Elevation of soluble interleukin-2 receptor in patients with non-small cell lung cancer treated with gefitinib View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11

AUTHORS

Shigenori Kanazawa, Kazuyuki Yamaguchi, Yoshimi Kinoshita, Yutaka Komiyama, Mikiko Muramatsu, Shosaku Nomura

ABSTRACT

PURPOSE: We previously reported that plasma thromboxan B(2), soluble P-selectin, and serum regulated on activation, normal T-cell expressed and secreted (RANTES) were elevated after gefitinib treatment. We hypothesized that gefitinib could activate T-lymphocytes via activated platelets, and so we measured serum levels of soluble interleukin-2 receptor (sIL-2R) in patients medicated with gefitinib. METHODS: Twenty-one patients with non-small cell lung cancer (NSCLC) were entered into this study. All patients received gefitinib over 2 weeks without severe adverse effects. Blood samples were withdrawn from all patients before and after the administration of gefitinib and plasma soluble P-selectin, serum RANTES, and serum sIL-2R were measured by enzyme-linked immunosolvent assay. In addition, we carried out the basic study of the interleukin-2 receptor (IL-2R) expression on CD4(+) lymphocytes by RANTES. RESULTS: Plasma soluble P-selectin, serum RANTES, and serum sIL-2R levels increased significantly in patients receiving gefitinib treatment for 1 and 2 weeks. RANTES did not induce the expression of IL-2R on CD4(+) lymphocyte. However, the anti-CD3 monoclonal antibody-induced expression of IL-2R was enhanced by the addition of RANTES. CONCLUSION: Our finding indicated that lymphocytes were activated by gefitinib treatment. We think that sIL-2R elevation after gefitinib administration may be a factor positively effecting patients with NSCLC. It is deemed possible that the effect of gefitinib is induced not only by its blocking of the tyrosine kinase of epidermal growth factor receptor but also by antitumor immunity via its activation of T-cells. More... »

PAGES

719-725

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-006-0120-x

DOI

http://dx.doi.org/10.1007/s00432-006-0120-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010228501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16835747


