N-myc downstream-regulated gene 1/Cap43 may function as tumor suppressor in endometrial cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Xiu-Hong Lv, Jia-Wei Chen, Gang Zhao, Zhen-Zhong Feng, Dao-Hua Yang, Wei-Wei Sun, Jin-Shuang Fan, Guang-Hui Zhu

ABSTRACT

PURPOSE: N-myc downstream-regulated gene 1 (NDRG1) reportedly regulates tumor progression in various cancers. Our previous studies showed that NDRG1 was aberrantly overexpressed in human endometrial cancer tissues. The purpose of the present study was to investigate the role of NDRG1 in endometrial carcinogenesis. METHODS: A short hairpin RNA (shRNA)-mediated gene silencing strategy was employed to stably suppress the expression of NDRG1 in endometrial cancer Ishikawa cells. The influence of NDRG1 silencing on cancer cell biological behaviors was examined through observing in vitro tumor cell proliferation, colony formation, cell migration and invasion. Moreover, the mammalian NDRG1 expression vector pcDNA3.1(+)/NDRG1 was constructed to determine the effects of NDRG1 overexpression on cell proliferation and migration. Additionally, gene expression microarray analysis was conducted to identify NDRG1 downstream target genes after NDRG1 knockdown. RESULTS: It was demonstrated that NDRG1 knockdown significantly enhanced Ishikawa cell proliferation and dramatically promoted cell migration and invasion. Furthermore, overexpression of NDRG1 in Ishikawa cells greatly inhibited cell proliferation and migration. Through microarray analysis and data mining, a large cohort of NDRG1-repressed target genes were identified. Additionally, through comparing the current microarray results with those obtained previously in studies of cervical and ovarian cancer cells conducted by us, 19 more specific common downstream target genes were identified. CONCLUSIONS: It was demonstrated that NDRG1 might carry out a tumor suppressor function during endometrial carcinogenesis. The identification of downstream target genes should afford meaningful hints for prospective investigations. The tumor suppressor function of NDRG1 may open a new window for the target therapy of endometrial cancer. More... »

PAGES

1703-1715

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-012-1249-4

DOI

http://dx.doi.org/10.1007/s00432-012-1249-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007189859

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22678098


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Growth Processes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometrial Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai University", 
          "id": "https://www.grid.ac/institutes/grid.39436.3b", 
          "name": [
            "Department of Pathology, Shanghai Jiaotong University Affiliated Shanghai First People\u2019s Hospital, NO.85, Wujin Road, 200080, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Xiu-Hong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University", 
          "id": "https://www.grid.ac/institutes/grid.39436.3b", 
          "name": [
            "Department of Pathology, Shanghai Jiaotong University Affiliated Shanghai First People\u2019s Hospital, NO.85, Wujin Road, 200080, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jia-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, 300060, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Gang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, Bengbu Medical College, 233030, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Zhen-Zhong", 
        "id": "sg:person.01200601705.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Shanghai Jiaotong University Affiliated Songjiang Hospital, 201601, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Dao-Hua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Shanghai Jiaotong University Affiliated Songjiang Hospital, 201601, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Wei-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Si Jing Hospital, Songjiang District, 201601, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Jin-Shuang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai University", 
          "id": "https://www.grid.ac/institutes/grid.39436.3b", 
          "name": [
            "Department of General Surgery, Shanghai Jiaotong University Affiliated Shanghai First People\u2019s Hospital, 200080, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Guang-Hui", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2008.00749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000485509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001413423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)00845-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003826327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2011.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005307130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2007.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005378520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006475926", 
