013-1580-4 schema:about N10e8d4f673d24db08392e94aee1f3d99
2 N25aada9c3316458a9c79fb797a47838e
3 N312530a193194f598a5eae73a84f86a1
4 N32dc96c69b474462bd79a7fef7bc40ec
5 N384e7850288341f4aeadddcea852fc6c
6 N51aec21408494c05912541893cb607c9
7 N588d8c34d0724d8984bb5a412c577cee
8 N5add9679378441bd956926e2859e4c64
9 N71c6cbaf95fc415cb76a5853da8d2a60
10 N72c2426cd015495aa0ca98d1cd129dc6
11 N72d9502b986f4b368f2af782aeab93e3
12 N7695382c8f5f47519c53e05d3ee2975d
13 N793a9a3aa9cd4d898e85beb54ece4464
14 N7e72a8ac9aaf413e8d5936435d24ff9e
15 N8645aa65682542a3b0ba4e6163ef9e56
16 N868befed4c0944328fa8cbaec6dea77a
17 N8f3d3eeab30748ea9a0aeaf0f0e2dd16
18 N8f41b7749d75443f92c005dc39dc1ea1
19 N950215dbaefa436295aff9843567620b
20 Nbd3706c043074e85b265ecccfaeee030
21 Nd20b49b3560c40879fe0b96b5d45e54a
22 Nd3b89f497da947aa8a654ad726fe8482
23 Ndcad0fb4af3949f28ea4735afd27bf43
24 Ne336cd913ade472bb0de29db75c332c5
25 Ne74d6e68d7fc400aa2539848a6e295f1
26 Neda90e48e0a645d382306a87e0ed4142
27 Nf09eaabc50424433a4e6b89da11b03b3
28 Nf29de2df2e76414599fa27764bb0dad5
29 anzsrc-for:11
30 anzsrc-for:1112
31 schema:author N866f30c6d255471cadc31398688bb038
32 schema:citation sg:pub.10.1007/bf02660770
33 sg:pub.10.1007/s00384-007-0315-x
34 sg:pub.10.1007/s11605-010-1250-7
35 sg:pub.10.1007/s11605-011-1725-1
36 sg:pub.10.1038/sj.bjc.6605508
37 sg:pub.10.1245/s10434-008-0168-8
38 sg:pub.10.1245/s10434-008-0217-3
39 https://app.dimensions.ai/details/publication/pub.1076895666
40 https://doi.org/10.1002/jso.21495
41 https://doi.org/10.1007/bf02660770
42 https://doi.org/10.1016/s0003-4975(98)00269-0
43 https://doi.org/10.1056/nejmoa032691
44 https://doi.org/10.1056/nejmra040958
45 https://doi.org/10.1097/00000658-199909000-00004
46 https://doi.org/10.1097/01.sla.0000145964.08365.01
47 https://doi.org/10.1097/sla.0b013e31815aa2c2
48 https://doi.org/10.1111/j.1440-1746.2007.05178.x
49 https://doi.org/10.1200/jco.2004.09.046
50 https://doi.org/10.1200/jco.2004.11.069
51 https://doi.org/10.1200/jco.2006.06.8353
52 schema:datePublished 2014-03
53 schema:datePublishedReg 2014-03-01
54 schema:description PURPOSE: The aim of this study is to evaluate the prognostic factors associated with primary cancer in patients with curatively resected stage IV colorectal cancer, based on lymph node status. METHODS: A total of 468 consecutive patients with curatively resected stage IV colorectal cancer from October 1994 to December 2010 were prospectively enrolled. Survival curves were constructed using the Kaplan-Meier method, and multivariate analysis assessed independent prognostic factors. RESULTS: During the median follow-up period of this study, which was 37 months (range 1-177), the 3- and 5-year overall survival rates were 66.5 and 52.1%, respectively, and the 3- and 5-year disease-free survival rates were 43.0 and 38.2%, respectively. According to multivariate analysis, adjuvant chemotherapy and the preoperative serum carcinoembryonic antigen (CEA) level were independent prognostic factors for overall survival, and primary tumor location and preoperative serum CEA level were independent variables for disease-free survival. For the patients with N0 and N1 tumors, the overall survival curves in the preoperative CEA groups differed significantly (P = 0.046 and P < 0.013, respectively). However, for patients with pN2 tumors, the overall survival did not differ significantly according to the preoperative CEA (P = 0.948). CONCLUSION: The preoperative serum CEA level is a reliable predictor of recurrence and survival after curative surgery in patients with metastatic colorectal cancer. A multidisciplinary approach that combines both complete resection and adjuvant chemotherapy may achieve improved overall survival in these patients.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N7a3d1a96642d468cbf8ea4856aefe99d
59 N893ccbd67f6d475d9adbef192bbae411
60 sg:journal.1313647
61 schema:name Prognostic factors associated with primary cancer in curatively resected stage IV colorectal cancer
62 schema:pagination 435-441
63 schema:productId N4a95e2425d264a3e9c24df9cce3e3630
64 N5894080ad4e74ac9a6095518d0345a25
65 N5a6117571d1c4b46910e93ae216357e0
66 Ncc19f76f46ac408aa035fe80edf8f80e
67 Neb348c068a97456d83419d382770ec78
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045806678
69 https://doi.org/10.1007/s00432-013-1580-4
70 schema:sdDatePublished 2019-04-10T21:32
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N1776fd5b0b844c20aaae46bb1b3c4ebd
73 schema:url http://link.springer.com/10.1007/s00432-013-1580-4
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0e12e6d23ad94368bef866bd9fdd2ac3 schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
78 rdf:type schema:Organization
79 N10e8d4f673d24db08392e94aee1f3d99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Neoplasm Staging
81 rdf:type schema:DefinedTerm
82 N1776fd5b0b844c20aaae46bb1b3c4ebd schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N1c5dff881b1d44ac83d21b3369660fd3 schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
85 rdf:type schema:Organization
86 N24bbd95e3c8945cf837f8d3ae160ce83 schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
87 rdf:type schema:Organization
