Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

Fátima Pérez-de-Heredia, Sonia Gómez-Martínez, Ligia-Esperanza Díaz, Ana M. Veses, Esther Nova, Julia Wärnberg, Inge Huybrechts, Krishna Vyncke, Odysseas Androutsos, Marika Ferrari, Gonzalo Palacios, Acki Wastlund, Éva Kovács, Frédéric Gottrand, Marcela González-Gross, Manuel J. Castillo, Michael Sjöstrom, Yannis Manios, Anthony Kafatos, Denes Molnár, Kurt Widhalm, Luis A. Moreno, Ascensión Marcos, on behalf of the HELENA Study Group

ABSTRACT

Percentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5-17.5 years, n = 405, 48.9% boys), considering age, sex, puberty and body mass index (BMI). CD3(+) (mature T cells), CD4(+) (T helper), CD8(+) (T cytotoxic), CD16(+)56(+) (natural killer), CD19(+) (B cells), CD3(+)CD45RA(+), CD4(+)CD45RA(+), CD8(+)CD45RA(+) (naïve), CD3(+)CD45RO(+), CD4(+)CD45RO(+) and CD8(+)CD45RO(+) (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) cell counts and CD3(+)/CD19(+) ratio, and lower CD3(+)CD45RA(+) and CD4(+)CD45RA(+) counts than boys. Age was associated with higher neutrophil counts and CD3(+)/CD19(+), and lower CD19(+) counts; in boys, with lower CD3(+)CD45RA(+), CD4(+)CD45RA(+) and CD8(+)CD45RA(+) counts as well; in girls, with higher WBC, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4(+), CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts. CONCLUSION: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations. More... »

PAGES

999-1014

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5

DOI

http://dx.doi.org/10.1007/s00431-015-2497-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037010869

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25665972


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456 rdf:type schema:Organization
457 https://www.grid.ac/institutes/grid.9679.1 schema:alternateName University of Pecs
458 schema:name Department of Pediatrics, University of Pécs, Pécs, Hungary
459 rdf:type schema:Organization
 




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