          "https://doi.org/10.1038/bjc.2011.68"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.098301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006920457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgr046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006946279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.144477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008332336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgl146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008362487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011025415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015202168", 
          "https://doi.org/10.1038/sj.onc.1204422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015202168", 
          "https://doi.org/10.1038/sj.onc.1204422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019622244", 
          "https://doi.org/10.1038/sj.onc.1207734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019622244", 
          "https://doi.org/10.1038/sj.onc.1207734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drup.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023336771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0867-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023661058", 
          "https://doi.org/10.1007/s10549-010-0867-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024165469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2010.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025014146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025689414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2156-5-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028374821", 
          "https://doi.org/10.1186/1471-2156-5-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2006.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028785554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3802/jgo.2009.20.2.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031164466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.232637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034463971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036602206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2002.tb01340.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037171543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2002.tb01340.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037171543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2008.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039995037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2011.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040367101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041049106", 
          "https://doi.org/10.1038/sj.onc.1210914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-6-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041873236", 
          "https://doi.org/10.1186/1471-2164-6-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2011.03.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043430693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043613573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043613573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme-10-0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048666718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.10.6388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051236114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051915418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357907.2011.568565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052398001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058610524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jwh.2010.2529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059291708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.17.6.1301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071530436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075271930", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "PURPOSE: N-myc downstream-regulated gene 1 (NDRG1) reportedly regulates tumor progression in various cancers. Our previous studies showed that NDRG1 was aberrantly overexpressed in human endometrial cancer tissues. The purpose of the present study was to investigate the role of NDRG1 in endometrial carcinogenesis.\nMETHODS: A short hairpin RNA (shRNA)-mediated gene silencing strategy was employed to stably suppress the expression of NDRG1 in endometrial cancer Ishikawa cells. The influence of NDRG1 silencing on cancer cell biological behaviors was examined through observing in vitro tumor cell proliferation, colony formation, cell migration and invasion. Moreover, the mammalian NDRG1 expression vector pcDNA3.1(+)/NDRG1 was constructed to determine the effects of NDRG1 overexpression on cell proliferation and migration. Additionally, gene expression microarray analysis was conducted to identify NDRG1 downstream target genes after NDRG1 knockdown.