Inpatient outcomes of preterm infants receiving ω-3 enriched lipid emulsion (SMOFlipid): an observational study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Nalin Choudhary, Kenneth Tan, Atul Malhotra

ABSTRACT

Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (< 32 weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017). Primary outcome studied was mortality and rates of severe neonatal morbidities. Univariate and multivariate regression was conducted to determine risk for mortality and PNALD. A total of 222 infants (epoch 1, 123 versus epoch 2, 99) were included in the study. A higher incidence of late onset sepsis (56 versus 30%, p < 0.005) was observed in epoch 1. There was no significant difference in mortality or rates of any other severe neonatal morbidity. The type of lipid emulsion did not have a significant effect on mortality or PNALD on regression analysis. CONCLUSION: Use of SMOFlipid as the primary lipid emulsion seems to have minimal effect on rates of clinically important neonatal outcomes; however, long-term effects need to be further evaluated. What is Known: • Many neonatal units have started replacing traditional soy-based lipid formulations with SMOFlipid (ω-3 enriched lipid emulsion), as the primary lipid component in parenteral nutrition for preterm infants. • While there is evidence associating improved liver function and balanced essential fatty acid levels in infants receiving SMOFlipid, there is a lack of evidence evaluating relevant clinical outcomes in infants receiving SMOFlipid versus traditional lipid formulations. What is New: • The influence of SMOFlipid on a series of clinical outcomes in an at-risk preterm population is presented. • SMOFlipid appears to be well tolerated in preterm infants with minimal side effects, and some growth benefits seen. More... »

PAGES

723-731

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-018-3112-3

DOI

http://dx.doi.org/10.1007/s00431-018-3112-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101042226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29445923


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Emulsions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fat Emulsions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Omega-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Premature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inpatients", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units, Neonatal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parenteral Nutrition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soybean Oil", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Monash University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choudhary", 
        "givenName": "Nalin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Monash Newborn, Monash Children\u2019s Hospital, Melbourne, Australia", 
            "The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia", 
            "Department of Paediatrics, Monash University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Kenneth", 
        "id": "sg:person.0643445267.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643445267.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Monash Newborn, Monash Children\u2019s Hospital, Melbourne, Australia", 
            "The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia", 
            "Department of Paediatrics, Monash University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malhotra", 
        "givenName": "Atul", 
        "id": "sg:person.0676104046.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676104046.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3182447daf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001025361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3182447daf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001025361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07315724.2002.10719248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001402249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpg.0000181841.07090.f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002583775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpg.0000181841.07090.f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002583775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpg.0000181841.07090.f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002583775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.112.056556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005137420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pedneo.2013.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005389970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3181adaee0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010585504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3181adaee0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010585504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3181adaee0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010585504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3181adaee0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010585504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012412411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012412411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0148607106030004351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022591712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd009172.