Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-04

AUTHORS

Ken Saida, Kenji Kawasaki, Kanae Hirabayashi, Yohei Akazawa, Seiko Kubota, Eriko Kasuga, Mai Kusakari, Takefumi Ishida, Masatomo Kitamura, Atsushi Baba, Kenichi Koike

ABSTRACT

Staphylococcal scalded skin syndrome (SSSS) demonstrates dermal symptoms due to exfoliative toxin (ET) A or ETB produced by Staphylococcus aureus. We examined the association between anti-ETA antibodies and SSSS onset in neonates. Three preterm infants carried an ETA-producing strain of S. aureus, manifesting as either SSSS or bullous impetigo; a full-term infant carrying the same strain was asymptomatic. The infants (n=106) were categorized into three groups according to their gestational age (GA) as follows: <30 weeks, 30-37 weeks, and >37 weeks. The measured levels of anti-ETA antibody in the three infants displaying SSSS were low before the onset of dermal symptoms; only the asymptomatic full-term infant displayed a high antibody level. Anti-ETA antibody levels in the preterm group with a GA of <30 weeks were statistically lower than those in the term infant group; the prevalences of anti-ETA antibodies above a cutoff value in the three groups of neonates were 55 % (18/33) among preterm infants with a GA <30 weeks, 73 % (25/34) among those with a GA of 30-37 weeks, and 90 % (35/39) among infants with a GA >37 weeks. CONCLUSION: The presence of anti-ETA antibodies below a particular cutoff level might be associated with SSSS onset in preterm infants. More... »

PAGES

551-555

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-014-2414-3

DOI

http://dx.doi.org/10.1007/s00431-014-2414-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051951228

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25194957


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