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Non-Small-Cell Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CCL5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gefitinib", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "P-Selectin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanazawa", 
        "givenName": "Shigenori", 
        "id": "sg:person.01340206206.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340206206.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamaguchi", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.01062160226.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062160226.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Neurology, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Yoshimi", 
        "id": "sg:person.0760331263.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760331263.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komiyama", 
        "givenName": "Yutaka", 
        "id": "sg:person.01036253614.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036253614.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Mikiko", 
        "id": "sg:person.01163424767.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163424767.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kishiwada City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415381.a", 
          "name": [
            "Division of Hematology, Kishiwada City Hospital, 1001 Gakuhara-cho, 596-8501, Kishiwada, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Shosaku", 
        "id": "sg:person.0637542245.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2005.05.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003700462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.07.215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004496831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-5002(96)00572-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009045336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02967051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011507258", 
          "https://doi.org/10.1007/bf02967051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02967051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011507258", 
          "https://doi.org/10.1007/bf02967051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1981.03310330021017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017947853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107602960501100409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020601089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107602960501100409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020601089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02523660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025059907", 
          "https://doi.org/10.1007/bf02523660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02523660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025059907", 
          "https://doi.org/10.1007/bf02523660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01192200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028096243", 
          "https://doi.org/10.1007/bf01192200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01192200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028096243", 
          "https://doi.org/10.1007/bf01192200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-5002(96)00608-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031008308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940701)74:1<38::aid-cncr2820740108>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033490377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(98)00045-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036450024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036473215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.176.2.587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041083321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042907590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67625-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049872875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.245.8.831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054140506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008218306355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056302636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199710000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199710000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199710000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1957166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062514969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3008337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062582067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3131876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062593378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074892319", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076847856", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077935357", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.23.16_suppl.3215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079369924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079573398", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079975041", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082982878", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.11.3378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083171128"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-11", 
    "datePublishedReg": "2006-11-01", 
