Expression of Krüppel-like factor 5 in human gastric carcinomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-02

AUTHORS

Mi Kyung Kwak, Hyuk-Joon Lee, Keun Hur, Do Joong Park, Hye Seung Lee, Woo Ho Kim, Kuhn Uk Lee, Kuk Jin Choe, Parry Guilford, Han-Kwang Yang

ABSTRACT

PURPOSE: Krüppel-like factor 5 (KLF5) is a zinc finger transcription factor, which has recently attracted attention because of its important regulatory activities linked to diverse functions such as cell growth, proliferation, differentiation, and tumorigenesis in a number of systems. However, its expression in human gastric cancer has not been described previously. In this study, we investigated the expression profile of KLF5 and the relationship between its clinicopathologic features and expression in gastric carcinomas. METHODS: Tissues were obtained from 247 gastric carcinoma patients who underwent curative gastrectomy (R0 resection) at the Department of Surgery, Seoul National University Hospital from January 1995 to June 1995, and these tissues were arranged in tissue array blocks. KLF5 expression was analyzed by immunohistochemical staining using anti-BTEB2 mouse monoclonal antibodies (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA). RESULTS: Overall KLF5 was found to be expressed in 45.7% (113/247) of tumor tissues. Moreover, its expression rate was significantly high in early-staged gastric cancer (63.2 vs. 38.0%, p < 0.001), in gastric cancer without lymph node metastasis (54.0 vs. 40.1%, p = 0.04), and in tumors <5 cm in size (53.0 vs. 38.1%, p = 0.02). The 5-year survival rate of patients with KLF5-positive tumors was higher than those of patients with KLF5-negative tumors, although this was not statistically significant (74.7 vs. 62.2%, p = 0.057). CONCLUSION: KLF5 expression rate was high in early-staged gastric cancer, in small gastric cancer tissues and in gastric cancer without lymph node metastasis. By univariate analysis, its expression was found to favor survival after surgery. Our study describes for the first time the expression profile of KLF5 in a large number of human gastric cancer tissues and suggests consistent results shown in many recent studies that reduction of KLF5 expression occurs in many types of human tumor. More... »

PAGES

163-167

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-007-0265-2

DOI

http://dx.doi.org/10.1007/s00432-007-0265-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019734816

