Ontology type: schema:ScholarlyArticle Open Access: True
2015-08
AUTHORSFátima Pérez-de-Heredia, Sonia Gómez-Martínez, Ligia-Esperanza Díaz, Ana M. Veses, Esther Nova, Julia Wärnberg, Inge Huybrechts, Krishna Vyncke, Odysseas Androutsos, Marika Ferrari, Gonzalo Palacios, Acki Wastlund, Éva Kovács, Frédéric Gottrand, Marcela González-Gross, Manuel J. Castillo, Michael Sjöstrom, Yannis Manios, Anthony Kafatos, Denes Molnár, Kurt Widhalm, Luis A. Moreno, Ascensión Marcos, on behalf of the HELENA Study Group
ABSTRACTPercentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5-17.5 years, n = 405, 48.9% boys), considering age, sex, puberty and body mass index (BMI). CD3(+) (mature T cells), CD4(+) (T helper), CD8(+) (T cytotoxic), CD16(+)56(+) (natural killer), CD19(+) (B cells), CD3(+)CD45RA(+), CD4(+)CD45RA(+), CD8(+)CD45RA(+) (naïve), CD3(+)CD45RO(+), CD4(+)CD45RO(+) and CD8(+)CD45RO(+) (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) cell counts and CD3(+)/CD19(+) ratio, and lower CD3(+)CD45RA(+) and CD4(+)CD45RA(+) counts than boys. Age was associated with higher neutrophil counts and CD3(+)/CD19(+), and lower CD19(+) counts; in boys, with lower CD3(+)CD45RA(+), CD4(+)CD45RA(+) and CD8(+)CD45RA(+) counts as well; in girls, with higher WBC, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4(+), CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts. CONCLUSION: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations. More... »
PAGES999-1014
http://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5
DOIhttp://dx.doi.org/10.1007/s00431-015-2497-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1037010869
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25665972
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Age Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Basophils",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Mass Index",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Eosinophils",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukocyte Count",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Monocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neutrophils",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Puberty",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reference Values",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sex Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sexual Maturation",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"School of Natural Sciences and Psychology, Liverpool John Moores University, James Parsons Building, Byrom Street, L3 3AF, Liverpool, UK",
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "P\u00e9rez-de-Heredia",
"givenName": "F\u00e1tima",
"id": "sg:person.0764326330.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764326330.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "G\u00f3mez-Mart\u00ednez",
"givenName": "Sonia",
"id": "sg:person.0616573015.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616573015.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "D\u00edaz",
"givenName": "Ligia-Esperanza",
"id": "sg:person.0576375263.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576375263.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Veses",
"givenName": "Ana M.",
"id": "sg:person.01327432246.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327432246.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Nova",
"givenName": "Esther",
"id": "sg:person.01151076113.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151076113.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Karolinska Institute",
"id": "https://www.grid.ac/institutes/grid.4714.6",
"name": [
"Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "W\u00e4rnberg",
"givenName": "Julia",
"id": "sg:person.01121014366.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121014366.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "International Agency For Research On Cancer",
"id": "https://www.grid.ac/institutes/grid.17703.32",
"name": [
"Department of Public Health, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium",
"International Agency for Research on Cancer, Dietary Exposure Assessment Group, Lyon, France"
],
"type": "Organization"
},
"familyName": "Huybrechts",
"givenName": "Inge",
"id": "sg:person.01106412325.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106412325.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ghent University",
"id": "https://www.grid.ac/institutes/grid.5342.0",
"name": [
"Department of Public Health, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium"
],
"type": "Organization"
},
"familyName": "Vyncke",
"givenName": "Krishna",
"id": "sg:person.01204135730.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204135730.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harokopio University",
"id": "https://www.grid.ac/institutes/grid.15823.3d",
"name": [
"Department of Nutrition & Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Androutsos",
"givenName": "Odysseas",
"id": "sg:person.01055016034.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055016034.35"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"CRA-NUT, Food and Nutrition Research Center, Agricultural Research Council Roma, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Ferrari",
"givenName": "Marika",
"id": "sg:person.01307033461.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307033461.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Technical University of Madrid",
"id": "https://www.grid.ac/institutes/grid.5690.a",
"name": [
"ImFine Research Group, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Palacios",
"givenName": "Gonzalo",
"id": "sg:person.01215035165.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215035165.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Karolinska Institute",
"id": "https://www.grid.ac/institutes/grid.4714.6",
"name": [
"Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Wastlund",
"givenName": "Acki",
"id": "sg:person.01005516230.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005516230.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Maximilian University of Munich",
"id": "https://www.grid.ac/institutes/grid.5252.0",
"name": [
"Department of Pediatrics, University of P\u00e9cs, P\u00e9cs, Hungary",
"Institute for Medical Information Processing, Biometrics and Epidemiology and German Centre for Vertigo and Balance Disorders, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany"
],