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023059459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/an.113.004770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023905395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2010.12.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026031114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.earlhumdev.2010.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026783202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1754.1993.tb00440.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028752912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.115.125138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030022321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12887-016-0611-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030545646", 
          "https://doi.org/10.1186/s12887-016-0611-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1740-8709.2011.00356.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033173181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.3.1073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033282772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000001121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036413576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000001121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036413576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/an.115.009084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037914873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejcn.2014.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042558388", 
          "https://doi.org/10.1038/ejcn.2014.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejcn.2014.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042558388", 
          "https://doi.org/10.1038/ejcn.2014.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0148607111424411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045309445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3205/000074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046104207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0148607115626921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046810537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.earlhumdev.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053306022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000000665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m069526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064192904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1m626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065017169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1m626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065017169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/71.1.245s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074569741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/83.6.1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077253074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/85.5.1171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077415616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-017-2888-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084021961", 
          "https://doi.org/10.1007/s00431-017-2888-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-017-2888-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084021961", 
          "https://doi.org/10.1007/s00431-017-2888-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (<\u200932\u00a0weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017). Primary outcome studied was mortality and rates of severe neonatal morbidities. Univariate and multivariate regression was conducted to determine risk for mortality and PNALD. A total of 222 infants (epoch 1, 123 versus epoch 2, 99) were included in the study. A higher incidence of late onset sepsis (56 versus 30%, p\u2009<\u20090.005) was observed in epoch 1. There was no significant difference in mortality or rates of any other severe neonatal morbidity. The type of lipid emulsion did not have a significant effect on mortality or PNALD on regression analysis.\nCONCLUSION: Use of SMOFlipid as the primary lipid emulsion seems to have minimal effect on rates of clinically important neonatal outcomes; however, long-term effects need to be further evaluated. What is Known: \u2022 Many neonatal units have started replacing traditional soy-based lipid formulations with SMOFlipid (\u03c9-3 enriched lipid emulsion), as the primary lipid component in parenteral nutrition for preterm infants. \u2022 While there is evidence associating improved liver function and balanced essential fatty acid levels in infants receiving SMOFlipid, there is a lack of evidence evaluating relevant clinical outcomes in infants receiving SMOFlipid versus traditional lipid formulations. What is New: \u2022 The influence of SMOFlipid on a series of clinical outcomes in an at-risk preterm population is presented. \u2022 SMOFlipid appears to be well tolerated in preterm infants with minimal side effects, and some growth benefits seen.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00431-018-3112-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017354", 