\nRESULTS: It was demonstrated that NDRG1 knockdown significantly enhanced Ishikawa cell proliferation and dramatically promoted cell migration and invasion. Furthermore, overexpression of NDRG1 in Ishikawa cells greatly inhibited cell proliferation and migration. Through microarray analysis and data mining, a large cohort of NDRG1-repressed target genes were identified. Additionally, through comparing the current microarray results with those obtained previously in studies of cervical and ovarian cancer cells conducted by us, 19 more specific common downstream target genes were identified.\nCONCLUSIONS: It was demonstrated that NDRG1 might carry out a tumor suppressor function during endometrial carcinogenesis. The identification of downstream target genes should afford meaningful hints for prospective investigations. The tumor suppressor function of NDRG1 may open a new window for the target therapy of endometrial cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-012-1249-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "138"
      }
    ], 
    "name": "N-myc downstream-regulated gene 1/Cap43 may function as tumor suppressor in endometrial cancer", 
    "pagination": "1703-1715", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "223f2e42c3edea15e96bffc0114c634f3e33c0374d3a4cf8996a2c87ad718326"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22678098"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-012-1249-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007189859"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-012-1249-4", 
      "https://app.dimensions.ai/details/publication/pub.1007189859"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00432-012-1249-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-012-1249-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-012-1249-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-012-1249-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-012-1249-4'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      82 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-012-1249-4 schema:about N10e6aa670fd24f749c3bbd358fd83067
2 N22104a36f4654a2db4051b2eae5757d4
3 N350a455ac4804b39a1077b701fb33280
4 N3f597bf85ee045249946d09148fcdbfb
5 N724619339ef447a6856d0f3ff1d26249
6 N7392f999f9b1491b8990740913a94d37
7 N7cd50340a0e34ce3911477e2485bf7ed
8 N876ab531455145d2a9e5c75b1381bad8
9 N8a91759ca7964bddb2c9c1ae24163153
10 Nd1188f215e33480e954fd2cef8ff7b4f
11 Nd1da5a55155d4257a5083a805a5f7abc
12 Nd5d6001d29934e00b90ad2f10019107d
13 Nd8a020e313b141ebb1d7dad9e840f2cd
14 Ndac00242857c4b939ee2aab86e389962
15 Ne9c64b5036f346a69e8ea3f014b392fe
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N7ccd50ee1cdd443f86b1d920ab3918dc
19 schema:citation sg:pub.10.1007/s10549-010-0867-2
20 sg:pub.10.1038/bjc.2011.68
21 sg:pub.10.1038/sj.onc.1204422
22 sg:pub.10.1038/sj.onc.1207734
23 sg:pub.10.1038/sj.onc.1210914
24 sg:pub.10.1186/1471-2156-5-27
25 sg:pub.10.1186/1471-2164-6-11
26 https://app.dimensions.ai/details/publication/pub.1075271930
27 https://doi.org/10.1016/j.bbrc.2011.03.140
28 https://doi.org/10.1016/j.canlet.2007.12.010
29 https://doi.org/10.1016/j.canlet.2011.06.001
30 https://doi.org/10.1016/j.cellsig.2006.09.004
31 https://doi.org/10.1016/j.drup.2008.08.005
32 https://doi.org/10.1016/j.leukres.2008.10.016
33 https://doi.org/10.1016/j.surg.2010.11.002
34 https://doi.org/10.1016/j.ygyno.2011.07.003
35 https://doi.org/10.1016/s0014-5793(99)00845-5
36 https://doi.org/10.1042/bj20040867
37 https://doi.org/10.1074/jbc.274.10.6388
38 https://doi.org/10.1074/jbc.m109.098301
39 https://doi.org/10.1074/jbc.m110.144477
40 https://doi.org/10.1074/jbc.m111.232637
41 https://doi.org/10.1086/302978
42 https://doi.org/10.1089/jwh.2010.2529
43 https://doi.org/10.1093/carcin/bgl146
44 https://doi.org/10.1093/carcin/bgr046
45 https://doi.org/10.1111/j.1349-7006.2002.tb01340.x
46 https://doi.org/10.1111/j.1349-7006.2008.00749.x
47 https://doi.org/10.1158/0008-5472.can-04-1623
48 https://doi.org/10.1158/0008-5472.can-06-0183
49 https://doi.org/10.1158/0008-5472.can-06-0943
50 https://doi.org/10.1158/0008-5472.can-08-4882
51 https://doi.org/10.1158/1078-0432.ccr-05-1962
52 https://doi.org/10.1371/journal.pone.0009641
53 https://doi.org/10.1677/jme-10-0035
54 https://doi.org/10.3109/07357907.2011.568565
55 https://doi.org/10.3802/jgo.2009.20.2.72
56 https://doi.org/10.3892/or.17.6.1301
57 schema:datePublished 2012-10
58 schema:datePublishedReg 2012-10-01