"type": "Organization"
},
"familyName": "Kov\u00e1cs",
"givenName": "\u00c9va",
"id": "sg:person.01140656230.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140656230.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Lille 2 Droit et Sant\u00e9",
"id": "https://www.grid.ac/institutes/grid.16780.38",
"name": [
"H\u00f4pital J de Flandre CHRU de Lille, Inserm U995, IFR114, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Lille 2, Lille, France"
],
"type": "Organization"
},
"familyName": "Gottrand",
"givenName": "Fr\u00e9d\u00e9ric",
"id": "sg:person.01012147002.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012147002.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"ImFine Research Group, Faculty of Physical Activity and Sport Sciences, Technical University of Madrid, Madrid, Spain",
"Department of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Gonz\u00e1lez-Gross",
"givenName": "Marcela",
"id": "sg:person.0640026256.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640026256.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Granada",
"id": "https://www.grid.ac/institutes/grid.4489.1",
"name": [
"Department of Medical Physiology, Faculty of Medicine, University of Granada, Granada, Spain"
],
"type": "Organization"
},
"familyName": "Castillo",
"givenName": "Manuel J.",
"id": "sg:person.01207316433.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207316433.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Karolinska Institute",
"id": "https://www.grid.ac/institutes/grid.4714.6",
"name": [
"Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden"
],
"type": "Organization"
},
"familyName": "Sj\u00f6strom",
"givenName": "Michael",
"id": "sg:person.01141203233.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141203233.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Harokopio University",
"id": "https://www.grid.ac/institutes/grid.15823.3d",
"name": [
"Department of Nutrition & Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Manios",
"givenName": "Yannis",
"id": "sg:person.01264414106.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264414106.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Crete",
"id": "https://www.grid.ac/institutes/grid.8127.c",
"name": [
"University of Crete School of Medicine, Department of Social Medicine, Preventive Medicine and Nutrition Clinic, Heraklion, Crete, Greece"
],
"type": "Organization"
},
"familyName": "Kafatos",
"givenName": "Anthony",
"id": "sg:person.07563302174.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07563302174.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pecs",
"id": "https://www.grid.ac/institutes/grid.9679.1",
"name": [
"Department of Pediatrics, University of P\u00e9cs, P\u00e9cs, Hungary"
],
"type": "Organization"
},
"familyName": "Moln\u00e1r",
"givenName": "Denes",
"id": "sg:person.01337520027.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337520027.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Salzburg",
"id": "https://www.grid.ac/institutes/grid.7039.d",
"name": [
"Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria"
],
"type": "Organization"
},
"familyName": "Widhalm",
"givenName": "Kurt",
"id": "sg:person.0622764500.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622764500.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zaragoza",
"id": "https://www.grid.ac/institutes/grid.11205.37",
"name": [
"GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain"
],
"type": "Organization"
},
"familyName": "Moreno",
"givenName": "Luis A.",
"id": "sg:person.01173163452.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173163452.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Ciencia y Tecnolog\u00eda de Alimentos y Nutrici\u00f3n",
"id": "https://www.grid.ac/institutes/grid.419129.6",
"name": [
"Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Marcos",
"givenName": "Ascensi\u00f3n",
"id": "sg:person.0636777570.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636777570.41"
],
"type": "Person"
},
{
"familyName": "on behalf of the HELENA Study Group",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1017/s0007114507833034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000237604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-4731(89)90088-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001112406"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-4731(89)90088-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001112406"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2008.184",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001546612",
"https://doi.org/10.1038/ijo.2008.184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/000456329503200603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003199270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/000456329503200603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003199270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0609.2009.01326.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005879688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ejcn.1601819",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006029107",
"https://doi.org/10.1038/sj.ejcn.1601819"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ejcn.1601819",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006029107",
"https://doi.org/10.1038/sj.ejcn.1601819"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2008.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009630790",
"https://doi.org/10.1038/ijo.2008.177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0021-9150(03)00134-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010541096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0021-9150(03)00134-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010541096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0021040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012132545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1651-2227.1992.tb12187.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013465421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s0029665112000092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014858263"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/adc.51.3.170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016682307"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ajhb.22421",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017595011"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2008.179",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018039284",