        "issn": [
          "0340-6199", 
          "1432-1076"
        ], 
        "name": "European Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "177"
      }
    ], 
    "name": "Inpatient outcomes of preterm infants receiving \u03c9-3 enriched lipid emulsion (SMOFlipid): an observational study", 
    "pagination": "723-731", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c464ba3cdd19e25fb1bd5b6c7fa532f693b5bcb5b3a51a13e176176c66baa301"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29445923"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7603873"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00431-018-3112-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101042226"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00431-018-3112-3", 
      "https://app.dimensions.ai/details/publication/pub.1101042226"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000603.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00431-018-3112-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00431-018-3112-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00431-018-3112-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00431-018-3112-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00431-018-3112-3'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      80 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00431-018-3112-3 schema:about N04e5dd65f1ca44698d1c3af7f85888e0
2 N151ce3f58fa645d3bf1f1844fdb9ae85
3 N2717ad0141ad4811a1c411a91e646aa4
4 N3305226fb6824e95ac8066002d7629eb
5 N3875ef54cb1b4e669c6468ebb14eb39c
6 N39e086ffb65947f2a5bcac84b37293cd
7 N3ba6270446ed447fb62cb7d8902da9ee
8 N4472ce6702224598991f8b22c0a4b8c8
9 N473957816bf94cd5b69ffe7b2372ee53
10 N4f7fb998d1f6486983923b0d97e4dc06
11 N592405250d2649a7bb6ea085ce5df134
12 N7ca55bce51ef4fb7a1cce9d9144c85f6
13 N9f4467c8bf684cef9bfeb702eee2da0d
14 Na8863d83805243a49a1bb1ec5146b079
15 Nab46257d02ac4a99ac3f37ea8e1fcf94
16 Nba593b2da0fe408981e68f7b99368e3a
17 Nd460598f54ea435ea4f96aa37076a1f2
18 Ne6f198a810284df1a51a3a8efac50055
19 Nf311939bd6b44511a569934f6c8236dc
20 anzsrc-for:11
21 anzsrc-for:1114
22 schema:author Nad4444cfa544432aab50fc2012e5ad75
23 schema:citation sg:pub.10.1007/s00431-017-2888-x
24 sg:pub.10.1038/ejcn.2014.118
25 sg:pub.10.1186/s12887-016-0611-0
26 https://doi.org/10.1002/14651858.cd009172.pub2
27 https://doi.org/10.1016/j.earlhumdev.2010.08.012
28 https://doi.org/10.1016/j.earlhumdev.2013.11.002
29 https://doi.org/10.1016/j.jpeds.2010.12.052
30 https://doi.org/10.1016/j.pedneo.2013.07.003
31 https://doi.org/10.1073/pnas.90.3.1073
32 https://doi.org/10.1080/07315724.2002.10719248
33 https://doi.org/10.1093/ajcn/71.1.245s
34 https://doi.org/10.1093/ajcn/83.6.1337
35 https://doi.org/10.1093/ajcn/85.5.1171
36 https://doi.org/10.1097/01.mpg.0000181841.07090.f4
37 https://doi.org/10.1097/mpg.0000000000000174
38 https://doi.org/10.1097/mpg.0000000000000280
39 https://doi.org/10.1097/mpg.0000000000000665
40 https://doi.org/10.1097/mpg.0000000000001121
41 https://doi.org/10.1097/mpg.0b013e3181adaee0
42 https://doi.org/10.1097/mpg.0b013e3182447daf
43 https://doi.org/10.1111/j.1440-1754.1993.tb00440.x
44 https://doi.org/10.1111/j.1740-8709.2011.00356.x
45 https://doi.org/10.1177/0148607106030004351
46 https://doi.org/10.1177/0148607111424411
47 https://doi.org/10.1177/0148607115626921
48 https://doi.org/10.1194/jlr.m069526
49 https://doi.org/10.1345/aph.1m626
50 https://doi.org/10.3205/000074
51 https://doi.org/10.3945/ajcn.112.056556
52 https://doi.org/10.3945/ajcn.115.125138
53 https://doi.org/10.3945/an.113.004770
54 https://doi.org/10.3945/an.115.009084
55 schema:datePublished 2018-05
56 schema:datePublishedReg 2018-05-01
57 schema:description Neonatal units have started to switch from using conventional soy-based to alternate lipid emulsions, like SMOFlipid. SMOFlipid has been associated with an improvement in biochemical parameters and delays progression of parenteral nutrition-associated liver disease (PNALD). This retrospective epoch study aimed to compare clinically relevant neonatal outcomes in preterm infants (< 32 weeks), receiving SMOFlipid versus Intralipid. We compared clinical outcomes in two epochs-epoch 1 (Intralipid, October 2013-June 2015) versus epoch 2 (SMOFlipid, July 2015-March 2017). Primary outcome studied was mortality and rates of severe neonatal morbidities. Univariate and multivariate regression was conducted to determine risk for mortality and PNALD. A total of 222 infants (epoch 1, 123 versus epoch 2, 99) were included in the study. A higher incidence of late onset sepsis (56 versus 30%, p < 0.005) was observed in epoch 1. There was no significant difference in mortality or rates of any other severe neonatal morbidity. The type of lipid emulsion did not have a significant effect on mortality or PNALD on regression analysis. CONCLUSION: Use of SMOFlipid as the primary lipid emulsion seems to have minimal effect on rates of clinically important neonatal outcomes; however, long-term effects need to be further evaluated. What is Known: • Many neonatal units have started replacing traditional soy-based lipid formulations with SMOFlipid (ω-3 enriched lipid emulsion), as the primary lipid component in parenteral nutrition for preterm infants. • While there is evidence associating improved liver function and balanced essential fatty acid levels in infants receiving SMOFlipid, there is a lack of evidence evaluating relevant clinical outcomes in infants receiving SMOFlipid versus traditional lipid formulations. What is New: • The influence of SMOFlipid on a series of clinical outcomes in an at-risk preterm population is presented. • SMOFlipid appears to be well tolerated in preterm infants with minimal side effects, and some growth benefits seen.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N34ecdb0d186c49c9a84797145de3038f
