Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01-22

AUTHORS

Jan Saenger, Maike Leible, Matthias H. Seelig, Martin R. Berger

ABSTRACT

Purpose Hematogenic metastasis of patients with colorectal cancer most frequently effects the liver; the prognosis of affected patients is dramatically worsened by the presence of this lesion. The aim of this study was to evaluate the effect of hepatic arterial chemoembolization (HACE) with irinotecan versus 5-fluorouracil as a standard agent in a rat liver metastasis model.Materials and methods Diffuse liver metastasis was induced by injecting 4×106 CC531-lac-Z rat colorectal carcinoma cells into the portal vein of male Wag/Rij rats. Irinotecan (10 mg/kg, 30 mg/kg, and 60 mg/kg) and 5-fluorouracil (40 mg/kg, 60 mg/kg, and 90 mg/kg) were administered concomitantly with degradable starch microspheres (30 mg/kg) for temporary embolization. The tumor cell load was determined quantitatively using a chemoluminescence assay.Results HACE with irinotecan induced a complete remission in 44% of the animals and the highest dose reduced the mean tumor cell load by 66% (P <0.001). In contrast, the highest dose of 5-FU caused a reduction of only 18% (P = 0.026) and altogether 23% complete remissions were observed in response to 5-FU. The sensitivity of CC531-lac-Z cells versus irinotecan (IC50 32 pM after 72 h) and 5-FU (IC50 80 µM) mirrored the effects observed in vivo on a qualitative basis.Conclusion In conclusion, the effect of HACE with irinotecan surpassed that of HACE with 5-FU and prompts further investigation in clinical trials. More... »

PAGES

203-210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00432-003-0523-x

DOI

http://dx.doi.org/10.1007/s00432-003-0523-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041714068

