Levels of VEGF-A mRNA in plasma from patients with colorectal carcinoma as possible surrogate marker of angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

Vanesa Garcia, Jose M. Garcia, Javier Silva, Cristina Peña, Gemma Dominguez, Yolanda Lorenzo, Raquel Diaz, Isabel Alonso, Antonio Colas, Alicia Hurtado, Antonio Sanchez, Felix Bonilla

ABSTRACT

PURPOSE: The regulator of angiogenesis most extensively studied is VEGF. VEGF mRNA in plasma from patients with colorectal cancer was analyzed as a possible surrogate marker of tumor angiogenesis. METHODS: VEGF mRNA was measured by quantitative PCR in plasma, tumors and circulating tumor cells from colorectal cancer patients. Circulating VEGF protein was analyzed by ELISA. Microvessel density was determined. RESULTS: Levels of VEGF mRNA and protein in plasma were higher in patients than in controls. VEGF mRNA was overexpressed in tumors with respect to normal tissues. Levels of VEGF protein were associated with VEGF mRNA in plasma, but no associations with tumor samples were found. A trend to statistical significance was shown between high VEGF mRNA and vascular invasion. MVD was not related to VEGF mRNA in plasma. CONCLUSIONS: Thus, VEGF mRNA could be a marker similar to VEGF protein in plasma. More... »

PAGES

1165-1171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-008-0405-3

DOI

http://dx.doi.org/10.1007/s00432-008-0405-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011032869

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18461364


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-008-0405-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-008-0405-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-008-0405-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-008-0405-3'


 

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