62 Naadf270427bb45d783b882caa777c395
63 sg:journal.1017354
64 schema:name Inpatient outcomes of preterm infants receiving ω-3 enriched lipid emulsion (SMOFlipid): an observational study
65 schema:pagination 723-731
66 schema:productId N2b56d97ec9f1405b89a485127fc70ad5
67 N7054a9dc70f3479da4659421c07cd826
68 N80904f108da8454c9bfdeb63665e5b75
69 Nb8718cc11b8a4e5ca8a69f2cf319bb7c
70 Nbecd3ab6c445448d81476b7e0d79d43e
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101042226
72 https://doi.org/10.1007/s00431-018-3112-3
73 schema:sdDatePublished 2019-04-10T16:55
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Ndf509970ccec4741aaeb931b37348ff9
76 schema:url https://link.springer.com/10.1007%2Fs00431-018-3112-3
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0073907d31164dcc9f03333d41a6280f schema:affiliation https://www.grid.ac/institutes/grid.1002.3
81 schema:familyName Choudhary
82 schema:givenName Nalin
83 rdf:type schema:Person
84 N04e5dd65f1ca44698d1c3af7f85888e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Parenteral Nutrition
86 rdf:type schema:DefinedTerm
87 N08a1bc8f325c4ceb9c0d99a028eb3656 rdf:first sg:person.0676104046.59
88 rdf:rest rdf:nil
89 N151ce3f58fa645d3bf1f1844fdb9ae85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Infant
91 rdf:type schema:DefinedTerm
92 N2717ad0141ad4811a1c411a91e646aa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Cohort Studies
94 rdf:type schema:DefinedTerm
95 N2b56d97ec9f1405b89a485127fc70ad5 schema:name nlm_unique_id
96 schema:value 7603873
97 rdf:type schema:PropertyValue
98 N3305226fb6824e95ac8066002d7629eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Phospholipids
100 rdf:type schema:DefinedTerm
101 N34ecdb0d186c49c9a84797145de3038f schema:issueNumber 5
102 rdf:type schema:PublicationIssue
103 N3875ef54cb1b4e669c6468ebb14eb39c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Liver Diseases
105 rdf:type schema:DefinedTerm
106 N39e086ffb65947f2a5bcac84b37293cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Inpatients
108 rdf:type schema:DefinedTerm
109 N3ba6270446ed447fb62cb7d8902da9ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Emulsions
111 rdf:type schema:DefinedTerm
112 N4472ce6702224598991f8b22c0a4b8c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Infant, Premature
114 rdf:type schema:DefinedTerm
115 N473957816bf94cd5b69ffe7b2372ee53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Retrospective Studies
117 rdf:type schema:DefinedTerm
118 N49ec70cc08e74585b5cc5f137ebeb4d3 rdf:first sg:person.0643445267.34
119 rdf:rest N08a1bc8f325c4ceb9c0d99a028eb3656
120 N4f7fb998d1f6486983923b0d97e4dc06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Fat Emulsions, Intravenous
122 rdf:type schema:DefinedTerm
123 N592405250d2649a7bb6ea085ce5df134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 N7054a9dc70f3479da4659421c07cd826 schema:name pubmed_id
127 schema:value 29445923
128 rdf:type schema:PropertyValue
129 N7ca55bce51ef4fb7a1cce9d9144c85f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Infant Mortality
131 rdf:type schema:DefinedTerm
132 N80904f108da8454c9bfdeb63665e5b75 schema:name dimensions_id
133 schema:value pub.1101042226
134 rdf:type schema:PropertyValue
135 N9f4467c8bf684cef9bfeb702eee2da0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 Na8863d83805243a49a1bb1ec5146b079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Fatty Acids, Omega-3
140 rdf:type schema:DefinedTerm
141 Naadf270427bb45d783b882caa777c395 schema:volumeNumber 177
142 rdf:type schema:PublicationVolume
143 Nab46257d02ac4a99ac3f37ea8e1fcf94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Risk Factors
145 rdf:type schema:DefinedTerm
146 Nad4444cfa544432aab50fc2012e5ad75 rdf:first N0073907d31164dcc9f03333d41a6280f
147 rdf:rest N49ec70cc08e74585b5cc5f137ebeb4d3
148 Nb8718cc11b8a4e5ca8a69f2cf319bb7c schema:name readcube_id
149 schema:value c464ba3cdd19e25fb1bd5b6c7fa532f693b5bcb5b3a51a13e176176c66baa301
150 rdf:type schema:PropertyValue
151 Nba593b2da0fe408981e68f7b99368e3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Infant, Newborn
153 rdf:type schema:DefinedTerm
154 Nbecd3ab6c445448d81476b7e0d79d43e schema:name doi
155 schema:value 10.1007/s00431-018-3112-3
156 rdf:type schema:PropertyValue
157 Nd460598f54ea435ea4f96aa37076a1f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 Ndf509970ccec4741aaeb931b37348ff9 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Ne6f198a810284df1a51a3a8efac50055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Soybean Oil
164 rdf:type schema:DefinedTerm
165 Nf311939bd6b44511a569934f6c8236dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Intensive Care Units, Neonatal
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
172 schema:name Paediatrics and Reproductive Medicine