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14740207


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Irinotecan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Measurements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microspheres", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saenger", 
        "givenName": "Jan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leible", 
        "givenName": "Maike", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, University Clinics Muenster, Muenster, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of General Surgery, University Clinics Muenster, Muenster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seelig", 
        "givenName": "Matthias H.", 
        "id": "sg:person.01062355255.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062355255.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Martin R.", 
        "id": "sg:person.01256203524.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s004230050199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005575327", 
          "https://doi.org/10.1007/s004230050199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1011062002851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036356931", 
          "https://doi.org/10.1023/a:1011062002851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-003-0495-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041271083", 
          "https://doi.org/10.1007/s00432-003-0495-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00402774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003074278", 
          "https://doi.org/10.1007/bf00402774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006643831825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015402288", 
          "https://doi.org/10.1023/a:1006643831825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004152180", 
          "https://doi.org/10.1038/bjc.1995.168"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-01-22", 
    "datePublishedReg": "2004-01-22", 
    "description": "Purpose Hematogenic metastasis of patients with colorectal cancer most frequently effects the liver; the prognosis of affected patients is dramatically worsened by the presence of this lesion. The aim of this study was to evaluate the effect of hepatic arterial chemoembolization (HACE) with irinotecan versus 5-fluorouracil as a standard agent in a rat liver metastasis model.Materials and methods Diffuse liver metastasis was induced by injecting 4\u00d7106 CC531-lac-Z rat colorectal carcinoma cells into the portal vein of male Wag/Rij rats. Irinotecan (10\u00a0mg/kg, 30\u00a0mg/kg, and 60\u00a0mg/kg) and 5-fluorouracil (40\u00a0mg/kg, 60\u00a0mg/kg, and 90\u00a0mg/kg) were administered concomitantly with degradable starch microspheres (30\u00a0mg/kg) for temporary embolization. The tumor cell load was determined quantitatively using a chemoluminescence assay.Results HACE with irinotecan induced a complete remission in 44% of the animals and the highest dose reduced the mean tumor cell load by 66% (P <0.001). In contrast, the highest dose of 5-FU caused a reduction of only 18% (P = 0.026) and altogether 23% complete remissions were observed in response to 5-FU. The sensitivity of CC531-lac-Z cells versus irinotecan (IC50 32 pM after 72\u00a0h) and 5-FU (IC50 80\u00a0\u00b5M) mirrored the effects observed in vivo on a qualitative basis.Conclusion In conclusion, the effect of HACE with irinotecan surpassed that of HACE with 5-FU and prompts further investigation in clinical trials.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00432-003-0523-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313647", 
        "issn": [
          "0171-5216", 
          "1432-1335"
        ], 
        "name": "Journal of Cancer Research and Clinical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "130"
      }
    ], 
    "keywords": [
      "hepatic arterial chemoembolization", 
      "tumor cell load", 
      "complete remission", 
      "liver metastases", 
      "high dose", 
      "rat liver metastasis model", 
      "male WAG/Rij", 
      "degradable starch microspheres", 
      "diffuse liver metastases", 
      "liver metastasis model", 
      "rat liver metastases", 
      "WAG/Rij", 
      "colorectal carcinoma cells", 
      "tumor cell reduction", 
      "arterial chemoembolization", 
      "colorectal cancer", 
      "portal vein", 
      "chemoluminescence assay", 
      "clinical trials", 
      "hematogenic metastasis", 
      "metastasis model", 
      "standard agents", 
      "irinotecan", 
      "temporary embolization", 
      "cell reduction", 
      "metastasis", 
      "carcinoma cells", 
      "starch microspheres", 
      "chemoembolization", 
      "remission", 
      "patients", 
      "further investigation", 
      "dose", 
      "conclusion", 
      "cells", 
      "embolization", 
      "prognosis", 
      "lesions", 
      "cancer", 
      "liver", 
      "trials", 
      "cell load", 
      "vein", 
      "effect", 
      "vivo", 
      "animals", 
      "Rij", 
      "reduction", 
      "assays", 
      "aim", 
      "agents", 
      "response", 
      "study", 
      "sensitivity", 
      "contrast", 
      "presence", 
      "quantification", 
      "investigation", 
      "microspheres", 
      "results", 
      "load", 
      "basis", 
      "model", 
      "materials", 
      "qualitative basis"
    ], 
    "name": "Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction", 