    "description": "PURPOSE: We previously reported that plasma thromboxan B(2), soluble P-selectin, and serum regulated on activation, normal T-cell expressed and secreted (RANTES) were elevated after gefitinib treatment. We hypothesized that gefitinib could activate T-lymphocytes via activated platelets, and so we measured serum levels of soluble interleukin-2 receptor (sIL-2R) in patients medicated with gefitinib.\nMETHODS: Twenty-one patients with non-small cell lung cancer (NSCLC) were entered into this study. All patients received gefitinib over 2 weeks without severe adverse effects. Blood samples were withdrawn from all patients before and after the administration of gefitinib and plasma soluble P-selectin, serum RANTES, and serum sIL-2R were measured by enzyme-linked immunosolvent assay. In addition, we carried out the basic study of the interleukin-2 receptor (IL-2R) expression on CD4(+) lymphocytes by RANTES.\nRESULTS: Plasma soluble P-selectin, serum RANTES, and serum sIL-2R levels increased significantly in patients receiving gefitinib treatment for 1 and 2 weeks. RANTES did not induce the expression of IL-2R on CD4(+) lymphocyte. However, the anti-CD3 monoclonal antibody-induced expression of IL-2R was enhanced by the addition of RANTES.\nCONCLUSION: Our finding indicated that lymphocytes were activated by gefitinib treatment. We think that sIL-2R elevation after gefitinib administration may be a factor positively effecting patients with NSCLC. It is deemed possible that the effect of gefitinib is induced not only by its blocking of the tyrosine kinase of epidermal growth factor receptor but also by antitumor immunity via its activation of T-cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00432-006-0120-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "132"
      }
    ], 
    "name": "Elevation of soluble interleukin-2 receptor in patients with non-small cell lung cancer treated with gefitinib", 
    "pagination": "719-725", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "30babdfeadcd9e2122508ae64c97dd4f26cedb1421c0a9656a0ff830705dc7c6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16835747"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902060"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-006-0120-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010228501"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-006-0120-x", 
      "https://app.dimensions.ai/details/publication/pub.1010228501"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13073_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00432-006-0120-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-006-0120-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-006-0120-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-006-0120-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-006-0120-x'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      80 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-006-0120-x schema:about N059949fe67cd4d6a8a2bab7526ccf710
2 N0ab92b87ac2d4cf482e507ab6304f58c
3 N0e8d6fc654474e3199136437fd314500
4 N14a3d279ec2f4b1e9d0376f899c233ad
5 N1607a1b453e74b97a780945465fbec39
6 N231626dd9305431984a17c63b36a55a8
7 N37c7994da8d442c58f9f2de9b1b5d2fe
8 N3ec73c921dff4d939e943b3c44ffd364
9 N5a1adf2d8ffa407489ef1ba7449acd41
10 N6d6f173cd7c04e538a08ed482063da1b
11 N75f50679ad28445b8e8cb6acc6f8fe85
12 N887c646bb08c42eba8464397e9542b85
13 N8d057cf90ebc458c8d32a1d0b7a46dfd
14 N91f3f7b6aff345f8ba1bc9ced086b105
15 N924553862a49485b83e3b5d83ae0e6c2
16 N9312eac7b9bc4ac79e0f2389e219bcdd
17 Nca5771a533e7424290b797ba1f49eebc
18 Nda47bc8a1a1c4114b0643155b7e2ff08
19 Nde00951f61154ed883321009e8a408a1
20 Ne0f9e0d783fe4c15adb5a7c3008568cd
21 Nfcf43db34ac14bae86e7dd19669f9dbe
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N95df5459f50a46768a2761811882ef9f
25 schema:citation sg:pub.10.1007/bf01192200
26 sg:pub.10.1007/bf02523660
27 sg:pub.10.1007/bf02967051
28 https://app.dimensions.ai/details/publication/pub.1074892319
29 https://app.dimensions.ai/details/publication/pub.1076847856
30 https://app.dimensions.ai/details/publication/pub.1077935357
31 https://app.dimensions.ai/details/publication/pub.1079573398
32 https://app.dimensions.ai/details/publication/pub.1079975041
33 https://app.dimensions.ai/details/publication/pub.1082982878
34 https://doi.org/10.1001/jama.1981.03310330021017
35 https://doi.org/10.1001/jama.245.8.831
36 https://doi.org/10.1002/1097-0142(19940701)74:1<38::aid-cncr2820740108>3.0.co;2-e
37 https://doi.org/10.1016/0169-5002(96)00572-7
38 https://doi.org/10.1016/s0140-6736(05)67625-8
39 https://doi.org/10.1016/s0163-7258(98)00045-x
40 https://doi.org/10.1016/s0169-5002(96)00608-3
41 https://doi.org/10.1023/a:1008218306355
42 https://doi.org/10.1056/nejmoa040938
43 https://doi.org/10.1084/jem.176.2.587
44 https://doi.org/10.1097/00000421-199710000-00002
45 https://doi.org/10.1126/science.1957166
46 https://doi.org/10.1126/science.3008337
47 https://doi.org/10.1126/science.3131876
48 https://doi.org/10.1158/1078-0432.ccr-03-0799
49 https://doi.org/10.1177/107602960501100409
50 https://doi.org/10.1200/jco.1997.15.11.3378
51 https://doi.org/10.1200/jco.2003.10.038
52 https://doi.org/10.1200/jco.2004.07.215
53 https://doi.org/10.1200/jco.2005.05.148
54 https://doi.org/10.1200/jco.2005.23.16_suppl.3215
55 schema:datePublished 2006-11
56 schema:datePublishedReg 2006-11-01
57 schema:description PURPOSE: We previously reported that plasma thromboxan B(2), soluble P-selectin, and serum regulated on activation, normal T-cell expressed and secreted (RANTES) were elevated after gefitinib treatment. We hypothesized that gefitinib could activate T-lymphocytes via activated platelets, and so we measured serum levels of soluble interleukin-2 receptor (sIL-2R) in patients medicated with gefitinib. METHODS: Twenty-one patients with non-small cell lung cancer (NSCLC) were entered into this study. All patients received gefitinib over 2 weeks without severe adverse effects. Blood samples were withdrawn from all patients before and after the administration of gefitinib and plasma soluble P-selectin, serum RANTES, and serum sIL-2R were measured by enzyme-linked immunosolvent assay. In addition, we carried out the basic study of the interleukin-2 receptor (IL-2R) expression on CD4(+) lymphocytes by RANTES. RESULTS: Plasma soluble P-selectin, serum RANTES, and serum sIL-2R levels increased significantly in patients receiving gefitinib treatment for 1 and 2 weeks. RANTES did not induce the expression of IL-2R on CD4(+) lymphocyte. However, the anti-CD3 monoclonal antibody-induced expression of IL-2R was enhanced by the addition of RANTES. CONCLUSION: Our finding indicated that lymphocytes were activated by gefitinib treatment. We think that sIL-2R elevation after gefitinib administration may be a factor positively effecting patients with NSCLC. It is deemed possible that the effect of gefitinib is induced not only by its blocking of the tyrosine kinase of epidermal growth factor receptor but also by antitumor immunity via its activation of T-cells.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N0ed5e4e9b3fb4dbc9baeaf99fdbad7ad