"https://doi.org/10.1038/ijo.2008.179"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm197406062902302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021033723"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1751-553x.2010.01223.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023289433"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1751-553x.2010.01223.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023289433"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00592-009-0101-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023603964",
"https://doi.org/10.1007/s00592-009-0101-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00592-009-0101-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023603964",
"https://doi.org/10.1007/s00592-009-0101-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ijo.0803227",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024058828",
"https://doi.org/10.1038/sj.ijo.0803227"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ijo.0803227",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024058828",
"https://doi.org/10.1038/sj.ijo.0803227"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1442-200x.2007.02450.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025031692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s1368980007000535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026483835"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s1368980007000535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026483835"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2008.185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027534096",
"https://doi.org/10.1038/ijo.2008.185"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.27.2.491",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029482306"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-3476(97)70200-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029645201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1567-5769(01)00044-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033247622"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2169/internalmedicine.50.5877",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034587501"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.inf.0000168835.01233.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037230969"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.inf.0000168835.01233.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037230969"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.inf.0000168835.01233.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037230969"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.maturitas.2011.12.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038980953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-3038.1998.tb00376.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041399120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jaci.2003.07.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045339247"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0609.2008.01052.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045790374"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.68.892",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046011518"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0090-1229(90)90172-m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046862758"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/cdli.9.5.959-965.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052423423"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11745-001-0713-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052438827",
"https://doi.org/10.1007/s11745-001-0713-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1532/lh96.04010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067733951"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074475439",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074943209",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083208037",
"type": "CreativeWork"
}
],
"datePublished": "2015-08",
"datePublishedReg": "2015-08-01",
"description": "Percentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5-17.5 years, n\u2009=\u2009405, 48.9% boys), considering age, sex, puberty and body mass index (BMI). CD3(+) (mature T cells), CD4(+) (T helper), CD8(+) (T cytotoxic), CD16(+)56(+) (natural killer), CD19(+) (B cells), CD3(+)CD45RA(+), CD4(+)CD45RA(+), CD8(+)CD45RA(+) (na\u00efve), CD3(+)CD45RO(+), CD4(+)CD45RO(+) and CD8(+)CD45RO(+) (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) cell counts and CD3(+)/CD19(+) ratio, and lower CD3(+)CD45RA(+) and CD4(+)CD45RA(+) counts than boys. Age was associated with higher neutrophil counts and CD3(+)/CD19(+), and lower CD19(+) counts; in boys, with lower CD3(+)CD45RA(+), CD4(+)CD45RA(+) and CD8(+)CD45RA(+) counts as well; in girls, with higher WBC, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3(+)CD45RO(+) and CD4(+)CD45RO(+) values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4(+), CD3(+)CD45RO(+) and CD4(+)CD45RO(+) counts.\nCONCLUSION: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00431-015-2497-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017354",
"issn": [
"0340-6199",
"1432-1076"
],
"name": "European Journal of Pediatrics",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "174"
}
],
"name": "Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents\u2014the HELENA study",
"pagination": "999-1014",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b04e88b288b9ee3a68a8cc0f812766b748bc48bf0dfb56e33e4af0f253aa8438"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25665972"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7603873"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00431-015-2497-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1037010869"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00431-015-2497-5",
"https://app.dimensions.ai/details/publication/pub.1037010869"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T16:34",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000482.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00431-015-2497-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00431-015-2497-5'
This table displays all metadata directly associated to this object as RDF triples.
459 TRIPLES
21 PREDICATES
84 URIs
38 LITERALS
26 BLANK NODES