    "pagination": "203-210", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041714068"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00432-003-0523-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14740207"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00432-003-0523-x", 
      "https://app.dimensions.ai/details/publication/pub.1041714068"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_393.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00432-003-0523-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00432-003-0523-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00432-003-0523-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00432-003-0523-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00432-003-0523-x'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      22 PREDICATES      113 URIs      99 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00432-003-0523-x schema:about N1c680f3773954190b16250d8a750d315
2 N3459c12658de421fb361383f81e01916
3 N3b2730bce4a84824996c875b3c951b42
4 N4cc2944712074efdac83ea307bf98646
5 N530f330ed79e48c1af2c07fc0023252c
6 N67ac997f8ae149f79a9920ac0e255de5
7 N6b88d9b19082432f8793f82f24420501
8 N6fe1a6e4ce7142a18c83759c27952544
9 Na116b30e06464475bb0467875fd31c73
10 Naeeb36b62b564c9cbe7d29d2552a9e31
11 Nb234428f7f3448b4968773f2d0287f8d
12 Nb247f116a9d44cd2bee2e766acaccf04
13 Nb9d7fb9a66394beea396cb9de748f19d
14 Nd91ccc1b21264a6786ffee9fee8ff306
15 Nf0b2d486d6e843b2bad407bdf9263e16
16 Nf73474574fac4c39ae30cf49a4f2b58d
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N86b22f5932224a6c86f3459f86776353
20 schema:citation sg:pub.10.1007/bf00402774
21 sg:pub.10.1007/s004230050199
22 sg:pub.10.1007/s00432-003-0495-x
23 sg:pub.10.1023/a:1006643831825
24 sg:pub.10.1023/a:1011062002851
25 sg:pub.10.1038/bjc.1995.168
26 schema:datePublished 2004-01-22
27 schema:datePublishedReg 2004-01-22
28 schema:description Purpose Hematogenic metastasis of patients with colorectal cancer most frequently effects the liver; the prognosis of affected patients is dramatically worsened by the presence of this lesion. The aim of this study was to evaluate the effect of hepatic arterial chemoembolization (HACE) with irinotecan versus 5-fluorouracil as a standard agent in a rat liver metastasis model.Materials and methods Diffuse liver metastasis was induced by injecting 4×106 CC531-lac-Z rat colorectal carcinoma cells into the portal vein of male Wag/Rij rats. Irinotecan (10 mg/kg, 30 mg/kg, and 60 mg/kg) and 5-fluorouracil (40 mg/kg, 60 mg/kg, and 90 mg/kg) were administered concomitantly with degradable starch microspheres (30 mg/kg) for temporary embolization. The tumor cell load was determined quantitatively using a chemoluminescence assay.Results HACE with irinotecan induced a complete remission in 44% of the animals and the highest dose reduced the mean tumor cell load by 66% (P <0.001). In contrast, the highest dose of 5-FU caused a reduction of only 18% (P = 0.026) and altogether 23% complete remissions were observed in response to 5-FU. The sensitivity of CC531-lac-Z cells versus irinotecan (IC50 32 pM after 72 h) and 5-FU (IC50 80 µM) mirrored the effects observed in vivo on a qualitative basis.Conclusion In conclusion, the effect of HACE with irinotecan surpassed that of HACE with 5-FU and prompts further investigation in clinical trials.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf Nd166297080884c6bbf7244966f8433aa
33 Nfba2ce9ad2174062b3f0904748f7590d
34 sg:journal.1313647
35 schema:keywords Rij
36 WAG/Rij
37 agents
38 aim
39 animals
40 arterial chemoembolization
41 assays
42 basis
43 cancer
44 carcinoma cells
45 cell load
46 cell reduction
47 cells
48 chemoembolization
49 chemoluminescence assay
50 clinical trials
51 colorectal cancer
52 colorectal carcinoma cells
53 complete remission
54 conclusion
55 contrast
56 degradable starch microspheres
57 diffuse liver metastases
58 dose
59 effect
60 embolization
61 further investigation
62 hematogenic metastasis
63 hepatic arterial chemoembolization
64 high dose
65 investigation
66 irinotecan
67 lesions
68 liver
69 liver metastases
70 liver metastasis model
71 load
72 male WAG/Rij
73 materials
74 metastasis
75 metastasis model
76 microspheres
77 model
78 patients
79 portal vein
80 presence
81 prognosis
82 qualitative basis
83 quantification
84 rat liver metastases
85 rat liver metastasis model
86 reduction
87 remission
88 response
89 results
90 sensitivity
91 standard agents
92 starch microspheres
93 study
94 temporary embolization
95 trials
96 tumor cell load
97 tumor cell reduction
98 vein
99 vivo
100 schema:name Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction
101 schema:pagination 203-210
102 schema:productId N0c0cfbfa79ff45c4be7054ba8e808359
103 Nc8e27a8e529b41d78e208ec56452d987
104 Nee94e2951ad348f49ae24fa680f43940
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041714068
106 https://doi.org/10.1007/s00432-003-0523-x
107 schema:sdDatePublished 2022-06-01T22:05
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N33564bc8753c4bf994681c97bd4ab2aa
110 schema:url https://doi.org/10.1007/s00432-003-0523-x
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N0c0cfbfa79ff45c4be7054ba8e808359 schema:name doi
115 schema:value 10.1007/s00432-003-0523-x
116 rdf:type schema:PropertyValue
117 N1b2a735149e74352ae10ab2c76540a4e schema:affiliation grid-institutes:grid.7497.d
118 schema:familyName Leible
119 schema:givenName Maike
120 rdf:type schema:Person
121 N1c680f3773954190b16250d8a750d315 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Rats