62 N23836a5e78ab44f3a9030a7bde35a2b9
63 sg:journal.1313647
64 schema:name Elevation of soluble interleukin-2 receptor in patients with non-small cell lung cancer treated with gefitinib
65 schema:pagination 719-725
66 schema:productId N4f0a150141944044aa39e66e7525087f
67 N58145647b7694673a4d269e0b4f0c189
68 N783f55e4c9af4108a2103d40b2e23c2a
69 N94bf3cf94b024a98bd37f092af733fc8
70 Nb9e5859ab7224a859e6b776b416f016b
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010228501
72 https://doi.org/10.1007/s00432-006-0120-x
73 schema:sdDatePublished 2019-04-11T14:27
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N88ebe6a6bdba485ca7d080f70b8569f1
76 schema:url http://link.springer.com/10.1007/s00432-006-0120-x
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N059949fe67cd4d6a8a2bab7526ccf710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Gefitinib
82 rdf:type schema:DefinedTerm
83 N0ab92b87ac2d4cf482e507ab6304f58c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Case-Control Studies
85 rdf:type schema:DefinedTerm
86 N0e8d6fc654474e3199136437fd314500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Lymphocyte Activation
88 rdf:type schema:DefinedTerm
89 N0ed5e4e9b3fb4dbc9baeaf99fdbad7ad schema:volumeNumber 132
90 rdf:type schema:PublicationVolume
91 N14a3d279ec2f4b1e9d0376f899c233ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Female
93 rdf:type schema:DefinedTerm
94 N1607a1b453e74b97a780945465fbec39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Male
96 rdf:type schema:DefinedTerm
97 N1fcc3594af4c4f98a8c4148a6a135396 rdf:first sg:person.01062160226.35
98 rdf:rest Nba6c03e0c11a4cd0887b9bfb396dba71
99 N231626dd9305431984a17c63b36a55a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name CD4 Antigens
101 rdf:type schema:DefinedTerm
102 N23836a5e78ab44f3a9030a7bde35a2b9 schema:issueNumber 11
103 rdf:type schema:PublicationIssue
104 N37c7994da8d442c58f9f2de9b1b5d2fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Quinazolines
106 rdf:type schema:DefinedTerm
107 N3ec73c921dff4d939e943b3c44ffd364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Prognosis
109 rdf:type schema:DefinedTerm
110 N4f0a150141944044aa39e66e7525087f schema:name doi
111 schema:value 10.1007/s00432-006-0120-x
112 rdf:type schema:PropertyValue
113 N58145647b7694673a4d269e0b4f0c189 schema:name readcube_id
114 schema:value 30babdfeadcd9e2122508ae64c97dd4f26cedb1421c0a9656a0ff830705dc7c6
115 rdf:type schema:PropertyValue
116 N5a1adf2d8ffa407489ef1ba7449acd41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Biomarkers, Tumor
118 rdf:type schema:DefinedTerm
119 N63aa8bb863404d5e805863fdafca3df1 rdf:first sg:person.01036253614.40
120 rdf:rest N8fa9db6f4c9f4ae1a2b0bc0e3759d473
121 N6d6f173cd7c04e538a08ed482063da1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name P-Selectin
123 rdf:type schema:DefinedTerm
124 N75f50679ad28445b8e8cb6acc6f8fe85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Lung Neoplasms
126 rdf:type schema:DefinedTerm
127 N783f55e4c9af4108a2103d40b2e23c2a schema:name nlm_unique_id
128 schema:value 7902060
129 rdf:type schema:PropertyValue
130 N887c646bb08c42eba8464397e9542b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Antineoplastic Agents
132 rdf:type schema:DefinedTerm
133 N88ebe6a6bdba485ca7d080f70b8569f1 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N8d057cf90ebc458c8d32a1d0b7a46dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Neoplasm Staging
137 rdf:type schema:DefinedTerm
138 N8fa9db6f4c9f4ae1a2b0bc0e3759d473 rdf:first sg:person.01163424767.75
139 rdf:rest Naac1df751d1d42bb9c401c98aac926af
140 N91f3f7b6aff345f8ba1bc9ced086b105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 N924553862a49485b83e3b5d83ae0e6c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Aged
145 rdf:type schema:DefinedTerm
146 N9312eac7b9bc4ac79e0f2389e219bcdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Aged, 80 and over
148 rdf:type schema:DefinedTerm
149 N94bf3cf94b024a98bd37f092af733fc8 schema:name pubmed_id
150 schema:value 16835747
151 rdf:type schema:PropertyValue
152 N95df5459f50a46768a2761811882ef9f rdf:first sg:person.01340206206.47
153 rdf:rest N1fcc3594af4c4f98a8c4148a6a135396
154 Naac1df751d1d42bb9c401c98aac926af rdf:first sg:person.0637542245.62
155 rdf:rest rdf:nil
156 Nb9e5859ab7224a859e6b776b416f016b schema:name dimensions_id
157 schema:value pub.1010228501
158 rdf:type schema:PropertyValue
159 Nba6c03e0c11a4cd0887b9bfb396dba71 rdf:first sg:person.0760331263.56
160 rdf:rest N63aa8bb863404d5e805863fdafca3df1
161 Nca5771a533e7424290b797ba1f49eebc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Middle Aged
163 rdf:type schema:DefinedTerm
164 Nda47bc8a1a1c4114b0643155b7e2ff08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Chemokine CCL5
166 rdf:type schema:DefinedTerm
167 Nde00951f61154ed883321009e8a408a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Receptors, Interleukin-2
169 rdf:type schema:DefinedTerm
170 Ne0f9e0d783fe4c15adb5a7c3008568cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nfcf43db34ac14bae86e7dd19669f9dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Carcinoma, Non-Small-Cell Lung