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17622557


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Small Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kruppel-Like Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwak", 
        "givenName": "Mi Kyung", 
        "id": "sg:person.01255550711.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255550711.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyuk-Joon", 
        "id": "sg:person.011242043254.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hur", 
        "givenName": "Keun", 
        "id": "sg:person.01141604530.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141604530.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Do Joong", 
        "id": "sg:person.014104715634.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104715634.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hye Seung", 
        "id": "sg:person.014357233714.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Woo Ho", 
        "id": "sg:person.016630576674.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kuhn Uk", 
        "id": "sg:person.01331173671.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331173671.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choe", 
        "givenName": "Kuk Jin", 
        "id": "sg:person.0755557617.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755557617.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Dunedin, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guilford", 
        "givenName": "Parry", 
        "id": "sg:person.0743471155.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743471155.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
            "Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Han-Kwang", 
        "id": "sg:person.015267175234.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.10.079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002067199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012340692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2004.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012388095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012388995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(00)00059-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018947398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/21.7.1527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025755144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.20.2528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027484177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-2-206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031701594", 
          "https://doi.org/10.1186/gb-2003-4-2-206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.15.2991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033478262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkf400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034380270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.5.1263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038574519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0177(200004)217:4<421::aid-dvdy9>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039263675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039342597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m311532200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039751949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.24.4807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039872728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041344817", 
          "https://doi.org/10.1038/sj.onc.1208497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041344817", 
          "https://doi.org/10.1038/sj.onc.1208497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(99)01406-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041978651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgi066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042053958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042699713", 
          "https://doi.org/10.1038/sj.onc.1205817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042699713", 
          "https://doi.org/10.1038/sj.onc.1205817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000870200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050546716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/simmen", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070919846"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02", 
    "datePublishedReg": "2008-02-01", 
    "description": "PURPOSE: Kr\u00fcppel-like factor 5 (KLF5) is a zinc finger transcription factor, which has recently attracted attention because of its important regulatory activities linked to diverse functions such as cell growth, proliferation, differentiation, and tumorigenesis in a number of systems. However, its expression in human gastric cancer has not been described previously. In this study, we investigated the expression profile of KLF5 and the relationship between its clinicopathologic features and expression in gastric carcinomas.\nMETHODS: Tissues were obtained from 247 gastric carcinoma patients who underwent curative gastrectomy (R0 resection) at the Department of Surgery, Seoul National University Hospital from January 1995 to June 1995, and these tissues were arranged in tissue array blocks. KLF5 expression was analyzed by immunohistochemical staining using anti-BTEB2 mouse monoclonal antibodies (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA).\nRESULTS: Overall KLF5 was found to be expressed in 45.7% (113/247) of tumor tissues. Moreover, its expression rate was significantly high in early-staged gastric cancer (63.2 vs. 38.0%, p < 0.001), in gastric cancer without lymph node metastasis (54.0 vs. 40.1%, p = 0.04), and in tumors <5 cm in size (53.0 vs. 38.1%, p = 0.02). The 5-year survival rate of patients with KLF5-positive tumors was higher than those of patients with KLF5-negative tumors, although this was not statistically significant (74.7 vs. 62.2%, p = 0.057).\nCONCLUSION: KLF5 expression rate was high in early-staged gastric cancer, in small gastric cancer tissues and in gastric cancer without lymph node metastasis. By univariate analysis, its expression was found to favor survival after surgery. Our study describes for the first time the expression profile of KLF5 in a large number of human gastric cancer tissues and suggests consistent results shown in many recent studies that reduction of KLF5 expression occurs in many types of human tumor.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-007-0265-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "134"
      }
    ], 
    "name": "Expression of Kr\u00fcppel-like factor 5 in human gastric carcinomas", 
    "pagination": "163-167", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e077409fbc7ba082d5e1c785328da2c0a580482009adc6ac1dbd4faee4944ec"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17622557"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-007-0265-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019734816"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-007-0265-2", 
      "https://app.dimensions.ai/details/publication/pub.1019734816"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13084_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00432-007-0265-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-007-0265-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-007-0265-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-007-0265-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-007-0265-2'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      65 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-007-0265-2 schema:about N015fabf0b48749399740c75c332a8d4d
2 N1ff477405a074169ab5cd28f87348b3f
3 N506174c600cf4c75a58bccdb1cd99166
4 N5cab16e303a34af38ed7fdc9dfbd5ffc
5 N5e9c2e04382944779441d5d57b0947d4
6 N750b5d221aaa4819b62cec271a9e94ae
7 N836885d694a54c5cbadb8591f2f40e2f
8 N8b5a81b43bd04d299a53501fd94dc50e
9 N8e3c2c6229074185b3a4259f63fa16f8
10 Nab87e147a2f549f7ace81430dfd7ad20
11 Nb0450a997d0d4e2fb9bf85b8cbd0bb44
12 Nba4442296d7b4fdb9ebdcf2abc79f758
13 Nd9e7a73df03840809661a93693b52354
14 Nf5978c7ca59e46b08653e2c3910aac2e
15 Nff539357b2594b4dabfe434f05c708e1
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N2458e1f58d89468697aabf7998afb4be
19 schema:citation sg:pub.10.1038/sj.onc.1205817
20 sg:pub.10.1038/sj.onc.1208497
21 sg:pub.10.1186/gb-2003-4-2-206
22 https://doi.org/10.1002/(sici)1097-0177(200004)217:4<421::aid-dvdy9>3.0.co;2-1
23 https://doi.org/10.1002/jcp.1111
24 https://doi.org/10.1002/pros.10205
25 https://doi.org/10.1016/j.febslet.2004.10.079
26 https://doi.org/10.1016/j.gene.2004.01.014
27 https://doi.org/10.1016/s0968-0004(99)01406-1
28 https://doi.org/10.1016/s1357-2725(00)00059-5
29 https://doi.org/10.1074/jbc.c000870200
30 https://doi.org/10.1074/jbc.m311532200
31 https://doi.org/10.1093/carcin/bgi066
32 https://doi.org/10.1093/nar/21.7.1527
33 https://doi.org/10.1093/nar/27.15.2991
34 https://doi.org/10.1093/nar/27.24.4807
35 https://doi.org/10.1093/nar/27.5.1263
36 https://doi.org/10.1093/nar/gkf400
37 https://doi.org/10.1158/1078-0432.ccr-05-0964
38 https://doi.org/10.1161/01.cir.102.20.2528
39 https://doi.org/10.2741/simmen
40 schema:datePublished 2008-02
41 schema:datePublishedReg 2008-02-01
42 schema:description PURPOSE: Krüppel-like factor 5 (KLF5) is a zinc finger transcription factor, which has recently attracted attention because of its important regulatory activities linked to diverse functions such as cell growth, proliferation, differentiation, and tumorigenesis in a number of systems. However, its expression in human gastric cancer has not been described previously. In this study, we investigated the expression profile of KLF5 and the relationship between its clinicopathologic features and expression in gastric carcinomas. METHODS: Tissues were obtained from 247 gastric carcinoma patients who underwent curative gastrectomy (R0 resection) at the Department of Surgery, Seoul National University Hospital from January 1995 to June 1995, and these tissues were arranged in tissue array blocks. KLF5 expression was analyzed by immunohistochemical staining using anti-BTEB2 mouse monoclonal antibodies (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA). RESULTS: Overall KLF5 was found to be expressed in 45.7% (113/247) of tumor tissues. Moreover, its expression rate was significantly high in early-staged gastric cancer (63.2 vs. 38.0%, p < 0.001), in gastric cancer without lymph node metastasis (54.0 vs. 40.1%, p = 0.04), and in tumors <5 cm in size (53.0 vs. 38.1%, p = 0.02). The 5-year survival rate of patients with KLF5-positive tumors was higher than those of patients with KLF5-negative tumors, although this was not statistically significant (74.7 vs. 62.2%, p = 0.057). CONCLUSION: KLF5 expression rate was high in early-staged gastric cancer, in small gastric cancer tissues and in gastric cancer without lymph node metastasis. By univariate analysis, its expression was found to favor survival after surgery. Our study describes for the first time the expression profile of KLF5 in a large number of human gastric cancer tissues and suggests consistent results shown in many recent studies that reduction of KLF5 expression occurs in many types of human tumor.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N682a29c11448417e84ddaf7c4a92175b