123 rdf:type schema:DefinedTerm
124 N33564bc8753c4bf994681c97bd4ab2aa schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N3459c12658de421fb361383f81e01916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Luminescent Measurements
128 rdf:type schema:DefinedTerm
129 N350b6a41b596470c85495155ad169a50 schema:affiliation grid-institutes:grid.7497.d
130 schema:familyName Saenger
131 schema:givenName Jan
132 rdf:type schema:Person
133 N3b2730bce4a84824996c875b3c951b42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Fluorouracil
135 rdf:type schema:DefinedTerm
136 N4117e512abeb42f99cacae4be3cc1aad rdf:first N1b2a735149e74352ae10ab2c76540a4e
137 rdf:rest Nffc178095887441f8bd054943f54ff64
138 N4cc2944712074efdac83ea307bf98646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Adenocarcinoma
140 rdf:type schema:DefinedTerm
141 N530f330ed79e48c1af2c07fc0023252c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Antineoplastic Agents, Phytogenic
143 rdf:type schema:DefinedTerm
144 N5908aaf92f8744d1b29207e3fa3f8c64 rdf:first sg:person.01256203524.22
145 rdf:rest rdf:nil
146 N67ac997f8ae149f79a9920ac0e255de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 N6b88d9b19082432f8793f82f24420501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Irinotecan
151 rdf:type schema:DefinedTerm
152 N6fe1a6e4ce7142a18c83759c27952544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Chemoembolization, Therapeutic
154 rdf:type schema:DefinedTerm
155 N86b22f5932224a6c86f3459f86776353 rdf:first N350b6a41b596470c85495155ad169a50
156 rdf:rest N4117e512abeb42f99cacae4be3cc1aad
157 Na116b30e06464475bb0467875fd31c73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Camptothecin
159 rdf:type schema:DefinedTerm
160 Naeeb36b62b564c9cbe7d29d2552a9e31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Microspheres
162 rdf:type schema:DefinedTerm
163 Nb234428f7f3448b4968773f2d0287f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Rats, Inbred Strains
165 rdf:type schema:DefinedTerm
166 Nb247f116a9d44cd2bee2e766acaccf04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Cell Line, Tumor
168 rdf:type schema:DefinedTerm
169 Nb9d7fb9a66394beea396cb9de748f19d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Dose-Response Relationship, Drug
171 rdf:type schema:DefinedTerm
172 Nc8e27a8e529b41d78e208ec56452d987 schema:name dimensions_id
173 schema:value pub.1041714068
174 rdf:type schema:PropertyValue
175 Nd166297080884c6bbf7244966f8433aa schema:volumeNumber 130
176 rdf:type schema:PublicationVolume
177 Nd91ccc1b21264a6786ffee9fee8ff306 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Male
179 rdf:type schema:DefinedTerm
180 Nee94e2951ad348f49ae24fa680f43940 schema:name pubmed_id
181 schema:value 14740207
182 rdf:type schema:PropertyValue
183 Nf0b2d486d6e843b2bad407bdf9263e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Antimetabolites, Antineoplastic
185 rdf:type schema:DefinedTerm
186 Nf73474574fac4c39ae30cf49a4f2b58d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Colonic Neoplasms
188 rdf:type schema:DefinedTerm
189 Nfba2ce9ad2174062b3f0904748f7590d schema:issueNumber 4
190 rdf:type schema:PublicationIssue
191 Nffc178095887441f8bd054943f54ff64 rdf:first sg:person.01062355255.01
192 rdf:rest N5908aaf92f8744d1b29207e3fa3f8c64
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
197 schema:name Oncology and Carcinogenesis
198 rdf:type schema:DefinedTerm
199 sg:journal.1313647 schema:issn 0171-5216
200 1432-1335
201 schema:name Journal of Cancer Research and Clinical Oncology
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01062355255.01 schema:affiliation grid-institutes:None
205 schema:familyName Seelig
206 schema:givenName Matthias H.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062355255.01
208 rdf:type schema:Person
209 sg:person.01256203524.22 schema:affiliation grid-institutes:grid.7497.d
210 schema:familyName Berger
211 schema:givenName Martin R.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22
213 rdf:type schema:Person
214 sg:pub.10.1007/bf00402774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003074278
215 https://doi.org/10.1007/bf00402774
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s004230050199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005575327
218 https://doi.org/10.1007/s004230050199
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s00432-003-0495-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041271083
221 https://doi.org/10.1007/s00432-003-0495-x
222 rdf:type schema:CreativeWork
223 sg:pub.10.1023/a:1006643831825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015402288
224 https://doi.org/10.1023/a:1006643831825
225 rdf:type schema:CreativeWork
226 sg:pub.10.1023/a:1011062002851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036356931
227 https://doi.org/10.1023/a:1011062002851
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/bjc.1995.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004152180
230 https://doi.org/10.1038/bjc.1995.168
231 rdf:type schema:CreativeWork
232 grid-institutes:None schema:alternateName Department of General Surgery, University Clinics Muenster, Muenster, Germany
233 schema:name Department of General Surgery, University Clinics Muenster, Muenster, Germany
234 rdf:type schema:Organization
235 grid-institutes:grid.7497.d schema:alternateName Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany
236 schema:name Unit of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 120, 69120, Heidelberg, Germany
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...