Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

Sing Yu Goldstein-Jackson, Georg Gosheger, Günter Delling, Wolfgang E. Berdel, G. Ulrich. Exner, Gernot Jundt, Jan-Nicolas Machatschek, Andreas Zoubek, Heribert Jürgens, Stefan S. Bielack, for the Cooperative Osteosarcoma Study Group COSS

ABSTRACT

PURPOSE: The aims of this analysis were to investigate the clinical features of extraskeletal osteosarcoma (ESOS) and examine the outcome after multi-modal therapy. METHODS: The co-operative osteosarcoma study-group database was searched for patients with extraskeletal osteosarcoma. Eligible patients were included in a retrospective analysis of patient, tumour and treatment related variables and outcome. As for conventional osteosarcoma, scheduled treatment included surgery and multi-agent chemotherapy. RESULTS: Seventeen eligible patients were identified with a median age of 44 years (range, 3-65 years). The thigh was the commonest tumour site. Two patients had a history of previous malignancies and two had primary metastases. Median follow-up was 3.2 years (range: 0.6-7.4 years) and at last follow-up, 11 patients were alive in complete remission, 3 patients were alive with disease and 3 patients had died of their disease. Three-year overall actuarial and event-free survival rates were 77% and 56%, respectively. Patients with macroscopically complete surgical remission had an improved overall survival (P = 0.0004). CONCLUSIONS: The patients in this retrospective study had a surprisingly good survival rate. This may be due to the combination of multi-agent chemotherapy with surgery, and we recommend this approach in the treatment of ESOS. More... »

PAGES

520-526

References to SciGraph publications

  • 2003-03. A low-grade extraskeletal osteosarcoma in SKELETAL RADIOLOGY
  • 2001-02. Extraskeletal osteosarcoma arising in myositis ossificans in SKELETAL RADIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00432-005-0687-7

    DOI

    http://dx.doi.org/10.1007/s00432-005-0687-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052072893

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15918046


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-005-0687-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-005-0687-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-005-0687-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-005-0687-7'


     

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