47 Nef28942217034da5a95806ecc249c71e
48 sg:journal.1313647
49 schema:name Expression of Krüppel-like factor 5 in human gastric carcinomas
50 schema:pagination 163-167
51 schema:productId N0276e879fa364358b59b729d0e22431a
52 N5082ee151ff0416c8bac14309ae9ce77
53 Nabeec05e06d44f1eac7403275f1b7e20
54 Nb6bba3bcb7bf47e0aff1b01827b4cd56
55 Nbce5e2b2059f433abc2710fc04fcc7ab
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019734816
57 https://doi.org/10.1007/s00432-007-0265-2
58 schema:sdDatePublished 2019-04-11T14:29
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N4367d0a4567a4b3a9c720e3edbb7ebec
61 schema:url https://link.springer.com/10.1007%2Fs00432-007-0265-2
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N00b4aa457c184a988114ba2b810eedfe rdf:first sg:person.015267175234.94
66 rdf:rest rdf:nil
67 N015fabf0b48749399740c75c332a8d4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Follow-Up Studies
69 rdf:type schema:DefinedTerm
70 N0276e879fa364358b59b729d0e22431a schema:name pubmed_id
71 schema:value 17622557
72 rdf:type schema:PropertyValue
73 N1ff477405a074169ab5cd28f87348b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Female
75 rdf:type schema:DefinedTerm
76 N2458e1f58d89468697aabf7998afb4be rdf:first sg:person.01255550711.50
77 rdf:rest N9ac5b2545b634146b24c4321831951b3
78 N26b6abf1d7b94d5f903334176e70fe62 rdf:first sg:person.0755557617.47
79 rdf:rest N7ed6194416d44101b2e868022ab788f1
80 N35966882c5ac4210b4a3c5d7fb91c712 rdf:first sg:person.014357233714.08
81 rdf:rest Ne34f303cc6b447b5a78bcc285b6dce50
82 N4367d0a4567a4b3a9c720e3edbb7ebec schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N506174c600cf4c75a58bccdb1cd99166 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Male
86 rdf:type schema:DefinedTerm
87 N5082ee151ff0416c8bac14309ae9ce77 schema:name readcube_id
88 schema:value 5e077409fbc7ba082d5e1c785328da2c0a580482009adc6ac1dbd4faee4944ec
89 rdf:type schema:PropertyValue
90 N5baaec3161524ec988e7eb0fba92f1b1 rdf:first sg:person.01331173671.41
91 rdf:rest N26b6abf1d7b94d5f903334176e70fe62
92 N5cab16e303a34af38ed7fdc9dfbd5ffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Gene Expression Regulation, Neoplastic
94 rdf:type schema:DefinedTerm
95 N5e9c2e04382944779441d5d57b0947d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Stomach Neoplasms
97 rdf:type schema:DefinedTerm
98 N682a29c11448417e84ddaf7c4a92175b schema:issueNumber 2
99 rdf:type schema:PublicationIssue
100 N750b5d221aaa4819b62cec271a9e94ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Humans
102 rdf:type schema:DefinedTerm
103 N7ed6194416d44101b2e868022ab788f1 rdf:first sg:person.0743471155.46
104 rdf:rest N00b4aa457c184a988114ba2b810eedfe
105 N836885d694a54c5cbadb8591f2f40e2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Survival Rate
107 rdf:type schema:DefinedTerm
108 N8b5a81b43bd04d299a53501fd94dc50e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Kruppel-Like Transcription Factors
110 rdf:type schema:DefinedTerm
111 N8e3c2c6229074185b3a4259f63fa16f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Prognosis
113 rdf:type schema:DefinedTerm
114 N9ac5b2545b634146b24c4321831951b3 rdf:first sg:person.011242043254.34
115 rdf:rest Nc47d1f5ce425468eb0176fbdea6fd411
116 Nab87e147a2f549f7ace81430dfd7ad20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Middle Aged
118 rdf:type schema:DefinedTerm
119 Nabeec05e06d44f1eac7403275f1b7e20 schema:name nlm_unique_id
120 schema:value 7902060
121 rdf:type schema:PropertyValue
122 Nb0450a997d0d4e2fb9bf85b8cbd0bb44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Lymphatic Metastasis
124 rdf:type schema:DefinedTerm
125 Nb6bba3bcb7bf47e0aff1b01827b4cd56 schema:name doi
126 schema:value 10.1007/s00432-007-0265-2
127 rdf:type schema:PropertyValue
128 Nba4442296d7b4fdb9ebdcf2abc79f758 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Immunoenzyme Techniques
130 rdf:type schema:DefinedTerm
131 Nbce5e2b2059f433abc2710fc04fcc7ab schema:name dimensions_id
132 schema:value pub.1019734816
133 rdf:type schema:PropertyValue
134 Nc47d1f5ce425468eb0176fbdea6fd411 rdf:first sg:person.01141604530.75
135 rdf:rest Nc8139b3444d547e388db593c225c594f
136 Nc8139b3444d547e388db593c225c594f rdf:first sg:person.014104715634.26
137 rdf:rest N35966882c5ac4210b4a3c5d7fb91c712
138 Nd9e7a73df03840809661a93693b52354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Lymph Nodes
140 rdf:type schema:DefinedTerm
141 Ne34f303cc6b447b5a78bcc285b6dce50 rdf:first sg:person.016630576674.47
142 rdf:rest N5baaec3161524ec988e7eb0fba92f1b1
143 Nef28942217034da5a95806ecc249c71e schema:volumeNumber 134
144 rdf:type schema:PublicationVolume
145 Nf5978c7ca59e46b08653e2c3910aac2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neoplasm Invasiveness
147 rdf:type schema:DefinedTerm
148 Nff539357b2594b4dabfe434f05c708e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Carcinoma, Small Cell
150 rdf:type schema:DefinedTerm
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
155 schema:name Oncology and Carcinogenesis
156 rdf:type schema:DefinedTerm
157 sg:journal.1313647 schema:issn 0171-5216
158 1432-1335
159 schema:name Journal of Cancer Research and Clinical Oncology
160 rdf:type schema:Periodical
161 sg:person.011242043254.34 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