59 schema:description PURPOSE: N-myc downstream-regulated gene 1 (NDRG1) reportedly regulates tumor progression in various cancers. Our previous studies showed that NDRG1 was aberrantly overexpressed in human endometrial cancer tissues. The purpose of the present study was to investigate the role of NDRG1 in endometrial carcinogenesis. METHODS: A short hairpin RNA (shRNA)-mediated gene silencing strategy was employed to stably suppress the expression of NDRG1 in endometrial cancer Ishikawa cells. The influence of NDRG1 silencing on cancer cell biological behaviors was examined through observing in vitro tumor cell proliferation, colony formation, cell migration and invasion. Moreover, the mammalian NDRG1 expression vector pcDNA3.1(+)/NDRG1 was constructed to determine the effects of NDRG1 overexpression on cell proliferation and migration. Additionally, gene expression microarray analysis was conducted to identify NDRG1 downstream target genes after NDRG1 knockdown. RESULTS: It was demonstrated that NDRG1 knockdown significantly enhanced Ishikawa cell proliferation and dramatically promoted cell migration and invasion. Furthermore, overexpression of NDRG1 in Ishikawa cells greatly inhibited cell proliferation and migration. Through microarray analysis and data mining, a large cohort of NDRG1-repressed target genes were identified. Additionally, through comparing the current microarray results with those obtained previously in studies of cervical and ovarian cancer cells conducted by us, 19 more specific common downstream target genes were identified. CONCLUSIONS: It was demonstrated that NDRG1 might carry out a tumor suppressor function during endometrial carcinogenesis. The identification of downstream target genes should afford meaningful hints for prospective investigations. The tumor suppressor function of NDRG1 may open a new window for the target therapy of endometrial cancer.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N741ad13e46fd4cd2a77c01ae86c59142
64 N7ecf79e22d014f138f5222bc1fc55519
65 sg:journal.1313647
66 schema:name N-myc downstream-regulated gene 1/Cap43 may function as tumor suppressor in endometrial cancer
67 schema:pagination 1703-1715
68 schema:productId N06c25b4087bf477a8390cd0c5a13c36d
69 N42ba1ceef2894b8397f0c36c3563cfe1
70 N5697661e4e91465cb4f2904d42038e66
71 Na58ec23c681a4182bc150eedc502eff1
72 Nc90b8bb2e9fb4f9fae239a9d16b626b5
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007189859
74 https://doi.org/10.1007/s00432-012-1249-4
75 schema:sdDatePublished 2019-04-10T20:41
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N84854965a55e4114b3bfc34b86221887
78 schema:url http://link.springer.com/10.1007/s00432-012-1249-4
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N06c25b4087bf477a8390cd0c5a13c36d schema:name doi
83 schema:value 10.1007/s00432-012-1249-4
84 rdf:type schema:PropertyValue
85 N10e6aa670fd24f749c3bbd358fd83067 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Prospective Studies
87 rdf:type schema:DefinedTerm
88 N15e346b6ef004ba28a49b6b212a7cb93 schema:name Department of Pathology, Si Jing Hospital, Songjiang District, 201601, Shanghai, People’s Republic of China
89 rdf:type schema:Organization
90 N18600b6a58d24173b72267998ee7022f schema:name Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, 300060, Tianjin, People’s Republic of China
91 rdf:type schema:Organization
92 N193dad7fbfc346bf9e9e223cc12b0015 rdf:first Nc0d2c73ded0041cfaff33140d0b75c4b
93 rdf:rest rdf:nil
94 N22104a36f4654a2db4051b2eae5757d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Gene Expression Regulation, Neoplastic
96 rdf:type schema:DefinedTerm
97 N31089ac3620f4af98498db490337910d rdf:first sg:person.01200601705.15
98 rdf:rest N4279d789c0424129bb305231ce5b989b
99 N3451d7a5fd4840be971955330ce27f9b rdf:first Nf50db21b78aa4682933fa09269297b81
100 rdf:rest N31089ac3620f4af98498db490337910d
101 N350a455ac4804b39a1077b701fb33280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Gene Silencing
103 rdf:type schema:DefinedTerm
104 N367b8836bda8425383d7be9621ee2206 schema:name Department of Pathology, Shanghai Jiaotong University Affiliated Songjiang Hospital, 201601, Shanghai, People’s Republic of China
105 rdf:type schema:Organization
106 N36899fb645dd44179f1f77f267e973ce schema:affiliation https://www.grid.ac/institutes/grid.39436.3b
107 schema:familyName Chen
108 schema:givenName Jia-Wei
109 rdf:type schema:Person
110 N3cb8d5cfe38a4bd59d9d03a9d2d1bc9a schema:affiliation N15e346b6ef004ba28a49b6b212a7cb93
111 schema:familyName Fan
112 schema:givenName Jin-Shuang
113 rdf:type schema:Person
114 N3f597bf85ee045249946d09148fcdbfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Endometrial Neoplasms
116 rdf:type schema:DefinedTerm
117 N4279d789c0424129bb305231ce5b989b rdf:first N5290159fb71844f6b4e88fc3c0efce7b
118 rdf:rest Naed9890e33da4ed8bb9ea0813eb3e6e1
119 N42ba1ceef2894b8397f0c36c3563cfe1 schema:name nlm_unique_id
120 schema:value 7902060
121 rdf:type schema:PropertyValue
122 N5290159fb71844f6b4e88fc3c0efce7b schema:affiliation N367b8836bda8425383d7be9621ee2206
123 schema:familyName Yang
124 schema:givenName Dao-Hua
125 rdf:type schema:Person
126 N5697661e4e91465cb4f2904d42038e66 schema:name readcube_id
