Survival of infiltrative hepatocellular carcinoma patients with preserved hepatic function after treatment with transarterial chemoembolization View Full Text


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Article Info

DATE

2013-04

AUTHORS

Eun Sun Jang, Jung-Hwan Yoon, Jin Wook Chung, Eun Ju Cho, Su Jong Yu, Jeong-Hoon Lee, Yoon Jun Kim, Hyo-Suk Lee, Chung Yong Kim

ABSTRACT

PURPOSE: Transarterial chemoembolization (TACE) is highly effective and safe therapeutic modality for unresectable hepatocellular carcinoma (HCC). However, the role of TACE for infiltrative HCC has never been elucidated owing to the concern about hepatic failure and subsequent mortality after the procedure. In this study, we aimed to document whether patients with infiltrative HCC would benefit from TACE. METHODS: Child-Pugh class A/B patients who were newly diagnosed as infiltrative HCC and treated with curative-intent TACE were enrolled. All radiological images were reviewed by a radiologist with more than 20 years of experience in TACE. RESULTS: Among 1,184 patients newly diagnosed as HCC, 233 (19.7 %) had infiltrative-type tumors and 128 (54.9 %) underwent curative-intent TACE. Although the median overall survival was 5.4 months (IQR 3.1-13.9 months) and 16 (12.5 %) patients had experienced significant complications, 19 (15.9 %) patients survived more than 2 years after the first diagnosis. In multivariable analysis, age >60 years old (HR 0.54, 95 % CI 0.31-0.92), Child-Pugh class A (HR 0.48, 95 % CI 0.30-0.76), and a major PVT without parasitic supply (HR 0.66, 95 % CI 0.44-0.99) were independent favorable prognostic factors. Development of significant complication after TACE was a significant hazard factor of survival (HR 1.99, 95 % CI 1.09-3.62). CONCLUSIONS: In carefully selected patients with preserved hepatic function and good performance, TACE may achieve long-term survival of infiltrative HCC patients with major PVT without parasitic supply. However, the risk of morbidity and immediate mortality after TACE should be considered to select subjects for the procedure. More... »

PAGES

635-643

References to SciGraph publications

  • 2011-11. Infiltrating Hepatocellular Carcinoma: Seeing the Tree through the Forest in JOURNAL OF GASTROINTESTINAL SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00432-012-1364-2

    DOI

    http://dx.doi.org/10.1007/s00432-012-1364-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003249866

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23283527


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