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
180 schema:name Clinical Sciences
181 rdf:type schema:DefinedTerm
182 sg:journal.1313647 schema:issn 0171-5216
183 1432-1335
184 schema:name Journal of Cancer Research and Clinical Oncology
185 rdf:type schema:Periodical
186 sg:person.01036253614.40 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
187 schema:familyName Komiyama
188 schema:givenName Yutaka
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036253614.40
190 rdf:type schema:Person
191 sg:person.01062160226.35 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
192 schema:familyName Yamaguchi
193 schema:givenName Kazuyuki
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062160226.35
195 rdf:type schema:Person
196 sg:person.01163424767.75 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
197 schema:familyName Muramatsu
198 schema:givenName Mikiko
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163424767.75
200 rdf:type schema:Person
201 sg:person.01340206206.47 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
202 schema:familyName Kanazawa
203 schema:givenName Shigenori
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340206206.47
205 rdf:type schema:Person
206 sg:person.0637542245.62 schema:affiliation https://www.grid.ac/institutes/grid.415381.a
207 schema:familyName Nomura
208 schema:givenName Shosaku
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62
210 rdf:type schema:Person
211 sg:person.0760331263.56 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
212 schema:familyName Kinoshita
213 schema:givenName Yoshimi
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760331263.56
215 rdf:type schema:Person
216 sg:pub.10.1007/bf01192200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028096243
217 https://doi.org/10.1007/bf01192200
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/bf02523660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025059907
220 https://doi.org/10.1007/bf02523660
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/bf02967051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011507258
223 https://doi.org/10.1007/bf02967051
224 rdf:type schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1074892319 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1076847856 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1077935357 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1079573398 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1079975041 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1082982878 schema:CreativeWork
231 https://doi.org/10.1001/jama.1981.03310330021017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017947853
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1001/jama.245.8.831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054140506
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/1097-0142(19940701)74:1<38::aid-cncr2820740108>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1033490377
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0169-5002(96)00572-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009045336
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0140-6736(05)67625-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049872875
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0163-7258(98)00045-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036450024
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0169-5002(96)00608-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031008308
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1023/a:1008218306355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056302636
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1056/nejmoa040938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042907590
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1084/jem.176.2.587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041083321
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1097/00000421-199710000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060113628
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.1957166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062514969
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.3008337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062582067
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.3131876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062593378
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1158/1078-0432.ccr-03-0799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036473215
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1177/107602960501100409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020601089
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1200/jco.1997.15.11.3378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083171128
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1200/jco.2003.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203891
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1200/jco.2004.07.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004496831
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1200/jco.2005.05.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003700462
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1200/jco.2005.23.16_suppl.3215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079369924
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
274 schema:name Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan
275 Department of Neurology, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan
276 First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan
277 rdf:type schema:Organization
278 https://www.grid.ac/institutes/grid.415381.a schema:alternateName Kishiwada City Hospital
279 schema:name Division of Hematology, Kishiwada City Hospital, 1001 Gakuhara-cho, 596-8501, Kishiwada, Osaka, Japan
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...