127 schema:value 223f2e42c3edea15e96bffc0114c634f3e33c0374d3a4cf8996a2c87ad718326
128 rdf:type schema:PropertyValue
129 N724619339ef447a6856d0f3ff1d26249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neoplasm Invasiveness
131 rdf:type schema:DefinedTerm
132 N7392f999f9b1491b8990740913a94d37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N741ad13e46fd4cd2a77c01ae86c59142 schema:issueNumber 10
136 rdf:type schema:PublicationIssue
137 N7a3c5521ee5b40e2af2e69a2fe496804 schema:affiliation https://www.grid.ac/institutes/grid.39436.3b
138 schema:familyName Lv
139 schema:givenName Xiu-Hong
140 rdf:type schema:Person
141 N7ccd50ee1cdd443f86b1d920ab3918dc rdf:first N7a3c5521ee5b40e2af2e69a2fe496804
142 rdf:rest Nee28277e115e4d1ea401a6722b8bee08
143 N7cd50340a0e34ce3911477e2485bf7ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cell Movement
145 rdf:type schema:DefinedTerm
146 N7ecf79e22d014f138f5222bc1fc55519 schema:volumeNumber 138
147 rdf:type schema:PublicationVolume
148 N84854965a55e4114b3bfc34b86221887 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N876ab531455145d2a9e5c75b1381bad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Genes, Tumor Suppressor
152 rdf:type schema:DefinedTerm
153 N8a91759ca7964bddb2c9c1ae24163153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Gene Knockdown Techniques
155 rdf:type schema:DefinedTerm
156 N8b6370f397834f5788881215c0b61a54 rdf:first N3cb8d5cfe38a4bd59d9d03a9d2d1bc9a
157 rdf:rest N193dad7fbfc346bf9e9e223cc12b0015
158 N96f071d166154243ab5cbac8fa4b256c schema:affiliation Ndb58b35b24a3424c979a3067bdfb0171
159 schema:familyName Sun
160 schema:givenName Wei-Wei
161 rdf:type schema:Person
162 Na58ec23c681a4182bc150eedc502eff1 schema:name pubmed_id
163 schema:value 22678098
164 rdf:type schema:PropertyValue
165 Naed9890e33da4ed8bb9ea0813eb3e6e1 rdf:first N96f071d166154243ab5cbac8fa4b256c
166 rdf:rest N8b6370f397834f5788881215c0b61a54
167 Nc0d2c73ded0041cfaff33140d0b75c4b schema:affiliation https://www.grid.ac/institutes/grid.39436.3b
168 schema:familyName Zhu
169 schema:givenName Guang-Hui
170 rdf:type schema:Person
171 Nc90b8bb2e9fb4f9fae239a9d16b626b5 schema:name dimensions_id
172 schema:value pub.1007189859
173 rdf:type schema:PropertyValue
174 Nd1188f215e33480e954fd2cef8ff7b4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cell Growth Processes
176 rdf:type schema:DefinedTerm
177 Nd1da5a55155d4257a5083a805a5f7abc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Nd5d6001d29934e00b90ad2f10019107d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Intracellular Signaling Peptides and Proteins
182 rdf:type schema:DefinedTerm
183 Nd8a020e313b141ebb1d7dad9e840f2cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cell Cycle Proteins
185 rdf:type schema:DefinedTerm
186 Ndac00242857c4b939ee2aab86e389962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Cell Transformation, Neoplastic
188 rdf:type schema:DefinedTerm
189 Ndb58b35b24a3424c979a3067bdfb0171 schema:name Department of Pathology, Shanghai Jiaotong University Affiliated Songjiang Hospital, 201601, Shanghai, People’s Republic of China
190 rdf:type schema:Organization
191 Ne9c64b5036f346a69e8ea3f014b392fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Cell Line, Tumor
193 rdf:type schema:DefinedTerm
194 Nee28277e115e4d1ea401a6722b8bee08 rdf:first N36899fb645dd44179f1f77f267e973ce
195 rdf:rest N3451d7a5fd4840be971955330ce27f9b
196 Nf50db21b78aa4682933fa09269297b81 schema:affiliation N18600b6a58d24173b72267998ee7022f
197 schema:familyName Zhao
198 schema:givenName Gang
199 rdf:type schema:Person
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:journal.1313647 schema:issn 0171-5216
207 1432-1335
208 schema:name Journal of Cancer Research and Clinical Oncology
209 rdf:type schema:Periodical
210 sg:person.01200601705.15 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
211 schema:familyName Feng
212 schema:givenName Zhen-Zhong
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15
214 rdf:type schema:Person
215 sg:pub.10.1007/s10549-010-0867-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023661058
216 https://doi.org/10.1007/s10549-010-0867-2
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/bjc.2011.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006475926
219 https://doi.org/10.1038/bjc.2011.68
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/sj.onc.1204422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015202168
222 https://doi.org/10.1038/sj.onc.1204422
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.onc.1207734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019622244
225 https://doi.org/10.1038/sj.onc.1207734
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.onc.1210914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041049106
228 https://doi.org/10.1038/sj.onc.1210914
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/1471-2156-5-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028374821