162 schema:familyName Lee
163 schema:givenName Hyuk-Joon
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34
165 rdf:type schema:Person
166 sg:person.01141604530.75 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
167 schema:familyName Hur
168 schema:givenName Keun
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141604530.75
170 rdf:type schema:Person
171 sg:person.01255550711.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
172 schema:familyName Kwak
173 schema:givenName Mi Kyung
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255550711.50
175 rdf:type schema:Person
176 sg:person.01331173671.41 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
177 schema:familyName Lee
178 schema:givenName Kuhn Uk
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331173671.41
180 rdf:type schema:Person
181 sg:person.014104715634.26 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
182 schema:familyName Park
183 schema:givenName Do Joong
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104715634.26
185 rdf:type schema:Person
186 sg:person.014357233714.08 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
187 schema:familyName Lee
188 schema:givenName Hye Seung
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08
190 rdf:type schema:Person
191 sg:person.015267175234.94 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
192 schema:familyName Yang
193 schema:givenName Han-Kwang
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94
195 rdf:type schema:Person
196 sg:person.016630576674.47 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
197 schema:familyName Kim
198 schema:givenName Woo Ho
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47
200 rdf:type schema:Person
201 sg:person.0743471155.46 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
202 schema:familyName Guilford
203 schema:givenName Parry
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743471155.46
205 rdf:type schema:Person
206 sg:person.0755557617.47 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
207 schema:familyName Choe
208 schema:givenName Kuk Jin
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755557617.47
210 rdf:type schema:Person
211 sg:pub.10.1038/sj.onc.1205817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042699713
212 https://doi.org/10.1038/sj.onc.1205817
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/sj.onc.1208497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041344817
215 https://doi.org/10.1038/sj.onc.1208497
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/gb-2003-4-2-206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031701594
218 https://doi.org/10.1186/gb-2003-4-2-206
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/(sici)1097-0177(200004)217:4<421::aid-dvdy9>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039263675
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/jcp.1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012340692
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/pros.10205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039342597
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.febslet.2004.10.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002067199
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.gene.2004.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012388095
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0968-0004(99)01406-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041978651
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s1357-2725(00)00059-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018947398
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.c000870200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050546716
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1074/jbc.m311532200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039751949
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/carcin/bgi066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042053958
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/nar/21.7.1527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025755144
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/nar/27.15.2991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033478262
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/nar/27.24.4807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039872728
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1093/nar/27.5.1263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038574519
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/nar/gkf400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034380270
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1158/1078-0432.ccr-05-0964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012388995
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/01.cir.102.20.2528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027484177
253 rdf:type schema:CreativeWork
254 https://doi.org/10.2741/simmen schema:sameAs https://app.dimensions.ai/details/publication/pub.1070919846
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.29980.3a schema:alternateName University of Otago
257 schema:name Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Dunedin, New Zealand
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
260 schema:name Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
261 Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
262 Department of Surgery, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, 110-744, Seoul, Korea
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...