173 rdf:type schema:DefinedTerm
174 sg:journal.1017354 schema:issn 0340-6199
175 1432-1076
176 schema:name European Journal of Pediatrics
177 rdf:type schema:Periodical
178 sg:person.0643445267.34 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
179 schema:familyName Tan
180 schema:givenName Kenneth
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643445267.34
182 rdf:type schema:Person
183 sg:person.0676104046.59 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
184 schema:familyName Malhotra
185 schema:givenName Atul
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676104046.59
187 rdf:type schema:Person
188 sg:pub.10.1007/s00431-017-2888-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1084021961
189 https://doi.org/10.1007/s00431-017-2888-x
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/ejcn.2014.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042558388
192 https://doi.org/10.1038/ejcn.2014.118
193 rdf:type schema:CreativeWork
194 sg:pub.10.1186/s12887-016-0611-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030545646
195 https://doi.org/10.1186/s12887-016-0611-0
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/14651858.cd009172.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023059459
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.earlhumdev.2010.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026783202
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.earlhumdev.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053306022
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.jpeds.2010.12.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026031114
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.pedneo.2013.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005389970
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1073/pnas.90.3.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033282772
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1080/07315724.2002.10719248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001402249
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/ajcn/71.1.245s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074569741
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/ajcn/83.6.1337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077253074
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/ajcn/85.5.1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077415616
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/01.mpg.0000181841.07090.f4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002583775
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/mpg.0000000000000174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060343238
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/mpg.0000000000000280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012412411
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/mpg.0000000000000665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060343256
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1097/mpg.0000000000001121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036413576
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/mpg.0b013e3181adaee0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010585504
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1097/mpg.0b013e3182447daf schema:sameAs https://app.dimensions.ai/details/publication/pub.1001025361
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/j.1440-1754.1993.tb00440.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028752912
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/j.1740-8709.2011.00356.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033173181
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1177/0148607106030004351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022591712
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1177/0148607111424411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045309445
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1177/0148607115626921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046810537
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1194/jlr.m069526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064192904
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1345/aph.1m626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065017169
244 rdf:type schema:CreativeWork
245 https://doi.org/10.3205/000074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046104207
246 rdf:type schema:CreativeWork
247 https://doi.org/10.3945/ajcn.112.056556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005137420
248 rdf:type schema:CreativeWork
249 https://doi.org/10.3945/ajcn.115.125138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030022321
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3945/an.113.004770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023905395
252 rdf:type schema:CreativeWork
253 https://doi.org/10.3945/an.115.009084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037914873
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
256 schema:name Department of Paediatrics, Monash University, Melbourne, Australia
257 Monash Newborn, Monash Children’s Hospital, Melbourne, Australia
258 Monash University, Melbourne, Australia
259 The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...