231 https://doi.org/10.1186/1471-2156-5-27
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/1471-2164-6-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041873236
234 https://doi.org/10.1186/1471-2164-6-11
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1075271930 schema:CreativeWork
237 https://doi.org/10.1016/j.bbrc.2011.03.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043430693
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.canlet.2007.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005378520
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.canlet.2011.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005307130
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.cellsig.2006.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028785554
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.drup.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023336771
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.leukres.2008.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039995037
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.surg.2010.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025014146
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.ygyno.2011.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040367101
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0014-5793(99)00845-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003826327
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1042/bj20040867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043613573
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1074/jbc.274.10.6388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051236114
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1074/jbc.m109.098301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006920457
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.m110.144477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008332336
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1074/jbc.m111.232637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034463971
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1086/302978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610524
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1089/jwh.2010.2529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059291708
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/carcin/bgl146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008362487
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/carcin/bgr046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006946279
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/j.1349-7006.2002.tb01340.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037171543
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1349-7006.2008.00749.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000485509
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/0008-5472.can-04-1623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011025415
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/0008-5472.can-06-0183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051915418
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/0008-5472.can-06-0943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024165469
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/0008-5472.can-08-4882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025689414
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1158/1078-0432.ccr-05-1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001413423
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1371/journal.pone.0009641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036602206
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1677/jme-10-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048666718
290 rdf:type schema:CreativeWork
291 https://doi.org/10.3109/07357907.2011.568565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052398001
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3802/jgo.2009.20.2.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031164466
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3892/or.17.6.1301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071530436
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.252957.e schema:alternateName Bengbu Medical College
298 schema:name Department of Pathology, Bengbu Medical College, 233030, Bengbu, Anhui, People’s Republic of China
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.39436.3b schema:alternateName Shanghai University
301 schema:name Department of General Surgery, Shanghai Jiaotong University Affiliated Shanghai First People’s Hospital, 200080, Shanghai, People’s Republic of China
302 Department of Pathology, Shanghai Jiaotong University Affiliated Shanghai First People’s Hospital, NO.85, Wujin Road, 200080, Shanghai, People’s Republic of China
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...