88 N25aada9c3316458a9c79fb797a47838e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Organoplatinum Compounds
90 rdf:type schema:DefinedTerm
91 N25daad811893448cbf29a9ffaf927151 rdf:first sg:person.01246232354.83
92 rdf:rest Ndf27382bb13749068272951d10f22925
93 N312530a193194f598a5eae73a84f86a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Adult
95 rdf:type schema:DefinedTerm
96 N32dc96c69b474462bd79a7fef7bc40ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Risk Factors
98 rdf:type schema:DefinedTerm
99 N360ec8c62dc54bc88f566814c98a5616 rdf:first sg:person.01316440011.46
100 rdf:rest N793b03f179814da1b4609f94d0d987d6
101 N384e7850288341f4aeadddcea852fc6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Lymphatic Metastasis
103 rdf:type schema:DefinedTerm
104 N41e25d9732bc4a329a0f99322767943c schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
105 rdf:type schema:Organization
106 N455cebb42dee43aca3066f35342bd51b rdf:first sg:person.01244247364.49
107 rdf:rest rdf:nil
108 N4a95e2425d264a3e9c24df9cce3e3630 schema:name readcube_id
109 schema:value da324132a6d23b840c0d057961aff0bcb21a092bac76edfb97a4b0e980e75a71
110 rdf:type schema:PropertyValue
111 N51aec21408494c05912541893cb607c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Camptothecin
113 rdf:type schema:DefinedTerm
114 N588d8c34d0724d8984bb5a412c577cee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Female
116 rdf:type schema:DefinedTerm
117 N5894080ad4e74ac9a6095518d0345a25 schema:name dimensions_id
118 schema:value pub.1045806678
119 rdf:type schema:PropertyValue
120 N5a6117571d1c4b46910e93ae216357e0 schema:name nlm_unique_id
121 schema:value 7902060
122 rdf:type schema:PropertyValue
123 N5add9679378441bd956926e2859e4c64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Magnetic Resonance Imaging
125 rdf:type schema:DefinedTerm
126 N71c6cbaf95fc415cb76a5853da8d2a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Aged
128 rdf:type schema:DefinedTerm
129 N72c2426cd015495aa0ca98d1cd129dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Colorectal Neoplasms
131 rdf:type schema:DefinedTerm
132 N72d9502b986f4b368f2af782aeab93e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Disease-Free Survival
134 rdf:type schema:DefinedTerm
135 N7695382c8f5f47519c53e05d3ee2975d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Positron-Emission Tomography
137 rdf:type schema:DefinedTerm
138 N793a9a3aa9cd4d898e85beb54ece4464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Middle Aged
140 rdf:type schema:DefinedTerm
141 N793b03f179814da1b4609f94d0d987d6 rdf:first sg:person.01036042356.80
142 rdf:rest N9a2ef4df0792476b92c25cb608a8884f
143 N7a32ddff9b7341f991c53b6ab5f74994 schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
144 rdf:type schema:Organization
145 N7a3d1a96642d468cbf8ea4856aefe99d schema:volumeNumber 140
146 rdf:type schema:PublicationVolume
147 N7e72a8ac9aaf413e8d5936435d24ff9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Antineoplastic Combined Chemotherapy Protocols
149 rdf:type schema:DefinedTerm
150 N8645aa65682542a3b0ba4e6163ef9e56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Tomography, X-Ray Computed
152 rdf:type schema:DefinedTerm
153 N866f30c6d255471cadc31398688bb038 rdf:first sg:person.01310235260.89
154 rdf:rest N25daad811893448cbf29a9ffaf927151
155 N868befed4c0944328fa8cbaec6dea77a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Predictive Value of Tests
157 rdf:type schema:DefinedTerm
158 N893ccbd67f6d475d9adbef192bbae411 schema:issueNumber 3
159 rdf:type schema:PublicationIssue
160 N8f3d3eeab30748ea9a0aeaf0f0e2dd16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Lymph Nodes
162 rdf:type schema:DefinedTerm
163 N8f41b7749d75443f92c005dc39dc1ea1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Multivariate Analysis
165 rdf:type schema:DefinedTerm
166 N950215dbaefa436295aff9843567620b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Aged, 80 and over
168 rdf:type schema:DefinedTerm
169 N99cae0542a034dd5b989bf415c8ede5b schema:name Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-710, Seoul, Korea
170 rdf:type schema:Organization
171 N9a2ef4df0792476b92c25cb608a8884f rdf:first sg:person.0727305260.27
172 rdf:rest N455cebb42dee43aca3066f35342bd51b
173 Nbd3706c043074e85b265ecccfaeee030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Fluorouracil
175 rdf:type schema:DefinedTerm
176 Ncc19f76f46ac408aa035fe80edf8f80e schema:name doi
177 schema:value 10.1007/s00432-013-1580-4
178 rdf:type schema:PropertyValue
179 Nd20b49b3560c40879fe0b96b5d45e54a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 Nd3b89f497da947aa8a654ad726fe8482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Kaplan-Meier Estimate
184 rdf:type schema:DefinedTerm
185 Ndcad0fb4af3949f28ea4735afd27bf43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Prognosis
187 rdf:type schema:DefinedTerm
188 Ndf27382bb13749068272951d10f22925 rdf:first sg:person.01073733706.95
189 rdf:rest N360ec8c62dc54bc88f566814c98a5616
190 Ne336cd913ade472bb0de29db75c332c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Male
192 rdf:type schema:DefinedTerm
193 Ne74d6e68d7fc400aa2539848a6e295f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Carcinoembryonic Antigen
195 rdf:type schema:DefinedTerm
