Expression of gastrin and its receptor in human gastric cancer tissues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10-14

AUTHORS

Keun Hur, Mi Kyung Kwak, Hyuk-Joon Lee, Do Joong Park, Hyeon Kook Lee, Hye Seung Lee, Woo Ho Kim, Dov Michaeli, Han-Kwang Yang

ABSTRACT

Purpose: Gastrin is a growth factor of cancerous and normal cells of the gastrointestinal tract, and its effect is known to be mediated by gastrin/cholecystokinin B (CCKB) receptor. This study was performed to investigate the prognostic significance and the expression profiles of gastrin and gastrin receptor in human gastric carcinoma tissues. Methods: We analyzed the expressions of gastrin and gastrin receptor by immunohistochemical staining using anti-gastrin Ab (Sigma, St. Louis, MO, USA) and anti-gastrin receptor Ab (Aphton Corp., Woodland, CA, USA) in 279 gastric adenocarcinoma patients. Patients’ clinicopathologic features and prognoses were analyzed. Results: The gastrin expression rate in these patients was 47.7% (133/279) and the gastrin receptor expression rate was 56.5% (158/279). Gastrin expression was significantly higher in men than in women (54.3% vs. 34.1%), and higher in differentiated gastric adenocarcinoma than in the undifferentiated type (55.1% vs. 43.0%). The gastrin receptor expression rate was also significantly higher in men than in women (61.2% vs. 47.3%), and was higher in the differentiated type than in the undifferentiated type (72.9% vs. 46.5%), and significantly higher in the intestinal type than in the diffuse type (75.2% vs. 42.9%). Gastrin and gastrin/CCKB receptor expressions were not found to be significant prognostic factors in themselves. When focused on correlation between the co-expression of gastrin and gastrin/CCKB receptor and the survival, the prognosis of patients positive for both gastrin and gastrin receptor was significantly poorer than for those negative for gastrin and gastrin receptor in diffuse-type gastric cancer patients. However, multivariate analysis showed that only TNM stage was an independent prognostic factor of survival in diffuse-type gastric cancer patients. Conclusions: This study shows that the expression rates of gastrin and gastrin receptor are high (about a half) in gastric carcinoma tissues, and that there is an association between gastrin and gastrin receptor expression. We also found that patients with diffuse-type gastric carcinoma tissues expressing both gastrin and gastrin receptor have a poorer prognosis than those negative for both, which suggests that gastrin acts as an autocrine growth factor in a subgroup of gastric carcinomas. More... »

PAGES

85-91

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-005-0043-y

DOI

http://dx.doi.org/10.1007/s00432-005-0043-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026571083

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16228228


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29 schema:description Purpose: Gastrin is a growth factor of cancerous and normal cells of the gastrointestinal tract, and its effect is known to be mediated by gastrin/cholecystokinin B (CCKB) receptor. This study was performed to investigate the prognostic significance and the expression profiles of gastrin and gastrin receptor in human gastric carcinoma tissues. Methods: We analyzed the expressions of gastrin and gastrin receptor by immunohistochemical staining using anti-gastrin Ab (Sigma, St. Louis, MO, USA) and anti-gastrin receptor Ab (Aphton Corp., Woodland, CA, USA) in 279 gastric adenocarcinoma patients. Patients’ clinicopathologic features and prognoses were analyzed. Results: The gastrin expression rate in these patients was 47.7% (133/279) and the gastrin receptor expression rate was 56.5% (158/279). Gastrin expression was significantly higher in men than in women (54.3% vs. 34.1%), and higher in differentiated gastric adenocarcinoma than in the undifferentiated type (55.1% vs. 43.0%). The gastrin receptor expression rate was also significantly higher in men than in women (61.2% vs. 47.3%), and was higher in the differentiated type than in the undifferentiated type (72.9% vs. 46.5%), and significantly higher in the intestinal type than in the diffuse type (75.2% vs. 42.9%). Gastrin and gastrin/CCKB receptor expressions were not found to be significant prognostic factors in themselves. When focused on correlation between the co-expression of gastrin and gastrin/CCKB receptor and the survival, the prognosis of patients positive for both gastrin and gastrin receptor was significantly poorer than for those negative for gastrin and gastrin receptor in diffuse-type gastric cancer patients. However, multivariate analysis showed that only TNM stage was an independent prognostic factor of survival in diffuse-type gastric cancer patients. Conclusions: This study shows that the expression rates of gastrin and gastrin receptor are high (about a half) in gastric carcinoma tissues, and that there is an association between gastrin and gastrin receptor expression. We also found that patients with diffuse-type gastric carcinoma tissues expressing both gastrin and gastrin receptor have a poorer prognosis than those negative for both, which suggests that gastrin acts as an autocrine growth factor in a subgroup of gastric carcinomas.
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37 B (CCKB) receptor
38 CCKB receptor expressions
39 CCKB receptors
40 TNM stage
41 adenocarcinoma
42 adenocarcinoma patients
43 analysis
44 anti-gastrin Ab
45 anti-gastrin receptor Ab
46 association
47 autocrine growth factor
48 cancer patients
49 cancer tissues
50 carcinoma
51 carcinoma tissues
52 cells
53 cholecystokinin B receptor
54 clinicopathologic features
55 correlation
56 differentiated gastric adenocarcinoma
57 differentiated type
58 diffuse type
59 diffuse-type gastric cancer patients
60 diffuse-type gastric carcinoma tissues
61 effect
62 expression
63 expression of gastrin
64 expression profiles
65 expression rate
66 factors
67 features
68 gastric adenocarcinoma
69 gastric adenocarcinoma patients
70 gastric cancer patients
71 gastric cancer tissues
72 gastric carcinoma
73 gastric carcinoma tissues
74 gastrin
75 gastrin expression
76 gastrin expression rate
77 gastrin receptor
78 gastrin receptor expression
79 gastrin receptor expression rate
80 gastrin/CCKB receptor
81 gastrin/CCKB receptor expressions
82 gastrin/cholecystokinin B receptor
83 gastrointestinal tract
84 growth factor
85 human gastric cancer tissues
86 human gastric carcinoma tissues
87 immunohistochemical staining
88 independent prognostic factor
89 intestinal type
90 men
91 multivariate analysis
92 normal cells
93 only TNM stage
94 patients
95 patients' clinicopathologic features
96 poor prognosis
97 profile
98 prognosis
99 prognosis of patients
100 prognostic factors
101 prognostic significance
102 rate
103 receptor Ab
104 receptor expression
105 receptor expression rate
106 receptors
107 significance
108 significant prognostic factors
109 stage
110 staining
111 study
112 subgroups
113 survival
114 tissue
115 tract
116 types
117 undifferentiated type
118 women
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