FISH analysis of chromosomes 3 and 6 on fine needle aspiration biopsy samples identifies distinct subgroups of uveal melanomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-04-02

AUTHORS

Laura Bonaldi, Edoardo Midena, Barbara Filippi, Elisabetta Tebaldi, Raffaella Marcato, Raffaele Parrozzani, Alberto Amadori

ABSTRACT

PurposeCircumstantial evidence suggests that development of uveal melanoma may be associated to two different pathogenetic pathways, either loss of chromosome 3 or extra copies of 6p (+6p). Chromosome 3 monosomy (−3) is detected in approximately half of uveal melanomas, and is strongly linked to metastatic disease, whereas +6p accounts for one-fourth of uveal melanomas with no clear clinical correlations. The aim of our study was to verify if the analysis of chromosomes 3 and 6 was able to distinguish two groups of patients for translating this approach in the clinical practise as prognostic tool.MethodsFluorescence in situ hybridisation (FISH) with probes for chromosome 3, 6p and 6q was used to analyze cytological material obtained by fine needle aspiration biopsy (FNAB) from 28 primary uveal melanomas, just before brachytherapy.ResultsAbnormalities affecting 6p and 6q were found in 14 tumors (50%), and −3 in 16 cases (57%). Interestingly, −3 and +6p were mutually exclusive in 23 cases (82%), whereas in two cases only (7%) they coexisted. In particular, +6p alone was present in 9 lesions (32%), −3 was the sole aberration in 11 cases (39%), and concomitant −3 and −6q in 3 other cases (11%).ConclusionsAlthough the patient cohort is limited, our findings confirm the hypothesis of a bifurcated pathogenetic model of uveal melanoma. Moreover, our results suggest that investigation of both markers on FNAB samples obtained in vivo could provide a clearer clinical picture of genetic lesions when no histological material is available for prognostic evaluation. More... »

PAGES

1123-1127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-008-0382-6

DOI

http://dx.doi.org/10.1007/s00432-008-0382-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048020482

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18386059


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