Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12

AUTHORS

Ma Yuxia, Tian Zhennan, Zhang Wei

ABSTRACT

PURPOSE: MicroRNAs are small, non-coding RNAs that are critical regulators of various diseases including cancer, and may represent a novel class of cancer biomarkers. Recent reports have highlighted the oncogenic aspects of miR-125b. However, the level and clinical relevance of circulating miR-125b transcripts in human serum of non-small-cell lung cancer (NSCLC) patients are unclear. The purpose of this study was to identify circulating miR-125b transcripts in human serum for use as a biomarker for stratification and prediction of prognosis in NSCLC. METHODS: We analyzed serum levels of miR-125b in 193 patients with different stages of NSCLC. Blood samples were collected before surgery and therapy. Quantitative reverse transcription-polymerase chain reaction of circulating miR-125b transcripts was performed directly in serum to improve the efficiency of miRNA assessment. Receiver operating characteristic analysis was used to evaluate the sensitivity and specificity of serum miR-125b. RESULTS: We found that serum miR-125b was consistently expressed in the non-tumor group and was significantly associated with NSCLC stage. miR-125b expression was capable of separating NSCLC patients from control groups with an area under the curve of 0.786. Furthermore, patients with high miR-125b expression displayed a significantly poorer prognosis compared with patients with low expression (p < 0.0001). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. CONCLUSIONS: We propose that serum miR-125b may represent a novel biomarker in NSCLC patients and that high miR-125b expression is an independent prognostic factor for survival. More... »

PAGES

2045-2050

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-012-1285-0

DOI

http://dx.doi.org/10.1007/s00432-012-1285-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032615259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22806310


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