196 Neb348c068a97456d83419d382770ec78 schema:name pubmed_id
197 schema:value 24414039
198 rdf:type schema:PropertyValue
199 Neda90e48e0a645d382306a87e0ed4142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Retrospective Studies
201 rdf:type schema:DefinedTerm
202 Nf09eaabc50424433a4e6b89da11b03b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Biomarkers, Tumor
204 rdf:type schema:DefinedTerm
205 Nf29de2df2e76414599fa27764bb0dad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Chemotherapy, Adjuvant
207 rdf:type schema:DefinedTerm
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:journal.1313647 schema:issn 0171-5216
215 1432-1335
216 schema:name Journal of Cancer Research and Clinical Oncology
217 rdf:type schema:Periodical
218 sg:person.01036042356.80 schema:affiliation N7a32ddff9b7341f991c53b6ab5f74994
219 schema:familyName Yun
220 schema:givenName Seong Hyeon
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036042356.80
222 rdf:type schema:Person
223 sg:person.01073733706.95 schema:affiliation N99cae0542a034dd5b989bf415c8ede5b
224 schema:familyName Park
225 schema:givenName Yoon Ah
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073733706.95
227 rdf:type schema:Person
228 sg:person.01244247364.49 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
229 schema:familyName Chun
230 schema:givenName Ho-Kyung
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244247364.49
232 rdf:type schema:Person
233 sg:person.01246232354.83 schema:affiliation N1c5dff881b1d44ac83d21b3369660fd3
234 schema:familyName Lee
235 schema:givenName Woo Yong
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246232354.83
237 rdf:type schema:Person
238 sg:person.01310235260.89 schema:affiliation N0e12e6d23ad94368bef866bd9fdd2ac3
239 schema:familyName Huh
240 schema:givenName Jung Wook
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89
242 rdf:type schema:Person
243 sg:person.01316440011.46 schema:affiliation N41e25d9732bc4a329a0f99322767943c
244 schema:familyName Cho
245 schema:givenName Yong Beom
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316440011.46
247 rdf:type schema:Person
248 sg:person.0727305260.27 schema:affiliation N24bbd95e3c8945cf837f8d3ae160ce83
249 schema:familyName Kim
250 schema:givenName Hee Cheol
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727305260.27
252 rdf:type schema:Person
253 sg:pub.10.1007/bf02660770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048099669
254 https://doi.org/10.1007/bf02660770
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s00384-007-0315-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024254359
257 https://doi.org/10.1007/s00384-007-0315-x
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s11605-010-1250-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014243381
260 https://doi.org/10.1007/s11605-010-1250-7
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s11605-011-1725-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002866874
263 https://doi.org/10.1007/s11605-011-1725-1
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.bjc.6605508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018300332
266 https://doi.org/10.1038/sj.bjc.6605508
267 rdf:type schema:CreativeWork
268 sg:pub.10.1245/s10434-008-0168-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018395516
269 https://doi.org/10.1245/s10434-008-0168-8
270 rdf:type schema:CreativeWork
271 sg:pub.10.1245/s10434-008-0217-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027039902
272 https://doi.org/10.1245/s10434-008-0217-3
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1076895666 schema:CreativeWork
275 https://doi.org/10.1002/jso.21495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032122246
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1007/bf02660770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048099669
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0003-4975(98)00269-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045316606
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejmra040958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848178
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/00000658-199909000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060135098
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1097/01.sla.0000145964.08365.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022055193
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/sla.0b013e31815aa2c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026128215
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1440-1746.2007.05178.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019382229
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1200/jco.2004.09.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051354561
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1200/jco.2004.11.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015531339
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1200/jco.2006.06.8353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012458227
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.264381.a schema:alternateName Sungkyunkwan University
300 schema:name Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...